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Sam Neill expresses gratitude for modern medicine that extended his life

<p>Sam Neill was diagnosed with stage three angioimmunoblastic T-cell lymphoma - a form of blood cancer in 2022. He has since gone into remission and in his latest interview, expressed his deep gratitude for the medical advancements that have made his recovery possible. </p> <p>He underwent chemotherapy after his cancer diagnosis, but it stopped working after three months. He then switched his treatment to a rare anti-cancer drug which led him into remission. </p> <p>In his recent appearance on Kate Thornton’s <em>White Wine Question Time</em> podcast,  he expressed his gratitude and optimism, praising the "strides" that have been made in modern medicine over the past two decades. </p> <p>“I’m in remission and as you see, I’m hard at work and enjoying life immensely,” he said.</p> <p>“I’m very grateful for not just the wonderful care I’ve had from doctors and nurses and so on, but also the strides that have been made in treating these things in the last few years." </p> <p>He then shared insights into his current treatment and acknowledged that while it remains challenging, things are improving. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/DAInw1goPgF/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/DAInw1goPgF/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by White Wine Question Time (@whitewine_questiontime)</a></p> </div> </blockquote> <p>“If this had happened to me 20 years ago, I wouldn’t be around to talk to you," he said. </p> <p>“I go in [for treatment] once a month now. But it used to be three times a month and it’s down to once a month now.</p> <p>“You have sort three or four horrible days afterwards and then all is well and you cheer up and I go to the gym and all that.”</p> <p>Despite the advances in medicine, in a previous interview with <em>Australian Story</em>, he admitted that he's aware the drug won't continue working forever, saying:  “I’m prepared for that.” </p> <p> “I know I’ve got it, but I’m not really interested in it. It’s out of my control. If you can’t control it, don’t get into it," he added of his cancer. </p> <p><em>Image: Instagram</em></p>

Caring

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Got no COVID-19 symptoms? A gene mutation might be the reason

<div class="copy"> <p>A global study has unearthed a possible genetic reason why some people infected with the virus that causes COVID-19 show no symptoms.</p> <p>Human leukocyte antigens – or HLAs – are important genes that support immune function in the human body, particularly in identifying viral pathogens.</p> <p>And a particular variation in the HLA-B complex has been found to at least double the likelihood that a person infected with SARS-CoV-2 will be asymptomatic.</p> <p>For people who inherit a copy of the HLA-B15 variant from one parent, there was a 2.4 times greater chance of avoiding symptoms. Homozygous carriers — born with copies of the variant from each parent — were 8.5 times more likely to avoid symptoms.</p> <p>It’s a somewhat common variant among certain ethnicities – about 1 in 10 people with European ancestry are potential carriers – but having the gene is not a guaranteed protector against coronavirus symptoms.</p> <p>The findings, <a href="https://doi.org/10.1038/s41586-023-06331-x" target="_blank" rel="noreferrer noopener" data-type="URL" data-id="https://doi.org/10.1038/s41586-023-06331-x">published</a> in <em>Nature</em>, have emerged from a joint study between researchers at the University of California San Fransisco and Australian institutions including Latrobe University, Monash University and the QIMR Berghofer Centre.</p> <p>The research came about almost by accident.</p> <div class="in-content-area content-third content-right"> </div> <p>Co-lead authors Professor Stephanie Gras from Latrobe and Jill Hollenbach from UCSF first met at a research conference in May 2022 and pooled their resources to track the association of possible gene variations with COVID-19 symptoms.</p> <p>Their teams narrowed a group of 30,000 people with high-quality HLA data to a cohort of about 1,500 unvaccinated people who tested positive for the virus. They then focussed on five locations of interest in the HLA genes while monitoring the emergence of symptoms to determine which variants, if any, might have a greater linkage to being COVID asymptomatic.</p> <p>“The [SARS-CoV-2] virus gets inside cells and ‘presents’ some small part of the virus on the surface via the HLA molecule,” Gras explains.</p> <p>“Those act as a red flag for T cells. The cell sends the signal to the T cell that it has been infected with the virus, and the T cells get activated and kill that [infected] cell.</p> <p>“HLA-B15 can actually present a small part of the spike protein that is very similar between SARS-CoV-2 and seasonal coronaviruses… [that] circulate every year in the population and give us the common cold during winter most of the time. They share some similarities.”</p> <p>The understanding provides a possible application for future treatments. Now an association between the variant and asymptomatic cases has been identified, the Gras and Hollenbach teams have begun to study the interaction between HLA-B15 and the SARS-CoV-2 spike protein at the atomic level.</p> <p>That research is already underway, including at the Australian Synchrotron at the Australian Nuclear Science and Technology Organisation.</p> <p>“We’re doing atomic-level models of proteins to understand the interaction,” Gras says.</p> <p>“We want to compare the T cells within people who are asymptomatic with HLA-B15 and people who are not asymptomatic with HLA-B15. Actually, HLA-B15 is not a magic bullet, you can have it and still have severe COVID.”</p> <p><em>Image credits: Getty Images</em></p> </div> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/health/covid/got-no-covid-19-symptoms-a-gene-mutation-might-be-the-reason/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/matthew-agius">Matthew Ward Agius</a>. </em></p> </div>

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“Irwin genes are strong”: Bindi shares adorable candid snap

<p>Bindi Irwin has delighted fans after sharing a sweet snap of her two-year-old daughter, Grace Warrior cuddling a giant tortoise.</p> <p>The wildlife warrior took to Instagram to share the sweet snap with a comparison photo of herself hugging a giant tortoise when she was around Grace’s age.</p> <p>“Holding my newborn daughter wondering if she’ll love wildlife like I did” she captioned one of the photos in the Reel.</p> <p>The next two photos showed comparison photos of the mother-daughter duo which showed that the apple doesn’t fall far from the tree.</p> <p>“Our Grace Warrior, the Wildlife Warrior," she captioned the post.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Bindi Irwin (@bindisueirwin)</a></p> </div> </blockquote> <p>The adorable photo has been praised by fans who commented how proud Steve Irwin would be of his daughter and granddaughter.</p> <p>"It’s in the Irwin blood! You guys have the most beautiful connection with wildlife and each other! Steve Irwin genes are strong!” wrote one fan.</p> <p>"Your dad is probably so so proud looking down,” commented a second person.</p> <p>"This gives me happy goosebumps babe,” wrote a third.</p> <p><em>Images: Instagram</em></p>

Family & Pets

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KISS concert halted as Gene Simmons falls ill on stage

<p>KISS singer Gene Simmons gave fans - and bandmates - a fright when dehydration got the better of him live on stage, and the group were forced to bring their entire concert to a halt. </p> <p>In a video from the event, KISS’ Paul Stanley can be seen addressing the crowd, telling them that “we’re gonna have to stop to take care of him. Because we love him, right?”</p> <p>He goes on to call for a cheer for Simmons, with the 73-year-old catching his breath on a chair on stage - the same chair that he remained in for the rest of the show, after a five minute break to assure he was well enough to continue.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="pt">Gene Simmons, baixista e vocalista do Kiss, passa mal e show é brevemente interrompido na Arena da Amazônia. <a href="https://t.co/nphJEj1PQo">pic.twitter.com/nphJEj1PQo</a></p> <p>— A Crítica (@ACritica) <a href="https://twitter.com/ACritica/status/1646372105523478529?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And while fans were concerned for the singer, he later took to social media to assure them that he was “fine” and looking forward to the band’s next stadium performance. </p> <p>“I’m fine. Yesterday at Manaus Stadium in Brazil, [I] experienced weakness because of dehydration,” he explained. “We stopped for about five minutes, I drank some water, and then all was well. Nothing serious.”</p> <p>“Brazil is hotter than hell!!” one fan responded, “so glad you're okay and I can't wait to see you in São Paulo! Take care, god of thunder!!”</p> <p>“Even the God of Thunder needs hydration,” another agreed. “Good to hear you're doing well.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Hey everybody, thanks for the good wishes. I’m fine. Yesterday at Manaus Stadium in Brazil, experienced weakness because of dehydration. We stopped for about five minutes, I drank some water, and then all was well. Nothing serious. Tomorrow, Bogota Stadium. See you there!</p> <p>— Gene Simmons (@genesimmons) <a href="https://twitter.com/genesimmons/status/1646530305791266818?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And as news broke around the world of what had gone down in Brazil, Simmons returned with another round of assurances, writing that it was “not a big deal” while again thanking everyone for their well wishes. </p> <p>“Last night we played Amazon jungle Stadium/Brazil. Humidity and temperature were sky high. I was dehydrated and was forced to sit for a song,” he said. “We got back on stage in 5 minutes &amp; finished the show.”</p> <p>It was enough for his fans, who were quick to share their delight that their star was okay, as well as voicing their excitement for upcoming shows - with a good portion of requests for the singer to take care of himself, and avoid a repeat performance. </p> <p>“Happy to hear you're doing better,” one wrote. “Even more happy it wasn’t anything serious.Ya'll take care.”</p> <p>“Frankly, I don’t know [how] you do it every night. You’re amazing!” another declared. </p> <p>Meanwhile, some could see the humour in it all now that their fears had been put to rest, with one joking “and who says playing music couldn't be dangerous”.</p> <p><em>Images: Twitter</em></p>

Caring

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Super rare pic of unrecognisable Gene Hackman

<p>For the first time in a long time, legendary actor Gene Hackman has been spotted out and about at the age of 93.</p> <p>The icon had been reclusive in recent years, and these are the first photos of him snapped in a very long time. </p> <p>The <em>Superman</em> star still seemed fit and looked quite healthy in the snaps taken in Santa Fe, New Mexico. </p> <p>The retired actor was spotted enjoying a fast food lunch at a parking lot after going through the Wendy’s drive-thru. </p> <p>He is still sporting his signature moustache in the rare sighting. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">New photos of Hollywood Legend Gene Hackman have been released. He is currently 93-years-old. These are the first photos of him in years. <a href="https://t.co/5pn1wXN81w">pic.twitter.com/5pn1wXN81w</a></p> <p>— Daily Loud (@DailyLoud) <a href="https://twitter.com/DailyLoud/status/1633270131324223489?ref_src=twsrc%5Etfw">March 8, 2023</a></p></blockquote> <p>Hackman’s last movie role was with Ray Romano and Christine Baranski in the 2004 comedy <em>Welcome To Mooseport</em>. </p> <p>In July 2004, Hackman was interviewed by Larry King, where he announced there were no new film projects lined-up and believed his acting career was over.</p> <p>Years later, the star confirmed his retirement while promoting his third novel <em>Escape From Andersonville</em>, back in 2008.</p> <p>In an interview with CQ in 2011, he was asked if he would ever come out of retirement to do another film, and he responded, “If I could do it in my own house, maybe, without them disturbing anything and just one or two people.”</p> <p>CQ also asked him, “how do you want to be remembered?"</p> <p>“As someone who tried to portray what was given to them in an honest fashion. I don't know, beyond that. I don't think about that often, to be honest. I'm at an age where I should think about it.” He said with a laugh.</p> <p>Hackman has long been one of the most highly regarded film actors of all time, leading his Mississippi Burning director Alan Parker to state that “he is incapable of bad work. Every director has a shortlist of actors he’d die to work with, and I’ll bet Gene’s on every one.”</p> <p>The thespian really made waves when he was nominated for an Oscar for the Best Supporting Actor category for the 1970s film<em> I Never Sang For My Father</em>.</p> <p>A year later, he became a leading man in incredible fashion, winning the Academy Award for Best Actor in his New York City Detective Jimmy 'Popeye' Doyle in <em>The French Connection</em> (1971). </p> <p>Hackman’s career only went up from there, with countless awards under his belt, including two Oscars, two BAFTA awards and two Golden Globes.</p> <p><em>Image credit: Getty</em></p>

Movies

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Severe COVID-19 linked to signs of ageing in the brain

<p dir="ltr">COVID-19 infection has been associated with the same molecular changes seen in ageing brains, including higher levels of activity from genes associated with the ageing process.</p> <p dir="ltr">As we age, our brains shrink - with a five percent decline in weight per decade after the age of 40 - while our memory and levels of neurotransmitters like serotonin and dopamine decline.</p> <p dir="ltr">With previous research finding that people who are infected with Covid can experience neurological conditions after they recover, as well as declines in cognitive performance that mimic accelerated ageing, a team of researchers from Harvard Medical School examined the brain tissue of 54 deceased people, including 21 who had severe Covid infections.</p> <p dir="ltr">They found that changes in how genes were expressed in the brains of Covid-infected people were similar to what is seen in older brains.</p> <p dir="ltr">Using a particular kind of analysis called whole-transcriptome sequencing, the team were able to investigate which genes were being switched on and off in a person at the time of their death, comparing brain samples from people infected with Covid and those who hadn’t been infected (from before the pandemic).</p> <p dir="ltr">In comparison to the uninfected group, the Covid group showed higher levels of activity for genes associated with immunity. Meanwhile, genes linked to cognition, memory and the activity of synapses, which are essential for helping impulses travel through the nervous system, had lower levels of expression.</p> <p dir="ltr">"We also observed significant associations of cellular response to DNA damage, mitochondrial function, regulation of response to stress and oxidative stress, vesicular transport, calcium homeostasis, and insulin signalling/secretion pathways previously associated with ageing processes and brain ageing," they wrote.</p> <p dir="ltr">"Altogether, our analyses suggest that many biological pathways that change with natural ageing in the brain also change in severe COVID-19."</p> <p dir="ltr">Also investigating the trigger of these changes, they found increased levels of activity in several inflammatory pathways associated with ageing in the brain, and that specific immune cells influence the expression of several of these genes.</p> <p dir="ltr">This supports the hypothesis that the neurological symptoms that can accompany Covid are caused by inflammation triggered by the virus.</p> <p dir="ltr">But they also explored the other hypothesis, that the neurological symptoms are caused by the virus infiltrating and infecting the brain - specifically the frontal cortex - by looking to see whether there was evidence of Covid RNA (which contains the virus’ genetic material it needs to replicate).</p> <p dir="ltr">“In agreement with previous studies, SARS-CoV-2 viral RNA was not detected in samples from individuals with COVID-19, suggesting that the observed gene expression changes are unlikely due to the effects of the viral RNA in the frontal cortex,” they wrote.</p> <p dir="ltr">With these findings, the researchers concluded that managing Covid-induced inflammation could protect against the development of the neurological symptoms associated with Covid.</p> <p dir="ltr">They also argue that following up with patients recovering from Covid could be beneficial in reducing the risk or delaying the neurological symptoms and cognitive decline.</p> <p dir="ltr">Speaking to <em>Nature</em>, neuropathologist Marianna Bugiani, who wasn’t involved in the study, said that it’s still difficult to know whether these changes to gene expression are permanent or whether they are also seen in people experiencing mild bouts of Covid.</p> <p dir="ltr">“It opens a plethora of questions that are important, not only for understanding the disease, but to prepare society for what the consequences of the pandemic might be,” she said.</p> <p><span id="docs-internal-guid-df4fb67d-7fff-854d-6942-559608bd9c1f">“And these consequences might not be clear for years.”<br /></span></p> <p>The researchers published their findings in the journal <a href="https://doi.org/10.1038/s43587-022-00321-w" target="_blank" rel="noopener"><em>Nature Aging</em></a>.</p> <p><em>Image: Getty Images</em></p>

Mind

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Chris Hemsworth’s Alzheimer’s gene doesn’t guarantee he’ll develop dementia

<p>Chris Hemsworth, famous for his role as the god Thor in Marvel Cinematic Universe movies, has announced he will be <a href="https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk" target="_blank" rel="noopener">taking a break</a> from acting after being told he has two copies of the <a href="https://www.nia.nih.gov/news/study-reveals-how-apoe4-gene-may-increase-risk-dementia" target="_blank" rel="noopener">APOE4 gene</a>, increasing his risk of Alzheimer’s.</p> <p>Having one copy of the <a href="https://www.science.org/doi/abs/10.1126/science.8346443" target="_blank" rel="noopener">APOE4 gene</a> increases your risk for Alzheimer’s 2-3 times. Two copies increases your risk 10-15 times.</p> <p>But the key here is “risk”. Having one or more copies of the gene doesn’t guarantee Chris or anyone else in a similar situation will go on to develop Alzheimer’s, the most common form of dementia.</p> <p><strong>Sharing the news</strong></p> <p>Hemsworth’s willingness to share his concerns about developing Alzheimer’s with millions should be applauded. It’s a reminder to all of us to keep an eye on our health and reduce our risk of future illness.</p> <p>Alzheimer’s, and dementia more broadly, is <a href="https://www.dementiastatistics.org/statistics/global-prevalence/" target="_blank" rel="noopener">set to challenge</a> health-care systems worldwide.</p> <p>In Australia alone there are <a href="https://www.dementia.org.au/statistics" target="_blank" rel="noopener">up to</a> 500,000 people with dementia, supported by almost 1.6 million carers. By 2036, about <a href="https://www.dementia.org.au/sites/default/files/NATIONAL/documents/The-economic-cost-of-dementia-in-Australia-2016-to-2056.pdf" target="_blank" rel="noopener">450 people</a> are predicted to be diagnosed daily. So understanding how APOE4 alters the risk for the major cause of dementia may be pivotal in preventing cases.</p> <p>But not all people with the APOE4 gene go on to develop Alzheimer’s. This means that there may be a combination of environmental factors interplaying with the gene that lead some people to develop Alzheimer’s, while others do not.</p> <p><strong>What’s APOE4 got to do with Alzheimer’s?</strong></p> <p>Most Australians have APOE3 or APOE2 genes. In Caucasians it’s only <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531868/" target="_blank" rel="noopener">about 15%</a>, like Hemsworth, who have inherited an APOE4 gene.</p> <p>The APOE gene types are best known for their role in modulating the metabolism of lipids (fats), such as cholesterol and triglycerides.</p> <p>They code for synthesis of different versions of the protein APOE, with subtle differences in structure. The APOE proteins become an integral part of lipoproteins in the blood. These are the fat-carrying particles your GP measures to consider your risk of heart disease.</p> <p>APOE proteins have a similar function in the brain, to modulate lipid levels. But in the context of Alzheimer’s, researchers study it for its effect on the integrity of brain cells.</p> <p>Accumulating evidence <a href="https://www.sciencedirect.com/science/article/pii/S0197458022000550" target="_blank" rel="noopener">suggests</a> APOE4, is associated with brain inflammation and cellular damage.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">APOE4 is the strongest genetic risk factor for Alzheimer’s disease. A study in <a href="https://twitter.com/Nature?ref_src=twsrc%5Etfw">@Nature</a> establishes a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease. <a href="https://t.co/bNsmDVPfFW">https://t.co/bNsmDVPfFW</a> <a href="https://t.co/58odE1JASl">pic.twitter.com/58odE1JASl</a></p> <p>— Nature Portfolio (@NaturePortfolio) <a href="https://twitter.com/NaturePortfolio/status/1594762841487249410?ref_src=twsrc%5Etfw">November 21, 2022</a></p></blockquote> <p><strong>Can we prevent Alzheimer’s?</strong></p> <p><strong>1. Look after your capillaries</strong></p> <p>Damaged and leaky blood vessels (capillaries) in the brain lead to inflammation, the death of brain cells and cognitive impairment. In fact, in Alzheimer’s, damaged capillaries are the earliest sign of the type of brain damage that causes disease.</p> <p>The protein encoded by the APOE4 gene may be less able to support healthy capillaries in the brain. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0163782709000563" target="_blank" rel="noopener">We suggested</a> APOE4 increases the abundance of specific complexes of lipoproteins and proteins in blood that silently damage brain capillaries, causing them to leak.</p> <p>We also see more brain capillary leakage in mice fed Western-style diets richer in saturated fats.</p> <p>The relationship between how the APOE proteins mediate lipid metabolism and capillary health in humans is poorly understood.</p> <p>But we have 60 years of research knowledge to say with confidence that eating foods good for the heart should also be good for the brain. This is particularly relevant for people with the APOE4 gene.</p> <p>So if you have the APOE4 gene and want to minimise your risk of Alzheimer’s, a healthy diet is a good place to start.</p> <figure class="align-center zoomable"><em><a href="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=3 2262w" alt="Capillaries" /></a></em><figcaption><em><span class="caption">Looking after your capillaries with a healthy diet is a good place to start.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/system-many-small-capillaries-branch-out-1745173364" target="_blank" rel="noopener">Shutterstock</a></span></em></figcaption></figure> <p><strong>2. Give your brain a break</strong></p> <p>Reducing unnecessary stimuli to “give your brain a rest” may have big impact over decades of your life. The latter may be a more important consideration if you have the APOE4 gene.</p> <p>That’s because the APOE gene is also linked to how the brain uses energy, which may lead to more <a href="https://www.frontiersin.org/articles/10.3389/fnmol.2018.00216/full" target="_blank" rel="noopener">oxidative stress and damage</a>.</p> <p>While we’ve yet to collect robust data in humans, take a digital detox now and again, plan some down time, and avoid unnecessary stress if you can.</p> <p><strong>Should we test for the APOE4 gene?</strong></p> <p>Some people might be tempted to get tested for the APOE4 gene, especially if there’s a family history of Alzheimer’s.</p> <p>But unless genetic testing is going to change your treatment (for instance, by taking certain medications to slow progression of brain damage), or your behaviour to minimise your risk Alzheimer’s, then testing is not justified.</p> <p>We can’t change the genes our parents gifted us, but we can change our environment.</p> <p>Poor diet, every drop of alcohol you drink, obesity and diabetes, high blood pressure and sedentary behaviour <a href="https://www.dementia.org.au/risk-reduction" target="_blank" rel="noopener">all contribute, over time</a>, to poorer vascular health and increase your risk of dementia.</p> <p>We’re still learning about how these risk factors for Alzheimer’s interact with the APOE4 gene. But there is no reason we shouldn’t all take greater responsibility for minimising our risk of dementia now, whether we have the APOE4 gene or not.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195094/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em>Writen by John Mamo. Republished with permission from <a href="https://theconversation.com/chris-hemsworths-alzheimers-gene-doesnt-guarantee-hell-develop-dementia-heres-what-we-can-all-do-to-reduce-our-risk-195094" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Instagram</em></p>

Mind

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This new tech could spell end for mouse plagues

<p dir="ltr">Invasive mice populations could be a thing of the past, thanks to a new genetic tool developed by a team of Australian scientists.</p> <p dir="ltr">Researchers at the University of Adelaide have developed t-CRISPR, which uses gene editing technology to alter the fertility gene in laboratory mice to make females infertile.</p> <p dir="ltr">“This is the first time that a new genetic tool has been identified to suppress invasive mouse populations by inducing female infertility,” said lead researcher Professor Paul Thomas.</p> <p dir="ltr">“The t-CRISPR approach uses cutting-edge DNA editing technology to make alterations to a female fertility gene. Once the population is saturated with the genetic modification, all the females that are generated will be infertile.</p> <p dir="ltr">“We are also developing new versions of t-CRISPR technology that are designed to target specific pest populations to prevent unwanted spread of the gene drive.”</p> <p dir="ltr">The new tool is based on an existing technology, CRISPR-Cas9 gene editing, which has largely been applied to limiting the spread of malaria by making male mosquitoes infertile.</p> <p dir="ltr"><strong>CRISPR 101</strong></p> <p dir="ltr">Since it was unveiled in 2012, the CRISPR method has been used to edit pieces of DNA inside the cells of organisms, primarily insects.</p> <p dir="ltr">“Up until now, this technology has been aimed at insects to try and limit the spread of malaria, which causes up to 500,000 deaths worldwide per year,” Luke Gierus, a post-graduate student and the paper’s co-first author, said.</p> <p dir="ltr">The technology relies on the Cas9 protein found in bacteria, which scientists can program to find and bind to almost any 20-letter sequence of DNA in a gene with the help of a piece of RNA that matches the target DNA sequence.</p> <p dir="ltr">When it finds the target, standard CRISPR cuts the DNA, and the process of repairing the DNA introduces mutations that can disable the gene.</p> <p dir="ltr">Other variations of CRISPR can also replace faulty genes, turn genes on or off, or change one letter of the DNA code to another.</p> <p dir="ltr">In this study, the team simulated what would happen when an edited version of a fertility gene on chromosome 17, which affects the ability of sperm to swim, was introduced to populations of mice. </p> <p dir="ltr">Males who carry one copy of this gene are infertile, while females are still fertile but only have one functioning version of the gene and can pass on either the functioning or non-functioning version to their offspring.</p> <p dir="ltr">In females that had a second edited chromosome that affected their fertility, they found that male offspring would all be infertile, while only 50 percent of female offspring would be fertile.</p> <p dir="ltr">They found that 250 mice with modified genes could eradicate a population of 200,000 mice on an island in around 20 years.</p> <p dir="ltr">“The use of t-CRISPR technology provides a humane approach to controlling invasive mice without the release of toxins into the environment. We are also working on strategies to prevent failed eradication due to the emergence of gene drive resistance in the target population,” Gierus said.</p> <p dir="ltr">While t-CRISPR has been developed to specifically target mice, CSIRO Group Leader for Environmental Mitigation and Resilience Dr Owain Edwards said it could be developed to use on other invasive animals.</p> <p dir="ltr">The researchers, who collaborated with CSIRO, the Centre for Invasive Species Solutions, the Genetic Biocontrol for Invasive Rodents (GBIRd) consortium and the US Department of Agriculture, were supported by both the South Australian and NSW governments.</p> <p dir="ltr">“These promising findings demonstrate how gene drive technology may be a game changer in managing the impacts of mice on our environment, community, and agricultural sector,” South Australian Deputy Premier Dr Susan Close said.</p> <p dir="ltr">“This cutting-edge research also highlights the global leadership of the South Australian research sector, in finding solutions to social, environmental and economic challenges.</p> <p dir="ltr">“The South Australian Government is proud to have supported this proof-of-concept, having granted the University of Adelaide $1 million through the Research and Innovation Fund.”</p> <p dir="ltr">They published their findings in the journal <em><a href="https://doi.org/10.1073/pnas.2213308119" target="_blank" rel="noopener">Proceedings of the National Academy of Sciences</a></em>.</p> <p><span id="docs-internal-guid-bca82366-7fff-dcca-05a4-83502245beac"></span></p> <p dir="ltr"><em>Image: ABC News</em></p>

Family & Pets

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"I’m the problem, it’s me": Why do musicians revisit their pain and doubt in their art?

<p>Taylor Swift’s latest album <em>Midnights</em> launched with the single <em><a href="https://youtu.be/b1kbLwvqugk">Anti-Hero</a>.</em> Anti-heroes in fiction are dark, complex characters who may question their moral compass but are ultimately trying to be led by their good intentions. Perhaps most humans feel like we are all anti-heroes lacking the right amount of courage, idealism, and morality – wanting to be heroic but struggling through familiar dark places. </p> <p>In <em>Anti-Hero</em>, Taylor shares emotional rawness and sings “It’s me, hi, I’m the problem, it’s me … everybody agrees.”</p> <p>“I don’t think I’ve delved this far into my insecurities in this detail before,” Swift said about the song in a video <a href="https://ew.com/music/taylor-swift-midnights-anti-hero-meaning/">on Instagram</a>. “I struggle a lot with the idea that my life has become unmanageably sized and, not to sound too dark, I struggle with the idea of not feeling like a person.”</p> <p>Taylor’s album reveals her struggle with her own insecurities and maybe common universal human emotions that everyone struggles to face. In <em>Labyrinth</em>, for example, she sings about heartbreak, and more specifically, the fear of falling in love again: "It only feels this raw right now Lost in the labyrinth of my mind Break up, break free, break through, break down."</p> <p>Much of the new album, and Swift’s discography in general, often revisits past heartbreaks, disappointments, and insecurities. Swift has talked about how <em>Midnights</em> is an album devoted to the kinds of soul-searching thoughts we have in the middle of the night.</p> <p>“This is a collection of music written in the middle of the night, a journey through terrors and sweet dreams,” Swift wrote. “The floors we pace and the demons we face. For all of us who have tossed and turned and decided to keep the lanterns lit and go searching — hoping that just maybe, when the clock strikes twelve… we’ll meet ourselves.”</p> <h2>Music and pain</h2> <p>Music has the potential to change our experience of intrusive thoughts and how we deal with pain. At an extreme level, when we revisit past traumatic experiences, we are often in danger of triggering a <a href="https://www.verywellmind.com/the-four-fear-responses-fight-flight-freeze-and-fawn-5205083">feared response</a>, that manifests as either fight/flight/freeeze or fawn, that can often re-traumatise individuals. </p> <p>When we identify with a song that expresses similar struggles to what we are experiencing we feel understood and not judged. Clinical psychologist <a href="https://janinafisher.com/pdfs/trauma.pdf">Dr Janina Fisher</a> has proposed that distancing ourselves from pain helps humans survive, yet an ongoing “self-alientation” of parts of ourselves that carries fear or shame lead to a disowning of self – the bad parts that Taylor relates to as being the things she hates about herself which causes a further suppression of feelings that can create further psychological distress.</p> <p>Expression is central to releasing emotion and connecting to music may be the key that allows the disowned parts of self to be re-integrated by expressing them in a new way. Music provides a creative outlet to re-script a new story of survival of the fear of the past with a renewed ability to see to the good things again in life. </p> <p>Musicians often imbue grief and trauma in their lyrics and melodies as autobiographical reflections into their art as a way of working through complex emotions and feelings - and by doing so, enlighten the listener to work through their own pain.</p> <h2>Music and connection</h2> <p>Music seems to be a way for music lovers to connect with artists stories of tragedy, which allows their own traumatic or painful memories to become more comfortably <a href="https://link.springer.com/chapter/10.1007/978-1-4899-1280-0_2">integrated</a> and accepted. </p> <p>Durham University studied 2,436 people within the United Kingdom and Finland to explore the reasons why we listen to sad music. Research suggested that music is a way that people regulate their mood, pleasure and pain. Professor Tuomas Eerola, Professor of Music Cognition in the Department of Music said “<a href="https://www.sciencedaily.com/releases/2016/06/160614155914.htm">previous research</a> in music psychology and film studies has emphasised the puzzling pleasure that people experience when engaging with tragic art.” </p> <p>The depth of loathing that Taylor taps into in <em>Anti-Hero</em> also affirms our own experience.</p> <p>It’s self confirming. Engaging with trauma in art allows us to rewrite the outcome from being victims of our circumstances to victors. We are either consumers or creators. </p> <h2>Mental health and music</h2> <p>As the <a href="https://www.who.int/data/gho/data/major-themes/health-and-well-being">World Health Organisation</a> states “there is no health without mental health”. </p> <p>A musician’s writing about trauma is a way of increasing mental health - of searching for understanding of themselves through self-reflection, it changes old thinking patterns and provides a new perspective and ways of thinking about themselves and others that can often <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804629/">heal emotional wounds</a>.</p> <p>Like telling your story through a <a href="https://www.apa.org/ptsd-guideline/treatments/narrative-exposure-therapy">trauma narrative</a>, music can help reduce its emotional impact. Music is a universal language that gives you the chance to be a protagonist in your life story, to see yourself as living through it heroically. </p> <p>Psychologists understand that the quickest way to understanding someone is through their wounds, and musicians too understand this power of music to comfort, console, encourage and exhort themselves and other broken hearts. </p> <p>Humans need to feel safe and in connection with others for survival, and music is the language that activates <a href="https://www.pnas.org/doi/10.1073/pnas.191355898">pleasure centres in the brain</a> and communicates <a href="https://psycnet.apa.org/record/2003-99991-007">powerful emotions</a>. </p> <p>If trauma causes distress to the brain and body and <a href="https://www.apa.org/ptsd-guideline/treatments/narrative-exposure-therapy">music enhances</a> psychological wellbeing, improves mood, emotions, reduces pain, anxiety, depression, and chronic stress, music has the potential to alleviate chronic disease and pain. </p> <p>Music is a vehicle that gathers strength from distress, and helps you grow brave by reflections and maybe the anti-hero’s and insecurities recreated through music may be the treasures found in darkness that we may not have seen in the light.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/im-the-problem-its-me-why-do-musicians-revisit-their-pain-and-doubt-in-their-art-193528" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Music

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Whether in war-torn Ukraine, Laos or Spain, kids have felt compelled to pick up crayons and put their experiences to paper

<p>“They still draw pictures!”</p> <p>So wrote the editors of an influential collection of children’s art that was <a href="https://www.afsc.org/document/they-still-draw-pictures-1938">compiled in 1938</a> during <a href="https://theconversation.com/ukraines-foreign-fighters-have-little-in-common-with-those-who-signed-up-to-fight-in-the-spanish-civil-war-178976">the Spanish Civil War</a>. </p> <p>Eighty years later, war continues to upend children’s lives in Ukraine, Yemen and elsewhere. In January, UNICEF <a href="https://www.unicef.org/globalinsight/reports/prospects-children-2022-global-outlook">projected</a> that 177 million children worldwide would require assistance due to war and political instability in 2022. This included <a href="https://www.unicef.org/emergencies/yemen-crisis">12 million children in Yemen</a>, <a href="https://www.unicef.org/emergencies/syrian-crisis">6.5 million in Syria</a> and <a href="https://www.unicef.org/appeals/myanmar">5 million in Myanmar</a>.</p> <p>The Russian invasion of Ukraine in February 2022 added 7 million more children to this number. To date, more than half of Ukraine’s children <a href="https://www.unicef.org/emergencies/war-ukraine-pose-immediate-threat-children">have been internally or externally displaced</a>. Many more have faced disruptions to education, health care and home life.</p> <p>And yet they, too, still draw pictures. In March, a charity called <a href="https://www.uakids.today/en">UA Kids Today</a>launched, offering a digital platform for kids to respond with art to Russia’s invasion and raise money for aid to Ukrainian families with children.</p> <p><a href="https://scholar.google.com/citations?user=7bfZyk8AAAAJ&amp;hl=en">As a scholar who studies</a> the ways wars affect societies’ most vulnerable members, I see much that can be learned from the art created by kids living in war-torn regions across place and time.</p> <h2>A century of children’s art</h2> <p>During <a href="https://www.nam.ac.uk/explore/boer-war">the Boer War</a> – a conflict waged from 1899 to 1902 between British troops and South African guerrilla forces – relief workers sought to teach orphaned girls the art of <a href="https://blogs.bodleian.ox.ac.uk/archivesandmanuscripts/2017/08/24/the-archive-of-emily-hobhouse-now-available/">lace-making</a>. During World War I, displaced children in Greece and Turkey learned to weave textiles and decorate pottery <a href="https://neareastmuseum.com/2015/08/13/every-stitch-a-story-near-east-industries/">as a means of making a living</a>. </p> <p>Over time, expression has replaced subsistence as the driver of children’s wartime artwork. No longer pressed to sell their productions, children are instead urged to put their emotions and experiences on display for the world to see. </p> <p>Novelist <a href="https://www.neh.gov/humanities/2015/novemberdecember/feature/the-talented-mr-huxley">Aldous Huxley</a> hinted at this goal in his introduction to the 1938 collection of Spanish Civil War art. </p> <p>Whether showing “explosions, the panic rush to shelter, [or] the bodies of victims,” <a href="https://library.ucsd.edu/speccoll/tsdp/frame.html">Huxley wrote</a>, these drawings revealed “a power of expression that evokes our admiration for the childish artists and our horror at the elaborate bestiality of modern war.”</p> <p><a href="https://www.poetryfoundation.org/poets/herbert-read">Herbert Read</a>, a World War I veteran and educational theorist, organized another show of children’s art during World War II. Unlike Huxley, Read found that scenes of war did not dominate the drawings he collected from British schoolchildren, even those exposed to the London Blitz. In a pamphlet for the exhibition, he highlighted “the sense of beauty and the enjoyment of life which they have expressed.”</p> <p>While the shows discussed by Read and Huxley differed in many ways, both men emphasized the form and composition of children’s artwork as much as their pictorial contents. Both also expressed the view that the creators of these drawings would play a critical role in the rebuilding of their war-torn communities. </p> <h2>A political tool</h2> <p>As with the children’s war art made during Huxley and Read’s time, the images coming out of Ukraine express a mix of horror, fear, hope and beauty.</p> <p>While planes, rockets and explosions appear in many of the pictures uploaded by <a href="https://www.uakids.today/en">UA Kids Today</a>, so do flowers, angels, Easter bunnies and peace signs.</p> <p>The managers of this platform – who are refugees themselves – have not been able to mount a physical exhibition of these works. But artists and curators elsewhere are beginning to do so.</p> <p>In Sarasota, Florida, artist Wojtek Sawa <a href="https://www.fox13news.com/news/new-sarasota-exhibit-features-artwork-of-ukrainian-children-coping-with-war">has opened a show</a> of Ukrainian children’s art that will be used to collect donations and messages from visitors. These will later be distributed to displaced children in Poland.</p> <p><a href="https://warchildhood.org/">The War Childhood Museum</a>, based in Sarajevo, Bosnia-Herzegovina, had recently concluded traveling exhibitions in Kyiv and Kherson when the Russian invasion started. The museum’s managing director, who has <a href="https://apnews.com/article/russia-ukraine-war-crimes-schools-d1e52368aced8b3359f4436ca7180811">spoken</a> out strongly about the need for cultural heritage protection in war, was able to retrieve several dozen artifacts from these shows a few days before the fighting commenced. Those toys and drawings, which tell the story of children’s experience during Russia’s previous effort to gain control of the Donbas region in 2014, <a href="https://warchildhood.org/2022/02/24/updates-from-ukraine/">will be featured</a> in shows opening elsewhere in Europe in 2022.</p> <p>By capturing the attention of journalists and the public, these exhibitions have been used to raise awareness, solicit funds and inspire commentary.</p> <p>However, children’s art from Ukraine has not yet played a role in political deliberations, as it did when peace activist Fred Branfman shared his collection of drawings by Laotian children and adults <a href="https://www.nytimes.com/2014/10/07/us/fred-branfman-laos-activist-dies-at-72.html">during his 1971 testimony</a> before Congress on the “<a href="https://legaciesofwar.org/about-laos/secret-war-laos/">Secret War</a>” the U.S. had been conducting in Laos since 1964. </p> <p>Nor is it yet clear whether this art will play a part in future war crimes trials, as the art of Auschwitz-Birkenau internee Yahuda Bacon <a href="https://www.economist.com/books-and-arts/2020/01/25/for-child-survivors-drawing-is-therapy-and-a-tool-of-justice">did during</a> the 1961 trial of Adolf Eichmann.</p> <h2>Windows into different worlds</h2> <p>Art historians <a href="https://www.massey.ac.nz/%7Ealock/hbook/bremner.htm">once thought</a> children’s drawings, no matter where they lived, revealed the world in a way that was unshaped by cultural conventions. </p> <p>But I don’t believe that children in all countries and conflicts represent their experiences in the same way. The drawings of children imprisoned in Nazi concentration camps during World War II are not formally or symbolically interchangeable with drawings made by children exposed to America’s bombing campaign in Laos. Nor can these be interpreted in the same way as images produced by Ukrainian, Yemeni, Syrian or Sudanese children today.</p> <p>To me, one of the most valuable features of children’s art is its power to highlight unique aspects of everyday life in distant places, while conveying a sense of what can be upended, lost or destroyed. </p> <p>A Laotian child’s <a href="https://legaciesofwar.org/programs/national-traveling-exhibition/illustrations-narratives/">drawing</a> of a horse that “ran back to the village” from the rice field after its owner was killed by a bomb offers a small window into the lives of subsistence rice farmers. The desert landscapes and <a href="https://www.bloomberg.com/news/articles/2016-09-30/yemen-s-historic-tower-houses-are-under-threat">urban architecture</a> of Yemen are equally distinctive, and Yemeni children’s drawings highlight those differences even as they express aspirations that viewers around the world may share.</p> <h2>The challenges of preservation</h2> <p>As an academic who has also worked in museums, I am always thinking about how artifacts from today’s conflicts will be preserved for exhibition in the future.</p> <p>There are significant challenges to preserving the drawings and paintings young people produce. </p> <p>First, children’s art is materially unstable. It is often made on paper, with crayons, markers and other ephemeral media. This makes it dangerous to display originals and demands care in the production of facsimiles. </p> <p>Second, children’s art is often hard to contextualize. The first-person commentaries that accompanied some of the Spanish Civil War drawings and most of the Laotian images <a href="https://library.ucsd.edu/speccoll/tsdp/frame.html">often provide</a> details about children’s localized experience but rarely about the timing of events, geographic locations or other crucial facts. </p> <p>Finally, much children’s war art suffers from uncertain authorship. With few full names recorded, it is hard to trace the fates of most child artists, nor is it generally possible to gather their adult reflections on their childhood creations. </p> <p>By noting these complications, I don’t want to detract from the remarkable fact that children still draw pictures during war. Their expressions are invaluable for documenting war and its impact, and it’s important to study them.</p> <p>Nevertheless, in researching children’s art, it is necessary to reflect that scholars and curators are – like the child artists themselves – often working at the limits of their knowledge.</p> <p><em>Image credits: Instagram</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/whether-in-war-torn-ukraine-laos-or-spain-kids-have-felt-compelled-to-pick-up-crayons-and-put-their-experiences-to-paper-181458" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Art

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Excelling as a musician takes practice and requires opportunities – not just lucky genes

<p>What makes talented musicians so good at what they do?</p> <p>There’s plenty of evidence that people can be born that way. Research findings suggest that about <a href="https://doi.org/10.1136/jmg.2007.056366">half of musical ability is inherited</a>. Even if that’s true, it doesn’t mean you must have musical talent in your genes to excel on the bass, oboe or drums. </p> <p>And even if you’re fortunate enough to belong to a family that includes musicians, you would still need to study, practice and get expert guidance to play well. </p> <p>As a <a href="https://scholar.google.com/citations?user=34DZlUIAAAAJ&amp;hl=en&amp;oi=ao">music professor and conductor</a>, I’ve seen the role that practice and experience play in propelling musicians toward mastery and success. There are some factors that help a musician get started – and heredity could be one of them. But musical skill is ultimately a complex interplay between <a href="https://doi.org/10.1177%2F0022429416680096">lots of practice and high-quality instruction</a>.</p> <h2>The role genes can play</h2> <p>Of course many great musicians, including some who are world famous, are related to other musical stars.</p> <p>Liza Minnelli, the famed actress, singer and dancer, is one of the late entertainer <a href="https://hollywoodlife.com/feature/judy-garland-kids-4728886/">Judy Garland’s three children</a>. <a href="https://people.com/music/jon-batiste-everything-to-know">Jon Batiste</a> – “The Late Show” bandleader, pianist and composer who has won Emmy, Oscar and Golden Globe awards – has at least 25 musicians in his family. Saxophonist Branford, trumpeter Wynton, trombonist Delfeayo and drummer Jason Marsalis are the <a href="https://www.npr.org/sections/coronavirus-live-updates/2020/04/02/825717204/ellis-marsalis-patriarch-of-new-orleans-most-famous-musical-family-has-died">sons of pianist Ellis Marsalis</a>.</p> <p>Singer and pianist <a href="https://www.notablebiographies.com/news/Ge-La/Jones-Norah.html">Norah Jones</a> is the daughter of Indian sitar player <a href="https://www.vogue.in/culture-and-living/content/norah-jones-on-her-relationship-with-pandit-ravi-shankar-september-2020-cover-interview-hope">Ravi Shankar</a>, though Jones had little contact with her renowned father while growing up.</p> <p>Absolute pitch, also known as perfect pitch, is the ability to recognize and name any note you hear anywhere. Researchers have found that it <a href="https://doi.org/10.1086/301704">may be hereditary</a>. But do you need it to be a great musician? Not really.</p> <h2>Most people are born with some musical ability</h2> <p>I define musical ability as the possession of talent or potential – the means to achieve something musical.</p> <p>Then there’s skill, which I define as what you attain by working at it.</p> <p>You need at least some basic musical ability to acquire musical skills. Unless you can hear and discern pitches and rhythms, you can’t reproduce them.</p> <p>But people may overestimate the role of genetics because, with very rare exceptions, <a href="https://www.apa.org/monitor/feb05/absolute">almost everyone can perceive pitches</a> and rhythms.</p> <p>My research regarding children’s musicality suggests measures of singing skills are <a href="https://doi.org/10.1177/0022429416666054">normally distributed</a> in the population. That is, pitch ability follows a <a href="https://www.investopedia.com/terms/b/bell-curve.asp">bell curve</a>: Most people are average singers. Not many are way below average or excellent. </p> <p>My team’s most recent research suggests that this distribution is <a href="https://doi.org/10.1177/00224294211032160">true for rhythm</a> in addition to pitch. </p> <p>Not surprisingly, some musical skills are correlated.</p> <p>The more training you have on specific musical skills, the <a href="https://doi.org/10.1177/00224294211011962">better you’ll test on certain others</a>. This is probably because musical experience enhances other musical abilities.</p> <p>To sum it up, an emerging body of research indicates that practice doesn’t make perfect. But for most people, it helps a lot.</p> <h2>Lessons and practice are essential</h2> <p>What about people who say they they can’t keep a beat? It turns out that they almost always can track a steady beat to music. They just haven’t done it enough.</p> <p>Indeed, the last time I gave a nonbeliever our lab’s test for rhythm perception, she performed excellently. For that and for singing, some people just need <a href="https://www.nytimes.com/2020/01/21/magazine/how-to-sing-in-tune.html">a little help</a> to move past assumptions they lack talent: You can’t say you’re incapable of something if you haven’t spent time trying. </p> <p>Some researchers and <a href="https://strategiesforinfluence.com/malcolm-gladwell-10000-hour-rule/">journalists have promoted</a> the idea it takes <a href="https://doi.org/10.1037/0033-295X.100.3.363">10,000 hours of practice or training to master</a> a new skill. </p> <p>Innate ability puts people at different starting lines toward musical mastery. But once you’ve started to study an instrument or singing style, skill development depends on many other factors. Getting lessons, practicing often and being in a musical family may make those more likely.</p> <p>For example, Lizzo, a hip-hop superstar and classically trained flute player, had the luck to <a href="https://www.thefamouspeople.com/profiles/lizzo-44986.php">grow up in family of music lovers</a>. They all had their own taste in music. Her success is a microcosm of why a well-rounded musical education for young people matters.</p> <p>The singers in the choir I lead at Penn State have a range of experience, from a little to a lot. Yet soon after they join it, they develop the ability to <a href="https://doi.org/10.1177/87551233211040726">pick a good key and starting pitch</a> as they get to know their own voices. </p> <p>Practicing more doesn’t change your baseline potential, it just changes what you can presently do. That is, if you practice a specific song over and over again, eventually you’re going to get better at it.</p> <p>Jonathon Heyward, the Baltimore Symphony’s new conductor, who has <a href="https://www.nytimes.com/2022/07/21/arts/music/jonathon-heyward-baltimore-symphony-orchestra.html">no musicians in his family</a>, has worked really hard to excel. He started taking cello lessons at age 10 and hasn’t stopped since, playing and practicing and studying.</p> <h2>Privilege can play a role</h2> <p>Socioeconomic factors can also enter the equation. While conducting research, I’ve seen high-income college students from high-income families, with more years of musical experience, perform better than their classmates who have lower-income backgrounds and had fewer opportunities.</p> <p>Genes can give someone a head start. At the same time, having a quiet space where you can practice on an acoustic instrument or a digital workstation might make a more decisive difference for the musical prospects of most children. The same goes for having money for private lessons or access to free classes.</p> <p>Even so, many of the best musicians, including jazz greats <a href="https://www.louisarmstronghouse.org/biography/">Louis Armstrong</a> and <a href="https://www.pbs.org/wnet/americanmasters/billie-holiday-about-the-singer/68/">Billie Holiday</a>, grew up facing many hardships.</p> <p>With the right conditions for practice and gaining experience, who knows where the next Liza or Lizzo will come from.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/excelling-as-a-musician-takes-practice-and-requires-opportunities-not-just-lucky-genes-186693" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Music

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What your dog’s facial expressions really mean

<p><strong>This is what your dog’s body language really means</strong></p> <p>Whether they’re running and playing at the dog park or giving a warning growl, dogs seem like they’re pretty good at communicating with one another, but what do your dog’s facial expressions really mean? Over thousands of years of living with humans, dogs have developed a range of facial expressions, and they’ve become pretty good at communicating with us too.</p> <p>We have a way to go before dog-to-human interaction is fluent in both directions, but fortunately, there are experts out there who have dedicated their lives to figuring out dog body language and dog expressions. It turns out, there’s a big difference between how your dog talks to other dogs and how it talks to you. Some studies even show that dogs prefer happy human faces to angry ones, so maybe they really do know what we’re thinking!</p> <p><strong>Making eye contact</strong></p> <p>A perfect example of the dichotomy between dog-to-dog and dog-to-human facial expressions is eye contact. Between dogs, eye contact signals aggression, according to dog sitting site Wag. Between humans, eye contact is an integral part of communication. We reward eye contact from other humans as well as dogs. After humans domesticated them, dogs developed an array of facial expressions. They also acquired the ability to use their gaze to win approval from and show love for their humans.</p> <p><strong>Breaking eye contact</strong></p> <p>Understanding what your dog’s facial expressions really mean also involves knowing what it means when your pooch breaks eye contact. When dogs stare at each other, they’re engaging in a power struggle that won’t end until one or the other breaks the gaze – and a fight could break out. With humans, dogs are perfectly comfortable breaking eye contact, and in no way is it a prelude to trouble. Rather, it indicates a comfortable rapport between a dog and its person.</p> <p><strong>Blinking or squinting during eye contact</strong></p> <p>If a dog blinks while making eye contact with you, it may be contemplating what you’re thinking, according to veterinarian Danielle Bernal. This dog expression might show up if you’ve just given a command. The same is true of squinting during eye contact, says Michael Schoeff, the proprietor of Premier Pups. “I’d read it as a sign of appeasement,” he says. “And that’s a good thing. Your dog lives to appease his human.”</p> <p><strong>Squinting or blinking in general</strong></p> <p>You’ve probably wondered why your dog makes weird faces. It could be because something is wrong. Squinting and repetitive blinking can mean something entirely different when a dog is not looking into your eyes, Schoeff explains. Squinting can signal pain or illness, and rapid blinking can indicate stress or fear.</p> <p>Fun fact: When a dog opens its eyes wide at another dog, it can signal aggression.</p> <p><strong>Eyebrow-raising</strong></p> <p>When your dog raises one eyebrow – or both – while making eye contact, it’s a sign of alertness and interest, says Schoeff. Here’s an opportunity for you to engage with your pup, maybe teach it a new trick. Do dogs mimic facial expressions? Try giving them the old eyebrow wiggle and see what happens!</p> <p><strong>Avoiding eye contact</strong></p> <p>A dog who avoids eye contact is likely having trust issues. “Dogs are aware that eye contact with humans signals trust and comfort,” Schoeff explains. A dog that avoids eye contact with humans is doing his best to avoid any kind of interaction, whether negative or positive. This can be common in rescue dogs, especially those who have had a tough life before finding their forever homes.</p> <p><strong>Tilting its head</strong></p> <p>That adorable head tilt? It’s exactly what it looks like, according to Schoeff: It means your dog is curious.</p> <p><strong>Lowering its head</strong></p> <p>When your dog lowers or bows its head while gazing up at you, it’s an act of submission, explains Schoeff. It’s not all that different from blinking or squinting during eye contact.</p> <p><strong>Flattening its ears</strong></p> <p>Watch it: This isn’t a good sign. If you see a dog pulling both ears tight against his head, it could be a sign of aggression or of fear. Alternatively, it could be a sign your dog has an ear infection, says Schoeff.</p> <p><strong>Yawning</strong></p> <p>Yes, a yawn could indicate tiredness, Bernal says. But it can also be associated with moments of stress, so look for context clues to figure out what your dog’s facial expressions really mean.</p> <p><strong>Lip-licking</strong></p> <p>A dog that’s licking its lips can be communicating a desire to submit to its human, Bernal tells us. Or it could indicate anxiety or dehydration, depending on the context. If nothing anxiety-provoking is happening at the moment, consider it a positive form of doggie communication – and make sure your pal’s water bowl is full!</p> <p><strong>Smiling or grinning</strong></p> <p>Yes, dogs smile, although it doesn’t necessarily signify happiness, contentment or agreement. When a dog lifts its lips to show its canine teeth and incisors, it’s a sign of excitement, says Bernal. This makes sense when you consider that pups tend to smile while out on walks or romping with pals at the dog park. A grinning dog face could also be a sign of submissiveness, but that’s usually when a dog is signalling to other dogs, not humans.</p> <p><strong>Nose wrinkling</strong></p> <p>You don’t need a dog expressions’ chart or canine behavioural specialist to recognise when your dog’s smile is more of a snarl, says Bernal. When your dog pulls its lips up vertically to display its front teeth while also wrinkling its muzzle, it’s angry – especially when it raises its ears up and stares steadily. There’s a good chance a growl is coming, and you’ll need to de-escalate the situation.</p> <p><strong>Grimacing</strong></p> <p>In humans, we understand the difference between a smile and a grimace. The same applies to dogs. When your dog draws its lips back horizontally so that you can see all its teeth, it indicates discomfort or fear, Bernal explains. This becomes even more obvious when it’s accompanied by ear-flattening.</p> <p><strong>When in doubt, consider Fido’s body language</strong></p> <p>Doggy facial expressions should be read in context, says Russell Hartstein, a certified dog and cat behaviourist and trainer. For example, a smile might indicate fear or aggression if the dog’s ears are flat or it’s growling or whimpering. But a smile on a relaxed and wiggly dog signals that all is good.</p> <p><em><span id="docs-internal-guid-7c0ce358-7fff-9d25-2000-1adfb5f71082">Written by Lauren Cahn. This article first appeared in <a href="https://www.readersdigest.co.nz/food-home-garden/pets/what-your-dogs-facial-expressions-really-mean" target="_blank" rel="noopener">Reader’s Digest</a>. For more of what you love from the world’s best-loved magazine, <a href="http://readersdigest.innovations.co.nz/c/readersdigestemailsubscribe?utm_source=over60&amp;utm_medium=articles&amp;utm_campaign=RDSUB&amp;keycode=WRA87V" target="_blank" rel="noopener">here’s our best subscription offer.</a></span></em></p> <p><em>Image: Getty Images</em></p>

Family & Pets

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"Sometimes I don’t have the words for things": how we are using art to research stigma and marginalisation

<p>There’s growing recognition that creative pursuits like painting, singing or dancing can have a <a href="https://www.culturehealthandwellbeing.org.uk/appg-inquiry/Publications/Creative_Health_Inquiry_Report_2017_-_Second_Edition.pdf">positive impact</a> on physical and mental health, can <a href="https://www.artshealthresources.org.uk/docs/what-is-the-evidence-on-the-role-of-the-arts-in-improving-health-and-well-being-a-scoping-review/">lessen isolation</a>, and can increase connection to community. </p> <p>Creative activities can also be an <a href="https://files.eric.ed.gov/fulltext/EJ1245315.pdf">effective and safe way</a> to learn about people’s life experiences, especially those that are upsetting or hard to talk about. </p> <p>Our team <a href="https://theconversation.com/what-this-collaboration-between-artists-and-health-care-leaders-teaches-us-about-living-through-covid-19-167637">uses art as a research tool</a> to help increase understanding about mental health and well-being, and to build better systems of care and support. </p> <p>We are using art to learn about stigma and marginalisation as a result of mental distress, disability or a refugee background. We collaborated with 35 people who identify as women, who have told us that making art and being creative is a powerful tool for self-empowerment.</p> <h2>Giving voice to the unsaid</h2> <p>Women who experience <a href="https://theconversation.com/we-still-stigmatize-mental-illness-and-that-needs-to-stop-169518">mental illness</a>, <a href="https://throughmyeyes.photography/work">disability</a> or who have a <a href="https://theconversation.com/building-trust-with-migrant-and-refugee-communities-is-crucial-for-public-health-measures-to-work-167180">refugee background</a> routinely experience stigma and discrimination. </p> <p>This can have profound impacts, including reduced <a href="https://cdn.who.int/media/docs/default-source/mental-health/quality-rights/update-2020-infosheet-dignity-final-01.pdf?sfvrsn=49c243fd_4">quality of life</a>, <a href="https://theconversation.com/structural-stigma-against-mental-illness-is-baked-in-to-our-health-system-and-that-affects-care-153943">barriers</a> to accessing health care, reduced <a href="https://pure.bond.edu.au/ws/portalfiles/portal/38131068/Impacts_of_stigma_and_discrimination_in_the_workplace_on_people_living_with_psychosis.pdf">employment prospects</a>, reduced access to <a href="https://www.ssi.org.au/images/stories/documents/publications/Final-SSI-Report-Women-at-risk.pdf">affordable housing</a> and diminished opportunity to <a href="https://wwda.org.au/2019/12/position-paper-the-status-of-women-and-girls-with-disability-in-australia/">experience motherhood</a>. </p> <p>The experience of stigma and discrimination often remains invisible. It can be upsetting to talk about and hard to describe. Creative activities, like making art, can help bring these experiences to light. Art can offer a way to express things that are tricky to say out loud. </p> <p>As one participant in our study reflected, "Sometimes I don’t have the words for things … [art was] a really alternative way to express something without having to necessarily have the words for it."</p> <p>Art can act like a mnemonic (prompting memories and recollections), can help people feel relaxed and safe when exploring upsetting experiences, can help people feel in control of their own stories, and enables them to share these stories in ways they feel comfortable with.</p> <p>In <a href="https://pubmed.ncbi.nlm.nih.gov/32731565/">our research</a> we used a form of art creation called “body mapping”. </p> <p>Body mapping <a href="https://journals.library.ualberta.ca/ari/index.php/ari/article/view/29337">involves</a> tracing your body onto a large piece of paper or fabric and then decorating this outline by drawing, painting, sewing, collage and writing. </p> <p>The body maps that participants created are visually striking, and each one tells a unique life story. These body maps were used as a jumping-off point to discuss the themes and experiences they encompass.</p> <h2>Mapping stigma</h2> <p>Participants explored the way stigma exists on a spectrum, ranging from subtle (indifference or ignorance) to overt (bullying, verbal and physical abuse). One participant wrote the words “now let’s add stigma” to her map to represent the way stigma had made it hard and scary to seek medical support. </p> <p>When we spoke about her map, she told us, "I thought mental illness was like you’re locked away in a psych ward and left to die, that there is no help […] that’s what I got from social media and television."</p> <p>Another participant represented her body as a multicoloured jigsaw puzzle to symbolise the “many fragments and pieces that makes you, you”. The jigsaw also represented her experience of healthcare, with doctors only seeing one piece of her and not acknowledging or offering support for other pieces. </p> <p>As she reflected, "People with disabilities are people first and they too have mental health needs just like the rest of the world. And I think that for far too long this cohort of people have been overlooked and underrepresented."</p> <p>Stigma was often identified as the reason participants felt the need to hide their feelings or pretend they were not struggling. </p> <p>One participant drew two bodies on her map to represent this, "That is showing that you do work to the point of exhaustion everyday to make sure that you’re presenting in an appropriate way, but actually behind the scenes is what people don’t see."</p> <p>Participants also used maps to celebrate their strength, resilience and the positive influences in their lives like friends, family, pets and nature. Making art was a common positive influence.</p> <p>Participants saw art as an avenue for self-expression, meditation, relaxation and a way to process feelings. Participants also told us making art as part of the research project allowed them to take stock and reflect on their experiences.</p> <p>They also used the research as an opportunity to reach new artistic heights. As one participant reflected, "My body map is by far the greatest piece of art I have created."</p> <h2>The power of art</h2> <p>An important takeaway from this work is the power and importance of art in well-being, health and social inclusion. </p> <p>Participants remarked that they wished body mapping workshops, or other free creative activities, were regularly accessible. </p> <p>Having a safe, supportive space to be creative and share their experiences with others was affirming and therapeutic. Art was a powerful way to share stories, shine a light on injustice, and encourage empathy and respect for difference. </p> <p>A participant said it best when they remarked, "It’s empowering for everybody to have a voice [through art] and to be able to tell their story. That’s powerful."</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/sometimes-i-dont-have-the-words-for-things-how-we-are-using-art-to-research-stigma-and-marginalisation-183819" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Art

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Keeping to the beat controlled by 69 genes – not just our feet

<p class="spai-bg-prepared">Are you a dancing queen or do you have two left feet? Turns out that keeping to the beat is partly to do with our <a class="spai-bg-prepared" href="https://www.nature.com/articles/news.2007.359" target="_blank" rel="noreferrer noopener">genetics</a>.</p> <p class="spai-bg-prepared">An international team of researchers conducted a study on the genetic variation of 606,825 individuals, all of whom completed a musical ability questionnaire (including “Can you clap in time with a musical beat?”), with some also participating in beat synchronisation experiments including telling rhythms apart (Phenotype Experiment 1) and tapping in time with music (Phenotype Experiment 2).</p> <p class="spai-bg-prepared">Of the participants, 91.57% said yes to the question, “Can you clap in time with a musical beat?” Those who said yes also scored higher in the rhythm perception and tapping synchrony experiments.  </p> <p class="spai-bg-prepared">Looking at the genetic variation, 69 genes showed significant difference between the rhythmic and arhythmic participants, with <em class="spai-bg-prepared">VRK2 </em>being the most strongly associated. This gene has been linked previously to behavioural and psychiatric traits (including depression, schizophrenia and developmental delay), suggesting a biological link between beat synchronisation and neurodevelopment.</p> <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p195164-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> </div> </div> <p class="spai-bg-prepared">Several physiology traits also seemed to be linked to beat synchronisation, including processing speed, grid strength, usual walking pace, and peak respiratory flow. These may be linked to the evolution of language and sociality through music in early humans.</p> <p class="spai-bg-prepared">For modern humans, our ability to keep the beat may help to predict developmental speech-language disorders, and serve as a mechanism for <a class="spai-bg-prepared" href="https://www.frontiersin.org/articles/10.3389/fnhum.2021.789467/full" target="_blank" rel="noreferrer noopener">rhythm-based rehabilitation</a>, including for <a class="spai-bg-prepared" href="https://cosmosmagazine.com/science/biology/bilingual-patients-recover-better-from-stroke/" target="_blank" rel="noreferrer noopener">stroke</a> and <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41598-017-16232-5" target="_blank" rel="noreferrer noopener">Parkinson’s disease</a>.</p> <p class="spai-bg-prepared">This study has been <a class="spai-bg-prepared" href="https://doi.org/10.1038/s41562-022-01359-x" target="_blank" rel="noreferrer noopener">published</a> in <em class="spai-bg-prepared">Nature Human Behaviour</em>.</p> <figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio spai-bg-prepared"> <div class="wp-block-embed__wrapper spai-bg-prepared"> <div class="entry-content-asset spai-bg-prepared"> <div class="embed-wrapper spai-bg-prepared"> <div class="inner spai-bg-prepared"><iframe class="spai-bg-prepared" title="The Go-Go's - We Got The Beat (Official Music Video)" src="https://www.youtube.com/embed/f55KlPe81Yw?feature=oembed" width="500" height="281" frameborder="0" allowfullscreen="allowfullscreen"></iframe></div> </div> </div> </div> </figure> <p class="spai-bg-prepared">We got the beat… well maybe some of us!</p> <p><img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=195164&amp;title=Keeping+to+the+beat+controlled+by+69+genes+%E2%80%93+not+just+our+feet" width="1" height="1" /></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/science/biology/keeping-the-beat-genetics/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/qamariya-nasrullah" target="_blank" rel="noopener">Qamariya Nasrullah</a>. Qamariya Nasrullah holds a PhD in evolutionary development from Monash University and an Honours degree in palaeontology from Flinders University.</em></p> <p><em>Image: Getty Images</em></p> </div>

Body

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13 secrets your smile can reveal about you

<p><strong>You’re lying</strong></p> <p>A smile can have a hidden meaning for a crafty person. “There is a smile called the ‘Duping’ smile or ‘Dupper’s Delight’ which is typically a little smile that comes across the face when a liar or deal-maker or cheating-winner thinks they have duped someone,” explains body language expert, Patti Wood. Another tool to decipher a gloating smile is that the smile may be a mismatch for the other person or people you are with so they feel left out and less than, she says.</p> <p><strong>You’re full of joy</strong></p> <p>Wood describes a ‘laughing smile’ as when the mouth is open upper and lower teeth showing. This comfortable and inviting face exudes joy and sincerity. “The head is usually thrown back,” adds Wood.</p> <p><strong>You want to put people at ease</strong></p> <p>Everyone wants to be a smooth socialiser – which is why you may want to improve your social interaction skills. Smiling helps too: there is a lot of evidence of body language mirroring, according to an article in Psychology Today. “We automatically copy the facial expressions of others. We reciprocate and in social groups it can be contagious. People respond to, and evaluate, those who smile differently and more positively than those who do not.”</p> <p><strong>You’re hiding how you really feel</strong></p> <p>Smiles are often used to cover up another emotion. “For example, someone might start to frown then cover this with a smile,” says Jonathan Gratch, the director for virtual human research at the Institute for Creative Technologies. “The nature of a smile also communicates subtle information about its authenticity.” Another tell-tale sign is if a smile starts and ends too quickly – that is seen as not genuine, he says.</p> <p><strong>You’re nervous</strong></p> <p>“Smile controls” are a set of facial muscles that can be used to regulate the smile expression, says Gratch. “These include things like pressing your lips together or activating the muscles that pull down on the corners of the mouth. These muscles are under voluntary control,” he affirms.</p> <p><strong>You’re under pressure</strong></p> <p>Sometimes under pressure, we react in ways that are incongruent with the situation at hand. “A common example of this is laughing when you receive bad news, freezing when you are in danger, or making jokes when you are uncomfortable,” says family and marriage therapist, Shadeen Francis. “These incongruous responses are just a few of the brain’s many ways of managing overwhelming emotional circumstances. An unexplainable smile may also be a signal of distress, especially when others are around.” Some studies, Francis says, have demonstrated that when under intense social distress, smiling was more common than in less alarming or in non-social situations.</p> <p><strong>You feel superior</strong></p> <p>Ironically, a smile can express contempt, says an article in Women’s Health. “The result is a conscious disconnect between outward expression and inner feelings. Other times, the disconnect may be unconscious, the result of pushing aside negative feelings. A person may have heard as a child that enraged feelings should never be expressed, so even the slightest inkling of anger is covered with a smile,” cites the article.</p> <p><strong>You’re in love (or lust)</strong></p> <p>Can a smile reflect sexual passion or true love? According to the same Women’s Health piece, “Social psychologists believe that deep love and passionate sexual attraction elicit entirely different types of smiles.” The article also states that “the more two people are in love, the more they show genuine smiles in each other’s company, and on the flip side, people who report high levels of sexual desire – but not a whole lot of love – show fewer genuine smiles and a greater number of other lip actions. In short, genuine smiles communicate the desire to be close; lip movements convey passion.”</p> <p><strong>You’re letting off stress</strong></p> <p>Smiling reduces stress and can improve your outlook. Stress levels were especially low in those with genuine smiles. Even those who forced a smile during an unpleasant task seemed to have lower stress levels, according to a WebMD article.</p> <p><strong>You’re fertile</strong></p> <p>Research out of the University of Western Australia suggests that gum disease can interfere with a woman’s chances to become pregnant, according to <em>Medical News Today</em>.  Even more reason to floss and catch up on your regular cleanings – time to call your dentist.</p> <p><strong>You want to feel happy</strong></p> <p>Smiling offers some surprising health benefits, but did you know it can be a blues buster? Yes, we smile when things are going well, but it turns out you can use a smile to cheer yourself up, according to a study published in the journal <em>Psychological Science</em>. Researchers recorded volunteers’ moods as they tricked them into smiling, and the bigger the smile, the better the volunteers felt.</p> <p><strong>Your marriage is likely to last</strong></p> <p>This is a crazy one: researchers asked volunteers to rate the intensity of people’s smiles in photos on a scale of one to ten. Afterwards, they checked the likelihood that the people were in a solid marriage. Sure enough, the people with the strongest smiles were the least likely to be divorced, reports<em> LiveScience</em>.</p> <p><strong>You’re practising social graces</strong></p> <p>Smiling should be an essential part of all human encounters when face-to-face, says the WebMD post. But we even do it over the phone.</p> <p><em><span id="docs-internal-guid-dca7e95a-7fff-9006-7f3e-37edb5c0ed87">Written by Erica Lamberg. This article first appeared in <a href="https://www.readersdigest.com.au/culture/13-secrets-your-smile-can-reveal-about-you" target="_blank" rel="noopener">Reader’s Digest</a>. For more of what you love from the world’s best-loved magazine, <a href="http://readersdigest.innovations.com.au/c/readersdigestemailsubscribe?utm_source=over60&amp;utm_medium=articles&amp;utm_campaign=RDSUB&amp;keycode=WRA87V" target="_blank" rel="noopener">here’s our best subscription offer.</a></span></em></p> <p><em>Image: Getty Images</em></p>

Beauty & Style

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Willy Wonka fun facts

<p dir="ltr"><strong>*Willy Wonka Willy Wonka everybody give a cheer HOORAY*</strong></p> <p dir="ltr">Don’t pretend you did not sing that like the Oompa Loompa’s did because that is such a classic. </p> <p dir="ltr">Obviously the one with the late Gene Wilder, even though the one with Johnny Depp isn’t that bad either. </p> <p dir="ltr"><em>Willy Wonka and the Chocolate Factory</em> came out in 1971 and was based on the 1964 book <em>Charlie and the Chocolate Factory </em><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">by British author Roald Dahl</span><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">.</span></p> <p dir="ltr">To this very day it remains a classic to grandparents, parents and even kids who grew up watching it. </p> <p dir="ltr">We all secretly wished we could visit Willy Wonka’s factory and consume all the chocolate possible…just like Augustus Gloop wanted to. </p> <p dir="ltr">But did you know that Willy Wonka’s factory wasn’t actually a factory? Yes, the movie has some delicious facts despite being released 51 years ago. </p> <ol> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Wonka’s limping entrance was Gene Wilder’s idea</strong></p> </li> </ol> <p dir="ltr">The first time everyone finally meets Willy Wonka is when he is limping. This idea came to Gene Wilder who suggested it would be perfect to keep the crowd on its toes.</p> <p dir="ltr">The director questioned why he would want to do that to which Gene responded: “Because from that time on, no one will know if I’m lying or telling the truth.”</p> <ol start="2"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Almost everything was edible</strong></p> </li> </ol> <p dir="ltr">Remember when Willy Wonka said “everything in this room is edible except for me”? Well they weren’t lying because everything in the factory was edible.</p> <p dir="ltr">Except for that floral cup he would drink from which was actually made from wax. Gene would bite into it and continue biting until the shot was perfect.</p> <ol start="3"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Chocolate river not actually made out of chocolate</strong></p> </li> </ol> <p dir="ltr">Would’ve been a dream come true had that river actually been made out of chocolate. It was however filled with brown-coloured water which eventually stunk up the place.</p> <p dir="ltr">In the remake, thick, fake chocolate was actually used. </p> <ol start="4"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Charlie and Wonka were close in real life</strong></p> </li> </ol> <p dir="ltr">Peter Ostrum, the actor who played Charlie, said Wilder “treated people with respect and dignity.” </p> <p dir="ltr">He said Wilder would always buy a chocolate bar after lunch and share it with him. </p> <ol start="5"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Not a factory</strong></p> </li> </ol> <p dir="ltr">The movie was filmed in Germany and Willy Wonka’s “factory” was in fact a power plant. </p> <p dir="ltr">The director chose that place on purpose so viewers would not immediately pick up where the story was set. </p> <ol start="6"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Roald Dahl HATED it</strong></p> </li> </ol> <p dir="ltr">Author Roald Dahl actually hated the film and refused to grant the film rights to a sequel. </p> <p dir="ltr">It was only 15 years after he died that a remake was approved.</p> <p dir="ltr"><em>Image: Getty</em></p>

Movies

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Feel connected to nature? It might be in your genes

<div><div class="copy"><p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><p><em>Image credits: Getty Images</em></p><em><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --> <img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <!-- End of tracking content syndication --></em></div><div id="contributors"><p><em>This article was originally published on <a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Jamie Priest. </em></p></div></div>

Mind

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Feel connected to nature? It might be in your genes

<p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><div class="copy"><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><div class="newsletter-box"><div id="wpcf7-f6-p181148-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div></div><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /></div><div id="contributors"><p><em><a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/jamie-priest" target="_blank" rel="noopener">Jamie Priest</a>. Jamie Priest is a science journalist at Cosmos. She has a Bachelor of Science in Marine Biology from the University of Adelaide.</em></p><p><em>Image: Getty Images</em></p></div>

Body

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Some endangered species can no longer survive in the wild. So should we alter their genes?

<p>Around the world, populations of many beloved species are declining at increasing rates. According to one <a href="https://www.theguardian.com/environment/2020/sep/30/world-plant-species-risk-extinction-fungi-earth">grim projection</a>, as many as 40% of the world’s species may be extinct by 2050. Alarmingly, many of these declines are caused by threats for which few solutions exist.</p> <p>Numerous species now depend on conservation breeding programs for their survival. But these programs typically do not encourage species to adapt and survive in the wild alongside intractable threats such as climate change and disease.</p> <p>This means some species can no longer exist in the wild, which causes major downstream effects on the ecosystem. Consider, for example, how a coral reef would struggle to function without corals.</p> <p>What if there was another way? My colleagues and I have developed an intervention method that aims to give endangered species the genetic features they need to survive in the wild.</p> <p><img src="https://images.theconversation.com/files/411140/original/file-20210714-13-1bf7ccv.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="bleached coral with fish" /> <span class="caption">Genetically altering coral may help them survive in a warmer world.</span> <span class="attribution"><span class="source">Rick Stuart-Smith</span></span></p> <h2>Bringing theory into practice</h2> <p>Over generations, natural selection enables species to adapt to threats. But in many instances today, the speed at which threats are developing is outpacing species’ ability to adapt.</p> <p>This problem is especially apparent in wildlife threatened by newly emerging infectious diseases such as chytridiomycosis in amphibians, and in climate-affected species such as corals.</p> <p>The toolkit my colleagues and I developed is called “targeted genetic intervention” or TGI. It works by increasing the occurrence or frequency of genetic features that impact an organism’s fitness in the presence of the threat. We outline the method in a recent <a href="https://www.sciencedirect.com/science/article/abs/pii/S0169534721003384">research paper</a>.</p> <p>The toolkit involves <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/artificial-selection">artificial selection</a> and <a href="https://www.frontiersin.org/articles/10.3389/fbioe.2019.00175/full">synthetic biology</a>. These tools are well established in agriculture and medicine but relatively untested as conservation tools. We explain them in more detail below.</p> <p>Many tools in our TGI toolkit have been discussed in theory in conservation literature in recent decades. But rapid developments in genome sequencing and synthetic biology mean some are now possible in practice.</p> <p>The developments have made it easier to understand the genetic basis of features which enable a species to adapt, and to manipulate them.</p> <p><img src="https://images.theconversation.com/files/442166/original/file-20220124-19-xc82dx.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="frog on wet rock" /> <span class="caption">Some animal species cannot adapt in time to survive threats such as disease.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is artificial selection?</h2> <p>Humans have long used artificial (or phenotypic) selection to promote desirable characteristics in animals and plants raised for companionship or food. This genetic alteration has led to organisms, such as domestic dogs and maize, that are dramatically different from their wild progenitors.</p> <p>Traditional artificial selection can lead to outcomes, such as high inbreeding rates, that affect the health and resilience of the organism and are undesirable for conservation. If you’ve ever owned a purebred dog, you might be aware of some of these genetic disorders.</p> <p>And when it comes to conservation, determining which individuals from a species are resistant to, say, a deadly pathogen would involve exposing the animal to the threat – clearly not in the interests of species preservation.</p> <p>Scientists in the livestock industry have developed a new approach to circumvent these problems. Called genomic selection, it combines data from laboratory work (such as a disease trial) with the genetic information of the animals to predict which individuals bear genetic features conducive to adaptation.</p> <p>These individuals are then chosen for breeding. Over subsequent generations, a population’s ability to survive alongside pervasive threats increases.</p> <p>Genomic selection has led to disease-resistant salmon and livestock that produce more milk and better tolerate heat. But it is yet to be tested in conservation.</p> <p><img src="https://images.theconversation.com/files/442161/original/file-20220124-27-11vyq0z.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="cows in green field" /> <span class="caption">Artificial selection has been used to develop traits that humans desire in livestock.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is synthetic biology?</h2> <p><a href="https://www.genome.gov/about-genomics/policy-issues/Synthetic-Biology">Synthetic biology</a> is a toolkit for promoting change in organisms. It includes methods such as transgenesis and gene editing, which can be used to introduce lost or novel genes or tweak specific genetic features.</p> <p>Recent synthetic biology tools such as <a href="https://medlineplus.gov/genetics/understanding/genomicresearch/genomeediting/">CRISPR-Cas9</a> have created a buzz in the medical world, and are also starting to gain the <a href="https://portals.iucn.org/library/node/48408">attention</a> of conservation biologists.</p> <p>Such tools can accurately tweak targeted genetic features in an individual organism – making it more able to adapt – while leaving the rest of the genome untouched. The genetic modifications are then passed on to subsequent generations.</p> <p>The method reduces the likelihood of unintended genetic changes that can occur with artificial selection.</p> <p>Synthetic biology methods are currently being trialled for conservation in multiple species around the world. These include the <a href="https://www.esf.edu/chestnut/resistance.htm">chestnut tree</a> and black-footed <a href="https://neo.life/2021/05/cloning-wildlife-and-editing-their-genes-to-protect-them-and-us/">ferrets</a> in the United States, and <a href="https://theconversation.com/gene-editing-is-revealing-how-corals-respond-to-warming-waters-it-could-transform-how-we-manage-our-reefs-143444">corals</a> in Australia.</p> <p>I am working with researchers at the University of Melbourne to develop TGI approaches in Australian frogs. We are trialling these approaches in the iconic southern corroboree frog, and plan to extend them to other species if they prove effective.</p> <p>Worldwide, the disease chytridiomycosis is devastating frog populations. Caused by the fungal pathogen <em>Batrachochytrium dendrobatidis</em>, it has led to the extinction of about <a href="https://www.nationalgeographic.com/animals/article/amphibian-apocalypse-frogs-salamanders-worst-chytrid-fungus">90 frog species</a> and declines in as many as 500 others.</p> <p>Many frog species now rely on conservation breeding for their continued survival. No effective solution for restoring chytrid-susceptible frogs to the wild exists, because the fungus cannot be eradicated.</p> <p><img src="https://images.theconversation.com/files/442155/original/file-20220124-23-cebr8a.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="gloved hand removed portion of DNA strand" /> <span class="caption">CRISPR technology could potentially be used to edit the genes of endangered species.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>Looking ahead</h2> <p>As with many conservation approaches, targeted genetic intervention is likely to involve trade-offs. For example, genetic features that make a species resistant to one disease may make it more susceptible to another.</p> <p>But the rapid rate of species declines means we should trial such potential solutions before it’s too late. The longer species are absent from an ecosystem, the greater the chance of irreversible environmental changes.</p> <p>Any genetic intervention of this type should involve all stakeholders, including Indigenous peoples and local communities. And caution should be taken to ensure species are fit for release and pose no risk to the environment.</p> <p>By bringing the concept of TGI to the attention of the public, government, and other scientists, we hope we will spur discussion and encourage research on its risks and benefits.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/175226/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><span><a href="https://theconversation.com/profiles/tiffany-kosch-1304685">Tiffany Kosch</a>, Research Fellow, <em><a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em></span></p> <p>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/some-endangered-species-can-no-longer-survive-in-the-wild-so-should-we-alter-their-genes-175226">original article</a>.</p> <p><em>Image: Melbourne Zoo</em></p>

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Willy Wonka star reveals Gene Wilder’s “favourite brat”

<p><span>A child star who had the opportunity to work alongside the infamous Gene Wilder has spoken out on the experience, 50 years since its first premier date.</span><br /><br /><em>Charlie and the Chocolate Factory </em><span>hit movie screens 50 years ago on June 30, 1971 and achieved rapid success almost overnight.</span><br /><br /><span>The film went on to become a phenomenon that was registered in the United States National Film Registry by the Library of Congress for being deemed “culturally, historically or aesthetically significant”.</span><br /><br /><span>The child actors Peter Ostrum, Julie Dawn Cole, Michael Bollner, Paris Themmen and Denise Nickerson – who played Charlie Bucket, Veruca Salt, Augustus Gloop, Mike Teavee and Violet Beauregarde – all came together for a virtual reunion in honour of the film’s anniversary.</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842239/willy-wonka.jpg" alt="" data-udi="umb://media/b9da36eca8c24fbeb170655d6cf92150" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The actors all had the opportunity to co-star together, and even got to explore the imagined Wonka Chocolate Factory.</span><br /><br /><span>The cast recounted such fond memories of exploring the film sets in Bavarian Germany and working with Gene Wilder.</span><br /><br /><span>Themmen admitted that he was indeed a “notorious troublemaker on the set.”</span><br /><br /><span>So much so that even Wilder called him “a handful”.</span><br /><br /><span>“I can corroborate that,” the actor, who played the television-obsessed rascal Mike Teavee, admitted.</span><br /><br /><span>“I was younger than the others. I was 11, they were 13 and was naturally just sort of more high-spirited and rambunctious.”</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842237/willy-wonka-1.jpg" alt="" data-udi="umb://media/a8d501bcedd64f7b97dd573169a7717a" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The now-62-year-old opened up about one brief moment he shared with Wilder, in 1976 during a fundraiser screening for the film <em>Silver Streak</em> at the Avon Theatre in Stamford, Connecticut.</span><br /><br /><span>“I sat at the back of the room and he gave his commentary and then I went up to the front of the room afterwards with my poster in hand,” Themmen relived with a smile.</span><br /><br /><span>“I said, ‘Hi, Gene, how you doing? I’m Paris Themmen, I was Mike Teavee in Willy Wonka.”</span><br /><br /><span>“And he said, ‘Oh you were a brat!’ And I flashed all the way back 50 years, or 40 years at that time, and said, ‘Well, I’m 50-something now and maybe not as much of a brat.’</span><br /><br /><span>And he signed my poster, ‘To my favourite brat.’”</span><br /><br /><span>Wilder died in 2016 at the age of 83 after a long vibrant career.</span><br /><br /><span>Cole, who played Veruca Salt, said: “I think people kind of want us to tell you that he was like Willy Wonka offset, but he wasn’t.</span><br /><br /><span>“He was such a lovely, kind man, very unassuming,” she said.</span><br /><br /><span>“He was just down to earth, not pretentious, he was just a wonderful person to be around and to work with,” said Ostrum, who played Charlie Bucket.</span></p>

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