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Why IBD is so hard to treat – and how scientists are making progress

<a href="https://theconversation.com/profiles/falk-hildebrand-1490022">Falk Hildebrand</a>, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a>; <a href="https://theconversation.com/profiles/katarzyna-sidorczuk-1490026">Katarzyna Sidorczuk</a>, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a>, and <a href="https://theconversation.com/profiles/wing-koon-1490274">Wing Koon</a>, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a> Inflammatory bowel disease (IBD) is a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478758/">life altering</a> chronic illness that is <a href="https://bmjopen.bmj.com/content/13/3/e065186">rising dramatically globally</a>. It is stubbornly difficult to treat, and many people find the treatments we have just don’t work for them. Over the last 30 years, there has been almost a 50% increase in cases – now affecting around 5 million people. Not to be confused with irritable bowel syndrome (IBS) which is a condition that affects the digestive system, IBD is more serious. It is the term for two severe illnesses called <a href="https://www.nhs.uk/conditions/crohns-disease/">Crohn’s disease</a> and <a href="https://www.nhs.uk/conditions/ulcerative-colitis/">ulcerative colitis</a>. More women are <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958616/#:%7E:text=Male%20predominance%20in%20IBD.,%2C%202.32%3A1%20in%20CD.">diagnosed with Crohn’s disease</a> while more men are affected by ulcerative colitis. People with IBD can experience a variety of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/">symptoms</a>, ranging from diarrhoea and blood in the stool, to weight loss and belly aches. On paper, this may sound no worse than mild food poisoning, however, this is no normal stomach upset. Experiences are often extreme; people with IBD can suffer excruciating pain and in some cases, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963331/">require surgery</a> to remove parts of the bowel. This is done by redirecting the bowel to a hole in the abdomen, where faeces are collected in a <a href="https://www.nhs.uk/conditions/colostomy/">colostomy bag</a>. However, we still don’t fully understand the cause of IBD. <h2>The impact of inflammation</h2> The main symptom of IBD is excessive and uncontrolled <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805548/">inflammation</a> – normally a sign of the body fighting off an infection. Although inflammation is an important aspect of our immune system, in IBD it is happening when the body is not under attack. Since we don’t know what causes this over-the-top reaction, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720971/">treatments</a> are limited to managing the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964397/">derailed immune system</a>. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373857/">Inflammation is controlled</a> by cell signalling. Our cells detect bacteria using receptors that attach to parts of bacteria. This activates the receptor, causing it to send a signal to proteins, and each protein sends on more signals, creating a signal cascade. This is what tells the body it’s under attack. Many treatments follow the strategy of intercepting signals and preventing the signal cascade from starting. However, they are <a href="https://journals.lww.com/co-gastroenterology/abstract/2022/07000/management_of_refractory_inflammatory_bowel.6.aspx">not effective</a> for many people. Scientists are trying to target a different protein network, called <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924159/">NOD2</a>, that often goes haywire in people with IBD but is not targeted by current treatments. A protein, called <a href="https://www.frontiersin.org/articles/10.3389/fphar.2021.650403/full">RIPK2</a>, seems like a promising target since it is <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939834/">only found</a> in this network. Researchers from the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485824/">European Molecular Biology Laboratory</a> are investigating its structure to help scientists design a new medication that will block the signals from this protein. <h2>Importance of the microbiome</h2> Another inspiration for new treatments comes from the bacteria residing in our guts. This community of bacteria, called the gut microbiome, has been associated with <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314516/">all sorts of health conditions</a> ranging from asthma to obesity. Gut bacteria work closely with our bodies and play a vital role in digesting food and managing our <a href="https://www.nature.com/articles/s41422-020-0332-7">immune system</a>. In a healthy person, there is a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143175/">fine balance</a> between gut bacteria and the immune system. Disruption of this balance can lead to disease, starting from minor discomfort to more severe, long-term conditions. Scientists are trying to understand how our bodies interact with gut bacteria, and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102608/">what changes</a> when people develop IBD. The gut microbiome is an ecosystem. Just like a forest has animals eating different things, microbes can form a <a href="https://www.frontiersin.org/articles/10.3389/fevo.2019.00153/full">food web</a>. Some bacteria will use up one type of food, while others feed off other foods. Some rely on the waste of other bacteria after they’ve eaten. It is now believed that disruption to the gut microbiome is a characteristic of IBD and contributes to its development and progression. It’s a chicken and egg situation. Is there a change in the bacteria and food web that alters our bodies? Or does something else in the body, like our immune system, change the food web, subsequently limiting which bacteria can grow? Scientists aren’t sure of the answer. Instead of trying to figure out what happens first, a team at the <a href="https://www.nature.com/articles/s41467-023-42112-w">Hudson Institute of Medical Research</a> in Australia have focused on investigating which interactions in the food web are the most affected in IBD. This could help scientists to prioritise certain gut bacteria, or their food source, to restore the balance in the microbiome and improve patients’ symptoms. Hopefully, this specialised targeting of the microbiome will lead to more effective and longer lasting treatments. Although we have a long way to go before these ideas for treatments can become a reality, it is a step in the right direction. Targeting a new signalling pathway will hopefully control the inflammation in more patients. And studying the microbiome may reveal how we can reverse changes associated with IBD. Since they are key features of IBD, these developments could allow doctors to stop the disease in the early stages and reduce complications.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/218307/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/falk-hildebrand-1490022">Falk Hildebrand</a>, Researcher in Bioinformatician, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a>; <a href="https://theconversation.com/profiles/katarzyna-sidorczuk-1490026">Katarzyna Sidorczuk</a>, Research Scientist in Metagenomics, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a>, and <a href="https://theconversation.com/profiles/wing-koon-1490274">Wing Koon</a>, PhD student in Bioinformatics, <a href="https://theconversation.com/institutions/quadram-institute-5557">Quadram Institute</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-ibd-is-so-hard-to-treat-and-how-scientists-are-making-progress-218307">original article</a>.

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"Do you hear it?": Worldwide hum global mystery baffles scientists

A perplexing phenomenon known as "The Worldwide Hum" has been capturing the attention of scientists and citizens alike, as an unusual low-frequency noise continues to puzzle experts. This mysterious hum, first recorded in 2012, has been reported by thousands of people worldwide, sparking investigations, online discussions and even <a href="https://www.thehum.info/" target="_blank" rel="noopener">the creation of an interactive map</a> documenting instances of the enigmatic sound. As researchers strive to unravel the mystery, individuals share their experiences, raising questions about its origin and effects. Described as a low rumbling or droning sound, "the hum" is often likened to the idling of a car or truck engine. What makes this phenomenon particularly intriguing is that it is not universally heard, with reports of the hum being exclusive to certain individuals. Some claim it is more pronounced at night than during the day, and louder indoors than outdoors. One Reddit user even compared it to the low-frequency vibrations felt when a passenger jet flies overhead. Since its first documentation, more than 6,500 instances of the hum have been reported globally, with new cases continually emerging. The interactive user-generated World Hum Map and Database Project captures the experiences of those who have encountered the sound, providing a comprehensive overview of its widespread occurrence. In some regions, authorities such as the Environment Protection Authority (EPA) have conducted investigations, as was the case in the NSW Waverley Council ten years ago. Despite these efforts, the source of the hum remains elusive. Individuals affected by the mysterious noise often find solace in online communities, where they share their experiences and discuss possible explanations. Some describe feeling as though they are "going insane", and say that the psychological impact of the persistent hum is actually very severe. Facebook support groups have become a platform for individuals to connect, share anecdotes and speculate about the origin of the sound. Theories range from the mundane – such as the use of headphones causing collective tinnitus – to more complex environmental factors. While tinnitus, a symptom of auditory system issues, has been proposed as a potential explanation, it does not account for the collective experience of the hum. Various theories, including industrial plants, ocean waves, lightning strikes and the proliferation of mobile phone towers, have been suggested over the years. However, none of these explanations have gained widespread acceptance or provided a conclusive answer. Dr Glen MacPherson, who initiated the World Hum Map and Database Project, experienced the hum firsthand on Canada's Sunshine Coast. Having debunked the idea of "hum hotspots", Dr MacPherson theorises that the hum may be a subjective phenomenon, akin to tinnitus, originating from within the individual rather than an external source. His 11 years of research highlight the complexity of the mystery, challenging initial assumptions and pointing towards the need for further investigation. As "The Worldwide Hum" continues to captivate the curiosity of scientists and citizens worldwide, the quest for understanding remains elusive. While theories abound, the true origin of the hum remains unknown, leaving both experts and individuals alike intrigued by a phenomenon that transcends geographic boundaries and defies conventional explanations. Image: Getty

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Surprise! Scientists find falls likely when texting and walking

It seems obvious that texting while walking is <a href="https://cosmosmagazine.com/people/behaviour/millennials-most-likely-to-text-and-drive/" target="_blank" rel="noreferrer noopener">risky</a> business. But while there has been plenty of research showing it’s a dangerous distraction, <a href="https://www.sciencedirect.com/science/article/abs/pii/S0966636217309670" target="_blank" rel="noreferrer noopener">some</a> <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179802" target="_blank" rel="noreferrer noopener">studies</a> have suggested that younger people are better at negotiating obstacles while on their phones. <div class="copy"> A study <a href="https://dx.doi.org/10.1016/j.heliyon.2023.e18366" target="_blank" rel="noreferrer noopener">published</a> in Heliyon has refuted this, finding that university students are more likely to fall if they walk while texting. It also found they’re less accurate texters while walking. “On any day it seems as many as 80% of people, both younger and older, may be head down and texting. I wondered: is this safe?” said senior author Dr Matthew Brodie, a neuroscientist and engineer at the University of New South Wales. “This has made me want to investigate the dangers of texting while walking. I wanted to know if these dangers are real or imagined and to measure the risk in a repeatable way.” Brodie and colleagues recruited 50 undergraduate students from UNSW to take part in the study. Participants walked across a specially built tiled surface, fitted with a tile that could slip out halfway through. They were asked to either walk across the surface normally, or walk across it while texting “the quick brown fox jumps over the lazy dog”. The students were strapped to safety harnesses so they couldn’t fall, and told they may or may not slip. <div style="position: relative; display: block; max-width: 100%;"> <div style="padding-top: 56.25%;"><iframe style="position: absolute; top: 0px; right: 0px; bottom: 0px; left: 0px; width: 100%; height: 100%;" src="https://players.brightcove.net/5483960636001/HJH3i8Guf_default/index.html?videoId=6332776122112" allowfullscreen="allowfullscreen"></iframe></div> </div> The methods used in the experiment. Credit: Heliyon Brodie et al. “What surprised me is how differently people responded to the threat of slipping,” says Brodie. “Some slowed down and took a more cautious approach. Others sped up in anticipation of slipping. Such different approaches reinforce how no two people are the same, and to better prevent accidents from texting while walking, multiple strategies may be needed.” The researchers recorded motion data from the students as they moved and slipped, analysing how stable they were. They found that texting while walking made the students significantly less stable. Specifically, the students “trunk angle” – the angle of their torsos – varied more when they were slipping while texting. This means they were less stable. Participants were also less accurate texters when they did it while walking as opposed to sitting down, and least accurate when they did slip over. “Pedestrians should therefore be discouraged through new educational and technology-based initiatives (for example a ‘texting lock’ on detection of walking) from texting while walking on roadside footpaths and other environments where substantial hazards to safety exist,” conclude the researchers in their paper. Image credits: Shutterstock <a href="https://cosmosmagazine.com/health/body-and-mind/texting-walking-falls/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/ellen-phiddian/">Ellen Phiddian</a>. </div>

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Arctic Ocean could be ice-free in summer by 2030s, say scientists – this would have global, damaging and dangerous consequences

<a href="https://theconversation.com/profiles/jonathan-bamber-102567">Jonathan Bamber</a>, <a href="https://theconversation.com/institutions/university-of-bristol-1211">University of Bristol</a> The Arctic Ocean could be ice-free in summer by the 2030s, even if we do a good job of reducing emissions between now and then. That’s the worrying conclusion of a new study in <a href="https://www.nature.com/articles/s41467-023-38511-8">Nature Communications</a>. Predictions of an ice-free Arctic Ocean have a long and complicated history, and the 2030s is sooner than most scientists had thought possible (though it is later than some had wrongly forecast). What we know for sure is the disappearance of sea ice at the top of the world would not only be an emblematic sign of climate breakdown, but it would have global, damaging and dangerous consequences. The Arctic has been experiencing climate heating <a href="https://theconversation.com/arctic-is-warming-nearly-four-times-faster-than-the-rest-of-the-world-new-research-188474">faster than any other part of the planet</a>. As it is at the frontline of climate change, the eyes of many scientists and local indigenous people have been on the sea ice that covers much of the Arctic Ocean in winter. This thin film of frozen seawater expands and contracts with the seasons, reaching a minimum area in September each year. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=184&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=184&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=184&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=232&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=232&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530136/original/file-20230605-19-mdh85y.gif?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=232&fit=crop&dpr=3 2262w" alt="Animation of Arctic sea ice from space" /></a><figcaption>Arctic sea ice grows until March and then shrinks until September. <a class="source" href="https://www.nasa.gov/feature/esnt/2022/nasa-finds-2022-arctic-winter-sea-ice-10th-lowest-on-record">NASA</a></figcaption></figure> The ice which remains at the end of summer is called multiyear sea ice and is considerably thicker than its seasonal counterpart. It acts as barrier to the transfer of both moisture and heat between the ocean and atmosphere. Over the past 40 years this multiyear sea ice has shrunk from around <a href="http://polarportal.dk/en/sea-ice-and-icebergs/sea-ice-extent0/">7 million sq km to 4 million</a>. That is a loss equivalent to roughly the size of India or 12 UKs. In other words, it’s a big signal, one of the most stark and dramatic signs of fundamental change to the climate system anywhere in the world. As a consequence, there has been considerable effort invested in determining when the Arctic Ocean might first become ice-free in summer, sometimes called a “blue ocean event” and defined as when the sea ice area drops below 1 million sq kms. This threshold is used mainly because older, thicker ice along parts of Canada and northern Greenland is expected to remain long after the rest of the Arctic Ocean is ice-free. We can’t put an exact date on the last blue ocean event, but one in the near future would likely mean open water at the North Pole for the first time in <a href="https://www.nature.com/articles/nature10581">thousands of years</a>. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=712&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=712&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=712&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=895&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=895&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530138/original/file-20230605-29-9uuhxu.png?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=895&fit=crop&dpr=3 2262w" alt="Annotated map of Arctic" /></a><figcaption>The thickest ice (highlighted in pink) is likely to remain even if the North Pole is ice-free. <a class="source" href="https://nsidc.org/arcticseaicenews/2015/05/new-tools-for-sea-ice-thickness/">NERC Center for Polar Observation and Modelling</a>, <a class="license" href="http://creativecommons.org/licenses/by-sa/4.0/">CC BY-SA</a></figcaption></figure> One problem with predicting when this might occur is that sea ice is notoriously difficult to model because it is influenced by both atmospheric and oceanic circulation as well as the flow of heat between these two parts of the climate system. That means that the climate models – powerful computer programs used to simulate the environment – need to get all of these components right to be able to accurately predict changes in sea ice extent. <h2>Melting faster than models predicted</h2> Back in the 2000s, an assessment of early generations of climate models found they generally <a href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2007GL029703">underpredicted the loss of sea ice</a> when compared to satellite data showing what actually happened. The models predicted a loss of about 2.5% per decade, while the observations were closer to 8%. The next generation of models did better but were <a href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2012GL052676">still not matching observations</a> which, at that time were suggesting a blue ocean event would happen by mid-century. Indeed, the latest <a href="https://www.ipcc.ch/report/sixth-assessment-report-working-group-i/">IPCC climate science report</a>, published in 2021, reaches a similar conclusion about the timing of an ice-free Arctic Ocean. As a consequence of the problems with the climate models, some scientists have attempted to extrapolate the observational record resulting in the controversial and, ultimately, incorrect assertion that this would happen <a href="https://www.theguardian.com/environment/2016/aug/21/arctic-will-be-ice-free-in-summer-next-year">during the mid 2010s</a>. This did not help the credibility of the scientific community and its ability to make reliable projections. <h2>Ice-free by 2030?</h2> The scientists behind the latest study have taken a different approach by, in effect, calibrating the models with the observations and then using this calibrated solution to project sea ice decline. This makes a lot of sense, because it reduces the effect of small biases in the climate models that can in turn bias the sea ice projections. They call these “observationally constrained” projections and find that the Arctic could become ice-free in summer as early as 2030, even if we do a good job of reducing emissions between now and then. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=394&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=394&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=394&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=495&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=495&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530365/original/file-20230606-21-usmovg.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=495&fit=crop&dpr=3 2262w" alt="Walruses on ice floe" /></a><figcaption>Walruses depend on sea ice. As it melts, they’re being forced onto land. outdoorsman / shutterstock</figcaption></figure> There is still plenty of uncertainty around the exact date – about <a href="https://agupubs.onlinelibrary.wiley.com/doi/full/10.1002/2016GL070067">20 years or so</a> – because of natural chaotic fluctuations in the climate system. But compared to previous research, the new study still brings forward the most likely timing of a blue ocean event by about a decade. <h2>Why this matters</h2> You might be asking the question: so what? Other than some polar bears not being able to hunt in the same way, why does it matter? Perhaps there are even benefits as the previous US secretary of state, Mike Pompeo, <a href="https://edition.cnn.com/2019/05/06/politics/pompeo-sea-ice-arctic-council/index.html">once declared</a> – it means ships from Asia can potentially save around 3,000 miles of journey to European ports in summer at least. But Arctic sea ice is an important component of the climate system. As it dramatically reduces the amount of sunlight absorbed by the ocean, removing this ice is predicted to further accelerate warming, through a process known as a positive feedback. This, in turn, will make the Greenland ice sheet <a href="https://agupubs.onlinelibrary.wiley.com/doi/full/10.1002/2014GL059770">melt faster</a>, which is already a major contributor to <a href="https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2021RG000757">sea level rise</a>. The loss of sea ice in summer would also mean changes in <a href="https://www.ipcc.ch/report/ar6/wg2/chapter/ccp6/">atmospheric circulation and storm tracks</a>, and fundamental shifts in ocean biological activity. These are just some of the <a href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2021RG000757">highly undesirable consequences</a> and it is fair to say that the disadvantages will far outweigh the slender benefits. <a href="https://theconversation.com/profiles/jonathan-bamber-102567">Jonathan Bamber</a>, Professor of Physical Geography, <a href="https://theconversation.com/institutions/university-of-bristol-1211">University of Bristol</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/arctic-ocean-could-be-ice-free-in-summer-by-2030s-say-scientists-this-would-have-global-damaging-and-dangerous-consequences-206974">original article</a>. Images: Getty

Travel Trouble

Deadly Colombian volcano could be about to erupt, warn scientists

<div class="copy"> On March 30, Colombia’s Geological Service raised its alert level on the volcano from yellow to orange. They warn that the volcano could erupt with a strength unseen in the last 10 years within “weeks or days”. President of Colombia Gustavo Petro on April 5 ordered the voluntary evacuation of about 2,500 families living near the volcano. Many locals have been unwilling to leave their belongings and livelihoods behind. Geologists monitoring the volcano have recorded thousands of tremors every day – an unprecedented number. Nevado del Ruiz, one of Colombia’s tallest peaks at 5,321 metres high, is located in a populated farming region. It is only 129 km west of the country’s capital city Bogotá. In 1985, the volcano erupted with tragic consequences. It triggered mudslides that nearly completely buried the town of Armero. More than 23,000 of the town’s 30,000 residents were killed. Despite humanity’s long history of living under the shadow of volcanoes and trying to understand them, geologists, seismologists and vulcanologists remain largely baffled by the lava-spewing behemoths. The last time the threat level of Nevado del Ruiz was raised, for example, was in 2012. For over a month in April of that year, residents were under orange alert. This was increased to red alert for two days in June. But no major eruption occurred. Recently, new methods for assessing the risk of volcanic eruption have been trialled from studying the <a href="https://cosmosmagazine.com/earth/volcano-breath-test-predict-eruptions/" target="_blank" rel="noreferrer noopener">chemical composition of the atmosphere</a> above active volcanoes to <a href="https://cosmosmagazine.com/earth/ai-volcano-eruptions/" target="_blank" rel="noreferrer noopener">utilising artificial intelligence</a> to try and make sense of the pattern of eruptions. University of Miami professor in marine geosciences Falk Amelung believes the threat should not be taken lightly. “This is a high-risk and well-monitored volcano, and right now, all the ingredients for a new eruption are there,” Amelung says in a university <a href="https://www.newswise.com/articles/is-colombia-s-deadly-nevado-del-ruiz-on-the-verge-of-a-major-eruption#!" target="_blank" rel="noreferrer noopener">press release</a> on Newswise. “A significant seismic swarm occurred on March 30, and this [low-magnitude] earthquake sequence strongly suggests that magma is on the move.” Like Mount St Helens in Washington state, US which famously erupted in 1980, killing 57 people, Nevado del Ruiz is a glacier-covered volcano. Amelung says that this places local residents under extra peril. “Even a relatively small eruption would melt the glacier,” Amelung explains. “Volcanic ash combined with the meltwater would form mudflows, known as lahars, that can travel fast and for several miles.” <div class="in-content-area content-third content-right"> </div> Amelung admits it is impossible to say with certainty what will happen. “This increased period of activity could well die down and nothing happens,” he says. Ironically, global warming over the last 38 years since the eruption which saw the inundation of Armero, means the glaciers that cover the volcano’s summit are smaller, lessening lahar hazards. “But it is also bad news in terms of eruption hazards because there is less pressure from the overburden to keep the magma at depth,” Amelung adds. <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=246260&title=Deadly+Colombian+volcano+could+be+about+to+erupt%2C+warn+scientists" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /></div> <div id="contributors"> This article was originally published on <a href="https://cosmosmagazine.com/earth/colombian-volcano-erupt/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Evrim Yazgin. Images: Getty </div>

Travel Trouble

Schumacher’s family suing German magazine over fake interview

Michael Schumacher’s family is preparing to take legal action against German tabloid magazine Die Aktuelle, for publishing an AI-generated “interview” with the star. The publication has been slammed for using Michael’s face on their April 15 front cover, promoting the piece as “the first interview” since the star’s skiing accident in December 2013. “No meagre, nebulous half-sentences from friends. But answers from him! By Michael Schumacher, 54!” read the text in the magazine. “It sounded deceptively real,” they added in the strapline, which was the only indicator that the piece was fake. The “interview” included quotes that insensitively described Schumacher’s recovery, following the accident where he suffered a serious brain injury. “I was so badly injured that I lay for months in a kind of artificial coma, because otherwise my body couldn’t have dealt with it all,” the quote read. “I’ve had a tough time but the hospital team has managed to bring me back to my family,” they added. It was only at the end of the article that the publication revealed that they used Character.ai, an AI chatbot, to create the interview. A spokesperson for Schumachers confirmed their intention to take legal action against Die Aktuelle to Reuters and ESPN. This isn’t the first time Schumacher’s family have taken action against Die Aktuelle. In 2015, Michael’s wife, Corinna Schumacher filed a lawsuit against the magazine after they used Corinna’s picture with the headline: “Corinna Schumacher – a new love makes her happy.” The story was actually about their daughter, Gina, but the lawsuit was dismissed. Image: Getty Images

Legal

Volcano breath test helps scientists predict deadly eruptions

Humanity has a long history of living in the shadows of active volcanoes. Prized for their rich, fertile soils – ideal for cultivating crops – and their local topography, it isn’t hard to see why living in active volcanic regions remains a worthwhile gamble. Volcanic eruptions, however, are notoriously difficult to predict but improving our diagnostic abilities is crucial for developing early warning procedures and evading disaster. External indicators such as earthquakes and deformation of the Earth’s crust are traditional methods of identifying an imminent eruption, however, not all eruptions give these early warning signs. But now a research team from the University of Tokyo has gained better insight into the relationship between changes in the magma composition and eruption, by studying the ratio of specific chemical isotopes in gas and steam emitted from fumaroles — holes and cracks in the earth’s surface. “When you compare a volcano with a human body, the conventional geophysical methods represented by observations of earthquakes and crustal deformation are similar to listening to the chest and taking body size measurements”, said Professor Hirochika Sumino from the Research Centre for Advanced Science and Technology, who led the study. “In these cases, it is difficult to know what health problem causes some noise in your chest or a sudden increase in your weight, without a detailed medical check. On the other hand, analysing the chemical and isotope composition of elements in fumarolic gases is like a breath or blood test. This means we are looking at actual material directly derived from magma to know precisely what is going on with the magma.” Previous research on gas associated with an eruption from a volcano in the Canary Islands in 2011 showed an increase in the ratio of heavier helium isotopes which are typical of mantle material. “We knew that the helium isotope ratio occasionally changes from a low value, similar to the helium found in the Earth’s crust, to a high value, like that in the Earth’s mantle, when the activity of magma increases,” said Sumino. “But we didn’t know why we had more mantle-derived helium during magmatic unrest.” Sumino and team sought the answers in fumerole gas around Kusatsu-Shirane, an active volcano 150 km northwest of Tokyo. Taking samples of the gas back to the lab every few months between 2014 and 2021, the researchers were able to ascertain precise measurements of the isotopic components, discovering a relationship between the ratio of argon-40 to helium-3 ( a ‘high value’ isotope of helium) and magmatic unrest. “Using computer models, we revealed that the ratio reflects how much the magma underground is foaming, making bubbles of volcanic gases which separate from the liquid magma,” explained Sumino. The extent to which the magma is foaming “controls how much magmatic gas is provided to the hydrothermal system beneath a volcano and how buoyant the magma is. The former is related to a risk of phreatic eruption, in which an increase in water pressure in the hydrothermal system causes the eruption. The latter would increase the rate of magma ascent, resulting in a magmatic eruption.” The research collaboration is now developing a portable type of mass spectrometer which could be used in the field for real time analysis, reducing the need to constantly collect and transport samples back to the lab – a challenging a time-consuming process. “Our next step is to establish a noble gas analysis protocol with this new instrument, to make it a reality that all active volcanoes — at least those which have the potential to cause disaster to local residents — are monitored 24 hours a day, seven days a week,” said Sumino. This article originally appeared on cosmosmagazine.com and was written by <a href="https://cosmosmagazine.com/earth/volcano-breath-test-predict-eruptions/" target="_blank" rel="noopener">Clare Kenyon</a>. Image: Getty

Travel Trouble

Obese yet malnourished toddler mummy sheds light on life in 17th century aristocratic Austria

In a creepy discovery published, a collaboration of German scientists have performed a ‘virtual autopsy’ on a mummified toddler’s body, found in a 17th century Austrian crypt. Buried in a wooden coffin that was slightly too small and deformed the skull, the young child’s body appeared to be both obese and malnourished. Researchers say the findings might provide a rare insight into historical Austrian aristocratic society. By using CT scanning, scientists were able to perform a ‘virtual autopsy’ on the mummy which was naturally mummified in the conditions of the crypt. Well-preserved soft tissue showed the child was a boy, overweight for his age, and radiocarbon dating suggests a date of death between 1550 and 1635 CE. By examining the formation and length of the body’s bones, plus evidence of tooth eruption, the researchers were able to estimate that the child was about one year old when he died. The bones also showed that despite being well-fed, the boy was malnourished, with his malformed ribs displaying signs of rachitic rosary. This condition presents in a pattern of prominent bony knobs at points where the rib joins cartilage and results from diseases associated with specific vitamin deficiencies such as rickets (vitamin D) and scurvy (vitamin C). Vitamin D is found in foods like salmon, tuna, mackerel and beef liver and egg yolks, but we typically only get around 10% of our required Vitamin D from our diets – the rest is made by our bodies when exposed to ultraviolet B (UVB) from the sun. “The combination of obesity along with a severe vitamin-deficiency can only be explained by a generally ‘good’ nutritional status along with an almost complete lack of sunlight exposure,” said Dr Andreas Nerlich of the Academic Clinic Munich-Bogenhausen and lead researcher. The child appears to have died from pneumonia, judging by the evidence of inflammation in the lungs. Rickets is known to make children more vulnerable to pneumonia, suggesting that, sadly, not only was the child malnourished, but that this condition may have also led to his untimely demise. “We have to reconsider the living conditions of high aristocratic infants of previous populations,” said Nerlich. Relatively little is known about aristocratic childhood in the late Renaissance period, so these mummified remains give key insights into life in Europe of a period generally known for its fervent creativity and intellectual development. “This is only one case,” said Nerlich, “but as we know that the early infant death rates generally were very high at that time, our observations may have considerable impact in the over-all life reconstruction of infants even in higher social classes.” To understand more about this period, researchers scoured historical records of the crypt and the family to whom the crypt belonged. Curiously, the child was buried in a simple, unmarked, wooden coffin, although he was dressed in an expensive silk hooded coat. The unmarked coffin appeared to have been slightly too small for the body such that the skull became deformed and was the only infant buried amongst the identifiable adult metal coffins in the crypt. Historical records of renovations on the crypt confirmed the radiocarbon dating, indicating the child was likely buried sometime after 1600 CE. The crypt belonged to the Counts of Starhemberg and traditionally was kept exclusively for the burial of heirs to their titles, and their wives, making the body likely to be that of the first-born (and only) son, Reichard Wilhelm, of Count Starhemberg. “We have no data on the fate of other infants of the family,” Nerlich said, regarding the unique burial. “According to our data, the infant was most probably [the count’s] first-born son after erection of the family crypt, so special care may have been applied.” This article originally appeared on <a href="https://cosmosmagazine.com/history/toddler-mummy-17thcentury-austria/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Clare Kenyon. Image: Andreas et al. (2022)

Travel Trouble

Sounds great: Scientists are manipulating dreams to prevent nightmares

It’s estimated that at any given time, around 4% of adults suffer <a href="https://cosmosmagazine.com/health/one-side-of-your-brain-might-be-giving-you-nightmares/" target="_blank" rel="noreferrer noopener">chronic nightmares</a> but researchers in Switzerland have a new approach which will be music to the ears of night-terror-sufferers. Basing their study on the relationship between the types of <a href="https://cosmosmagazine.com/science/biology/nightmares-and-night-terrors-in-kids-when-do-they-stop-being-normal/" target="_blank" rel="noreferrer noopener">emotions experienced in dreams</a> and our emotional well-being, researchers have investigated how to help people by manipulating emotions in their dreams. Traditional methods to help chronic nightmare patients involves ‘imagery rehearsal therapy’, during which they are coached to rehearse the dream scenario during the day and redirect it towards a more positive ending. A <a href="https://link.springer.com/article/10.1007/s11818-021-00320-w" target="_blank" rel="noreferrer noopener">2021 study</a> of 28 participants showed 3 in 5 patients benefitted from this approach, however, it doesn’t work for everyone. <div class="newsletter-box"> <div id="wpcf7-f6-p220659-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> In a <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(22)01477-4" target="_blank" rel="noreferrer noopener">study from Geneva University</a>, over a two-week period, researchers asked a group of 18 patients to create an association between the positively redirected version of their dream and a sound during an imagination exercise. The patients then wore wireless headbands during night which would play the specific sound during the REM (Rapid Eye Movement) stage of sleep – when <a href="https://www.mayoclinic.org/diseases-conditions/nightmare-disorder/symptoms-causes/syc-20353515" target="_blank" rel="noreferrer noopener">nightmares typically occur</a>. When compared to 18 patients who undertook only the image rehearsal therapy, those who received the combined rehearsal and sound therapy had fewer nightmares. This trend continued even after three months post-intervention, with those receiving combination therapy also reporting experiencing more positive emotions such as ‘joy’ in their dreams. “We were positively surprised by how well the participants respected and tolerated the study procedures, for example performing imagery rehearsal therapy every day and wearing the sleep headband during the night,” says Lampros Perogamvros, senior author of the study and a psychiatrist at the Sleep Laboratory of the Geneva University Hospitals and the University of Geneva. “We observed a fast decrease of nightmares, together with dreams becoming emotionally more positive. For us, researchers and clinicians, these findings are very promising both for the study of emotional processing during sleep and for the development of new therapies.” <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=220659&title=Sounds+great%3A+Scientists+are+manipulating+dreams+to+prevent+nightmares" width="1" height="1" /> <div id="contributors"> <a href="https://cosmosmagazine.com/health/sounds-great-preventing-nightmares/" target="_blank" rel="noopener">This article</a> was originally published on Cosmos Magazine and was written by Clare Kenyon. Image: Getty Images </div>

Mind

Manipulating light can induce psychedelic experiences – and scientists aren’t quite sure why

For millennia, people have used mind-altering techniques to achieve different states of consciousness, envision spiritual figures, connect with nature, or simply for the fun of it. Psychedelic substances, in particular, have a long and controversial <a href="https://theconversation.com/psychedelic-drugs-can-be-almost-as-life-altering-as-near-death-experiences-189325">history</a>. But for just as long, people have been having these experiences without drugs too, using <a href="https://www.mdpi.com/2076-3425/11/1/101">rhythmic techniques such as rocking, chanting or drumming</a>. Perhaps the most powerful technique of this kind is flickering light, called “ganzflicker”. Ganzflicker effects can be achieved by turning a light on and off, or by alternating colours in a rapid, rhythmic pattern (like a strobe). This can create an instant psychedelic experience. Ganzflicker elicits striking visual phenomena. People can see geometric shapes and illusory colours but sometimes also complex objects, such as animals and faces – all without any chemical stimulants. Sometimes ganzflicker can even lead to altered states of consciousness (such as losing a sense of time or space) and emotions (ranging from fear to euphoria). Although its effects are little known today, ganzflicker has influenced and inspired many people through the ages, including the two of us. We are an art historian and brain scientist working together on an interactive showcase of ganzflicker techniques used in science and art. Our collaboration has culminated in the museum exhibition <a href="https://reshannereeder.com/ganzflicker-exhibit">“Ganzflicker: art, science, and psychedelic experience”</a>, which is part of the 2022 <a href="https://www.beinghumanfestival.org/">Being Human festival</a>. Ganzflicker’s effects were first documented in 1819 by the physiologist <a href="https://www.karger.com/Article/FullText/235945">Jan E. Purkinje</a>. Purkinje discovered that illusory patterns could appear if he faced the sun and waved his hand in front of his closed eyelids. Near the end of the 19th century, an English toymaker and amateur scientist, <a href="https://www.nature.com/articles/051200c0">Charles Benham</a>, produced the first commercially available flicker device: a top with a monochrome pattern that, when spun, produced illusory colours that swirled around the disc. Modified versions of Benham’s “artificial spectrum top” were used in experiments well into the 20th century. William Grey Walter, a pioneering neurophysiologist and cybernetician, <a href="https://link.springer.com/chapter/10.1007/978-3-642-70911-1_17">pushed flicker effects further</a> by using electric strobe lights, synchronised with the brain’s rhythms. Fascinated by the mind-altering potential of Walter’s machinery, the artist Brion Gysin, in collaboration with writer William S. Burroughs and mathematician Ian Sommerville, invented the <a href="http://mindcontrol-research.net/wp-content/uploads/2016/12/14_2_dream-machine-plans.pdf">Dreamachine</a> (1962). <h2>The swinging 60s of drug-free psychedelics</h2> A Dreamachine consists of an upright cylinder with patterns cut into it and a lightbulb suspended at its centre. When spun on a turntable at 78rpm, the flickering patterns (viewed through closed eyelids) can cause trance-like hallucinations. Gysin thought of the Dreamachine as a new kind of artwork – “the first art object to be seen with the eyes closed” – and a form of entertainment, which he believed could replace the television. Others saw the Dreamachine’s potential to be a source of spiritual inspiration. Burroughs thought it could be <a href="https://faroutmagazine.co.uk/brion-gysin-the-pioneering-artist-who-invented-the-dreamachine/">used to</a> “storm the citadels of enlightenment”. The poet Alan Ginsberg said: “It sets up optical fields as religious and mandalic as hallucinogenic drugs – it’s like being able to have jewelled biblical designs and landscapes without taking chemicals.” Flicker experiments in art did not stop with the Dreamachine. Others included Tony Conrad’s groundbreaking structuralist film <a href="https://fourthree.boilerroom.tv/film/flicker-tony-conrad">The Flicker</a> (1966), which was the first artwork to include the warning “may induce epileptic seizures or produce mild symptoms of shock treatment in certain persons”. The conceptual artist James Turrell’s <a href="https://jamesturrell.com/work/bindu-shards/">Bindu Shards</a> (2010) was an enclosed globe that bombards the observer with strobe light. And, more recently, Collective Act created its own <a href="https://dreamachine.world/">Dreamachine</a> (2022) , a public planetarium-style artwork inspired by Gysin’s which toured the UK. <h2>The science of ganzflicker</h2> Two hundred years after Jan Purkinje documented the physiological properties of ganzflicker, scientists still do not have a definitive explanation for how it works. A recent theory proposes that visual phenomena may be the result of interactions between external flicker and the brain’s natural rhythmic electrical pulses, with more intense images manifesting <a href="https://theconversation.com/pseudo-hallucinations-why-some-people-see-more-vivid-mental-images-than-others-test-yourself-here-163025">when the frequencies of flicker and the brain are closest</a>. It is also likely that a strong visual flicker influences brain states. Meaningful visions, altered conscious states and heightened emotions may be the result of <a href="https://www.nature.com/articles/s41467-020-18591-6">imaginative suggestion</a>, which is amplified by the trance-inducing properties of <a href="https://www.mdpi.com/2076-3425/11/1/101">rhythmic stimulation</a>. What is perhaps most powerful about ganzflicker is its universality. Engineers, mathematicians, artists, historians and scientists have all been united by this modest, drug-free means of eliciting dramatic changes in consciousness. The new wave of popularity on this topic will undoubtedly lead to illuminating discoveries in the coming years. Image credits: Getty Images This article originally appeared on <a href="https://theconversation.com/manipulating-light-can-induce-psychedelic-experiences-and-scientists-arent-quite-sure-why-192885" target="_blank" rel="noopener">The Conversation</a>.

Art

It took scientists 100 years to track these eels to their breeding ground

The life of a European eel isn’t an easy one. They’re critically endangered, must travel up to 10,000 km to get to their spawning point and then when they get there they <a href="https://en.wikipedia.org/wiki/Eel_life_history#European_eel" target="_blank" rel="noopener">probably die</a>. But they’re also incredibly difficult to keep track of. In the 1920s a Danish biologist named Johannes Schmidt, discovered the <a href="https://en.wikipedia.org/wiki/Sargasso_Sea" target="_blank" rel="noopener">Sargasso Sea</a> – due east of North America – had eel larvae. He spent the next 20 years trying to confirm his finding. But in the century since, researchers have been unable to sample either eggs or spawning adults. Now, a team from Europe has published a paper in <a href="https://www.nature.com/articles/s41598-022-19248-8" target="_blank" rel="noopener">Scientific Reports</a> that shows the first direct evidence of adult European eels migrating to the Sargasso Sea to breed. This provides vitally needed information on the life cycle of these slippery suckers. “The European Eel is critically endangered, so it is important that we solve the mystery surrounding their complete life-cycle to support efforts to protect the spawning area of this important species,” <a href="https://www.gov.uk/government/news/ancient-mystery-of-european-eel-migration-unravelled-to-help-combat-decline-of-critically-endangered-species" target="_blank" rel="noopener">says project lead Ros Wright from the UK Environment Agency.</a> “This is the first time we’ve been able to track eels to the Sargasso Sea … Their journey will reveal information about eel migration that has never been known before.” The team attached satellite tags to 26 female eels that were in rivers in the Azores archipelago – an autonomous region of Portugal in the North Atlantic Ocean – and then waited. When tracking had been done before in areas within Europe, like the Baltic and North Sea, the migratory routes were tracked up to 5000 kilometres, but the tracking had not gone for long enough, and the eels were heading in the right direction, but never made it all the way to the Sargasso Sea. <div class="newsletter-box"> <div id="wpcf7-f6-p219813-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> “The data from the tags were used to identify migratory routes that extended up to 5000 km from release, and which suggested routes taken by eels migrating from different countries converge when passing the Azores,” <a href="https://www.nature.com/articles/s41598-022-19248-8" target="_blank" rel="noopener">the team wrote in their paper.</a> “However, although eels were tracked for six months or more, their migration speed was insufficient to reach the Sargasso Sea for the first presumed spawning period after migration commenced, prompting the hypothesis that the spawning migration period of eels may extend to more than 18 months.” So, the team went directly to Azores to try and get the last leg of the journey, tracking 26 of the female eels with ‘X tags’. These collect data every two minutes and when the tag releases from the eel and bobs to the surface it then connects to the ARGOS satellite. Of course, not every single one worked. Only 23 tags communicated with the system; two became detached from the eels within a week. But the remainder provided a wealth of data to the team. Average migration speed was between 3 and 12 kilometres a day, and they were tracked from 40 days all the way to 366 days. Five of the eels ended up in within the Sargasso Sea boundaries while one eel made it all the way to the presumed breeding area Schmidt discovered those many years before. This isn’t the first time that eels have been tracked in this way. A study published last year, also in <a href="https://www.nature.com/articles/s41598-021-02325-9" target="_blank" rel="noopener">Scientific Reports</a>, which Cosmos covered at the time, looked at the spawning migrations of the Australasian short-finned eel. They found that the eels travelled for five months, around 2,620 km from south-Eastern Australia, as far north as the Coral Sea in Northern Queensland. The researchers in the European eel case still have much to do. The eels didn’t move fast enough to be able to make it to the spawning period on time, which means we still don’t really understand the life cycle. “Rather than make a rapid migration to spawn at the earliest opportunity, European eels may instead make a long, slow spawning migration at depth that conserves their energy and reduces mortality risk,” the team wrote. There’s also questions of what mechanisms the eels use to be able to correctly navigate to the Sargasso Sea. As usual in science, one answer has led to plenty more questions. <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=219813&title=It+took+scientists+100+years+to+track+these+eels+to+their+breeding+ground" width="1" height="1" /> <div id="contributors"> <a href="https://cosmosmagazine.com/nature/animals/european-eels-life-cycle-tracking-schmidt-sargasso-sea/" target="_blank" rel="noopener">This article</a> was originally published on Cosmos Magazine and was written by Jacinta Bowler. Image: Getty Images </div>

Family & Pets

Realistic androids coming closer, as scientists teach a robot to share your laughter

Do you ever laugh at an inappropriate moment? A team of Japanese researchers has taught a robot when to laugh in social situations, which is a major step towards creating an android that will be “like a friend.” “We think that one of the important functions of conversational AI is empathy,” says Dr Koji Inoue, an assistant professor at Kyoto University’s Graduate School of Informatics, and lead author on a paper describing the research, <a href="https://doi.org/10.3389/frobt.2022.933261" target="_blank" rel="noreferrer noopener">published</a> in Frontiers in Robotics and AI. “Conversation is, of course, multimodal, not just responding correctly. So we decided that one way a robot can empathize with users is to share their laughter, which you cannot do with a text-based chatbot.” The researchers trained an AI with data from 80 speed dating dialogues, from a matchmaking marathon with Kyoto University students. (Imagine meeting a future partner at exercise designed to teach a robot to laugh…) “Our biggest challenge in this work was identifying the actual cases of shared laughter, which isn’t easy, because as you know, most laughter is actually not shared at all,” says Inoue. “We had to carefully categorise exactly which laughs we could use for our analysis and not just assume that any laugh can be responded to.” They then added this system to a hyper-realistic android named <a href="https://robots.ieee.org/robots/erica/" target="_blank" rel="noreferrer noopener">Erica</a>, and tested the robot on 132 volunteers. <div class="newsletter-box"> <div id="wpcf7-f6-p214084-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> Participants listened to one of three different types of dialogue with Erica: one where she was using the shared laughter system, one where she didn’t laugh at all, and one where she always laughed whenever she heard someone else do it. They then gave the interaction scores for empathy, naturalness, similarity to humans, and understanding. The researchers found that the shared-laughter system scored higher than either baseline. While they’re pleased with this result, the researchers say that their system is still quite rudimentary: they need to categorise and examine lots of other types of laughter before Erica’s chuckling naturally. “There are many other laughing functions and types which need to be considered, and this is not an easy task. We haven’t even attempted to model unshared laughs even though they are the most common,” says Inoue. Plus, it doesn’t matter how realistic a robot’s laugh is if the rest of its conversation is unnatural. “Robots should actually have a distinct character, and we think that they can show this through their conversational behaviours, such as laughing, eye gaze, gestures and speaking style,” says Inoue. “We do not think this is an easy problem at all, and it may well take more than 10 to 20 years before we can finally have a casual chat with a robot like we would with a friend.” <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=214084&title=Realistic+androids+coming+closer%2C+as+scientists+teach+a+robot+to+share+your+laughter" width="1" height="1" /> <div id="contributors"> <a href="https://cosmosmagazine.com/technology/robot-laugh/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/ellen-phiddian" target="_blank" rel="noopener">Ellen Phiddian</a>. Ellen Phiddian is a science journalist at Cosmos. She has a BSc (Honours) in chemistry and science communication, and an MSc in science communication, both from the Australian National University. Image: Getty Images </div>

Technology

Scientists have mimicked an embryo’s heart to unlock the secrets of how blood cells are born

Stem cells are the starting point for all other cells in our bodies. The <a href="https://www.eurostemcell.org/blood-stem-cells-pioneers-stem-cell-research" target="_blank" rel="noopener">first such cells to be found</a> were blood stem cells – as the name suggests, they give rise to different types of blood cells. But there’s much we don’t know about how these cells develop in the first place. In a study published today in <a href="https://doi.org/10.1016/j.celrep.2022.111339" target="_blank" rel="noopener">Cell Reports</a>, we have shown how a lab simulation of an embryo’s beating heart and circulation lead to the development of human blood stem cell precursors. The tiny device mimics embryonic blood flow, allowing us to directly observe human embryonic blood formation under the microscope. These results may help us understand how we can produce life-saving therapies for patients who need new blood stem cells. <h2>Growing life-saving therapies in the lab</h2> To treat aggressive blood cancers such as leukaemia, patients often need extremely high doses of chemotherapy; a <a href="https://www.cancer.nsw.gov.au/myeloma/diagnosis-and-treatment/treatment/types-of-treatment/stem-cell-transplant#:%7E:text=A%20stem%20cell%20transplant%20involves%20killing%20blood%20cells,they%20are%20collected%20beforehand%20and%20kept%20in%20storage." target="_blank" rel="noopener">blood stem cell transplant</a> then regenerates blood after the treatment. These are life-saving therapies but are restricted to patients who have a suitable tissue-matched donor of blood stem cells. A way around this problem would be to grow more blood stem cells in the lab. Unfortunately, past experiments have shown that harvested adult blood stem cells lose their transplantation potential if grown in the lab. The discovery of <a href="https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell" target="_blank" rel="noopener">induced pluripotent stem cells</a> – stem cells made out of adult cells – in 2006 led to a promising new approach. Induced pluripotent stem cells are made from the patient’s own cells, so there is no problem with tissue rejection, or the ethical issues surrounding the use of IVF embryos. These cell lines are similar to embryonic stem cells, so they have the potential to form any tissue or cell type – hence, they are “pluripotent”. In theory, pluripotent stem cell lines could provide an unlimited supply of cells for blood regeneration because <a href="https://en.wikipedia.org/wiki/Immortalised_cell_line" target="_blank" rel="noopener">they are immortalised</a> – they can grow in the lab indefinitely. But the development of processes to allow us to grow particular types of tissues, organs and cell types – such as blood – has been slow and will take decades to advance. One must mimic the complex process of embryogenesis in the dish! <h2>Engineering an embryonic heart</h2> Current understanding of how embryonic blood stem cells develop is based on animal models. Experiments with anaesthetised zebrafish embryos have shown that blood stem cells arise in the wall of <a href="https://pubmed.ncbi.nlm.nih.gov/20154733/" target="_blank" rel="noopener">the main blood vessel, the aorta</a>, shortly after the first heartbeat. For ethical reasons, it’s obvious this type of study is not possible in human embryos. This is why we wanted to engineer an embryonic heart model in the lab. To achieve this, we used <a href="https://www.elveflow.com/microfluidic-reviews/general-microfluidics/a-general-overview-of-microfluidics/" target="_blank" rel="noopener">microfluidics</a> – an approach that involves manipulating extremely small volumes of liquids. The first step in generating blood stem cells from pluripotent stem cells is to coax the latter to form the site where blood stem cells start growing. This is known as the AGM region (aorta-gonad-mesonephros) of the embryo. Our miniature heart pump and circulation (3 by 3 centimetres) mimics the mechanical environment in which blood stem cells form in the human embryo. The device pumps culture media – liquids used to grow cells – around a microfluidic circuit to copy what the embryo heart does. <h2>A step closer to treatment</h2> Once we got the cells to form the AGM region by stimulating cells on day two of starting our cell culture, we applied what’s known as pulsatile circulatory flow from day 10 to day 26. Blood precursors entered the artificial circulation from blood vessels lining the microfluidic channels. Then, we harvested the circulating cells and grew them in culture, showing that they developed into various blood components – white blood cells, red blood cells, platelets, and others. In-depth analysis of gene expression in single cells showed that circulatory flow generated aortic and blood stem precursor cells found in the AGM of human embryos. This means our study has shown how pulsatile circulatory flow enhances the formation of blood stem cell precursors from pluripotent stem cells. It’s knowledge we can use in the future. The next step in our research is to scale up the production of blood stem cell precursors, and to test their transplant potential in immune-deficient mice that can accept human transplants. We can do this by using large numbers of pluripotent stem cells grown in bioreactors that also mechanically stimulate blood stem cell formation. If we can easily produce blood stem cells from pluripotent stem cell lines, it would provide a plentiful supply of these cells to help treatments of cancer or genetic blood diseases. This article originally appeared on <a href="https://theconversation.com/scientists-have-mimicked-an-embryos-heart-to-unlock-the-secrets-of-how-blood-cells-are-born-190530" target="_blank" rel="noopener">The Conversation</a>. Image: UNSW

Body

Scientist shares the confronting truth about using sunscreen

A pharmaceutical scientist has shared the confronting truth about what happens to your skin over time if you don’t apply sunscreen past the face. Hannah English shared the eye-opening reality of a 92-year-old woman with serious sun damage on her neck after she used UV protective moisturisers exclusively on her face for 40 years. The photographs of the elderly woman show her neck noticeably covered in wrinkles, sunspots and discoloration, while her face appeared flawless with hardly any damage. Hannah shared the photos as a warning to start wearing SPF everywhere that is exposed to the sun, including the easy-to-miss neck area. “It’s not too late to start wearing SPF daily,” Hannah said on Instagram. “Don’t forget your neck and chest. And probably hands.” “This is a real photo of a real person who used sunscreen on the face but not the neck for 40 years or more,” Hannah went on. <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/reel/CiMkSYuvG4X/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/CiMkSYuvG4X/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Hannah English (@ms_hannah_e)</a> </div> </blockquote> “Do you see the difference?” Hannah said she believed the woman only started applying sunscreen on her face 40 years ago. “She was in her 50s so there’s plenty of time for you to start wearing sunscreen every day,” she said. Doctor Avi Bitterman, a dermatologist from New York, originally shared the photograph on social media to show the consequences of not using sunscreen on the commonly-neglected area. “Cheek and neck of a 92-year-old female, who used UV-protective moisturisers on her face but not on the neck for more than 40 years,” Dr Bitterman said on Twitter. The picture was published in the Journal of the European Academy of Dermatology and Venereology to show the benefits of daily thorough UV protection. Image credits: Instagram

Beauty & Style

State-run German museums disclose works acquired during Nazi era

A Munich-based foundation that oversees the art collections of museums located throughout the titular German state is set to publicly disclose the origins of over 1,000 works acquired during the Nazi rule. The Bavarian State Painting Collections is launching an extensive database that includes information regarding over 1,200 paintings that researchers have found were acquired during the National Socialist period, or had ownership links to Nazi officials. There are a series of artworks that were given to museums and galleries during this time that are often subject to legal claims from descendants of persecuted Jewish families. Operating since 1999, a specialised unit dedicated to origin research has been reviewing all the ownership records of each and every artwork in the Bavarian State Paintings Collections that were created before 1945, and have been acquired since 1933. Throughout the database notes, a statement will accompany each artwork to alert people of its proper origins. This protocol is in keeping with the 1998 Washington Principles and the 1999 Joint Declaration of the Federal Government, both of which mounted calls for greater transparency surrounding the provenances of artworks believed to be subject to restitution claims. Other initiatives have been put into practice around the world, with <a href="https://oversixty.com.au/entertainment/art/new-york-museums-now-required-to-acknowledge-art-stolen-under-nazi-rule">museums and galleries in New York</a> now now legally required to acknowledge art stolen under the Nazi regime. The new state law requires New York museums to display signage alongside works of art from before 1945 that are known to have been stolen or forcibly sold during the Nazi rule. According to legislation and expert testimony, the Germans looted 600,000 works of art during World War II. Image credits: Getty Images

Art

Oops! Scientists identify the neurons responsible for learning from mistakes

Have you ever driven past an intersection and registered you should have turned right a street ago, or been in a conversation and, as soon as the words are out of your mouth, realised you really shouldn’t have said that thing you just did? It’s a phenomenon known as performance monitoring; an internal signal produced by the brain that lets you know when you’ve made a mistake. Performance monitoring is a kind of self-generated feedback that’s essential to managing our daily lives. Now, neuroscientists have discovered that signals from <a href="https://cosmosmagazine.com/science/biology/brain-pleasers-the-neurons-that-respond-to-singing/" target="_blank" rel="noreferrer noopener">neurons</a> in the brain’s medial frontal cortex are responsible for it. A <a href="https://www.science.org/doi/10.1126/science.abm9922" target="_blank" rel="noreferrer noopener">new study</a> published in Science reports that these signals are used to give humans the flexibility to learn new tasks and the focus to develop highly specific skills. “Part of the magic of the human brain is that it is so flexible,” says senior author Ueli Rutishauser, professor of Neurosurgery, Neurology, and Biomedical Sciences at Cedars-Sinai Medical Center, US. “We designed our study to decipher how the brain can generalise and specialise at the same time, both of which are critical for helping us pursue a goal.” They found that the performance monitoring signals help improve future attempts of a particular task by passing information to other areas of the brain. They also help the brain adjust its focus by signalling how much conflict or difficulty was encountered during the task. “An ‘Oops!’ moment might prompt someone to pay closer attention the next time they chat with a friend, or plan to stop at the store on the way home from work,” explains first author Zhongzheng Fu, researcher in the Rutishauser Laboratory at Cedars-Sinai. The team recorded the activity of more than 1000 neurons in the medial frontal cortexes of human epilepsy patients (who had existing electrode brain implants to help locate the focus of their seizures) while they performed complex cognitive tasks. <div class="newsletter-box"> <div id="wpcf7-f6-p190553-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> In the first task, called the Stroop task, participants’ reading- and colour naming skills were tested. Viewing the written name of the colour, such as “red”, printed in the ink of a different colour, such as blue, they were asked to name the ink colour rather than the written word. In the second task – the Multi-Source Interference Task (MSIT) – participants were shown three digits on a screen (two the same number and the other unique) and had to press a button associated with the unique number while resisting the tendency to press the other (because it appears twice). The researchers noted that two types of neurons seemed to be at work: “error” neurons fired strongly after a mistake was made, while “conflict” neurons fired in response to the difficulty of the task. “When we observed the activity of neurons in this brain area, it surprised us that most of them only become active after a decision or an action was completed,” says Fu. “This indicates that this brain area plays a role in evaluating decisions after the fact, rather than making them.” Scientists have known for some time that there are two types of performance monitoring: domain general and domain specific. Domain general performance monitoring tells us when something goes wrong, which allows people to perform new tasks with little instruction. Domain specific monitoring tells them what went wrong, and is one way that people perfect individual skills. Previously it was thought that the different neurons responsible for these two forms were located in distinct parts of the brain, but this research has found that they’re actually intermingled in the medial frontal cortex. According to Rutishauser, understanding the mechanisms behind performance monitoring is critical to perfecting the treatment of certain psychiatric disorders in which it is extreme, for example obsessive compulsive disorder (overactive monitoring) and schizophrenia (underactive). <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=190553&title=Oops%21+Scientists+identify+the+neurons+responsible+for+learning+from+mistakes." width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <div id="contributors"> <a href="https://cosmosmagazine.com/science/biology/neurons-performance-monitoring/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/imma-perfetto" target="_blank" rel="noopener">Imma Perfetto</a>. Imma Perfetto is a science writer at Cosmos. She has a Bachelor of Science with Honours in Science Communication from the University of Adelaide. Image: Getty Images </div>

Body

How QR codes work and what makes them dangerous – a computer scientist explains

Among the many changes brought about by the pandemic is the widespread use of QR codes, graphical representations of digital data that can be printed and later scanned by a smartphone or other device. QR codes have a <a href="https://www.forbes.com/sites/forbescommunicationscouncil/2021/03/25/how-the-pandemic-saved-the-qr-code-from-extinction/" target="_blank" rel="noopener">wide range of uses</a> that help people avoid contact with objects and close interactions with other people, including for sharing <a href="https://www.cnbc.com/2021/08/21/qr-codes-have-replaced-restaurant-menus-industry-experts-say-it-isnt-a-fad.html" target="_blank" rel="noopener">restaurant menus</a>, email list sign-ups, car and home sales information, and checking in and out of medical and professional appointments. QR codes are a close cousin of the bar codes on product packaging that cashiers scan with infrared scanners to let the checkout computer know what products are being purchased. Bar codes store information along one axis, horizontally. QR codes store information in both vertical and horizontal axes, which allows them to hold significantly more data. That extra amount of data is what makes QR codes so versatile. Anatomy of a QR code While it is easy for people to read Arabic numerals, it is hard for a computer. Bar codes encode alphanumeric data as a series of black and white lines of various widths. At the store, bar codes record the set of numbers that specify a product’s ID. Critically, data stored in bar codes is redundant. Even if part of the bar code is destroyed or obscured, it is still possible for a device to read the product ID. QR codes are designed to be scanned using a camera, such as those found on your smartphone. QR code scanning is built into many camera apps for Android and iOS. QR codes are most often used to store web links; however, they can store arbitrary data, such as text or images. When you scan a QR code, the QR reader in your phone’s camera deciphers the code, and the resulting information triggers an action on your phone. If the QR code holds a URL, your phone will present you with the URL. Tap it, and your phone’s default browser will open the webpage. QR codes are composed of several parts: data, position markers, quiet zone and optional logos. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=372&fit=crop&dpr=1 600w, https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=372&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=372&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=467&fit=crop&dpr=1 754w, https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=467&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/451140/original/file-20220309-17-1jkfl5t.png?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=467&fit=crop&dpr=3 2262w" alt="a black-and-white pattern with four numerical markers attached to arrows pointing to portions of the pattern" /></a><figcaption>The QR code anatomy: data (1), position markers (2), quiet zone (3) and optional logos (4). Scott Ruoti, <a class="license" href="http://creativecommons.org/licenses/by-nd/4.0/" target="_blank" rel="noopener">CC BY-ND</a></figcaption></figure> The data in a QR code is a series of dots in a square grid. Each dot represents a one and each blank a zero in binary code, and the patterns encode sets of numbers, letters or both, including URLs. At its smallest this grid is 21 rows by 21 columns, and at its largest it is 177 rows by 177 columns. In most cases, QR codes use black squares on a white background, making the dots easy to distinguish. However, this is not a strict requirement, and QR codes can use any color or shape for the dots and background. Position markers are squares placed in a QR code’s top-left, top-right, and bottom-left corners. These markers let a smartphone camera or other device orient the QR code when scanning it. QR codes are surrounded by blank space, the quiet zone, to help the computer determine where the QR code begins and ends. QR codes can include an optional logo in the middle. Like barcodes, QR codes are designed with data redundancy. Even if as much as 30% of the QR code is destroyed or difficult to read, <a href="https://www.businessinsider.com/what-is-a-qr-code?op=1" target="_blank" rel="noopener">the data can still be recovered</a>. In fact, logos are not actually part of the QR code; they cover up some of the QR code’s data. However, due to the QR code’s redundancy, the data represented by these missing dots can be recovered by looking at the remaining visible dots. Are QR codes dangerous? QR codes are not inherently dangerous. They are simply a way to store data. However, just as it can be hazardous to click links in emails, visiting URLs stored in QR codes can also be risky in several ways. The QR code’s URL can take you to a phishing website that tries to <a href="https://www.ic3.gov/Media/Y2022/PSA220118" target="_blank" rel="noopener">trick you</a> into entering your username or password for another website. The URL could take you to a legitimate website and trick that website into doing something harmful, such as giving an attacker access to your account. While such an attack requires a flaw in the website you are visiting, such vulnerabilities are <a href="https://developer.mozilla.org/en-US/docs/Glossary/Cross-site_scripting" target="_blank" rel="noopener">common on the internet</a>. The URL can take you to a malicious website that tricks another website you are logged into on the same device to take an unauthorized action. A malicious URL could open an application on your device and cause it to take some action. Maybe you’ve seen this behavior when you clicked a Zoom link, and the Zoom application opened and automatically joined a meeting. While such behavior is ordinarily benign, an attacker could use this to trick some apps into revealing your data. It is critical that when you open a link in a QR code, you ensure that the URL is safe and comes from a trusted source. Just because the QR code has a logo you recognize doesn’t mean you should click on the URL it contains. There is also a slight chance that the app used to scan the QR code could contain a vulnerability that allows <a href="https://www.lifewire.com/how-to-protect-yourself-from-malicious-qr-codes-2487772" target="_blank" rel="noopener">malicious QR codes to take over your device</a>. This attack would succeed by just scanning the QR code, even if you don’t click the link stored in it. To avoid this threat, you should use trusted apps provided by the device manufacturer to scan QR codes and avoid downloading custom QR code apps.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/177217/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/scott-ruoti-1318954" target="_blank" rel="noopener">Scott Ruoti</a>, Assistant Professor of Computer Science, <a href="https://theconversation.com/institutions/university-of-tennessee-688" target="_blank" rel="noopener">University of Tennessee</a> This article is republished from <a href="https://theconversation.com" target="_blank" rel="noopener">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-qr-codes-work-and-what-makes-them-dangerous-a-computer-scientist-explains-177217" target="_blank" rel="noopener">original article</a>. Image: Getty Images

Technology

Genetic discovery may help scientists reverse hearing loss

Neuroscience researchers have found a master gene that controls the development of special sensory cells in the ears – potentially opening the door to reversing hearing loss. A team led by Jaime García-Añoveros of Northwestern University, US, established that a gene called Tbx2 controls the development of ear hair cells in mice. The findings of their study are <a href="https://www.nature.com/articles/s41586-022-04668-3" target="_blank" rel="noreferrer noopener">published today in Nature</a>. What are hair cells? Hair cells are the sensory cells in our ears that detect sound and then transmit a message to our brains. They are so named because they have tiny hairlike structures called stereocilia. “The ear is a beautiful organ,” says García-Añoveros. “There is no other organ in a mammal where the cells are so precisely positioned.” Hair cells are found in a structure called the organ of Corti, in the cochlea in the inner ear. The organ of Corti sits on top of the basilar membrane. Sound waves are funnelled through our ear canal and cause the eardrum (also known as the tympanic membrane) and ossicles (tiny bones called the malleus, incus and stapes) to vibrate. The vibrations, or waves, are transmitted through fluid in the cochlea, causing the basilar membrane to move as well. When the basilar membrane moves, the stereocilia tilt, causing ion channels in the hair cell membrane to open. This stimulates the hair cell to release neurotransmitter chemicals, which will transmit the sound signal to the brain via the auditory nerve. <figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"> <div class="wp-block-embed__wrapper"> <div class="entry-content-asset"> <div class="embed-wrapper"> <div class="inner"><iframe title="2-Minute Neuroscience: The Cochlea" src="https://www.youtube.com/embed/WeQluId1hnQ?feature=oembed" width="500" height="281" frameborder="0" allowfullscreen="allowfullscreen"></iframe></div> </div> </div> </div> </figure> <h2> </h2> Hair cells and hearing loss There are actually two types of hair cells: inner and outer. We need both types to hear effectively. The outer hair cells change their shape and amplify sound for the inner hair cells, which transmit the vibrations to the brain. <div class="newsletter-box"> <div id="wpcf7-f6-p190195-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> <form class="wpcf7-form mailchimp-ext-0.5.61 init" action="/science/genetic-discovery-reverse-hearing-loss/#wpcf7-f6-p190195-o1" method="post" novalidate="novalidate" data-status="init"> <input class="wpcf7-form-control wpcf7-text referer-page" name="referer-page" type="hidden" value="https://cosmosmagazine.com/health/" data-value="https://cosmosmagazine.com/health/" aria-invalid="false" /> </form> </div> </div> “It’s like a ballet,” says García-Añoveros. “The outers crouch and jump and lift the inners further into the ear.” Hair cells develop before we are born and do not typically divide to create new versions of themselves. As we age, our hair cells die, <a href="https://cosmosmagazine.com/health/hair-cell-loss-may-explain-hearing-loss/">leading to hearing loss</a>. Loss of outer hair cells is particularly common. According to the US Centers for Disease Control, about 8.5% of adults aged 55-64 in the US experience “disabling” hearing loss, with that number increasing to nearly 25% in people aged 65-74, and 50% in those 75 and older. Could we one day reverse hearing loss? Since hair cells don’t usually divide, we may be able to reverse hearing loss if we can reprogram stem cells or other cells in the ear to become hair cells to replace those that die. Scientists have already produced artificial hair cells, but until now didn’t know how to direct the cell to become an inner or an outer hair cell. The team at Northwestern discovered that a gene called Tbx2 controls the development of both inner and outer hair cells. If Tbx2 is “switched on” to produce the protein TBX2, the cell develops into an inner hair cell. If Tbx2 is “off”, it becomes an outer hair cell. “Our finding gives us the first clear cell switch to make one type versus the other,” García-Añoveros explains. The finding is a step towards learning how we can reprogram the cells that usually provide structural support for the hair cells to become inner or outer hair cells themselves – replacing dead hair cells and preventing or reversing hearing loss. “We can now figure out how to make specifically inner or outer hair cells and identify why the latter are more prone to dying,” García-Añoveros says. “We have overcome a major hurdle.”  <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=190195&title=Genetic+discovery+may+help+scientists+reverse+hearing+loss" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" />  <div id="contributors"> <a href="https://cosmosmagazine.com/science/genetic-discovery-reverse-hearing-loss/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/matilda-handlsey-davis" target="_blank" rel="noopener">Matilda Handsley-Davis</a>. Matilda is a science writer at Cosmos. She holds a Bachelor of Arts and a Bachelor of Science (Honours) from the University of Adelaide. Image: Getty Images </div>

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Wearing shoes in the house is just plain gross, says the verdict from scientists who study indoor contaminants

You probably clean your shoes if you step in something muddy or disgusting (please pick up after your dog!). But when you get home, do you always de-shoe at the door? Plenty of Australians don’t. For many, what you <a href="https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/jam.13250">drag in on the bottom of your shoes</a> is the last thing on the mind as one gets home. We are environmental chemists who have spent a decade examining the indoor environment and the contaminants people are exposed to in their own homes. Although our examination of the indoor environment, via our <a href="https://www.360dustanalysis.com/">DustSafe program</a>, is far from complete, on the question of whether to shoe or de-shoe in the home, the science leans toward the latter. It is best to leave your filth outside the door. <h2>What contaminants are in your home, and how did they get there?</h2> People spend up to 90% of their time indoors, so the question of whether or not to wear shoes in the house is not a trivial one. The policy focus is typically on the outdoor environment for soil, air quality and environmental public health risks. However, there is growing regulatory interest in the question of <a href="https://ncc.abcb.gov.au/sites/default/files/resources/2021/Handbook-Indoor-Air-Quality.pdf">indoor</a> <a href="https://www.euro.who.int/en/media-centre/sections/press-releases/2021/new-who-global-air-quality-guidelines-aim-to-save-millions-of-lives-from-air-pollution">air quality</a>. The matter <a href="https://www.tandfonline.com/doi/abs/10.1080/09603123.2018.1457141?journalCode=cije2">building up</a> inside your home includes not just dust and dirt from people and pets shedding hair and skin. About a third of it is <a href="https://pubs.acs.org/doi/10.1021/es9003735">from outside</a>, either blown in or <a href="https://www.washingtonpost.com/health/how-the-dust-in-your-home-may-affect-your-health/2019/07/19/9f716068-a351-11e9-bd56-eac6bb02d01d_story.html">tramped</a> in on those offensive shoe bottoms. Some of the microorganisms present on shoes and floors are <a href="https://www.cambridge.org/core/journals/epidemiology-and-infection/article/mechanisms-for-floor-surfaces-or-environmental-ground-contamination-to-cause-human-infection-a-systematic-review/37BF6318BD1473C4918A23C843B25D05">drug-resistant pathogens</a>, including hospital-associated infectious agents (germs) that are very difficult to treat. Add in cancer-causing toxins from <a href="https://www.tandfonline.com/doi/full/10.1080/10408444.2018.1528208">asphalt road residue</a> and endocrine-disrupting <a href="https://www.tandfonline.com/doi/full/10.1080/23273747.2016.1148803">lawn chemicals</a>, and you might view the filth on your shoes in a new light. <h2>A roll-call of indoor nasties</h2> Our work has involved the measurement and assessment of exposure to a range of harmful substances found inside homes including: <ul> <li> <a href="https://www.newscientist.com/article/2231210-antibiotic-resistance-genes-can-be-passed-around-by-bacteria-in-dust/">antibiotic-resistant genes</a> (genes that make bacteria resistant to antibiotics) </li> <li> <a href="https://pubs.acs.org/doi/10.1021/acs.estlett.0c00587">disinfectant chemicals in the home environment</a> </li> <li> <a href="https://doi.org/10.1016/j.envpol.2021.117064">microplastics</a> </li> <li> the <a href="https://bmjopen.bmj.com/content/11/5/e044833.citation-tools">perfluorinated chemicals</a> (also known as PFAS or “forever chemicals” because of their tendency to remain in the body and not break down) used ubiquitously in a multitude of industrial, domestic and food packaging products </li> <li> <a href="http://hdl.handle.net/1959.14/1276977">radioactive elements</a>. </li> </ul> A strong focus of our work has involved assessing levels of <a href="https://theconversation.com/house-dust-from-35-countries-reveals-our-global-toxic-contaminant-exposure-and-health-risk-172499">potentially toxic metals (such as arsenic, cadmium and lead)</a> inside homes across <a href="https://doi.org/10.1021/acs.est.1c04494">35 nations (including Australia)</a>. These contaminants – and most importantly the dangerous neurotoxin lead – are odourless and colourless. So there is no way of knowing whether the dangers of lead exposure are only in your <a href="https://doi.org/10.1016/j.envint.2021.106582">soils</a> or your <a href="https://www.abcb.gov.au/sites/default/files/resources/2020/Lead_in_Plumbing_Products_and_Materials.pdf">water pipes</a>, or if they are also on your <a href="https://theconversation.com/house-dust-from-35-countries-reveals-our-global-toxic-contaminant-exposure-and-health-risk-172499">living room floor</a>. The <a href="https://theconversation.com/house-dust-from-35-countries-reveals-our-global-toxic-contaminant-exposure-and-health-risk-172499">science</a> suggests a very strong connection between the lead inside your <a href="https://www.mapmyenvironment.com/">home and that in your yard soil</a>. The most likely reason for this connection is dirt blown in from your yard or trodden in on your shoes, and on the furry paws of your adorable pets. This connection speaks to the priority of making sure matter from your outdoor environment stays exactly there (we have tips <a href="https://www.360dustanalysis.com/pages/interpreting-your-results">here</a>). A recent Wall Street Journal <a href="https://www.wsj.com/articles/heres-why-ill-be-keeping-my-shoes-on-in-your-shoeless-home-11644503227">article</a> argued shoes in the home aren’t so bad. The author made the point that E. coli – dangerous bacteria that develop in the intestines of many mammals, including humans – is so widely distributed that it’s pretty much everywhere. So it should be no surprise it can be swabbed on shoe bottoms (96% of shoe bottoms, as the article pointed out). But let’s be clear. Although it’s nice to be scientific and stick with the term E. coli, this stuff is, put more simply, the bacteria associated with poo. Whether it is ours or Fido’s, it has the potential to make us very sick if we are exposed at high levels. And let’s face it – it is just plain gross. Why walk it around inside your house if you have a very simple alternative – to take your shoes off at the door? <h2>On balance, shoeless wins</h2> So are there disadvantages to having a shoe-free household? Beyond the <a href="https://www.washingtonpost.com/lifestyle/wellness/feet-toes-broken-pain-covid/2021/01/11/470d2efa-4a05-11eb-a9f4-0e668b9772ba_story.html">occasional stubbed toe</a>, from an environmental health standpoint there aren’t many downsides to having a shoe-free house. Leaving your shoes at the entry mat also leaves potentially harmful pathogens there as well. We all know prevention is far better than treatment and taking shoes off at the door is a basic and easy prevention activity for many of us. Need shoes for foot support? Easy – just have some “indoor shoes” that never get worn outside. There remains the issue of the “sterile house syndrome,” which refers to increased rates of allergies among children. Some argue it’s related to overly sterile households. Indeed, some dirt is probably beneficial as <a href="https://www.jacionline.org/article/S0091-6749(10)00907-3/fulltext">studies</a> have indicated it helps develop your immune system and reduce allergy risk. But there are better and less gross ways to do that than walking around inside with your filthy shoes on. Get outside, go for a bushwalk, enjoy the great outdoors. Just don’t bring the muckier parts of it inside to build up and contaminate our homes. Image credits: Getty Images This article originally appeared in <a href="https://theconversation.com/wearing-shoes-in-the-house-is-just-plain-gross-the-verdict-from-scientists-who-study-indoor-contaminants-177542" target="_blank" rel="noopener">The Conversation</a>.

Home & Garden

Scientists creating inhalable Covid vaccine

Scientists are a step closer to creating an inhalable “aerogel” vaccine that successfully induces an immune response against Covid. Researchers at Penn State University developed and patented a gel-like material, called an "aerogel," to deliver antimicrobials to the lungs to treat bacterial respiratory infections, particularly tuberculosis. Graduate student in biomedical engineering and a lead author of the <a href="https://www.psu.edu/news/story/inhalable-aerogel-triggers-immunity-covid-19-mice-may-block-transmission/" target="_blank" rel="noopener">study</a> Atip Lawanprasert said there was an advantage to the inhalable formulation for those who don’t like needles. “One is avoidance of needles. Inhalable vaccines might be able to help increase the rate of vaccination because so many people are afraid of injections,” he said. “No matter how high the efficacy of a vaccine, if people don’t get it, then it’s not useful.” Scott Medina, an assistant professor of biomedical engineering at the university, said the team started working on the inhalable vaccine when the pandemic began. “When the pandemic started, we decided to develop an inhalable formulation for COVID-19 by combining our aerogel with a nucleic acid-encoded antigen — specifically, DNA that encodes the SARS-CoV-2 proteins,” he said. Their Covid formula, also known as CoMiP (coronavirus mimetic particle), was created to target alveolar macrophages, a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells. “Alveolar macrophages represent attractive targets for inhalable vaccines because they are abundant within the lungs, and previous evidence has suggested that they may be important in early COVID-19 pathogenesis,” Medina explained. “Alveolar macrophages are one of our key defenders against viral infection because they serve to present antigens to the rest of the immune system.” The CoMips were tested on mice which were then given a booster dose two weeks later. The samples from the animals were collected 14 days after the vaccine, and day 28, after the booster, which found no significant change in the systemic antibody levels between mice who received CoMiP and those that didn't. The researchers also collected samples from immunised mice to assess differences in the total and spike-protein specific lung mucosal IgA antibodies - the predominant antibody isotype in the mucosal immune system They found a significant increase in the total IgA for mice vaccinated with CoMiPs, but IgA specifically targeting the SARS-CoV-2 spike protein was lower than expected for the vaccinated animals. Medina said data was “encouraging” but more will need to be done. Image: Shutterstock

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Wearing shoes in the house is just plain gross, says the verdict from scientists who study indoor contaminants

Scientists creating inhalable Covid vaccine