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What are the new COVID booster vaccines? Can I get one? Do they work? Are they safe?

<p><em><a href="https://theconversation.com/profiles/paul-griffin-1129798">Paul Griffin</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p>As the COVID virus continues to <a href="https://pubmed.ncbi.nlm.nih.gov/36680207/">evolve</a>, so does our vaccine response. From <a href="https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/new-covid-19-vaccines-available-to-target-current-variants?language=en">December 11</a>, Australians will have access to <a href="https://www.health.gov.au/news/atagi-recommendations-on-use-of-the-moderna-and-pfizer-monovalent-omicron-xbb15-covid-19-vaccines?language=en">new vaccines</a> that offer better protection.</p> <p>These “monovalent” booster vaccines are expected to be a <a href="https://theconversation.com/cdc-greenlights-two-updated-covid-19-vaccines-but-how-will-they-fare-against-the-latest-variants-5-questions-answered-213341">better match</a> for currently circulating strains of SARS-CoV-2, the virus that causes COVID.</p> <p>Pfizer’s monovalent vaccine will be <a href="https://www.health.gov.au/ministers/the-hon-mark-butler-mp/media/new-covid-19-vaccines-available-to-target-current-variants?language=en">available</a> to eligible people aged five years and older. The Moderna monovalent vaccine can be used for those aged 12 years and older.</p> <p>Who is eligible for these new boosters? How do they differ from earlier ones? Do they work? Are they safe?</p> <h2>Who’s eligible for the new boosters?</h2> <p>The federal government has accepted the Australian Technical Advisory Group (ATAGI) recommendation to use the new vaccines, after Australia’s regulator <a href="https://www.tga.gov.au/products/covid-19/covid-19-vaccines/covid-19-vaccines-regulatory-status">approved their use last month</a>. However, vaccine eligibility has remained the same since September.</p> <p>ATAGI <a href="https://www.health.gov.au/news/atagi-recommendations-on-use-of-the-moderna-and-pfizer-monovalent-omicron-xbb15-covid-19-vaccines?language=en">recommends</a> Australians aged over 75 get vaccinated if it has been six months or more since their last dose.</p> <p>People aged 65 to 74 are recommended to have a 2023 booster if they haven’t already had one.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=315&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/560533/original/file-20231120-21-4igdnx.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=396&amp;fit=crop&amp;dpr=3 2262w" alt="" /></a><figcaption><span class="caption">For people without risk factors.</span> <span class="attribution"><a class="source" href="https://www.health.gov.au/sites/default/files/2023-10/atagi-recommended-covid-19-vaccine-doses.pdf">Health.gov.au</a></span></figcaption></figure> <p>Adults aged 18 to 64 <em>with</em> underlying risk factors that increase their risk of severe COVID are also recommended to have a 2023 booster if they haven’t had one yet. And if they’ve already had a 2023 booster, they can consider an additional dose.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=311&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/560532/original/file-20231120-26-70jfyr.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=391&amp;fit=crop&amp;dpr=3 2262w" alt="" /></a><figcaption><span class="caption">Advice for people with risk factors.</span> <span class="attribution"><a class="source" href="https://www.health.gov.au/sites/default/files/2023-10/atagi-recommended-covid-19-vaccine-doses.pdf">Health.gov.au</a></span></figcaption></figure> <p>For adults aged 18 to 64 <em>without</em> underlying risk factors who have already received a 2023 booster, an additional dose isn’t recommended. But if you’re aged 18 to 64 and haven’t had a booster in 2023, you can consider an additional dose.</p> <p>Additional doses aren’t recommended for children <em>without</em> underlying conditions that increase their risk of severe COVID. A primary course is not recommended for children aged six months to five years <em>without</em> additional risk factors.</p> <h2>Monovalent, bivalent? What’s the difference?</h2> <p><strong>From monovalent</strong></p> <p>The initial COVID vaccines were “monovalent”. They had one target – the original viral strain.</p> <p>But as the virus mutated, we assigned new letters of the Greek alphabet to each variant. This brings us to Omicron. With this significant change, we saw “immune evasion”. The virus had changed so much the original vaccines didn’t provide sufficient immunity.</p> <p><strong>To bivalent</strong></p> <p>So vaccines were updated to target an early Omicron subvariant, BA.1, plus the original ancestral strain. With two targets, these were the first of the “bivalent” vaccines, which were approved in Australia <a href="https://theconversation.com/omicron-specific-vaccines-may-give-slightly-better-covid-protection-but-getting-boosted-promptly-is-the-best-bet-190736">in 2022</a>.</p> <p>Omicron continued to evolve, leading to more “immune escape”, contributing to repeated waves of transmission.</p> <p>The vaccines were updated again in <a href="https://theconversation.com/havent-had-covid-or-a-vaccine-dose-in-the-past-six-months-consider-getting-a-booster-199096">early 2023</a>. These newer bivalent vaccines target two strains – the ancestral strain plus the subvariants BA.4 and BA.5.</p> <p><strong>Back to monovalent</strong></p> <p>Further changes in the virus have meant our boosters needed to be updated again. This takes us to the recent announcement.</p> <p>This time the booster targets another subvariant of Omicron known as XBB.1.5 (sometimes known as <a href="https://theconversation.com/the-kraken-subvariant-xbb-1-5-sounds-scary-but-behind-the-headlines-are-clues-to-where-covids-heading-198158">Kraken</a>).</p> <p>This vaccine is monovalent once more, meaning it has only one target. The target against the original viral strain has been removed.</p> <p>According to advice given to the World Health Organization <a href="https://www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines">in May</a>, this is largely because immunity to this original strain is no longer required (it’s no longer infecting humans). Raising immunity to the original strain may also hamper the immune response to the newer component, but we’re not sure if this is occurring or how important this is.</p> <p>The United States <a href="https://theconversation.com/cdc-greenlights-two-updated-covid-19-vaccines-but-how-will-they-fare-against-the-latest-variants-5-questions-answered-213341">approved</a> XBB.1.5-specific vaccines from Pfizer and Moderna in <a href="https://www.fda.gov/news-events/press-announcements/fda-takes-action-updated-mrna-covid-19-vaccines-better-protect-against-currently-circulating">mid-September</a>. These updated vaccines have also been <a href="https://www.tga.gov.au/sites/default/files/2023-10/auspar-spikevax-xbb.1.5-231012.pdf">approved in</a> places including Europe, Canada, Japan and Singapore.</p> <p>In Australia, the Therapeutic Goods Administration (TGA) approved them <a href="https://www.tga.gov.au/products/covid-19/covid-19-vaccines/covid-19-vaccines-regulatory-status">in October</a>.</p> <h2>Do these newer vaccines work?</h2> <p>Evidence for the efficacy of these new monovalent vaccines comes from the results of research <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&amp;id=CP-2023-PI-02409-1&amp;d=20231117172310101">Pfizer</a> and <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">Moderna</a> submitted to the TGA.</p> <p>Evidence also comes from a <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">preprint</a> (preliminary research available online that has yet to be independently reviewed) and an update Pfizer <a href="https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-09-12/10-COVID-Modjarrad-508.pdf">presented</a> to the US Centers for Disease Control.</p> <p>Taken together, the available evidence shows the updated vaccines produce good levels of antibodies in <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">laboratory studies</a>, <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">in humans</a> and <a href="https://www.tga.gov.au/resources/auspar/auspar-spikevax-xbb15">mice</a> when compared to previous vaccines and when looking at multiple emerging variants, including EG.5 (sometimes known as <a href="https://theconversation.com/the-who-has-declared-eris-a-variant-of-interest-how-is-it-different-from-other-omicron-variants-211276">Eris</a>). This variant is the one causing high numbers of cases around the world currently, including in Australia. It is very similar to the XBB version contained in the updated booster.</p> <p>The updated vaccines should also cover <a href="https://theconversation.com/how-evasive-and-transmissible-is-the-newest-omicron-offshoot-ba-2-86-that-causes-covid-19-4-questions-answered-212453">BA.2.86 or Pirola</a>, according to <a href="https://www.tga.gov.au/sites/default/files/2023-10/auspar-spikevax-xbb.1.5-231012.pdf">early results</a> from clinical trials and the US <a href="https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant.html">Centers for Disease Control</a>. This variant is responsible for a rapidly increasing proportion of cases, with case numbers growing <a href="https://twitter.com/BigBadDenis/status/1725310295596560662?s=19">in Australia</a>.</p> <p>It’s clear the virus is going to continue to evolve. So performance of these vaccines against new variants will continue to be closely monitored.</p> <h2>Are they safe?</h2> <p>The <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&amp;id=CP-2023-PI-02409-1&amp;d=20231117172310101">safety</a> of the updated vaccines has also been shown to be similar to previous versions. Studies <a href="https://www.medrxiv.org/content/10.1101/2023.08.22.23293434v2">comparing them</a> found no significant difference in terms of the adverse events reported.</p> <p>Given the availability of the updated vaccines, some countries have removed their approval for earlier versions. This is because newer versions are a closer match to currently circulating strains, rather than any safety issue with the older vaccines.</p> <h2>What happens next?</h2> <p>The availability of updated vaccines is a welcome development, however this is not the end of the story. We need to make sure eligible people get vaccinated.</p> <p>We also need to acknowledge that vaccination should form part of a comprehensive strategy to limit the impact of COVID from now on. That includes measures such as mask wearing, social distancing, focusing on ventilation and air quality, and to a lesser degree hand hygiene. Rapidly accessing antivirals if eligible is also still important, as is keeping away from others if you are infected.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/217804/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/paul-griffin-1129798"><em>Paul Griffin</em></a><em>, Professor, Infectious Diseases and Microbiology, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-are-the-new-covid-booster-vaccines-can-i-get-one-do-they-work-are-they-safe-217804">original article</a>.</em></p>

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13 tiny changes that will make your home instantly happier

<p><strong>Keep clutter minimal</strong></p><p>A stack of books. A pile of papers. Knick-knacks everywhere! If objects are crowding every surface of your home, you’re not alone. The first step to being truly happy in your space is to figure out what to keep, and what to let go. “A cluttered room is much more likely to produce, and contribute to, a cluttered mind,” says professional organiser Marie Kondo, author of the bestseller <em>The Life-Changing Magic of Tidying Up</em>. “I believe that only in an uncluttered room, which enables an uncluttered mind, can you truly focus your attention and your energy on the matters in your life which are preventing you from reaching your truest happiness.”</p><p>According to design psychologist Sally Augustin, the powerful mental effects of clutter have roots in our evolution. “In our early days as a species, our lives depended on continually surveying the environment and seeing if anything was going to eat us,” she says. “Today we continue to survey our environment, and too many things make this subconscious reviewing more difficult, which is why the visual complexity of clutter is so stressful.” A study from Princeton University shows that too much disorganised stimuli simply overwhelms the brain.</p><p><strong>Display meaningful objects</strong></p><p>The process of letting go of ‘stuff’ doesn’t mean you should live in a stark environment, according to Dr Augustin that would feel alien to us. Kondo’s method uses the test of whether an object ‘sparks joy’ in your heart. “When you decide what to keep based on what sparks joy, you are establishing and reaffirming to yourself what is most important to you,” she says. It’s not about the latest home design styles, it’s how an object makes you feel.</p><p>Still love showing off that soccer trophy from third grade? Keep it! As far as how much to display, balance out the chaos in your life with a visually quieter environment. The amount that feels right may vary from person to person, but Dr Augustin suggests four or five pictures in a room and a couple of objects on a surface, depending on the size. Kondo says an added benefit of going through your possessions is learning how to get rid of mental baggage as well as the physical. “The skills you learn can be applied in your life well beyond deciding on which souvenir coffee mug to keep,” she says.</p><p><strong>Create a calming space</strong></p><p>Finding a ‘sanctuary’ in your home gives your mind a place to go to rest and restore, helping you feel more at peace. It doesn’t have to be a whole room, it could be a reading nook, a knitting or craft space, or even a ‘home spa’ in your bathroom. </p><p>In carving out your sacred space, Dr Augustin suggests bright but muted colours like sage, soft textures like flannel, warm light, and curved lines in patterns and objects instead of straight lines. Studies show we prefer curved lines because we see sharp transitions, such as right angles, as more of a threat.</p><p><strong>Bring nature inside</strong></p><p>Studies have shown nature to be calming to our psyche, so one way to feel happier in your space is to bring plants inside. “Bringing nature into your home definitely has powerful psychological effects,” says interior designer and design psychology coach <a href="http://www.happystartsathome.com/">Rebecca West</a>. “Peace lilies are one of my favourites because they’re easy-to-care-for and do well in low light conditions.” Dr Augustin also suggests avoiding spiky plants.</p><p>“We associate comfort with curvy shapes and not spiky ones, which make us more alert,” she says. Houseplants have the added benefit of helping to refresh the air in a room, making you healthier, according to research. “But if you aren’t blessed with a green thumb, then fresh flowers or even a print of a garden or a wall mural of trees can affect some of that same profound healing,” West says. “Even having natural wood furniture in your home partnered with green accessories or wall paint can bring that outdoor feeling inside.”</p><p><strong>Make your space more social</strong></p><p>Humans are pro-social beings, so your home should also be a place where you feel comfortable inviting friends over. Consider buying home items that lend themselves to socialising: a barbecue, a fire pit to gather around, or board games for game night. Plus, make sure your rooms are arranged for easy socialising. “If you want your living room to be ready for a book club, then it should be arranged to focus on conversation, not a giant TV,” West says. Dr Augustin suggests considering your guests’ varying personalities as well.</p><p>“Extroverts would prefer couches and introverts would prefer an individual chair, so you should have a range of options,” she says. “Arrange the furniture so people can make easy eye contact with each other, but also so they can gracefully break eye contact and look at something else, like a fish tank, a piece of art, or a window with a view.” These ‘positive distractions’ can help you and your guests adhere to humans’ preferred length of eye contact; about three seconds, according to <a href="http://rsos.royalsocietypublishing.org/content/3/7/160086">research</a>.</p><p><strong>Use light well</strong></p><p>Psychologists have long known that light has an effect on our emotions. So when choosing what kind of light to have in your home, think about what feelings you’re trying to elicit in the space. “Warm light with warm light bulbs is better for when you’re socialising and relaxing, where blue and cooler light is better when you’re trying to do a really analytic task,” Dr Augustin says. So cool light might be better for a home office, but use warm light in the living and dining rooms.</p><p>“When people are having dinner parties they bring in candles, which are a warmer light – something we figured out eons ago which aligns with <a href="http://www.ledinside.com/knowledge/2013/12/lighting_psychology_cognitive_and_emotional_responses_to_lighting">modern research</a>,” she says. During the day, open the curtains and keep the windows clean to let the sun in. “Natural light is great for our mood,” Dr Augustin says. “But if a space is really glarey because you have lots of shiny surfaces, some of the positive ramifications of daylight evaporate because glare is stressful.”</p><p><strong>Keep it clean</strong></p><p>Having a clean home can have physical as well as mental benefits – less stuff means fewer things for dust and dirt to accumulate on, and you’ll be more likely to keep it clean because it won’t be so overwhelming. “The less clutter there is in your home, the easier it is to do basic cleaning chores, which let’s be honest, spark joy in almost nobody!”</p><p>Kondo says. Instead, you can use the time you save to do other things you enjoy more. But sometimes, a good cleaning can actually help you feel less stressed and anxious. “If you find yourself feeling frantic and overwhelmed, taking a moment to tidy up the kitchen or your bed can really calm those nerves and bring more focus into your mind,” West says.</p><p><strong>Make the bedroom a retreat</strong></p><p>Our mood improves when we wake up ‘on the right side of the bed’ after a good night’s sleep, and not getting good sleep has been <a href="https://sleepfoundation.org/sleep-disorders-problems/depression-and-sleep">linked to depression</a>. One way to feel more relaxed is to banish any reminders of unpleasant tasks in the bedroom. “If you have your home office in your bedroom, it’s great if the room is laid out so that when you’re actually lying down to go to sleep you don’t see your desk and all the piles of papers,” Dr Augustin says. Ideally, the bedroom should be one space to keep tidy.</p><p>“If you can’t put your whole home in order, try to have at least one room, such as the master bedroom, that gives you peace and respite from it all,” West says. Blackout curtains can also ensure the room is dark enough for good sleep. “It’s better for our health when the conditions are darker for sleep,” Dr Augustin says. “You can pull them during the day to let the daylight in.”</p><p><strong>Find storage solutions that work</strong></p><p>Even if your living spaces are clean, if every time you open that cupboard you’re pegged with an avalanche of stuff, it will still make you feel bogged down. “Simple storage methods are the best because they are the easiest to maintain,” says Kondo, who prefers shoe boxes. “Some people devise their storage strategies like a ‘Jenga’ tower, and we all know what happens when one piece is removed!”</p><p>Plus, being able to see everything you have also keeps you from buying new stuff you actually don’t need. If everything is simple and easy to access, it becomes not only routine, but a healthy habit, Kondo says. “You will always find ‘that thing’ you are looking for much easier, and that extra 10 or 15 minutes you save can be used to do something you truly enjoy.”</p><p><strong>Choose mood-boosting colours</strong></p><p>Your wall colour can affect your mood, so it might be time for a new coat of paint. Colour psychology is an entire field dedicated to understanding the impact shades have on us. “It’s the saturation and brightness levels of hues that determine our emotional response,” Dr Augustin says. “We’re calmer and in a more positive mood in colours that are not too saturated but relatively bright like sage green, and we’re more energised around colours that are more saturated and less bright, like a Kelly green [an intense, pure green].”</p><p>Energising colours make you happier in a place you work, like a kitchen, laundry or exercise room, whereas muted colours are better for a relaxing space, like a family room. Certain colours are associated culturally as well, which can help us feel at home in the space. “Our culture links yellow with kitchens and blue with restfulness, a good option for bedrooms,” Dr Augustin says.</p><p><strong>Use the power of scent</strong></p><p><a href="https://academic.oup.com/chemse/article/30/suppl_1/i248/270387/Effects-of-Fragrance-on-Emotions-Moods-and">Studies have shown</a> smell has psychological effects, so use oils or candles to evoke good feelings in your home. “Researchers have learnt that lavender helps people fall asleep so that can be good for the bedroom, and lemon can be good to smell when you’re trying to do cognitive work like in your home office,” Dr Augustin says.</p><p>Floral scents also elicit positive emotions. But don’t lay it on too strong – scents will continue to have an effect even after your nose gets used to them. “Any smell in too great a concentration is off-putting and stress-generating,” she says.</p><p><strong>Fill your home with good memories</strong></p><p>Let everything in your house bring up positive memories of things and people you love. “Each time you look at that picture of you and your friends in Paris, or see the painting you did that turned out better than you ever expected, it helps you keep perspective and connect you with what is good and wonderful in your life,” West says.</p><p>On the other hand, purge the things that remind you of negative experiences and bring you down. “A stuffed animal from an ex-boyfriend, or a piece of furniture that you inherited but have never really liked, can keep you stuck in the past,” she says. “Life is too short to be surrounded by stuff you don’t like.”</p><p><em>Image credits: Getty Images</em></p><p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/food-home-garden/home-tips/13-tiny-changes-that-will-make-your-home-instantly-happier?pages=1" target="_blank" rel="noopener">Reader's Digest</a>.</em></p>

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New booster vaccine approved in Australia

<p dir="ltr">An additional vaccine has been <a href="https://www.9news.com.au/national/astrazeneca-booster-shots-provisionally-approved-australia-therapeutic-goods-administration/cb666fd3-dff2-4603-8a56-663b7ad0b225" target="_blank" rel="noopener">granted provisional approval</a> to be used as a booster shot by the Therapeutic Goods Administration (TGA).</p><p dir="ltr">The TGA announced that a vaccine produced by AstraZeneca, called Vaxzevria, could be administered to individuals over the age of 18 who are yet to receive their third, ‘booster’ dose of a COVID-19 vaccine.</p><p dir="ltr">However, the TGA continues to recommend that Australians choose Moderna or Pfizer over the newly-approved jab.</p><p dir="ltr">“The third (booster) dose may be given if clinically indicated with reference to official guidance regarding the use of a heterologous third dose (e.g. mRNA vaccine),” it said in a statement.</p><p dir="ltr">“This means that the decision to receive Vaxzevria as a booster must be made in consultation with a medical professional.”</p><p dir="ltr">Dr Vinod Balasubramaniam, a virologist from Monash University’s Jeffrey Cheah School of Medicine and Health Sciences in Malaysia, said the addition of a third vaccine is particularly important as the world battles the Omicron variant.</p><p dir="ltr">“It’s important to increase the vaccine portfolio in the fight against COVID-19, in particular against the current highly contagious Omicron variant, a multi-pronged approach is definitely needed for us to win the war,” he <a href="https://www.scimex.org/newsfeed/expert-reaction-tga-provisionally-approves-astrazeneca-boosters-for-ages-18" target="_blank" rel="noopener">said</a>.</p><p dir="ltr">“Diversifying the vaccine portfolio in including AstraZeneca vaccines as part of the booster dose regimen is important, especially when used as a mix-and-match for individuals who experienced adverse reactions with their primary vaccinations with other types of vaccines.”</p><p dir="ltr">Dr Andy Files, a senior research fellow at the Menzies Institute for Medical Research within the University of Tasmania, agreed and noted that the mix-and-match approach has been proved as an effective way of protecting people from the virus.</p><p dir="ltr">“From a basic immunology perspective, swapping vaccines should help to focus the immune response on the SARS-CoV-2 spike protein encoded in the vaccines, rather than the other components of the vaccine, thus providing the intended boost in protection against the coronavirus,” he explained.</p><p dir="ltr">“The AstraZeneca booster will be most useful for people that had strong side effects to the mRNA vaccines or have histories of myocarditis or pericarditis.”</p><p><span id="docs-internal-guid-7a08a62b-7fff-6267-485c-f7fb04a89364"></span></p><p dir="ltr"><em>Image: Getty Images</em></p>

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Pfizer booster may offer important protection against Omicron variant

<p dir="ltr">Pfizer has announced that a booster of its COVID-19 vaccine may improve protection against the new Omicron variant of the virus.</p> <p dir="ltr">Pfizer and its partner BioNTech said on Wednesday that while two doses of the vaccine may not be sufficient protection against the Omicron variant, lab tests showed that a booster shot increased people’s levels of antibodies capable of fighting Omicron by 25-fold. For those who have not yet received a booster, two doses should still prevent severe disease or death.</p> <p dir="ltr">Health authorities in Australia, the US and around the world have been urging those eligible to get a third dose as soon as they are able. Dr Mikael Dolsten, Pfizer’s chief scientific officer, told the<span> </span><em>Associated Press,<span> </span></em>"Go and get your third boost as soon as possible. This is comforting and a very positive message that we now have a plan that will induce immunity that is likely to protect from infection, symptomatic illness and severe disease from now across the entire winter season."</p> <p dir="ltr">US President Joe Biden said the Pfizer booster news was “very encouraging” although he cautioned, “that’s the lab report. There’s more studies going on.” The findings were announced in a press release and have not yet been subject to scientific review.</p> <p dir="ltr">Pfizer tested blood samples taken a month after a booster had been administered and found that people had levels of Omicron-neutralising antibodies that were similar to amounts proven protective against earlier variants after two doses.</p> <p dir="ltr">It’s important to note that scientists don’t yet know how big a threat the Omicron variant is. Delta remains responsible for most of the current COVID-19 cases around the world, but the Omicron variant carries an unusually large number of mutations, and scientists are working quickly to learn how easily it spreads, whether it causes more serious illness than other variants, and how resistant it might be to vaccines.</p> <p dir="ltr"><em>Image: Jasmin Merdan</em></p>

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WHO director general calls for moratorium on vaccine boosters

<p><span style="font-weight: 400;">As countries around the world attempt to vaccinate their populations against COVID-19, the World Health Organisation has called for a moratorium on supplementary “booster” shots, citing global inequalities in access to the jabs.</span></p> <blockquote class="twitter-tweet"> <p dir="ltr">.<a href="https://twitter.com/WHO?ref_src=twsrc%5Etfw">@WHO</a> director general <a href="https://twitter.com/DrTedros?ref_src=twsrc%5Etfw">@DrTedros</a> is calling for a moratorium on booster shoots in wealthy countries until the end of Sept, to get more vaccine to low income countries.</p> — Helen Branswell (@HelenBranswell) <a href="https://twitter.com/HelenBranswell/status/1422909510558093318?ref_src=twsrc%5Etfw">August 4, 2021</a></blockquote> <p><span style="font-weight: 400;">The statement came hours after a San Francisco hospital began offering “supplemental doses” of the Pfizer and Moderna vaccines to recipients of the Johnson &amp; Johnson vaccine.</span></p> <p><span style="font-weight: 400;">Additionally, countries including Israel have already begun offering booster Pfizer doses to elderly people, while Germany and France are planning to administer booster doses to those who were vaccinated early on in the rollout, as well as elderly people and those with compromised immune systems.</span></p> <p><span style="font-weight: 400;">According to </span><em><a rel="noopener" href="https://www.washingtonpost.com/world/europe/covid-booster-vaccines-europe/2021/08/03/dddf18f4-f45d-11eb-a636-18cac59a98dc_story.html" target="_blank"><span style="font-weight: 400;">The Washington Post</span></a></em><span style="font-weight: 400;">, the UK is prepared to administer booster shots from September, pending approval from national health experts.</span></p> <p><span style="font-weight: 400;">Currently, about 29 percent of the world’s population has received one dose of a COVID-19 vaccine.</span></p> <p><span style="font-weight: 400;">However, this number drops to just one percent in low-income countries, according to </span><a rel="noopener" href="https://ourworldindata.org/covid-vaccinations" target="_blank"><span style="font-weight: 400;">Our World in Data</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">“I understand the concern of all governments to protect their people from the Delta variant,” WHO director general Dr Tedros Adhannom Ghebryesus said on Wednesday. “But we cannot accept countries that have already used most of the global supply of vaccines using even more of it.”</span></p> <blockquote class="twitter-tweet"> <p dir="ltr">The price of vaccine inequity is the unnecessary loss of human lives - someone's parent, child, partner or friend. We have the tools and the means to deliver them to the people whose lives could still be saved. Let's use them NOW. <a href="https://twitter.com/hashtag/VaccinEquity?src=hash&amp;ref_src=twsrc%5Etfw">#VaccinEquity</a></p> — Tedros Adhanom Ghebreyesus (@DrTedros) <a href="https://twitter.com/DrTedros/status/1425108886818856965?ref_src=twsrc%5Etfw">August 10, 2021</a></blockquote> <p><a rel="noopener" href="https://www.nature.com/articles/d41586-021-02109-1" target="_blank"><span style="font-weight: 400;">An analysis</span></a><span style="font-weight: 400;"> conducted by the organisation has found that if the 11 countries rolling out or considering rolling out booster shots were to give a third dose to everyone over the age of 50, they would use roughly 440 million doses from the global supply.</span></p> <p><span style="font-weight: 400;">“We need an urgent reversal, from the majority of vaccines going to high-income countries, to the majority going to low-income countries,” Tedros said.</span></p>

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