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Royal photographers weigh in on photo editing fiasco

<p>Royal photographers, brothers Zak and Samir Hussein have opened up about the realities of altering royal images - including what is and isn't allowed. </p> <p>"It's pretty clear what we're allowed to do – we're allowed to basically use darkroom techniques," Samir - who has also taken official portraits of members of the royal family - told <em>9Honey</em>. </p> <p>He then explained what darkroom techniques entail: "So what photographers in the days when they were shooting film used to do in the dark rooms.</p> <p>"We're pretty limited in what we can do, it's sort of a basic crop, maybe a bit of colour correcting and that's how we edit our photos basically.</p> <p>"Sometimes you look at picture and you think 'Oh, if I crop it like this, it will stand out more, this will be more impactful'. So it's usually, if I'm honest, when looking back at the picture that's taken, that's the first thing I look at – how can this be cropped to make it have the impact that it should really."</p> <p>Zak, who has taken many photos of Prince Harry and Meghan as well as other royal family members agreed and said that the photographers do their best to get the shot right to reduce the need for editing. </p> <p>"You try and get it right first time around when you're taking the picture," he told 9Honey. </p> <p>"Ideally, you don't want to have to do too much to the picture but yeah, it's very basic what we do.</p> <p>"I think cropping is really important because you're trying to find the best version of that picture, so if it means cropping in tighter to make it a nice portrait or keeping it wider to show more in what's going on in the event.</p> <p>"It's pretty basic what we do to the picture because it's all about when you take the picture, you're looking through the viewfinder [and] that's when you want to get it right."</p> <p>The topic of re-touching royal photos sensationally <a href="https://www.oversixty.com.au/lifestyle/family-pets/princess-kate-sensationally-speaks-out-over-photo-fiasco" target="_blank" rel="noopener">made headlines</a> over a manipulated image posted by Kate Middleton, and has now made its way back into the spotlight following the launch of the <a href="https://www.oversixty.com.au/entertainment/art/incredible-treasure-trove-of-unseen-royal-images" target="_blank" rel="noopener">new exhibition</a> at The King's Gallery exhibition in the Buckingham Palace.</p> <p>The exhibition which runs until October 6 has noted darkroom techniques including  cropping and framing out backgrounds or brightening up levels in a few of the negatives, including one label that read: "retouching is an essential part of photography.</p> <p>"Analogue retouching can occur at three stages: Modifying the negative, Manipulating the image during printing, direct retouching on the final print."</p> <p><em>Image: 9Honey/ </em><em>Royal Collection Trust / © His Majesty King Charles III 2024.</em></p>

Art

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Got no COVID-19 symptoms? A gene mutation might be the reason

<div class="copy"> <p>A global study has unearthed a possible genetic reason why some people infected with the virus that causes COVID-19 show no symptoms.</p> <p>Human leukocyte antigens – or HLAs – are important genes that support immune function in the human body, particularly in identifying viral pathogens.</p> <p>And a particular variation in the HLA-B complex has been found to at least double the likelihood that a person infected with SARS-CoV-2 will be asymptomatic.</p> <p>For people who inherit a copy of the HLA-B15 variant from one parent, there was a 2.4 times greater chance of avoiding symptoms. Homozygous carriers — born with copies of the variant from each parent — were 8.5 times more likely to avoid symptoms.</p> <p>It’s a somewhat common variant among certain ethnicities – about 1 in 10 people with European ancestry are potential carriers – but having the gene is not a guaranteed protector against coronavirus symptoms.</p> <p>The findings, <a href="https://doi.org/10.1038/s41586-023-06331-x" target="_blank" rel="noreferrer noopener" data-type="URL" data-id="https://doi.org/10.1038/s41586-023-06331-x">published</a> in <em>Nature</em>, have emerged from a joint study between researchers at the University of California San Fransisco and Australian institutions including Latrobe University, Monash University and the QIMR Berghofer Centre.</p> <p>The research came about almost by accident.</p> <div class="in-content-area content-third content-right"> </div> <p>Co-lead authors Professor Stephanie Gras from Latrobe and Jill Hollenbach from UCSF first met at a research conference in May 2022 and pooled their resources to track the association of possible gene variations with COVID-19 symptoms.</p> <p>Their teams narrowed a group of 30,000 people with high-quality HLA data to a cohort of about 1,500 unvaccinated people who tested positive for the virus. They then focussed on five locations of interest in the HLA genes while monitoring the emergence of symptoms to determine which variants, if any, might have a greater linkage to being COVID asymptomatic.</p> <p>“The [SARS-CoV-2] virus gets inside cells and ‘presents’ some small part of the virus on the surface via the HLA molecule,” Gras explains.</p> <p>“Those act as a red flag for T cells. The cell sends the signal to the T cell that it has been infected with the virus, and the T cells get activated and kill that [infected] cell.</p> <p>“HLA-B15 can actually present a small part of the spike protein that is very similar between SARS-CoV-2 and seasonal coronaviruses… [that] circulate every year in the population and give us the common cold during winter most of the time. They share some similarities.”</p> <p>The understanding provides a possible application for future treatments. Now an association between the variant and asymptomatic cases has been identified, the Gras and Hollenbach teams have begun to study the interaction between HLA-B15 and the SARS-CoV-2 spike protein at the atomic level.</p> <p>That research is already underway, including at the Australian Synchrotron at the Australian Nuclear Science and Technology Organisation.</p> <p>“We’re doing atomic-level models of proteins to understand the interaction,” Gras says.</p> <p>“We want to compare the T cells within people who are asymptomatic with HLA-B15 and people who are not asymptomatic with HLA-B15. Actually, HLA-B15 is not a magic bullet, you can have it and still have severe COVID.”</p> <p><em>Image credits: Getty Images</em></p> </div> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/health/covid/got-no-covid-19-symptoms-a-gene-mutation-might-be-the-reason/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/matthew-agius">Matthew Ward Agius</a>. </em></p> </div>

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“Irwin genes are strong”: Bindi shares adorable candid snap

<p>Bindi Irwin has delighted fans after sharing a sweet snap of her two-year-old daughter, Grace Warrior cuddling a giant tortoise.</p> <p>The wildlife warrior took to Instagram to share the sweet snap with a comparison photo of herself hugging a giant tortoise when she was around Grace’s age.</p> <p>“Holding my newborn daughter wondering if she’ll love wildlife like I did” she captioned one of the photos in the Reel.</p> <p>The next two photos showed comparison photos of the mother-daughter duo which showed that the apple doesn’t fall far from the tree.</p> <p>“Our Grace Warrior, the Wildlife Warrior," she captioned the post.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Bindi Irwin (@bindisueirwin)</a></p> </div> </blockquote> <p>The adorable photo has been praised by fans who commented how proud Steve Irwin would be of his daughter and granddaughter.</p> <p>"It’s in the Irwin blood! You guys have the most beautiful connection with wildlife and each other! Steve Irwin genes are strong!” wrote one fan.</p> <p>"Your dad is probably so so proud looking down,” commented a second person.</p> <p>"This gives me happy goosebumps babe,” wrote a third.</p> <p><em>Images: Instagram</em></p>

Family & Pets

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KISS concert halted as Gene Simmons falls ill on stage

<p>KISS singer Gene Simmons gave fans - and bandmates - a fright when dehydration got the better of him live on stage, and the group were forced to bring their entire concert to a halt. </p> <p>In a video from the event, KISS’ Paul Stanley can be seen addressing the crowd, telling them that “we’re gonna have to stop to take care of him. Because we love him, right?”</p> <p>He goes on to call for a cheer for Simmons, with the 73-year-old catching his breath on a chair on stage - the same chair that he remained in for the rest of the show, after a five minute break to assure he was well enough to continue.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="pt">Gene Simmons, baixista e vocalista do Kiss, passa mal e show é brevemente interrompido na Arena da Amazônia. <a href="https://t.co/nphJEj1PQo">pic.twitter.com/nphJEj1PQo</a></p> <p>— A Crítica (@ACritica) <a href="https://twitter.com/ACritica/status/1646372105523478529?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And while fans were concerned for the singer, he later took to social media to assure them that he was “fine” and looking forward to the band’s next stadium performance. </p> <p>“I’m fine. Yesterday at Manaus Stadium in Brazil, [I] experienced weakness because of dehydration,” he explained. “We stopped for about five minutes, I drank some water, and then all was well. Nothing serious.”</p> <p>“Brazil is hotter than hell!!” one fan responded, “so glad you're okay and I can't wait to see you in São Paulo! Take care, god of thunder!!”</p> <p>“Even the God of Thunder needs hydration,” another agreed. “Good to hear you're doing well.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Hey everybody, thanks for the good wishes. I’m fine. Yesterday at Manaus Stadium in Brazil, experienced weakness because of dehydration. We stopped for about five minutes, I drank some water, and then all was well. Nothing serious. Tomorrow, Bogota Stadium. See you there!</p> <p>— Gene Simmons (@genesimmons) <a href="https://twitter.com/genesimmons/status/1646530305791266818?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And as news broke around the world of what had gone down in Brazil, Simmons returned with another round of assurances, writing that it was “not a big deal” while again thanking everyone for their well wishes. </p> <p>“Last night we played Amazon jungle Stadium/Brazil. Humidity and temperature were sky high. I was dehydrated and was forced to sit for a song,” he said. “We got back on stage in 5 minutes &amp; finished the show.”</p> <p>It was enough for his fans, who were quick to share their delight that their star was okay, as well as voicing their excitement for upcoming shows - with a good portion of requests for the singer to take care of himself, and avoid a repeat performance. </p> <p>“Happy to hear you're doing better,” one wrote. “Even more happy it wasn’t anything serious.Ya'll take care.”</p> <p>“Frankly, I don’t know [how] you do it every night. You’re amazing!” another declared. </p> <p>Meanwhile, some could see the humour in it all now that their fears had been put to rest, with one joking “and who says playing music couldn't be dangerous”.</p> <p><em>Images: Twitter</em></p>

Caring

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Super rare pic of unrecognisable Gene Hackman

<p>For the first time in a long time, legendary actor Gene Hackman has been spotted out and about at the age of 93.</p> <p>The icon had been reclusive in recent years, and these are the first photos of him snapped in a very long time. </p> <p>The <em>Superman</em> star still seemed fit and looked quite healthy in the snaps taken in Santa Fe, New Mexico. </p> <p>The retired actor was spotted enjoying a fast food lunch at a parking lot after going through the Wendy’s drive-thru. </p> <p>He is still sporting his signature moustache in the rare sighting. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">New photos of Hollywood Legend Gene Hackman have been released. He is currently 93-years-old. These are the first photos of him in years. <a href="https://t.co/5pn1wXN81w">pic.twitter.com/5pn1wXN81w</a></p> <p>— Daily Loud (@DailyLoud) <a href="https://twitter.com/DailyLoud/status/1633270131324223489?ref_src=twsrc%5Etfw">March 8, 2023</a></p></blockquote> <p>Hackman’s last movie role was with Ray Romano and Christine Baranski in the 2004 comedy <em>Welcome To Mooseport</em>. </p> <p>In July 2004, Hackman was interviewed by Larry King, where he announced there were no new film projects lined-up and believed his acting career was over.</p> <p>Years later, the star confirmed his retirement while promoting his third novel <em>Escape From Andersonville</em>, back in 2008.</p> <p>In an interview with CQ in 2011, he was asked if he would ever come out of retirement to do another film, and he responded, “If I could do it in my own house, maybe, without them disturbing anything and just one or two people.”</p> <p>CQ also asked him, “how do you want to be remembered?"</p> <p>“As someone who tried to portray what was given to them in an honest fashion. I don't know, beyond that. I don't think about that often, to be honest. I'm at an age where I should think about it.” He said with a laugh.</p> <p>Hackman has long been one of the most highly regarded film actors of all time, leading his Mississippi Burning director Alan Parker to state that “he is incapable of bad work. Every director has a shortlist of actors he’d die to work with, and I’ll bet Gene’s on every one.”</p> <p>The thespian really made waves when he was nominated for an Oscar for the Best Supporting Actor category for the 1970s film<em> I Never Sang For My Father</em>.</p> <p>A year later, he became a leading man in incredible fashion, winning the Academy Award for Best Actor in his New York City Detective Jimmy 'Popeye' Doyle in <em>The French Connection</em> (1971). </p> <p>Hackman’s career only went up from there, with countless awards under his belt, including two Oscars, two BAFTA awards and two Golden Globes.</p> <p><em>Image credit: Getty</em></p>

Movies

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Queen Elizabeth’s 21st birthday speech edited in Harry and Meghan doco

<p dir="ltr">Prince Harry and Meghan Markle’s new documentary has edited the Queen’s 21st birthday speech to give it a completely new meaning.</p> <p dir="ltr">The first three episodes of the Sussexes new documentary <em>Harry and Meghan</em> have now aired on Netflix.</p> <p dir="ltr">And now voice coach Susie Ashfield has pointed out that in the first episode, the Queen's speech – in which she says “whole life whether it be long or short shall be devoted to your service and to the service of our great Imperial family to which we all belong” – is included.</p> <p dir="ltr">Then she takes viewers to episode three, in which the Queen’s speech has been edited, giving it a completely new meaning.</p> <p dir="ltr">“I declare before you all that my whole life whether it be long or short shall be devoted to the service of our great Imperial family to which we all belong.”</p> <p dir="ltr">She shared another video showing glaring edits of the late Monarch titled: “The Queen Vs Netflix. Spot the difference…”.</p> <p dir="ltr">“I wasn't going to say anything about the Harry and Meghan Netflix documentary because it's nothing to do with me,” she said.</p> <p>"I'm a communications coach. I help people make speeches."</p> <p dir="ltr" style="font-size: 16px; box-sizing: inherit; margin: 0px 0px 5px; padding: 0px; border: 0px; vertical-align: baseline; color: #323338; font-family: Roboto, Rubik, 'Noto Kufi Arabic', 'Noto Sans JP', sans-serif; background-color: #ffffff; outline: none !important;"> </p> <div class="embed" style="font-size: 16px; box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; vertical-align: baseline; outline: none !important;"><iframe class="embedly-embed" style="box-sizing: inherit; margin: 0px; padding: 0px; border-width: 0px; border-style: initial; vertical-align: baseline; width: 619px; max-width: 100%; outline: none !important;" title="tiktok embed" src="https://cdn.embedly.com/widgets/media.html?src=https%3A%2F%2Fwww.tiktok.com%2Fembed%2Fv2%2F7176949431789505798&amp;display_name=tiktok&amp;url=https%3A%2F%2Fwww.tiktok.com%2F%40royal_family_2022%2Fvideo%2F7176949431789505798%3Fis_copy_url%3D1%26is_from_webapp%3Dv1%26q%3DSusie%2520Ashfield%2520%26t%3D1671075706777&amp;image=https%3A%2F%2Fp16-sign-va.tiktokcdn.com%2Fobj%2Ftos-maliva-p-0068%2F76ca61686cde4add87422c08f0ebf380_1671013766%3Fx-expires%3D1671094800%26x-signature%3Da9QorsOB83kO1sfr6MVMnQwclsE%253D&amp;key=5b465a7e134d4f09b4e6901220de11f0&amp;type=text%2Fhtml&amp;schema=tiktok" width="340" height="700" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen"></iframe></div> <p> </p> <p dir="ltr">“But I really like speeches, which is why when somebody told me about some potential editing that might have happened on the Queen's 21st birthday speech. I had to check it out.</p> <p dir="ltr">“So let's play a game together. Spot the difference,” she said, before showing part of the Queen's unedited speech.</p> <p dir="ltr">“I should like to make that dedication now, it is very simple,” Queen Elizabeth II is heard saying.</p> <p dir="ltr">“I declare before you all that my whole life, whether it be long or short, shall be devoted to your service, and to the service of our great Imperial family to which we all belong.”</p> <p dir="ltr">Susie then points out: “That was the original, unedited copy and the transcript reads the same. Now let's look at Harry and Meghan's version."</p> <p dir="ltr">The Queen’s voice is then heard saying: “I declare before you all that my whole life whether it be long or short shall be devoted to the service of our great Imperial family to which we all belong.</p> <p dir="ltr">“Did you hear the difference?" asks Susie. "And did you notice how just removing a few words changes the meaning of the statement entirely?"</p> <p dir="ltr">The words 'to your service and' were edited out of the Queen's speech.</p> <p dir="ltr">“I don't know what the lesson to learn is here, but I suppose if you are going to be speaking and it will be recorded there is a chance you will get misquoted, your words might get taken out of context or in this case some part might be removed to change the meaning of the statement itself.</p> <p dir="ltr">“So try not to let that happen to you. And if it does happen to you, remember there will be some people out there who might notice.”</p> <p dir="ltr"><em>Images: TikTok/Getty</em></p>

TV

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Toni Collette forced to edit statement announcing divorce

<p dir="ltr">Toni Collette has edited her statement announcing her divorce from husband David Galafassi after explosive images of him kissing another woman surfaced.</p> <p dir="ltr">The Aussie actress, 50, took to Instagram to confirm that she and husband Galafassi, 44, have broken up after photos emerged of him making out with another woman.</p> <p dir="ltr">However, just a few days later, Collette was forced to edit her statement to explain that she and Galafassi had been separated for a “substantial period”.</p> <p dir="ltr">Her new statement reads: “After a substantial period of separation, it is with grace and gratitude that we announce we are divorcing.</p> <p dir="ltr">“We’re united in our decision and part with continuing respect and care for each other.</p> <p dir="ltr">“Our kids are of paramount importance to us and we will continue to thrive as a family, albeit a different shape.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/Cl3-GTgBYtF/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cl3-GTgBYtF/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by TONI COLLETTE (@toni_collette_official)</a></p> </div> </blockquote> <p dir="ltr">“We’re thankful for the space and love you grant us as we evolve and move through this transition peacefully.</p> <p dir="ltr">“Big thanks.”</p> <p dir="ltr">Collette’s shock statement came less than 24 hours after the paparazzi images were published in the Daily Mail.</p> <p dir="ltr">The pair share two children together, aged 14 and 11, and split their time between Australia and the United States.</p> <p dir="ltr">They first met back in 2002 at the launch of Galafassi’s band Gelbison's debut album Metal Detector in Sydney.</p> <p dir="ltr">They ran into each other again a few days later and Collette said “he was the first person I saw when I walked in the door”.</p> <p dir="ltr">“He kissed me on the cheek and I just kind of melted. I planned to stay for ten minutes… I was there for 12 hours. It was a good day,” she said at the time.</p> <p dir="ltr"><em>Images: Getty</em></p>

Relationships

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Severe COVID-19 linked to signs of ageing in the brain

<p dir="ltr">COVID-19 infection has been associated with the same molecular changes seen in ageing brains, including higher levels of activity from genes associated with the ageing process.</p> <p dir="ltr">As we age, our brains shrink - with a five percent decline in weight per decade after the age of 40 - while our memory and levels of neurotransmitters like serotonin and dopamine decline.</p> <p dir="ltr">With previous research finding that people who are infected with Covid can experience neurological conditions after they recover, as well as declines in cognitive performance that mimic accelerated ageing, a team of researchers from Harvard Medical School examined the brain tissue of 54 deceased people, including 21 who had severe Covid infections.</p> <p dir="ltr">They found that changes in how genes were expressed in the brains of Covid-infected people were similar to what is seen in older brains.</p> <p dir="ltr">Using a particular kind of analysis called whole-transcriptome sequencing, the team were able to investigate which genes were being switched on and off in a person at the time of their death, comparing brain samples from people infected with Covid and those who hadn’t been infected (from before the pandemic).</p> <p dir="ltr">In comparison to the uninfected group, the Covid group showed higher levels of activity for genes associated with immunity. Meanwhile, genes linked to cognition, memory and the activity of synapses, which are essential for helping impulses travel through the nervous system, had lower levels of expression.</p> <p dir="ltr">"We also observed significant associations of cellular response to DNA damage, mitochondrial function, regulation of response to stress and oxidative stress, vesicular transport, calcium homeostasis, and insulin signalling/secretion pathways previously associated with ageing processes and brain ageing," they wrote.</p> <p dir="ltr">"Altogether, our analyses suggest that many biological pathways that change with natural ageing in the brain also change in severe COVID-19."</p> <p dir="ltr">Also investigating the trigger of these changes, they found increased levels of activity in several inflammatory pathways associated with ageing in the brain, and that specific immune cells influence the expression of several of these genes.</p> <p dir="ltr">This supports the hypothesis that the neurological symptoms that can accompany Covid are caused by inflammation triggered by the virus.</p> <p dir="ltr">But they also explored the other hypothesis, that the neurological symptoms are caused by the virus infiltrating and infecting the brain - specifically the frontal cortex - by looking to see whether there was evidence of Covid RNA (which contains the virus’ genetic material it needs to replicate).</p> <p dir="ltr">“In agreement with previous studies, SARS-CoV-2 viral RNA was not detected in samples from individuals with COVID-19, suggesting that the observed gene expression changes are unlikely due to the effects of the viral RNA in the frontal cortex,” they wrote.</p> <p dir="ltr">With these findings, the researchers concluded that managing Covid-induced inflammation could protect against the development of the neurological symptoms associated with Covid.</p> <p dir="ltr">They also argue that following up with patients recovering from Covid could be beneficial in reducing the risk or delaying the neurological symptoms and cognitive decline.</p> <p dir="ltr">Speaking to <em>Nature</em>, neuropathologist Marianna Bugiani, who wasn’t involved in the study, said that it’s still difficult to know whether these changes to gene expression are permanent or whether they are also seen in people experiencing mild bouts of Covid.</p> <p dir="ltr">“It opens a plethora of questions that are important, not only for understanding the disease, but to prepare society for what the consequences of the pandemic might be,” she said.</p> <p><span id="docs-internal-guid-df4fb67d-7fff-854d-6942-559608bd9c1f">“And these consequences might not be clear for years.”<br /></span></p> <p>The researchers published their findings in the journal <a href="https://doi.org/10.1038/s43587-022-00321-w" target="_blank" rel="noopener"><em>Nature Aging</em></a>.</p> <p><em>Image: Getty Images</em></p>

Mind

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Chris Hemsworth’s Alzheimer’s gene doesn’t guarantee he’ll develop dementia

<p>Chris Hemsworth, famous for his role as the god Thor in Marvel Cinematic Universe movies, has announced he will be <a href="https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk" target="_blank" rel="noopener">taking a break</a> from acting after being told he has two copies of the <a href="https://www.nia.nih.gov/news/study-reveals-how-apoe4-gene-may-increase-risk-dementia" target="_blank" rel="noopener">APOE4 gene</a>, increasing his risk of Alzheimer’s.</p> <p>Having one copy of the <a href="https://www.science.org/doi/abs/10.1126/science.8346443" target="_blank" rel="noopener">APOE4 gene</a> increases your risk for Alzheimer’s 2-3 times. Two copies increases your risk 10-15 times.</p> <p>But the key here is “risk”. Having one or more copies of the gene doesn’t guarantee Chris or anyone else in a similar situation will go on to develop Alzheimer’s, the most common form of dementia.</p> <p><strong>Sharing the news</strong></p> <p>Hemsworth’s willingness to share his concerns about developing Alzheimer’s with millions should be applauded. It’s a reminder to all of us to keep an eye on our health and reduce our risk of future illness.</p> <p>Alzheimer’s, and dementia more broadly, is <a href="https://www.dementiastatistics.org/statistics/global-prevalence/" target="_blank" rel="noopener">set to challenge</a> health-care systems worldwide.</p> <p>In Australia alone there are <a href="https://www.dementia.org.au/statistics" target="_blank" rel="noopener">up to</a> 500,000 people with dementia, supported by almost 1.6 million carers. By 2036, about <a href="https://www.dementia.org.au/sites/default/files/NATIONAL/documents/The-economic-cost-of-dementia-in-Australia-2016-to-2056.pdf" target="_blank" rel="noopener">450 people</a> are predicted to be diagnosed daily. So understanding how APOE4 alters the risk for the major cause of dementia may be pivotal in preventing cases.</p> <p>But not all people with the APOE4 gene go on to develop Alzheimer’s. This means that there may be a combination of environmental factors interplaying with the gene that lead some people to develop Alzheimer’s, while others do not.</p> <p><strong>What’s APOE4 got to do with Alzheimer’s?</strong></p> <p>Most Australians have APOE3 or APOE2 genes. In Caucasians it’s only <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531868/" target="_blank" rel="noopener">about 15%</a>, like Hemsworth, who have inherited an APOE4 gene.</p> <p>The APOE gene types are best known for their role in modulating the metabolism of lipids (fats), such as cholesterol and triglycerides.</p> <p>They code for synthesis of different versions of the protein APOE, with subtle differences in structure. The APOE proteins become an integral part of lipoproteins in the blood. These are the fat-carrying particles your GP measures to consider your risk of heart disease.</p> <p>APOE proteins have a similar function in the brain, to modulate lipid levels. But in the context of Alzheimer’s, researchers study it for its effect on the integrity of brain cells.</p> <p>Accumulating evidence <a href="https://www.sciencedirect.com/science/article/pii/S0197458022000550" target="_blank" rel="noopener">suggests</a> APOE4, is associated with brain inflammation and cellular damage.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">APOE4 is the strongest genetic risk factor for Alzheimer’s disease. A study in <a href="https://twitter.com/Nature?ref_src=twsrc%5Etfw">@Nature</a> establishes a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease. <a href="https://t.co/bNsmDVPfFW">https://t.co/bNsmDVPfFW</a> <a href="https://t.co/58odE1JASl">pic.twitter.com/58odE1JASl</a></p> <p>— Nature Portfolio (@NaturePortfolio) <a href="https://twitter.com/NaturePortfolio/status/1594762841487249410?ref_src=twsrc%5Etfw">November 21, 2022</a></p></blockquote> <p><strong>Can we prevent Alzheimer’s?</strong></p> <p><strong>1. Look after your capillaries</strong></p> <p>Damaged and leaky blood vessels (capillaries) in the brain lead to inflammation, the death of brain cells and cognitive impairment. In fact, in Alzheimer’s, damaged capillaries are the earliest sign of the type of brain damage that causes disease.</p> <p>The protein encoded by the APOE4 gene may be less able to support healthy capillaries in the brain. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0163782709000563" target="_blank" rel="noopener">We suggested</a> APOE4 increases the abundance of specific complexes of lipoproteins and proteins in blood that silently damage brain capillaries, causing them to leak.</p> <p>We also see more brain capillary leakage in mice fed Western-style diets richer in saturated fats.</p> <p>The relationship between how the APOE proteins mediate lipid metabolism and capillary health in humans is poorly understood.</p> <p>But we have 60 years of research knowledge to say with confidence that eating foods good for the heart should also be good for the brain. This is particularly relevant for people with the APOE4 gene.</p> <p>So if you have the APOE4 gene and want to minimise your risk of Alzheimer’s, a healthy diet is a good place to start.</p> <figure class="align-center zoomable"><em><a href="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=3 2262w" alt="Capillaries" /></a></em><figcaption><em><span class="caption">Looking after your capillaries with a healthy diet is a good place to start.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/system-many-small-capillaries-branch-out-1745173364" target="_blank" rel="noopener">Shutterstock</a></span></em></figcaption></figure> <p><strong>2. Give your brain a break</strong></p> <p>Reducing unnecessary stimuli to “give your brain a rest” may have big impact over decades of your life. The latter may be a more important consideration if you have the APOE4 gene.</p> <p>That’s because the APOE gene is also linked to how the brain uses energy, which may lead to more <a href="https://www.frontiersin.org/articles/10.3389/fnmol.2018.00216/full" target="_blank" rel="noopener">oxidative stress and damage</a>.</p> <p>While we’ve yet to collect robust data in humans, take a digital detox now and again, plan some down time, and avoid unnecessary stress if you can.</p> <p><strong>Should we test for the APOE4 gene?</strong></p> <p>Some people might be tempted to get tested for the APOE4 gene, especially if there’s a family history of Alzheimer’s.</p> <p>But unless genetic testing is going to change your treatment (for instance, by taking certain medications to slow progression of brain damage), or your behaviour to minimise your risk Alzheimer’s, then testing is not justified.</p> <p>We can’t change the genes our parents gifted us, but we can change our environment.</p> <p>Poor diet, every drop of alcohol you drink, obesity and diabetes, high blood pressure and sedentary behaviour <a href="https://www.dementia.org.au/risk-reduction" target="_blank" rel="noopener">all contribute, over time</a>, to poorer vascular health and increase your risk of dementia.</p> <p>We’re still learning about how these risk factors for Alzheimer’s interact with the APOE4 gene. But there is no reason we shouldn’t all take greater responsibility for minimising our risk of dementia now, whether we have the APOE4 gene or not.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195094/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em>Writen by John Mamo. Republished with permission from <a href="https://theconversation.com/chris-hemsworths-alzheimers-gene-doesnt-guarantee-hell-develop-dementia-heres-what-we-can-all-do-to-reduce-our-risk-195094" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Instagram</em></p>

Mind

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This new tech could spell end for mouse plagues

<p dir="ltr">Invasive mice populations could be a thing of the past, thanks to a new genetic tool developed by a team of Australian scientists.</p> <p dir="ltr">Researchers at the University of Adelaide have developed t-CRISPR, which uses gene editing technology to alter the fertility gene in laboratory mice to make females infertile.</p> <p dir="ltr">“This is the first time that a new genetic tool has been identified to suppress invasive mouse populations by inducing female infertility,” said lead researcher Professor Paul Thomas.</p> <p dir="ltr">“The t-CRISPR approach uses cutting-edge DNA editing technology to make alterations to a female fertility gene. Once the population is saturated with the genetic modification, all the females that are generated will be infertile.</p> <p dir="ltr">“We are also developing new versions of t-CRISPR technology that are designed to target specific pest populations to prevent unwanted spread of the gene drive.”</p> <p dir="ltr">The new tool is based on an existing technology, CRISPR-Cas9 gene editing, which has largely been applied to limiting the spread of malaria by making male mosquitoes infertile.</p> <p dir="ltr"><strong>CRISPR 101</strong></p> <p dir="ltr">Since it was unveiled in 2012, the CRISPR method has been used to edit pieces of DNA inside the cells of organisms, primarily insects.</p> <p dir="ltr">“Up until now, this technology has been aimed at insects to try and limit the spread of malaria, which causes up to 500,000 deaths worldwide per year,” Luke Gierus, a post-graduate student and the paper’s co-first author, said.</p> <p dir="ltr">The technology relies on the Cas9 protein found in bacteria, which scientists can program to find and bind to almost any 20-letter sequence of DNA in a gene with the help of a piece of RNA that matches the target DNA sequence.</p> <p dir="ltr">When it finds the target, standard CRISPR cuts the DNA, and the process of repairing the DNA introduces mutations that can disable the gene.</p> <p dir="ltr">Other variations of CRISPR can also replace faulty genes, turn genes on or off, or change one letter of the DNA code to another.</p> <p dir="ltr">In this study, the team simulated what would happen when an edited version of a fertility gene on chromosome 17, which affects the ability of sperm to swim, was introduced to populations of mice. </p> <p dir="ltr">Males who carry one copy of this gene are infertile, while females are still fertile but only have one functioning version of the gene and can pass on either the functioning or non-functioning version to their offspring.</p> <p dir="ltr">In females that had a second edited chromosome that affected their fertility, they found that male offspring would all be infertile, while only 50 percent of female offspring would be fertile.</p> <p dir="ltr">They found that 250 mice with modified genes could eradicate a population of 200,000 mice on an island in around 20 years.</p> <p dir="ltr">“The use of t-CRISPR technology provides a humane approach to controlling invasive mice without the release of toxins into the environment. We are also working on strategies to prevent failed eradication due to the emergence of gene drive resistance in the target population,” Gierus said.</p> <p dir="ltr">While t-CRISPR has been developed to specifically target mice, CSIRO Group Leader for Environmental Mitigation and Resilience Dr Owain Edwards said it could be developed to use on other invasive animals.</p> <p dir="ltr">The researchers, who collaborated with CSIRO, the Centre for Invasive Species Solutions, the Genetic Biocontrol for Invasive Rodents (GBIRd) consortium and the US Department of Agriculture, were supported by both the South Australian and NSW governments.</p> <p dir="ltr">“These promising findings demonstrate how gene drive technology may be a game changer in managing the impacts of mice on our environment, community, and agricultural sector,” South Australian Deputy Premier Dr Susan Close said.</p> <p dir="ltr">“This cutting-edge research also highlights the global leadership of the South Australian research sector, in finding solutions to social, environmental and economic challenges.</p> <p dir="ltr">“The South Australian Government is proud to have supported this proof-of-concept, having granted the University of Adelaide $1 million through the Research and Innovation Fund.”</p> <p dir="ltr">They published their findings in the journal <em><a href="https://doi.org/10.1073/pnas.2213308119" target="_blank" rel="noopener">Proceedings of the National Academy of Sciences</a></em>.</p> <p><span id="docs-internal-guid-bca82366-7fff-dcca-05a4-83502245beac"></span></p> <p dir="ltr"><em>Image: ABC News</em></p>

Family & Pets

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Tabloid slammed for bizarre photoshop edit of Kate Middleton

<p>British publication The Mirror appears to have edited a photo of Kate Middleton to the point where she is almost unrecognisable.</p> <p>The popular UK-based tabloid covered a story about the Royal Family attending a Remembrance Day service at the Cenotaph in London recently.</p> <p>Joining Kate Middleton at the event were King Charles III, Queen Consort Camilla, Prince William and the Princess of Wales. Despite the attendance of the other royals, the outlet still chose to use a sombre photo of Catherine on the front page.</p> <p>The tabloid was then widely called out for the bizarre photoshop edit of that image. A very confused audience took to social media, calling out the publication for the rough photoshop hatchet job of the Princess.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">When i saw an image of kate doing rounds on Twitter, i thought it was photoshoped. This morning I went to my local co-op and took this pic of todays <a href="https://twitter.com/hashtag/DailyMirror?src=hash&amp;ref_src=twsrc%5Etfw">#DailyMirror</a>. Surely <a href="https://twitter.com/hashtag/KateMiddleton?src=hash&amp;ref_src=twsrc%5Etfw">#KateMiddleton</a> doesn’t look like this? <a href="https://t.co/kysKlr27zt">pic.twitter.com/kysKlr27zt</a></p> <p>— HK (@hasifah23) <a href="https://twitter.com/hasifah23/status/1592082881781805056?ref_src=twsrc%5Etfw">November 14, 2022</a></p></blockquote> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">What in the ever loving god did they do to Princess Catherine’s picture? How disgusting to photoshop the photo in this way! <a href="https://t.co/ziMhSnVy2h">pic.twitter.com/ziMhSnVy2h</a></p> <p>— Royal Tea With Brittany (@brittanygadoury) <a href="https://twitter.com/brittanygadoury/status/1591962064050098176?ref_src=twsrc%5Etfw">November 14, 2022</a></p></blockquote> <p>Both The Royal Family or The Mirror are yet to comment.</p> <p><em>Images: Twitter</em></p>

Beauty & Style

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Excelling as a musician takes practice and requires opportunities – not just lucky genes

<p>What makes talented musicians so good at what they do?</p> <p>There’s plenty of evidence that people can be born that way. Research findings suggest that about <a href="https://doi.org/10.1136/jmg.2007.056366">half of musical ability is inherited</a>. Even if that’s true, it doesn’t mean you must have musical talent in your genes to excel on the bass, oboe or drums. </p> <p>And even if you’re fortunate enough to belong to a family that includes musicians, you would still need to study, practice and get expert guidance to play well. </p> <p>As a <a href="https://scholar.google.com/citations?user=34DZlUIAAAAJ&amp;hl=en&amp;oi=ao">music professor and conductor</a>, I’ve seen the role that practice and experience play in propelling musicians toward mastery and success. There are some factors that help a musician get started – and heredity could be one of them. But musical skill is ultimately a complex interplay between <a href="https://doi.org/10.1177%2F0022429416680096">lots of practice and high-quality instruction</a>.</p> <h2>The role genes can play</h2> <p>Of course many great musicians, including some who are world famous, are related to other musical stars.</p> <p>Liza Minnelli, the famed actress, singer and dancer, is one of the late entertainer <a href="https://hollywoodlife.com/feature/judy-garland-kids-4728886/">Judy Garland’s three children</a>. <a href="https://people.com/music/jon-batiste-everything-to-know">Jon Batiste</a> – “The Late Show” bandleader, pianist and composer who has won Emmy, Oscar and Golden Globe awards – has at least 25 musicians in his family. Saxophonist Branford, trumpeter Wynton, trombonist Delfeayo and drummer Jason Marsalis are the <a href="https://www.npr.org/sections/coronavirus-live-updates/2020/04/02/825717204/ellis-marsalis-patriarch-of-new-orleans-most-famous-musical-family-has-died">sons of pianist Ellis Marsalis</a>.</p> <p>Singer and pianist <a href="https://www.notablebiographies.com/news/Ge-La/Jones-Norah.html">Norah Jones</a> is the daughter of Indian sitar player <a href="https://www.vogue.in/culture-and-living/content/norah-jones-on-her-relationship-with-pandit-ravi-shankar-september-2020-cover-interview-hope">Ravi Shankar</a>, though Jones had little contact with her renowned father while growing up.</p> <p>Absolute pitch, also known as perfect pitch, is the ability to recognize and name any note you hear anywhere. Researchers have found that it <a href="https://doi.org/10.1086/301704">may be hereditary</a>. But do you need it to be a great musician? Not really.</p> <h2>Most people are born with some musical ability</h2> <p>I define musical ability as the possession of talent or potential – the means to achieve something musical.</p> <p>Then there’s skill, which I define as what you attain by working at it.</p> <p>You need at least some basic musical ability to acquire musical skills. Unless you can hear and discern pitches and rhythms, you can’t reproduce them.</p> <p>But people may overestimate the role of genetics because, with very rare exceptions, <a href="https://www.apa.org/monitor/feb05/absolute">almost everyone can perceive pitches</a> and rhythms.</p> <p>My research regarding children’s musicality suggests measures of singing skills are <a href="https://doi.org/10.1177/0022429416666054">normally distributed</a> in the population. That is, pitch ability follows a <a href="https://www.investopedia.com/terms/b/bell-curve.asp">bell curve</a>: Most people are average singers. Not many are way below average or excellent. </p> <p>My team’s most recent research suggests that this distribution is <a href="https://doi.org/10.1177/00224294211032160">true for rhythm</a> in addition to pitch. </p> <p>Not surprisingly, some musical skills are correlated.</p> <p>The more training you have on specific musical skills, the <a href="https://doi.org/10.1177/00224294211011962">better you’ll test on certain others</a>. This is probably because musical experience enhances other musical abilities.</p> <p>To sum it up, an emerging body of research indicates that practice doesn’t make perfect. But for most people, it helps a lot.</p> <h2>Lessons and practice are essential</h2> <p>What about people who say they they can’t keep a beat? It turns out that they almost always can track a steady beat to music. They just haven’t done it enough.</p> <p>Indeed, the last time I gave a nonbeliever our lab’s test for rhythm perception, she performed excellently. For that and for singing, some people just need <a href="https://www.nytimes.com/2020/01/21/magazine/how-to-sing-in-tune.html">a little help</a> to move past assumptions they lack talent: You can’t say you’re incapable of something if you haven’t spent time trying. </p> <p>Some researchers and <a href="https://strategiesforinfluence.com/malcolm-gladwell-10000-hour-rule/">journalists have promoted</a> the idea it takes <a href="https://doi.org/10.1037/0033-295X.100.3.363">10,000 hours of practice or training to master</a> a new skill. </p> <p>Innate ability puts people at different starting lines toward musical mastery. But once you’ve started to study an instrument or singing style, skill development depends on many other factors. Getting lessons, practicing often and being in a musical family may make those more likely.</p> <p>For example, Lizzo, a hip-hop superstar and classically trained flute player, had the luck to <a href="https://www.thefamouspeople.com/profiles/lizzo-44986.php">grow up in family of music lovers</a>. They all had their own taste in music. Her success is a microcosm of why a well-rounded musical education for young people matters.</p> <p>The singers in the choir I lead at Penn State have a range of experience, from a little to a lot. Yet soon after they join it, they develop the ability to <a href="https://doi.org/10.1177/87551233211040726">pick a good key and starting pitch</a> as they get to know their own voices. </p> <p>Practicing more doesn’t change your baseline potential, it just changes what you can presently do. That is, if you practice a specific song over and over again, eventually you’re going to get better at it.</p> <p>Jonathon Heyward, the Baltimore Symphony’s new conductor, who has <a href="https://www.nytimes.com/2022/07/21/arts/music/jonathon-heyward-baltimore-symphony-orchestra.html">no musicians in his family</a>, has worked really hard to excel. He started taking cello lessons at age 10 and hasn’t stopped since, playing and practicing and studying.</p> <h2>Privilege can play a role</h2> <p>Socioeconomic factors can also enter the equation. While conducting research, I’ve seen high-income college students from high-income families, with more years of musical experience, perform better than their classmates who have lower-income backgrounds and had fewer opportunities.</p> <p>Genes can give someone a head start. At the same time, having a quiet space where you can practice on an acoustic instrument or a digital workstation might make a more decisive difference for the musical prospects of most children. The same goes for having money for private lessons or access to free classes.</p> <p>Even so, many of the best musicians, including jazz greats <a href="https://www.louisarmstronghouse.org/biography/">Louis Armstrong</a> and <a href="https://www.pbs.org/wnet/americanmasters/billie-holiday-about-the-singer/68/">Billie Holiday</a>, grew up facing many hardships.</p> <p>With the right conditions for practice and gaining experience, who knows where the next Liza or Lizzo will come from.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/excelling-as-a-musician-takes-practice-and-requires-opportunities-not-just-lucky-genes-186693" target="_blank" rel="noopener">The Conversation</a>. </em></p>

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Keeping to the beat controlled by 69 genes – not just our feet

<p class="spai-bg-prepared">Are you a dancing queen or do you have two left feet? Turns out that keeping to the beat is partly to do with our <a class="spai-bg-prepared" href="https://www.nature.com/articles/news.2007.359" target="_blank" rel="noreferrer noopener">genetics</a>.</p> <p class="spai-bg-prepared">An international team of researchers conducted a study on the genetic variation of 606,825 individuals, all of whom completed a musical ability questionnaire (including “Can you clap in time with a musical beat?”), with some also participating in beat synchronisation experiments including telling rhythms apart (Phenotype Experiment 1) and tapping in time with music (Phenotype Experiment 2).</p> <p class="spai-bg-prepared">Of the participants, 91.57% said yes to the question, “Can you clap in time with a musical beat?” Those who said yes also scored higher in the rhythm perception and tapping synchrony experiments.  </p> <p class="spai-bg-prepared">Looking at the genetic variation, 69 genes showed significant difference between the rhythmic and arhythmic participants, with <em class="spai-bg-prepared">VRK2 </em>being the most strongly associated. This gene has been linked previously to behavioural and psychiatric traits (including depression, schizophrenia and developmental delay), suggesting a biological link between beat synchronisation and neurodevelopment.</p> <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p195164-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> </div> </div> <p class="spai-bg-prepared">Several physiology traits also seemed to be linked to beat synchronisation, including processing speed, grid strength, usual walking pace, and peak respiratory flow. These may be linked to the evolution of language and sociality through music in early humans.</p> <p class="spai-bg-prepared">For modern humans, our ability to keep the beat may help to predict developmental speech-language disorders, and serve as a mechanism for <a class="spai-bg-prepared" href="https://www.frontiersin.org/articles/10.3389/fnhum.2021.789467/full" target="_blank" rel="noreferrer noopener">rhythm-based rehabilitation</a>, including for <a class="spai-bg-prepared" href="https://cosmosmagazine.com/science/biology/bilingual-patients-recover-better-from-stroke/" target="_blank" rel="noreferrer noopener">stroke</a> and <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41598-017-16232-5" target="_blank" rel="noreferrer noopener">Parkinson’s disease</a>.</p> <p class="spai-bg-prepared">This study has been <a class="spai-bg-prepared" href="https://doi.org/10.1038/s41562-022-01359-x" target="_blank" rel="noreferrer noopener">published</a> in <em class="spai-bg-prepared">Nature Human Behaviour</em>.</p> <figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio spai-bg-prepared"> <div class="wp-block-embed__wrapper spai-bg-prepared"> <div class="entry-content-asset spai-bg-prepared"> <div class="embed-wrapper spai-bg-prepared"> <div class="inner spai-bg-prepared"><iframe class="spai-bg-prepared" title="The Go-Go's - We Got The Beat (Official Music Video)" src="https://www.youtube.com/embed/f55KlPe81Yw?feature=oembed" width="500" height="281" frameborder="0" allowfullscreen="allowfullscreen"></iframe></div> </div> </div> </div> </figure> <p class="spai-bg-prepared">We got the beat… well maybe some of us!</p> <p><img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=195164&amp;title=Keeping+to+the+beat+controlled+by+69+genes+%E2%80%93+not+just+our+feet" width="1" height="1" /></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/science/biology/keeping-the-beat-genetics/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/qamariya-nasrullah" target="_blank" rel="noopener">Qamariya Nasrullah</a>. Qamariya Nasrullah holds a PhD in evolutionary development from Monash University and an Honours degree in palaeontology from Flinders University.</em></p> <p><em>Image: Getty Images</em></p> </div>

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Why an edit button for Twitter is not as simple as it seems

<p>Most people who use Twitter have had the experience: you fire off a quick tweet, realise it contains a typo, then get annoyed you can’t click “edit” to fix it. Twitter users have been <a href="https://www.fastcompany.com/90376786/a-brief-history-of-not-being-able-to-edit-your-tweets" target="_blank" rel="noopener">clamouring for an edit button for years</a>.</p> <p>Elon Musk, who has recently been buying up shares in the microblogging platform and has made a <a href="https://www.abc.net.au/news/2022-04-15/elon-musk-offer-to-buy-twitter-worlds-richest-man/100994580" target="_blank" rel="noopener">US$48 billion offer</a> for the whole company, asked his 82 million followers if they wanted an edit button. His (deeply unscientific) poll attracted 4.4 million responses, with 73% in favour.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Do you want an edit button?</p> <p>— Elon Musk (@elonmusk) <a href="https://twitter.com/elonmusk/status/1511143607385874434?ref_src=twsrc%5Etfw">April 5, 2022</a></p></blockquote> <p>Other social media platforms let you edit posts after you’ve sent them. It seems like it would be a simple feature to add – so why doesn’t Twitter do it?</p> <p>Well, the time may at last have arrived. Independent of Musk’s poll, Twitter has confirmed that <a href="https://www.theverge.com/2022/4/5/23011327/twitter-edit-button-blue-test" target="_blank" rel="noopener">an edit button may be in the works</a>. Enterprising users have even dug out some hints of what it <a href="https://techcrunch.com/2022/04/18/twitters-in-development-edit-button-offers-hints-as-to-how-the-feature-could-work/" target="_blank" rel="noopener">might look like</a>.</p> <p><strong>So what’s the fuss about?</strong></p> <p>Why has Twitter been so opposed to an edit button? The answer might be that it isn’t as simple as it appears.</p> <p>The first thing to know about tweets is that, unlike posts on many other platforms, there is fundamentally no way for Twitter to pull them back after they are sent. The reason is that Twitter has what’s called an Application Programming Interface (or API) which allows third parties such as other apps or researchers to download tweets in real time.</p> <p>That’s what powers Twitter clients such as TweetDeck, TweetBot, Twitteriffic and Echofon, which together account for some <a href="https://techcrunch.com/2018/08/17/6-million-users-had-installed-third-party-twitter-clients/" target="_blank" rel="noopener">6 million users</a>.</p> <p>Once third parties have downloaded tweets, there’s no way for Twitter to get them back or edit them. It’s a bit like an email – once I’ve sent it and you’ve downloaded it, there’s no way for me to delete it from your machine.</p> <p>If a user <em>were</em> to edit a tweet, the most Twitter could do is send out a message saying “please edit this tweet” – but the third party could choose whether or not to actually do it. (This is currently what happens when tweets are “deleted”.)</p> <p><strong>Cats and dogs</strong></p> <p>More importantly, an edit button might have unintended consequences, and could be weaponised.</p> <p>Consider this. I, a cat lover, decide to tweet “I love cats!”</p> <p>Then you, being also a cat lover (because why wouldn’t you be), decide to quote my tweet, agreeing “I do too!” (Remember when Twitter used to be this innocent?)</p> <p>Now, what happens if I edit my original tweet to declare “I love dogs”? You are now misrepresented as a dog-lover, and when your cat-loving friends see this (which they will when I reply to your tweet, mentioning them all), they disown you.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=192&fit=crop&dpr=1 600w, https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=192&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=192&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=241&fit=crop&dpr=1 754w, https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=241&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/459030/original/file-20220421-70799-6mgarp.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=241&fit=crop&dpr=3 2262w" alt="A screenshot showing a tweet reading " /></a><figcaption><em><span class="caption">A Twitter edit button could be used to change statements after others have retweeted or endorsed them.</span> <span class="attribution"><span class="source">The Conversation</span></span></em></figcaption></figure> <p>Yes, this is contrived, but it doesn’t take much imagination to see how the edit button might be used in this fashion, particularly by things such as bot armies. Will Twitter users be happy to trade this possibility for the convenience of fixing typos in their tweets?</p> <p><strong>‘Warts and all’: a bug or a feature?</strong></p> <p>Twitter has built its reputation on being the most “real-time” of the social media platforms – the place where <a href="https://www.nature.com/articles/ngeo832" target="_blank" rel="noopener">earthquakes are reported quicker than by scientific instruments</a>. However, for many people the “warts and all” nature of Twitter postings is starting to look like a bug, rather than a feature.</p> <p>Will an edit button change Twitter’s unique brand? There may be ways to ameliorate this, such as only allowing edits within a short time of posting, but it is surely a consideration for the company.</p> <p>More generally, the design of media platforms shapes the type of discussion that occurs on them.</p> <p>The presence of the “like” and “retweet” buttons on Twitter encourage users to create content that will entice others to click these buttons, and make their content spread further. This, in turn, shapes the nature of conversation that occurs on the platform.</p> <p>Similarly, websites use algorithms and design to “<a href="https://doi.org/10.1080/1369118X.2018.1476570" target="_blank" rel="noopener">nudge</a>” users in particular directions – such as to buy a product.</p> <p>There is a rich body of research into the ways discourse is shaped by the design of social media platforms, which establishes that every “affordance” a user is given affects the conversation that ends up taking place.</p> <p>This means that beyond the fundamental technological challenges, Twitter must think about the possible unintended consequences of seemingly simple changes – even to the level of a humble edit button. The medium shapes the message, and Twitter must think carefully about what sorts of messages they want their platform to shape.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/181623/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/lewis-mitchell-266859" target="_blank" rel="noopener">Lewis Mitchell</a>, Professor of Data Science, <a href="https://theconversation.com/institutions/university-of-adelaide-1119" target="_blank" rel="noopener">University of Adelaide</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com" target="_blank" rel="noopener">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-an-edit-button-for-twitter-is-not-as-simple-as-it-seems-181623" target="_blank" rel="noopener">original article</a>.</em></p> <p><em>Image: Getty Images</em></p>

Technology

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Willy Wonka fun facts

<p dir="ltr"><strong>*Willy Wonka Willy Wonka everybody give a cheer HOORAY*</strong></p> <p dir="ltr">Don’t pretend you did not sing that like the Oompa Loompa’s did because that is such a classic. </p> <p dir="ltr">Obviously the one with the late Gene Wilder, even though the one with Johnny Depp isn’t that bad either. </p> <p dir="ltr"><em>Willy Wonka and the Chocolate Factory</em> came out in 1971 and was based on the 1964 book <em>Charlie and the Chocolate Factory </em><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">by British author Roald Dahl</span><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">.</span></p> <p dir="ltr">To this very day it remains a classic to grandparents, parents and even kids who grew up watching it. </p> <p dir="ltr">We all secretly wished we could visit Willy Wonka’s factory and consume all the chocolate possible…just like Augustus Gloop wanted to. </p> <p dir="ltr">But did you know that Willy Wonka’s factory wasn’t actually a factory? Yes, the movie has some delicious facts despite being released 51 years ago. </p> <ol> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Wonka’s limping entrance was Gene Wilder’s idea</strong></p> </li> </ol> <p dir="ltr">The first time everyone finally meets Willy Wonka is when he is limping. This idea came to Gene Wilder who suggested it would be perfect to keep the crowd on its toes.</p> <p dir="ltr">The director questioned why he would want to do that to which Gene responded: “Because from that time on, no one will know if I’m lying or telling the truth.”</p> <ol start="2"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Almost everything was edible</strong></p> </li> </ol> <p dir="ltr">Remember when Willy Wonka said “everything in this room is edible except for me”? Well they weren’t lying because everything in the factory was edible.</p> <p dir="ltr">Except for that floral cup he would drink from which was actually made from wax. Gene would bite into it and continue biting until the shot was perfect.</p> <ol start="3"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Chocolate river not actually made out of chocolate</strong></p> </li> </ol> <p dir="ltr">Would’ve been a dream come true had that river actually been made out of chocolate. It was however filled with brown-coloured water which eventually stunk up the place.</p> <p dir="ltr">In the remake, thick, fake chocolate was actually used. </p> <ol start="4"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Charlie and Wonka were close in real life</strong></p> </li> </ol> <p dir="ltr">Peter Ostrum, the actor who played Charlie, said Wilder “treated people with respect and dignity.” </p> <p dir="ltr">He said Wilder would always buy a chocolate bar after lunch and share it with him. </p> <ol start="5"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Not a factory</strong></p> </li> </ol> <p dir="ltr">The movie was filmed in Germany and Willy Wonka’s “factory” was in fact a power plant. </p> <p dir="ltr">The director chose that place on purpose so viewers would not immediately pick up where the story was set. </p> <ol start="6"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Roald Dahl HATED it</strong></p> </li> </ol> <p dir="ltr">Author Roald Dahl actually hated the film and refused to grant the film rights to a sequel. </p> <p dir="ltr">It was only 15 years after he died that a remake was approved.</p> <p dir="ltr"><em>Image: Getty</em></p>

Movies

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Feel connected to nature? It might be in your genes

<div><div class="copy"><p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><p><em>Image credits: Getty Images</em></p><em><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --> <img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <!-- End of tracking content syndication --></em></div><div id="contributors"><p><em>This article was originally published on <a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Jamie Priest. </em></p></div></div>

Mind

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Feel connected to nature? It might be in your genes

<p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><div class="copy"><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><div class="newsletter-box"><div id="wpcf7-f6-p181148-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div></div><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /></div><div id="contributors"><p><em><a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/jamie-priest" target="_blank" rel="noopener">Jamie Priest</a>. Jamie Priest is a science journalist at Cosmos. She has a Bachelor of Science in Marine Biology from the University of Adelaide.</em></p><p><em>Image: Getty Images</em></p></div>

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Some endangered species can no longer survive in the wild. So should we alter their genes?

<p>Around the world, populations of many beloved species are declining at increasing rates. According to one <a href="https://www.theguardian.com/environment/2020/sep/30/world-plant-species-risk-extinction-fungi-earth">grim projection</a>, as many as 40% of the world’s species may be extinct by 2050. Alarmingly, many of these declines are caused by threats for which few solutions exist.</p> <p>Numerous species now depend on conservation breeding programs for their survival. But these programs typically do not encourage species to adapt and survive in the wild alongside intractable threats such as climate change and disease.</p> <p>This means some species can no longer exist in the wild, which causes major downstream effects on the ecosystem. Consider, for example, how a coral reef would struggle to function without corals.</p> <p>What if there was another way? My colleagues and I have developed an intervention method that aims to give endangered species the genetic features they need to survive in the wild.</p> <p><img src="https://images.theconversation.com/files/411140/original/file-20210714-13-1bf7ccv.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="bleached coral with fish" /> <span class="caption">Genetically altering coral may help them survive in a warmer world.</span> <span class="attribution"><span class="source">Rick Stuart-Smith</span></span></p> <h2>Bringing theory into practice</h2> <p>Over generations, natural selection enables species to adapt to threats. But in many instances today, the speed at which threats are developing is outpacing species’ ability to adapt.</p> <p>This problem is especially apparent in wildlife threatened by newly emerging infectious diseases such as chytridiomycosis in amphibians, and in climate-affected species such as corals.</p> <p>The toolkit my colleagues and I developed is called “targeted genetic intervention” or TGI. It works by increasing the occurrence or frequency of genetic features that impact an organism’s fitness in the presence of the threat. We outline the method in a recent <a href="https://www.sciencedirect.com/science/article/abs/pii/S0169534721003384">research paper</a>.</p> <p>The toolkit involves <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/artificial-selection">artificial selection</a> and <a href="https://www.frontiersin.org/articles/10.3389/fbioe.2019.00175/full">synthetic biology</a>. These tools are well established in agriculture and medicine but relatively untested as conservation tools. We explain them in more detail below.</p> <p>Many tools in our TGI toolkit have been discussed in theory in conservation literature in recent decades. But rapid developments in genome sequencing and synthetic biology mean some are now possible in practice.</p> <p>The developments have made it easier to understand the genetic basis of features which enable a species to adapt, and to manipulate them.</p> <p><img src="https://images.theconversation.com/files/442166/original/file-20220124-19-xc82dx.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="frog on wet rock" /> <span class="caption">Some animal species cannot adapt in time to survive threats such as disease.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is artificial selection?</h2> <p>Humans have long used artificial (or phenotypic) selection to promote desirable characteristics in animals and plants raised for companionship or food. This genetic alteration has led to organisms, such as domestic dogs and maize, that are dramatically different from their wild progenitors.</p> <p>Traditional artificial selection can lead to outcomes, such as high inbreeding rates, that affect the health and resilience of the organism and are undesirable for conservation. If you’ve ever owned a purebred dog, you might be aware of some of these genetic disorders.</p> <p>And when it comes to conservation, determining which individuals from a species are resistant to, say, a deadly pathogen would involve exposing the animal to the threat – clearly not in the interests of species preservation.</p> <p>Scientists in the livestock industry have developed a new approach to circumvent these problems. Called genomic selection, it combines data from laboratory work (such as a disease trial) with the genetic information of the animals to predict which individuals bear genetic features conducive to adaptation.</p> <p>These individuals are then chosen for breeding. Over subsequent generations, a population’s ability to survive alongside pervasive threats increases.</p> <p>Genomic selection has led to disease-resistant salmon and livestock that produce more milk and better tolerate heat. But it is yet to be tested in conservation.</p> <p><img src="https://images.theconversation.com/files/442161/original/file-20220124-27-11vyq0z.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="cows in green field" /> <span class="caption">Artificial selection has been used to develop traits that humans desire in livestock.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is synthetic biology?</h2> <p><a href="https://www.genome.gov/about-genomics/policy-issues/Synthetic-Biology">Synthetic biology</a> is a toolkit for promoting change in organisms. It includes methods such as transgenesis and gene editing, which can be used to introduce lost or novel genes or tweak specific genetic features.</p> <p>Recent synthetic biology tools such as <a href="https://medlineplus.gov/genetics/understanding/genomicresearch/genomeediting/">CRISPR-Cas9</a> have created a buzz in the medical world, and are also starting to gain the <a href="https://portals.iucn.org/library/node/48408">attention</a> of conservation biologists.</p> <p>Such tools can accurately tweak targeted genetic features in an individual organism – making it more able to adapt – while leaving the rest of the genome untouched. The genetic modifications are then passed on to subsequent generations.</p> <p>The method reduces the likelihood of unintended genetic changes that can occur with artificial selection.</p> <p>Synthetic biology methods are currently being trialled for conservation in multiple species around the world. These include the <a href="https://www.esf.edu/chestnut/resistance.htm">chestnut tree</a> and black-footed <a href="https://neo.life/2021/05/cloning-wildlife-and-editing-their-genes-to-protect-them-and-us/">ferrets</a> in the United States, and <a href="https://theconversation.com/gene-editing-is-revealing-how-corals-respond-to-warming-waters-it-could-transform-how-we-manage-our-reefs-143444">corals</a> in Australia.</p> <p>I am working with researchers at the University of Melbourne to develop TGI approaches in Australian frogs. We are trialling these approaches in the iconic southern corroboree frog, and plan to extend them to other species if they prove effective.</p> <p>Worldwide, the disease chytridiomycosis is devastating frog populations. Caused by the fungal pathogen <em>Batrachochytrium dendrobatidis</em>, it has led to the extinction of about <a href="https://www.nationalgeographic.com/animals/article/amphibian-apocalypse-frogs-salamanders-worst-chytrid-fungus">90 frog species</a> and declines in as many as 500 others.</p> <p>Many frog species now rely on conservation breeding for their continued survival. No effective solution for restoring chytrid-susceptible frogs to the wild exists, because the fungus cannot be eradicated.</p> <p><img src="https://images.theconversation.com/files/442155/original/file-20220124-23-cebr8a.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="gloved hand removed portion of DNA strand" /> <span class="caption">CRISPR technology could potentially be used to edit the genes of endangered species.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>Looking ahead</h2> <p>As with many conservation approaches, targeted genetic intervention is likely to involve trade-offs. For example, genetic features that make a species resistant to one disease may make it more susceptible to another.</p> <p>But the rapid rate of species declines means we should trial such potential solutions before it’s too late. The longer species are absent from an ecosystem, the greater the chance of irreversible environmental changes.</p> <p>Any genetic intervention of this type should involve all stakeholders, including Indigenous peoples and local communities. And caution should be taken to ensure species are fit for release and pose no risk to the environment.</p> <p>By bringing the concept of TGI to the attention of the public, government, and other scientists, we hope we will spur discussion and encourage research on its risks and benefits.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/175226/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><span><a href="https://theconversation.com/profiles/tiffany-kosch-1304685">Tiffany Kosch</a>, Research Fellow, <em><a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em></span></p> <p>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/some-endangered-species-can-no-longer-survive-in-the-wild-so-should-we-alter-their-genes-175226">original article</a>.</p> <p><em>Image: Melbourne Zoo</em></p>

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“We can fix it”: Dad sparks debate over Disney book edits

<p><span style="font-weight: 400;">A dad has sparked some controversy online after </span><a rel="noopener" href="https://au.news.yahoo.com/dad-edits-daughter-disney-princess-210152973.html" target="_blank"><span style="font-weight: 400;">sharing edits</span></a><span style="font-weight: 400;"> to his daughter’s Disney Princess books to combat gender stereotypes.</span></p> <p><span style="font-weight: 400;">The parent took to his TikTok account (</span><a rel="noopener" href="https://www.tiktok.com/@dcaspers?is_copy_url=1&amp;is_from_webapp=v1" target="_blank"><span style="font-weight: 400;">@dcaspers</span></a><span style="font-weight: 400;">) to share pages from his daughter’s “Step Into Reading” books starring Disney princesses and the edits he makes to inspire his daughters.</span></p> <p><span style="font-weight: 400;">In one video of his now-viral series, he takes issue with a book featuring Ariel from </span><em><span style="font-weight: 400;">The Little Mermaid</span></em><span style="font-weight: 400;">. In it, Ariel struggles to bake a cake for Prince Eric, and @dcaspers is quick to change it.</span></p> <p><span style="font-weight: 400;">“Ariel changes her body, leaves her friends and family … and now she’s baking, all for him,” he writes over the clip.</span></p> <p><span style="font-weight: 400;">The dad then shows the changes he made to the book, swapping Ariel’s piping bag full of icing for a slice of pizza.</span></p> <p><span style="font-weight: 400;">“Instead of baking, Ariel orders a pizza,” he writes.</span></p> <p><span style="font-weight: 400;">“While the prince eats his pizza… with a fork,” he continues, “She finds her new love… in TikTok.”</span></p> <p><span style="font-weight: 400;"><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7845262/dad-hack1.jpg" alt="" data-udi="umb://media/e3fc4d5a65c1435f8839a77e47a1c308" /></span></p> <p><em><span style="font-weight: 400;">Image: @dcaspers / TikTok</span></em></p> <p><span style="font-weight: 400;">In another clip, the dad focuses on Rapunzel from </span><em><span style="font-weight: 400;">Tangled</span></em><span style="font-weight: 400;"> and writes, “Teaching my daughters not to settle for the stereotypes”.</span></p> <p><span style="font-weight: 400;">In the original reader, Rapunzel enters a pie-baking contest and wins a blue ribbon, “which her bf (boyfriend) approves” of. But, after the changes, Rapunzel considers “her future” in front of a sign for Harvard University, and her boyfriend Eugene bakes her a pie “because she’s top in her class”.</span></p> <p><span style="font-weight: 400;"><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7845263/dad-hack2.jpg" alt="" data-udi="umb://media/c189a0575b1345dd8ef6d6902e26f769" /></span></p> <p><em><span style="font-weight: 400;">Image: @dcaspers / TikTok</span></em></p> <p><span style="font-weight: 400;">Many users have shared their approval of the dad’s efforts, while others believe they could do more harm than Disney’s original works.</span></p> <p><span style="font-weight: 400;">“You are such a great dad. This is what we should teach our daughters, not that women do the cooking, cleaning and chores,” one commenter said.</span></p> <p><span style="font-weight: 400;">“I honestly love this! I can’t stand stereotypes, and for Disney to use them when most little kids look up to/love them is awful. You’re amazing,” another wrote.</span></p> <p><span style="font-weight: 400;">“What’s wrong with baking? And how is spending all your time on social media better than a fun activity that anyone could do?” one person argued, referring to the Ariel video.</span></p> <p><span style="font-weight: 400;">“The baking is a metaphor here. She pursued a goal, and achieved it successfully, while being cheered on by a loved one.. How can you see the bad in this?” another said, challenging his Rapunzel edits.</span></p> <p><span style="font-weight: 400;">“Bruh, just don’t buy the book if it offends you,” a third user suggested.</span></p> <p><span style="font-weight: 400;">In response to the critics, one person wrote, “Why is everyone upset about a dad wanting to teach his daughters to be strong and independent?”</span></p> <p><span style="font-weight: 400;">Despite the controversy, this dad has shown how he wants to challenge the messages and stories his daughters see and gone the extra mile to do it.</span></p> <p><em><span style="font-weight: 400;">Image: @dcaspers / TikTok</span></em></p>

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Willy Wonka star reveals Gene Wilder’s “favourite brat”

<p><span>A child star who had the opportunity to work alongside the infamous Gene Wilder has spoken out on the experience, 50 years since its first premier date.</span><br /><br /><em>Charlie and the Chocolate Factory </em><span>hit movie screens 50 years ago on June 30, 1971 and achieved rapid success almost overnight.</span><br /><br /><span>The film went on to become a phenomenon that was registered in the United States National Film Registry by the Library of Congress for being deemed “culturally, historically or aesthetically significant”.</span><br /><br /><span>The child actors Peter Ostrum, Julie Dawn Cole, Michael Bollner, Paris Themmen and Denise Nickerson – who played Charlie Bucket, Veruca Salt, Augustus Gloop, Mike Teavee and Violet Beauregarde – all came together for a virtual reunion in honour of the film’s anniversary.</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842239/willy-wonka.jpg" alt="" data-udi="umb://media/b9da36eca8c24fbeb170655d6cf92150" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The actors all had the opportunity to co-star together, and even got to explore the imagined Wonka Chocolate Factory.</span><br /><br /><span>The cast recounted such fond memories of exploring the film sets in Bavarian Germany and working with Gene Wilder.</span><br /><br /><span>Themmen admitted that he was indeed a “notorious troublemaker on the set.”</span><br /><br /><span>So much so that even Wilder called him “a handful”.</span><br /><br /><span>“I can corroborate that,” the actor, who played the television-obsessed rascal Mike Teavee, admitted.</span><br /><br /><span>“I was younger than the others. I was 11, they were 13 and was naturally just sort of more high-spirited and rambunctious.”</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842237/willy-wonka-1.jpg" alt="" data-udi="umb://media/a8d501bcedd64f7b97dd573169a7717a" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The now-62-year-old opened up about one brief moment he shared with Wilder, in 1976 during a fundraiser screening for the film <em>Silver Streak</em> at the Avon Theatre in Stamford, Connecticut.</span><br /><br /><span>“I sat at the back of the room and he gave his commentary and then I went up to the front of the room afterwards with my poster in hand,” Themmen relived with a smile.</span><br /><br /><span>“I said, ‘Hi, Gene, how you doing? I’m Paris Themmen, I was Mike Teavee in Willy Wonka.”</span><br /><br /><span>“And he said, ‘Oh you were a brat!’ And I flashed all the way back 50 years, or 40 years at that time, and said, ‘Well, I’m 50-something now and maybe not as much of a brat.’</span><br /><br /><span>And he signed my poster, ‘To my favourite brat.’”</span><br /><br /><span>Wilder died in 2016 at the age of 83 after a long vibrant career.</span><br /><br /><span>Cole, who played Veruca Salt, said: “I think people kind of want us to tell you that he was like Willy Wonka offset, but he wasn’t.</span><br /><br /><span>“He was such a lovely, kind man, very unassuming,” she said.</span><br /><br /><span>“He was just down to earth, not pretentious, he was just a wonderful person to be around and to work with,” said Ostrum, who played Charlie Bucket.</span></p>

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