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New study suggests weight loss drugs like Ozempic could help with knee pain. Here’s why there may be a link

<a href="https://theconversation.com/profiles/giovanni-e-ferreira-1030477">Giovanni E. Ferreira</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/christina-abdel-shaheed-425241">Christina Abdel Shaheed</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> The drug semaglutide, commonly known by the brand names Ozempic or Wegovy, was <a href="https://theconversation.com/the-rise-of-ozempic-how-surprise-discoveries-and-lizard-venom-led-to-a-new-class-of-weight-loss-drugs-219721">originally developed</a> to help people with type 2 diabetes manage their blood sugar levels. However, researchers have discovered it may help with other health issues, too. Clinical trials show semaglutide can be effective for <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032183">weight loss</a>, and hundreds of thousands of people around the world are using it <a href="https://theconversation.com/considering-taking-a-weight-loss-drug-like-ozempic-here-are-some-potential-risks-and-benefits-219312">for this purpose</a>. Evidence has also shown the drug can help manage <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2306963">heart failure</a> and <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403347">chronic kidney disease</a> in people with obesity and type 2 diabetes. Now, a study published in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403664">New England Journal of Medicine</a> has suggested semaglutide can improve knee pain in people with obesity and osteoarthritis. So what did this study find, and how could semaglutide and osteoarthritis pain be linked? <h2>Osteoarthritis and obesity</h2> Osteoarthritis is a common joint disease, affecting <a href="https://www.aihw.gov.au/reports/chronic-musculoskeletal-conditions/osteoarthritis">2.1 million Australians</a>. Most people with osteoarthritis <a href="https://theconversation.com/do-you-have-knee-pain-from-osteoarthritis-you-might-not-need-surgery-heres-what-to-try-instead-236779">have pain</a> and find it difficult to perform common daily activities such as walking. The knee is <a href="https://pubmed.ncbi.nlm.nih.gov/37675071/">the joint most commonly affected</a> by osteoarthritis. Being overweight or obese is a <a href="https://pubmed.ncbi.nlm.nih.gov/25447976/">major risk factor</a> for osteoarthritis in the knee. The link between the two conditions <a href="https://pubmed.ncbi.nlm.nih.gov/26821091/">is complex</a>. It involves a combination of increased load on the knee, <a href="https://www.nature.com/articles/s41413-023-00301-9">metabolic factors</a> such as high cholesterol and high blood sugar, and inflammation. For example, elevated blood sugar levels increase the production of inflammatory molecules in the body, which can damage the cartilage in the knee, and lead to the <a href="https://pubmed.ncbi.nlm.nih.gov/30712918/">development of osteoarthritis</a>. Weight loss is strongly recommended to reduce the pain of knee osteoarthritis in people who are overweight or obese. <a href="https://pubmed.ncbi.nlm.nih.gov/31908149/">International</a> and <a href="https://www.safetyandquality.gov.au/sites/default/files/2024-08/osteoarthritis-knee-clinical-care-standard-2024.pdf">Australian guidelines</a> suggest losing as little as 5% of body weight can help. But losing weight with just diet and exercise can be difficult for many people. <a href="https://pubmed.ncbi.nlm.nih.gov/26180980/">One study</a> from the United Kingdom found the annual probability of people with obesity losing 5% or more of their body weight was less than one in ten. Semaglutide has recently entered the market as a potential alternative route to weight loss. It comes from a class of drugs known as GLP-1 receptor agonists and works by increasing a person’s sense of fullness. <h2>Semaglutide for osteoarthritis?</h2> The rationale for the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2403664">recent study</a> was that while we know weight loss alleviates symptoms of knee osteoarthritis, the effect of GLP-1 receptor agonists was yet to be explored. So the researchers set out to understand what effect semaglutide might have on knee osteoarthritis pain, alongside body weight. They randomly allocated 407 people with obesity and moderate osteoarthritis into one of two groups. One group received semaglutide once a week, while the other group received a placebo. Both groups were treated for 68 weeks and received counselling on diet and physical activity. At the end of the treatment phase, researchers measured changes in knee pain, function, and body weight. As expected, those taking semaglutide lost more weight than those in the placebo group. People on semaglutide lost around 13% of their body weight on average, while those taking the placebo lost around 3% on average. More than 70% of people in the semaglutide group lost at least 10% of their body weight compared to just over 9% of people in the placebo group. The study found semaglutide reduced knee pain significantly more than the placebo. Participants who took semaglutide reported an additional 14-point reduction in pain on a 0–100 scale compared to the placebo group. This is much greater than the pain reduction in another <a href="https://pubmed.ncbi.nlm.nih.gov/36511925/">recent study</a> among people with obesity and knee osteoarthritis. This study investigated the effects of a diet and exercise program compared to an attention control (where participants are provided with information about nutrition and physical activity). The results here saw only a 3-point difference between the intervention group and the control group on the same scale. The amount of pain relief reported in the semaglutide trial is also larger than that reported with commonly used pain medicines such as <a href="https://pubmed.ncbi.nlm.nih.gov/35442752/">anti-inflammatories</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/35137418/">opioids</a> and <a href="https://www.bmj.com/content/372/bmj.m4825">antidepressants</a>. Semaglutide also improved knee function compared to the placebo. For example, people who took semaglutide could walk about 42 meters further than those on the placebo in a six-minute walking test. <h2>How could semaglutide reduce knee pain?</h2> It’s not fully clear how semaglutide helps with knee pain from osteoarthritis. One explanation may be that when a person loses weight, there’s less stress on the joints, which reduces pain. But recent studies have also suggested semaglutide and other GLP-1 receptor agonists might have <a href="https://www.sciencedirect.com/science/article/pii/S1043661822002651">anti-inflammatory</a> properties, and could even protect against <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6731440/">cartilage wear and tear</a>. While the results of this new study are promising, it’s too soon to regard semaglutide as a “miracle drug” for knee osteoarthritis. And as this study was funded by the drug company that makes semaglutide, it will be important to have independent studies in the future, to confirm the findings, or not. The study also had strict criteria, excluding some groups, such as those taking opioids for knee pain. One in seven Australians seeing a GP for their knee osteoarthritis <a href="https://pubmed.ncbi.nlm.nih.gov/34527976/">are prescribed opioids</a>. Most participants in the trial were white (61%) and women (82%). This means the study may not fully represent the average person with knee osteoarthritis and obesity. It’s also important to consider semaglutide can have a range of <a href="https://theconversation.com/considering-taking-a-weight-loss-drug-like-ozempic-here-are-some-potential-risks-and-benefits-219312">side effects</a>, including gastrointestinal symptoms and fatigue. There are some concerns that semaglutide could reduce <a href="https://www.sciencealert.com/experts-are-concerned-drugs-like-ozempic-may-cause-muscle-loss">muscle mass</a> and <a href="https://www.healthline.com/health-news/ozempic-muscle-mass-loss">bone density</a>, though we’re still learning more about this. Further, it can be difficult to access. <h2>I have knee osteoarthritis, what should I do?</h2> Osteoarthritis is a disease caused by multiple factors, and it’s important to take <a href="https://www.safetyandquality.gov.au/standards/clinical-care-standards/osteoarthritis-knee-clinical-care-standard/information-consumers-osteoarthritis-knee-clinical-care-standard">a multifaceted approach</a> to managing it. Weight loss is an important component for those who are overweight or obese, but so are other aspects of <a href="https://theconversation.com/do-you-have-knee-pain-from-osteoarthritis-you-might-not-need-surgery-heres-what-to-try-instead-236779">self-management</a>. This might include physical activity, pacing strategies, and other positive lifestyle changes such as improving sleep, healthy eating, and so on.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/243159/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/giovanni-e-ferreira-1030477">Giovanni E. Ferreira</a>, NHMRC Emerging Leader Research Fellow, Institute of Musculoskeletal Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/christina-abdel-shaheed-425241">Christina Abdel Shaheed</a>, Associate Professor, School of Public Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Shutterstocl This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/new-study-suggests-weight-loss-drugs-like-ozempic-could-help-with-knee-pain-heres-why-there-may-be-a-link-243159">original article</a>.

Body

Humanising AI could lead us to dehumanise ourselves

<a href="https://theconversation.com/profiles/raffaele-f-ciriello-1079723">Raffaele F Ciriello</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/angelina-ying-chen-2230113">Angelina Ying Chen</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Irish writer John Connolly <a href="https://www.goodreads.com/quotes/3147986-the-nature-of-humanity-its-essence-is-to-feel-another-s">once said</a>: "The nature of humanity, its essence, is to feel another’s pain as one’s own, and to act to take that pain away." For most of our history, we believed empathy was a uniquely human trait – a special ability that set us apart from machines and other animals. But this belief is now being challenged. As AI becomes a bigger part of our lives, entering even our most intimate spheres, we’re faced with a philosophical conundrum: could attributing human qualities to AI diminish our own human essence? Our <a href="https://www.researchgate.net/publication/375086411_Feels_Like_Empathy_How_Emotional_AI_Challenges_Human_Essence">research</a> suggests it can. <h2>Digitising companionship</h2> In recent years, AI “companion” apps such as Replika have attracted millions of users. Replika allows users to create custom digital partners to engage in intimate conversations. Members who pay for <a href="https://help.replika.com/hc/en-us/articles/360032500052-What-is-Replika-Pro#:%7E:text=Replika%20Pro%20gives%20you%20access,relationship%20status%20to%20Romantic%20Partner.">Replika Pro</a> can even turn their AI into a “romantic partner”. Physical AI companions aren’t far behind. Companies such as JoyLoveDolls are selling <a href="https://www.joylovedolls.com/collections/sex-robots">interactive sex robots</a> with customisable features including breast size, ethnicity, movement and AI responses such as moaning and flirting. While this is currently a niche market, history suggests today’s digital trends will become tomorrow’s global norms. With about <a href="https://www.statista.com/chart/31243/respondents-who-feel-fairly-or-very-lonely/">one in four</a> adults experiencing loneliness, the demand for AI companions will grow. <h2>The dangers of humanising AI</h2> Humans have long attributed human traits to non-human entities – a tendency known as anthropomorphism. It’s no surprise we’re doing this with AI tools such as ChatGPT, which appear to “think” and “feel”. But why is humanising AI a problem? For one thing, it allows AI companies to exploit our tendency to form attachments with human-like entities. Replika is <a href="https://replika.com">marketed</a> as “the AI companion who cares”. However, to avoid legal issues, the company elsewhere points out Replika isn’t sentient and merely learns through millions of user interactions. Some AI companies overtly <a href="https://www.space.gov.au/news-and-media/akin-assistive-ai-improve-life-space-and-earth">claim</a> their AI assistants have empathy and can even anticipate human needs. Such claims are misleading and can take advantage of people seeking companionship. Users may become <a href="https://theconversation.com/i-tried-the-replika-ai-companion-and-can-see-why-users-are-falling-hard-the-app-raises-serious-ethical-questions-200257">deeply emotionally invested</a> if they believe their AI companion truly understands them. This raises serious ethical concerns. A user <a href="https://www.researchgate.net/publication/374505266_Ethical_Tensions_in_Human-AI_Companionship_A_Dialectical_Inquiry_into_Replika">will hesitate</a> to delete (that is, to “abandon” or “kill”) their AI companion once they’ve ascribed some kind of sentience to it. But what happens when said companion unexpectedly disappears, such as if the user can no longer afford it, or if the company that runs it shuts down? While the companion may not be real, the feelings attached to it are. <h2>Empathy – more than a programmable output</h2> By reducing empathy to a programmable output, do we risk diminishing its true essence? To answer this, let’s first think about what empathy really is. Empathy involves responding to other people with understanding and concern. It’s when you share your friend’s sorrow as they tell you about their heartache, or when you feel joy radiating from someone you care about. It’s a profound experience – rich and beyond simple forms of measurement. A fundamental difference between humans and AI is that humans genuinely feel emotions, while AI can only simulate them. This touches on the <a href="https://www.researchgate.net/publication/375086411_Feels_Like_Empathy_How_Emotional_AI_Challenges_Human_Essence">hard problem of consciousness</a>, which questions how subjective human experiences arise from physical processes in the brain. While AI can simulate understanding, any “empathy” it purports to have is a result of programming that mimics empathetic language patterns. Unfortunately, AI providers have a financial incentive to trick users into growing attached to their seemingly empathetic products. <h2>The dehumanAIsation hypothesis</h2> Our “dehumanAIsation hypothesis” highlights the ethical concerns that come with trying to reduce humans to some basic functions that can be replicated by a machine. The more we humanise AI, the more we risk dehumanising ourselves. For instance, depending on AI for emotional labour could make us less tolerant of the imperfections of real relationships. This could weaken our social bonds and even lead to emotional deskilling. Future generations may become less empathetic – losing their grasp on essential human qualities as emotional skills continue to be commodified and automated. Also, as AI companions become more common, people may use them to replace real human relationships. This would likely increase loneliness and alienation – the very issues these systems claim to help with. AI companies’ collection and analysis of emotional data also poses significant risks, as these data could be used to manipulate users and maximise profit. This would further erode our privacy and autonomy, taking <a href="https://theconversation.com/explainer-what-is-surveillance-capitalism-and-how-does-it-shape-our-economy-119158">surveillance capitalism</a> to the next level. <h2>Holding providers accountable</h2> Regulators need to do more to hold AI providers accountable. AI companies should be honest about what their AI can and can’t do, especially when they risk exploiting users’ emotional vulnerabilities. Exaggerated claims of “genuine empathy” should be made illegal. Companies making such claims should be fined – and repeat offenders shut down. Data privacy policies should also be clear, fair and without hidden terms that allow companies to exploit user-generated content. We must preserve the unique qualities that define the human experience. While AI can enhance certain aspects of life, it can’t – and shouldn’t – replace genuine human connection.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/240803/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/raffaele-f-ciriello-1079723">Raffaele F Ciriello</a>, Senior Lecturer in Business Information Systems, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/angelina-ying-chen-2230113">Angelina Ying Chen</a>, PhD student , <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/humanising-ai-could-lead-us-to-dehumanise-ourselves-240803">original article</a>.

Technology

Loneliness could kill you

<a href="https://theconversation.com/profiles/gillian-leithman-414232">Gillian Leithman</a>, <a href="https://theconversation.com/institutions/concordia-university-1183">Concordia University</a> Independence is glorified in North American culture as a symbol of strength. As a society, we value individual achievement and extol self-reliance. I am an expert on aging and retirement and I also help employees transition from work to retirement by facilitating seminars and workshops in corporate Canada. And I often wonder however if our “go at it alone” attitude has led us down a lonely and isolating path. Here are some recent stats: <ul> <li> 40 per cent of Americans <a href="https://hbr.org/cover-story/2017/09/work-and-the-loneliness-epidemic">don’t feel close to others</a> at any given time. And the number of lonely Americans has doubled since the 1980s. </li> <li> <a href="http://www.carp.ca/2017/06/05/loneliness-survey-results/">In a recent Canadian Association of Retired People poll</a>, 16 per cent of Canadians indicated that they lacked companionship </li> <li> Fifteen per cent in the CARP poll said they had nobody to turn to or talk to </li> <li> Fifteen per cent were unhappy doing things alone. </li> </ul> I suspect that these numbers are even higher among the general Canadian population, not just CARP members. According to science, loneliness shortens our lifespan. <a href="https://news.uchicago.edu/article/2014/02/16/aaas-2014-loneliness-major-health-risk-older-adults">Twice as much as obesity.</a> Yes, you read that right. Dr. John <a href="http://psychology.uchicago.edu/people/faculty/cacioppo/">Cacioppo</a>, the world’s foremost authority on loneliness, maintains that the number of people in your life does not inoculate you from experiencing loneliness. Rather, it’s the feeling of being lonely that places the brain and body at risk. Cacioppo equates feeling lonely with feeling hungry. We compromise our survival and well-being when either is ignored. We are biologically hardwired to respond to our environment. When we experience low blood-sugar levels, we crave food. The feeling of our stomachs being empty is a warning sign to eat and it’s essential to our very survival. When we feel lonely, we desire connection with others, much like the loud rumble that your tummy makes when hungry. <h2>A lonely brain is restless</h2> Loneliness triggers “hyper-vigilance.” That is your brain is on the lookout for social threats, which consequently puts us on the defensive. We become more reactive to negative events and perceive daily hassles as more stressful. A lonely brain awakens often, experiences fragmented sleep and cannot recover from the day’s stressful events. A lonely brain is also subject to an increase in depressive symptoms and has difficulty self-regulating. That is why you may find yourself irritable and impulsive. A lonely brain is also at risk of cognitive and physical decline. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23232034">A three-year Dutch study</a> followed more than 2,000 participants aged 65 to 86. While none of the participants had signs of dementia at the outset of the study, results revealed that those who reported feeling lonely had a 64 per cent increase in the risk of developing dementia. People also experience an increase in loneliness when they retire from work. That’s why you want <a href="http://rewiretoretire.com/delay-retirement/">to make sure that you’re retiring to something</a>, and that you have friends outside of your place of employment. <h2>A lonely body</h2> Loneliness also affects the body. Psychologist <a href="https://irp.nih.gov/pi/stephen-suomi">Stephen Suomi’s</a> research indicates that loneliness distorts the expression of certain genes. An experiment separating newborn primates from their mothers during their first four months of life resulted in the altered development of immunity-related genes that help the body fight viruses. Social psychologist <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633610/">Lisa Jaremka’s research</a> indicates that lonely people have higher levels of activated viruses in their system and are at greater risk of suffering from chronic inflammation, which has been linked to Type 2 diabetes, arthritis, heart disease and even suicide. While obesity increases your odds of an early death by 20 per cent, loneliness increases <a href="https://www.ucsf.edu/news/2012/06/12184/loneliness-linked-serious-health-problems-and-death-among-elderly">your odds by 45 per cent</a>. What are we to do with an emotional state that is so powerful that it can alter our brains, compromise our physiology and cut short our longevity? <h2>The antidote to loneliness</h2> <ol> <li> Seek out connection: We all need a tribe! </li> <li> Stop denying and accept “feeling lonely” as simply a craving for connection. </li> <li> Acknowledge the consequences of prolonged loneliness. If you ignore hunger, you starve. Same is true of our need for belonging. If you feel lonely, reach out to others. </li> <li> Recognize that quality relationships are most effective at feeding this void. </li> </ol> We are physiologically and psychologically primed for connection. The next time you feel lonely and out of sorts, acknowledge it as a signal that you are in need of connection and seek out companionship. Your body and your brain will be thankful that you did, and you may even increase your longevity.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/87217/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/gillian-leithman-414232">Gillian Leithman</a>, Assistant Professor of professional business skills and aging, retirement, and knowledge management researcher, <a href="https://theconversation.com/institutions/concordia-university-1183">Concordia University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/loneliness-could-kill-you-87217">original article</a>.

Caring

Trying to lose weight? Here’s why your genetics could be just as important as your exercise regime

<a href="https://theconversation.com/profiles/henry-chung-1279176">Henry Chung</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>; <a href="https://theconversation.com/profiles/chris-mcmanus-2226445">Chris McManus</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>, and <a href="https://theconversation.com/profiles/sally-waterworth-2226444">Sally Waterworth</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a> Weight loss is a complicated process. There are so many factors involved including your diet, how much sleep you get each night and the kind of exercise you do. Our recent study shows that your <a href="https://www.tandfonline.com/doi/full/10.1080/02701367.2024.2404981">specific genetic profile</a> may also have a dominant effect on how well you lose weight through exercise. This might explain why two people who do an identical workout will see very different results. We identified 14 genes that appeared to significantly contribute to how much weight a person lost through running. This suggests that some of us have a natural talent when it comes to burning fat and losing weight through exercise. To conduct our study, we recruited 38 men and women born in the UK aged between 20 and 40. None of the participants regularly exercised at the start of the study. The group was randomly divided, with one half following a strict eight-week endurance programme that consisted of three weekly runs of 20-30 minutes. The other group acted as a <a href="https://www.britannica.com/science/control-group">control</a>. They were instructed to refrain from exercise and continue their daily routines as normal over this study period, including diet and lifestyle habits. All participants conducted a running test to see how far they could run in 12 minutes, and were weighed before and after the study period. This was to gauge their initial fitness level and see how much they changed over the duration of the study. <a href="https://www.nhs.uk/conditions/obesity/">Body mass index</a> (BMI) was also calculated. Additionally, a saliva sample was collected from each person with a <a href="https://muhdo.com/?gclid=Cj0KCQjwiIOmBhDjARIsAP6YhSUB3WI81JP4Q_snYLhh-SBVNeCJNy2m63C8bKJFvO-nJ5UsHuCCdqMaAhTeEALw_wcB">DNA test kit</a> at the end of the study to assess their unique genetic profile. It’s important to note that everyone who participated in the study had a similar body weight, BMI and aerobic fitness level at the start of the study. This is beneficial for <a href="https://casp-uk.net/news/homogeneity-in-research/">multiple reasons</a>. It meant everyone was at the same starting point, and some <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/confounding-variable">confounding variables</a> were already controlled for such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128125/">fitness level</a>. This ultimately improves accuracy in interpreting the results. <h2>Exercise genes</h2> Everyone in the exercise group managed to lose weight – around 2kg on average. The control group, on the other hand, put on a little bit of weight. While a 2kg weight loss may not sound like a lot, it’s significant considering the exercise regime only lasted eight weeks and participants made no <a href="https://www.intechopen.com/chapters/87186">changes to their diet</a>. More significant, however, was the large variation in results among those that exercised – with an up to 10kg difference in weight loss between some of the participants. In fact, everyone within the exercise group improved at different rates. Since we controlled for factors such as the <a href="https://pubmed.ncbi.nlm.nih.gov/3529283/">intensity, duration and frequency</a> of the exercises and used participants who’d had a similar body weight and fitness level at the start of the study, this suggests that some people naturally benefited more than others from endurance training. When we looked at the genetic profiles of our participants, we found that differences in each person’s response to the exercise was strongly associated with their specific genetics. We showed there was a strong linear correlation between the amount of weight participants lost and 14 genes that have previously been shown to be associated with body weight, metabolism or <a href="https://www.nature.com/articles/s41380-018-0017-5">psychological conditions</a> that affect BMI. The greater number of these genes a participant had, the more weight they lost. Our results also revealed that around 63% of the variance in weight lost among participants were explained by the genes identified. For example, research has shown the <a href="https://www.ncbi.nlm.nih.gov/gene/10891">PPARGC1A gene</a> plays a role in metabolism and the <a href="https://link.springer.com/article/10.1007/S11033-020-05801-Z">use of fats for energy</a> while exercising. Our study found that all participants who lost more than 1.5kg from exercise had this gene. Those who lost less than this did not have this gene. Our findings align with what <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249501&s2=P875440273_1683331208925004155">previous studies</a> have shown. But while previous papers have only looked at the link between individual genes and weight loss, ours is the first to show that 14 different genes appear to work in combination to affect whether a person loses weight from endurance exercise. <h2>Piece of the puzzle</h2> Our study also suggests that while some people possess genes that make it easier for them to get fit and lose weight, people with these favourable genetics can only flourish if they actually exercise. In fact, our control group also had a number of these listed genes, but without exercise these genes could not activate, and so the participants did not lose any weight. While our study provides compelling findings, it’s not without limitations. Since we only looked at endurance-based exercise, it will be important for future studies to investigate whether there are similar links between weight loss, genetics and combinations of different types of training (such as a mixture of endurance and strength sessions into a training plan). It’s also worth mentioning that exercise is only <a href="https://www.who.int/activities/controlling-the-global-obesity-epidemic">one piece of the puzzle</a> when it comes to weight loss. So even if you have all 14 of these genes, you won’t lose any weight or get fit if you don’t exercise and maintain a healthy diet and sleep pattern. On the flip side, someone that only has a few of these favourable genes can still benefit if they exercise and are mindful of other aspects of their lifestyle.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/240506/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/henry-chung-1279176">Henry Chung</a>, Lecturer in Sport and Exercise Science, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>; <a href="https://theconversation.com/profiles/chris-mcmanus-2226445">Chris McManus</a>, Lecturer, School of Sport, Rehabilitation and Exercise Sciences, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>, and <a href="https://theconversation.com/profiles/sally-waterworth-2226444">Sally Waterworth</a>, Lecturer, School of Sport, Rehabilitation and Exercise Sciences, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/trying-to-lose-weight-heres-why-your-genetics-could-be-just-as-important-as-your-exercise-regime-240506">original article</a>.

Body

No time for a holiday? A ‘workation’ could be the answer

<a href="https://theconversation.com/profiles/mariachiara-barzotto-1449459">Mariachiara Barzotto</a>, <a href="https://theconversation.com/institutions/university-of-bath-1325">University of Bath</a> Imagine this: you’re lounging on the beach, waves crashing in the background. A laptop sits on the table next to your iced coffee. In between meetings, you dip into the ocean or explore a hiking trail. This is the ideal vision of “workations” – a blend of work and vacation that is <a href="https://www.peoplemanagement.co.uk/article/1882649/rise-workation-hr-encourage-blurring-lines-home-away#:%7E:text=Since%20many%20people%20shifted%20to,having%20to%20take%20annual%20leave.">gaining popularity</a> worldwide. A workation allows employees to work remotely from a holiday spot, and is part of a larger shift towards more flexible working arrangements, accelerated by the COVID pandemic and the rise of digital technology. <a href="https://www.tandfonline.com/doi/full/10.1080/16078055.2022.2134199#d1e474">Workations</a> can last from a few days to several weeks. The concept can be appealing to both employees and companies, but there are challenges too. So, understanding its benefits and limitations is important for workers and employers alike. The most obvious benefit for employees is enjoying a new environment while staying productive. The typical work environment can become monotonous, potentially leading to burnout, decreased creativity and dissatisfaction. A workation offers an escape from this day-to-day grind, providing a refreshing change of scenery. It combines the mental break of a vacation with the flexibility of working remotely, allowing workers to balance their professional and personal lives and <a href="https://www.jstage.jst.go.jp/article/abas/20/1/20_0210112a/_pdf">enhance their creativity</a>. This flexibility may be particularly beneficial for those with high workloads or tight schedules, as they no longer need to sacrifice time away from work to relax. And companies can also reap rewards from approving workations among their staff. One of the most significant advantages is employee retention. Flexible work arrangements are among <a href="https://buffer.com/state-of-remote-work/2023">the top priorities</a> for employees in today’s job market, helping to reduce staff turnover. Offering the option of a workation could also make a company more attractive to prospective employees. And workers who are free to work from inspiring locations may return to their tasks less stressed, and more motivated and engaged. Studies show that remote workers often demonstrate <a href="https://journals.sagepub.com/doi/full/10.1177/1529100615593273">increased organisational commitment</a>. Another advantage is the potential for cost savings. With more employees working remotely, companies may reduce their need for large office spaces or the expensive perks offered in corporate environments such as gyms, canteens and the staffing that goes with them. But there can be challenges too. The boundary between work and leisure can become blurred, and some employees may find it <a href="https://tuprints.ulb.tu-darmstadt.de/7578/1/Dissertation_Reinke_Always%20Online%20-%20Boundary%20Management%20and%20Well-being.pdf%20">hard to disconnect from work</a> – defeating the object of travelling to a different workplace. The allure of finishing “just one more task” can prevent employees from truly enjoying their surroundings, potentially leading to exhaustion instead of rejuvenation. Time zone differences can also be a challenge. Juggling meetings and collaborating with colleagues in different time zones can lead to irregular work hours that make it hard to maintain a healthy work-life balance. Distractions are another concern. Beaches, tourist attractions or even the simple novelty of being in a new place can make it difficult to focus on work tasks. Employees need to have a strong sense of discipline to remain productive. For companies, one of the primary challenges is ensuring that employees remain productive. Monitoring performance without feeling intrusive can be a tricky balance for managers to strike. Security is another major concern. Remote work often involves accessing company networks and handling sensitive information. When employees work from unfamiliar locations – particularly in public spaces such as cafes – there may be increased risks related to cybersecurity. Ensuring that employees follow security protocols, use secure wifi and protect sensitive data is crucial. Lastly, workations might not be feasible for all roles. This can lead to disparities in who can take advantage of the opportunity, potentially leading to bad feeling among other staff. For the concept of workations to succeed, both employees and employers should set clear expectations, establish boundaries, and focus on maintaining productivity while allowing time for relaxation. But, if managed properly, they could become a staple of modern work culture. In a world where flexibility and wellbeing are increasingly valued, workations offer a unique opportunity to blend productivity with personal fulfilment, reshaping how we think about work and leisure. <h2>Nine tips for having a successful workation</h2> 1. Choose the right destination Opt for a location with reliable internet access and where the time difference between colleagues and clients is manageable. 2. Set clear boundaries Establish dividing lines between your work and vacation time, and communicate these boundaries with your employer and colleagues. 3. Ensure you have the right tech set-up Bring all the necessary equipment, including noise-cancelling headphones. Double-check that you have remote access to all necessary material before leaving. 4. Plan for cybersecurity Use a secure virtual private network (VPN) to protect company data, and follow your company’s cybersecurity policies to the letter. 5. Understand your company’s remote work policy Read up on things like flexibility in terms of location, time zones, working hours and refunds for co-working spaces or tech tools. 6. Set realistic expectations Don’t expect your workation to feel like a full vacation. Plan your leisure activities around your work schedule. Be prepared to work longer or odd hours if your company operates in a different time zone. 7. Consider the local infrastructure Research amenities such as medical services, food delivery and transport. These might be important if you stay in a more remote or unfamiliar area. Have a contingency plan for health emergencies and check visa requirements. 8. Prepare for flexibility Be ready for unexpected issues like slow internet or disruptions due to local events. Back-up plans, such as access to a co-working space or alternative accommodation, can save you from unnecessary stress. 9. Stay organised Keep a work schedule and a checklist of tasks to ensure that you remain as productive as you are in your regular work environment.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/240485/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/mariachiara-barzotto-1449459">Mariachiara Barzotto</a>, Senior Lecturer in Management Strategy and Organisation, <a href="https://theconversation.com/institutions/university-of-bath-1325">University of Bath</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/no-time-for-a-holiday-a-workation-could-be-the-answer-240485">original article</a>.

Travel Tips

Readers response: What career path could you have seen yourself taking but didn’t?

When it comes to work, we often pick a career path and stick with the same industry for most of our working lives. However, it's not uncommon to have regrets over work, given many people pick their career paths as a young adult. We asked our readers what career path they could you have seen themselves taking but didn’t, and the response was overwhelming. Here's what they said. Jill Waterhouse - Nursing, but my parents wouldn't let me. I would have loved to have been a nursery nurse. After coming to Australia I did become a medical secretary, so I suppose I was a bit there. Nola Martin - Primary school teacher but my father wouldn't let me. Unforgivable. Peter King - Medicine, but ended up doing aviation instead. Joy Saker - Speech therapist, but I would have had to live at home for another 4 years. Helen McKee - I always wanted to be a police officer. Charlie Hedges - Wanted to be a doctor in space but could not afford the many years of college. Christina Hutchings - I wanted to be a librarian. Sue Nixon - I wish I was an airline stewardess or researcher, something to do with travel. Image credits: Shutterstock

Retirement Life

New study finds epilepsy drug could reduce sleep apnoea symptoms

New research has found that a drug used for epilepsy could be used to reduce the symptoms of sleep apnoea. Obstructive sleep apnoea, which affects about one in 20 people, according to the National Institute for Health and Care Excellence in England, includes symptoms like snoring and it causes a person's breathing to start and stop during the night, with many requiring an aid to help keep their airways open. An international study has identified that taking sulthiame, a drug sold under the brand name Ospolot in Europe, may help prevent patients' breathing from temporarily stopping. This provides an additional option for those unable to use mechanical breathing aids like the Cpap machines. “The standard treatment for obstructive sleep apnoea is sleeping with a machine that blows air through a face mask to keep the airways open. Unfortunately, many people find these machines hard to use over the long term, so there is a need to find alternative treatments,” Prof Jan Hedner from Sahlgrenska university hospital and the University of Gothenburg in Sweden said. Researchers conducted a randomised controlled trial of almost 300 obstructive sleep apnoea patients across Europe, who did not use Cpap machines. They were divided into four groups and given either a placebo or different strengths of sulthiame. The study measured patients’ breathing, oxygen levels, heart rhythm, eye movements, as well as brain and muscle activity while asleep. It found after 12 weeks, those taking sulthiame had up to 50% fewer occasions where their breathing stopped, and higher levels of oxygen in their blood. However, a bigger study needs to be done to confirm the beneficial effects on a larger group. The findings, were presented at the European Respiratory Society Congress in Vienna, Austria. Erika Radford, the head of health advice at Asthma + Lung UK said the findings were a positive step forward in moving away from having to rely on mechanical breathing equipment. “This potential alternative to the current main treatment would make it easier for people to manage their condition,” she said. Image: Shutterstock

Body

Crowds, water guns and protests: could ‘slow tourism’ be the answer to an overtourism backlash?

<a href="https://theconversation.com/profiles/amy-errmann-1360032">Amy Errmann</a>, <a href="https://theconversation.com/institutions/auckland-university-of-technology-1137">Auckland University of Technology</a> With overtourism in the spotlight as the travel industry continues to rebound after the pandemic, popular destinations around the world are feeling the strain. Bali is overwhelmed by <a href="https://thebalisun.com/concerns-increasing-about-impact-of-trash-and-traffic-on-bali-tourists/">waste and traffic</a>, Australia’s sacred sites have suffered <a href="https://www.bbc.com/news/world-australia-50151344">environmental damage</a>, New York is facing rising rents <a href="https://www.theguardian.com/us-news/2023/oct/23/new-york-airbnb-crackdown-rules-housing">due to short-term rentals</a>, and Singapore’s scenic spots are becoming <a href="https://www.channelnewsasia.com/singapore/overtourism-locals-tourists-sustainable-tourism-stb-focus-4517681">clogged with crowds</a>. Frustrated locals are pushing back – from <a href="https://www.nzherald.co.nz/travel/barcelona-locals-spray-tourists-with-water-guns-during-protest-over-housing-costs/FUFHXKO5X5F5NNPSU6ELNVGSIA/">spraying water at tourists </a>in Barcelona to <a href="https://adventure.com/venice-locals-squatting-against-overtourism-photography/">organising protests in Venice</a>. As the northern hemisphere high season ends, Aotearoa New Zealand is preparing for an influx of visitors ahead of its summer tourism season. And much like those other <a href="https://www.nytimes.com/2024/09/08/world/europe/greece-cruise-ships-tourists-islands.html">tourist hotspots</a>, the government is looking at how to manage the negative effects of tourism on local communities and the environment. This includes tripling the <a href="https://www.theguardian.com/world/article/2024/sep/04/new-zealand-to-nearly-triple-tourist-tax-for-international-visitors">international tourist tax</a> from NZ$35 to $100. The aim of the increase is to <a href="https://www.theguardian.com/world/2022/aug/11/new-zealand-tourism-minister-makes-pitch-to-the-rich-as-he-spurns-10-a-day-travellers">attract tourists</a> who are more mindful of their impact and willing to contribute to its mitigation, while also <a href="https://theconversation.com/welcome-to-nz-now-pay-up-the-risks-and-rewards-of-raising-the-foreign-tourist-tax-232138">reducing visitor numbers</a> to protect the country’s unique landscapes and cultures. But are there other ways the tourism industry can evolve to ensure benefits for both travellers and the communities they are visiting? So called “slow travel” could be the answer. <h2>Hunting the perfect photo</h2> Overtourism isn’t just about too many people in one place. It’s also about how people travel. <a href="https://edition.cnn.com/travel/social-media-tourism-effect-scn-wellness/index.html">Instagram-famous</a> landmarks draw massive crowds, <a href="https://www.rnz.co.nz/news/national/406195/visitors-ignore-ban-continue-to-visit-mermaid-pools-in-northland-hapu">disrupting local life</a> and sometimes even <a href="https://www.nzherald.co.nz/travel/vermot-town-famous-for-fall-foliage-bans-instagram-tourists-from-streets/BHKEYKKUTNHORFT6QCZ5TW333A/#google_vignette">leading to closures</a>. Travellers often pack their itineraries with as many sights as possible, racing from one place to another in a frenzy to capture the perfect photo. This hurried approach not only creates <a href="https://www.cntraveler.com/galleries/2015-06-19/barcelona-bhutan-places-that-limit-tourist-numbers">congestion</a> but also limits <a href="https://www.nature.com/articles/s41599-024-02859-z">meaningful engagement with the destination</a>. And it’s not just a numbers game. The way tourists behave also plays a critical role. A <a href="https://www.rnz.co.nz/national/programmes/ninetonoon/audio/2018690535/tropical-trash-the-impact-of-holidaying-in-the-pacific">2019 report</a> from the United Nations raised concerns about trash from tourists in developing small island states, including the Pacific Islands. According to the report, a tourist visiting these communities produced about 7kg of waste a day, compared to about 2.5kg produced by a local. The issue is not necessarily about travelling less, but about <a href="https://www.sciencedirect.com/science/article/pii/S2211973623000284">travelling more responsibly</a>. The tourism industry needs to be encouraging travel habits that allow both visitors and locals to enjoy tourism without compromising the integrity of the destination. <h2>The rise of slow travel</h2> Mindfulness – being fully present in the moment – has gained popularity since the 1970s. The concept has influenced a number of sectors, including <a href="https://slowfoodauckland.co.nz/">slow food</a>, <a href="https://ourwayoflife.co.nz/slow-fashion-101-what-to-buy-and-what-to-avoid-to-reduce-your-clothing-footprint/">slow fashion</a>, and now <a href="https://www.lakewanaka.co.nz/wanaka-stories/how-to-be-a-slow-mindful-traveler-in-wanaka/">slow travel</a>. It’s about <a href="https://link.springer.com/chapter/10.1007/978-3-031-63569-4_44#:%7E:text=Slow%20travel%2C%20mindful%20travel%2C%20or,spiritual%20well%2Dbeing%20of%20people">experiencing destinations</a> at a relaxed pace, focusing on deeper connections with local cultures and sustainability. This often means <a href="https://guestnewzealand.com/about-us/eco-travels-new-zealand/">staying longer in fewer places</a> and choosing eco-friendly transport. Understanding slow travel and mindfulness is important because they create <a href="https://www.forbes.com/sites/rogersands/2024/06/08/the-beauty-of-slow-travel/">richer, more memorable experiences</a>. Fast, <a href="https://www.sciencedirect.com/science/article/pii/S0261517724000487">hectic travel</a> often leaves little positive impact. Slow immersive travel, on the other hand, fosters lasting memories and reduces overtourism, pollution and cultural damage. <a href="https://www.tandfonline.com/doi/full/10.1080/00913367.2024.2325144">Research</a> shows when we consciously immerse ourselves in our surroundings we can have more meaningful experiences. Surprisingly, <a href="https://www.sciencedirect.com/science/article/pii/S0261517724000487">even luxury travel</a> – often dismissed as wasteful – can encourage respect and mindfulness for those who invest financially and mentally in their journey, unlike cheaper, mainstream tourism. Activities such as “<a href="https://www.sciencedirect.com/science/article/pii/S2666957921000197">forest bathing</a>”, <a href="https://www.visitutah.com/articles/mindful-hiking">hiking</a> or engaging with <a href="https://www.outofyourcomfortzone.net/a-guide-to-slow-travel-immersing-yourself-in-local-cultures/">local cultures</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723984/">boost wellbeing and meaning</a>, going beyond just “taking a photo for likes”. This mindful approach can <a href="https://www.sciencedirect.com/science/article/pii/S0160738321001419">change our behaviour on a personal level</a>. By focusing attention on fewer experiences, <a href="https://www.tandfonline.com/doi/full/10.1080/00913367.2024.2325144">travellers can heighten</a> their sense of awe and appreciation, making the travel more memorable. This idea is evident in “<a href="https://journals.sagepub.com/doi/abs/10.1177/002216786200200102?casa_token=PrIQTkCMjx0AAAAA:wtswfg0cuEuQec0zVg-Mbf9MuXYoqhQkWbaQCGdjxWkYUpVOwBu8Op5jC6V4nOghnow3xpwN3fDn">peak experiences</a>”. Disney, for example, creates <a href="https://ideaexchange.uakron.edu/docam/vol9/iss2/6/">emotionally-charged moments</a> that stick in visitors’ minds. Other experiences, such as “<a href="https://journals.sagepub.com/doi/full/10.1177/14614448211072808">digital detoxes</a>” or <a href="https://academic.oup.com/jcr/article-abstract/45/6/1142/4999270">pilgrimages</a> can leave a contemplative impression. By concentrating on a single aspect of a visit, it <a href="https://www.sciencedirect.com/science/article/pii/S0160738320300797?casa_token=Np4PXLk5RqsAAAAA:Q3440A-lsf-XTAWuboPPbIcnvBAhk8nnIoWyF-gynHkSPmyPaykzfpBhTLbFDBHZEX0bbtZJgQ">becomes special and memorable</a>. Even in busy places like Disneyland, focusing on one unique element can make the experience feel slower and more meaningful. <h2>The sustainability of tourism</h2> In the <a href="https://www.sciencedirect.com/science/article/pii/S0261517724000487">Faroe Islands</a>, slow travel helps protect local traditions and landscapes by encouraging thoughtful visitor behaviour, such as using local guides to minimise environmental impact. New Zealand can leverage its natural beauty to offer similar immersive experiences. <a href="https://www.nzherald.co.nz/travel/travel-well-what-is-mindful-hiking-walking-for-wellbeing-boost/67MYS6ZSNXC7ZH6OTZ2DLBGFL4/">Tramping</a> (hiking), for example, can promote a mindful connection with the environment. But even here, there needs to be a focus on balancing tourism with preservation. Popular spots, such as the Department of Conservation huts and the Te Araroa Trail, are <a href="https://www.wildernessmag.co.nz/te-araroa-trail-shows-pressure/">already becoming crowded</a>. It is essential to educate visitors on <a href="https://www.mpi.govt.nz/outdoor-activities/tramping-tips-to-prevent-spreading-pests-and-diseases/biosecurity-considerations-walking-and-tramping/">responsible practices</a> – such as cleaning equipment – to ensure they understand their <a href="https://www.doc.govt.nz/heritage-and-visitor-strategy#:%7E:text=The%20natural%2C%20cultural%20and%20historic,wellbeing%2C%20enabling%20communities%20to%20thrive.">role in protecting nature</a>. Travel that fosters a deeper appreciation for local cultures and environments benefits both visitors and the destinations they explore. The challenge is finding the right balance – encouraging meaningful travel experiences while still ensuring accessibility for all.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/238316/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/amy-errmann-1360032">Amy Errmann</a>, Senior Lecturer, Marketing & International Business, <a href="https://theconversation.com/institutions/auckland-university-of-technology-1137">Auckland University of Technology</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/crowds-water-guns-and-protests-could-slow-tourism-be-the-answer-to-an-overtourism-backlash-238316">original article</a>.

Travel Trouble

New device could help GPs detect Alzheimer's in minutes

GPs could soon be able to screen their patients for Alzheimer's Disease in a matter of minutes, using a handheld device the size of a credit card. The first-of-a-kind finger-prick blood test was developed by engineers at Melbourne's Monash University and it can detect the hallmark protein biomarkers of early Alzheimer's Disease within minutes. This could become an important tool for doctors in diagnosing patients before the symptoms progress. In Australia alone there are around 420,000 people living with dementia, with that number set to double by 2054. Associate Professor Sudha Mokkapati, from Monash Materials Science and Engineering, helped lead the development of the testing device. "Detecting very early disease in large populations could dramatically change the trajectory of this burdening disease for many patients, and shave millions off associated healthcare costs," Mokkapati said. "We've completed testing that shows the technology is highly advanced by design and capable of detecting ultra-low levels of several disease biomarkers in blood." The device also has the potential to remove the need for laboratory-based pathology tests, making diagnoses faster and cheaper. The university is currently seeking funding to complete the next stage - clinical validation, which will help bring the device one step closer to reality. "Most patients with neurodegenerative disease are typically diagnosed at advanced stages. Sadly, treatments targeting late-onset disease provide limited therapeutic benefit," Associate Professor Matthew Pase, at Monash's School of Psychological Sciences, said. "Earlier screening could change the outlook for many patients diagnosed with cognitive impairment, increasing the chance of halting or slowing symptom development and the rapid progression of the disease." Image: Monash University/ Nine

Caring

Readers response: If you could spend your retirement anywhere in the world, where would you go?

When it comes to retirement, many people decide to spend their golden years travelling the globe. Alternatively, others prefer to stay closer to come to spend valuable quality time with their closest friends and family. We asked our readers where they would spend their retirement if they could choose anywhere in the world, and the response was overwhelming. Here's what they said. Tracee Williams Mason - A cruise ship. Kay Little-Ohmsen - Right where I am. Sunshine Coast and have been for 48 years. Cheryl Barrett - On the Greek island of Naxos. Bruce Hopkins - Travelling around the world. Bob Holl - Cruising the Whitsunday Islands. Steve Tracy - Back to Japan where I spent the 25 happiest years of my life. Terry Dolman - Where I live in South Australia for half the year, Vietnam for the other half. Bev Martin - Florida. Sandra Tiplady Schellings - At the beach! Sonia Davis - Darwin. Sally O'Neill - European cruise and cruising around the Greek Isles. Image credits: Shutterstock

International Travel

We reviewed the health habits of centenarians. These 4 things could lead to a longer life

<a href="https://theconversation.com/profiles/zhaoli-dai-keller-1547476">Zhaoli Dai-Keller</a>, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a> and <a href="https://theconversation.com/profiles/perminder-sachdev-46869">Perminder Sachdev</a>, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a> The number of centenarians around the world rose from <a href="https://population.un.org/wpp/Download/Standard/Population/">151,000 in 2000</a> to 573,000 in 2021. People are living longer, and we can expect to see more people reach 100 in the years to come. Centenarians <a href="https://academic.oup.com/biomedgerontology/article/67A/4/395/623695">exemplify successful ageing</a>, often experiencing <a href="https://agmr.hapres.com/htmls/AGMR_1264_Detail.html">fewer chronic diseases</a> and maintaining independence in daily life well into their 90s. While <a href="https://link.springer.com/article/10.1186/s12979-016-0066-z">genetics contribute</a> to longevity, modifiable factors account for more than 60% <a href="https://pubmed.ncbi.nlm.nih.gov/14624729/">of successful aging</a>. But what sort of factors specifically contribute to living to 100? To find out, we reviewed lifestyle and health habits of centenarians and near-centenarians (those aged 95–99) worldwide. Our <a href="https://link.springer.com/article/10.1007/s11357-024-01247-4">recent review</a> included 34 observational studies published since 2000. Here are four key factors we found contribute to extreme longevity. <h2>1. A diverse diet with controlled salt intake</h2> Centenarians and near-centenarians typically had a balanced and diverse diet. We found, on average, they consumed between 57% and 65% of their energy intake from carbohydrates, 12% to 32% from protein, and 27% to 31% from fat. Their diets included staple foods (such as rice and wheat), fruits, vegetables, and protein-rich foods like poultry, fish and legumes, with moderate red meat consumption. This dietary pattern, similar to the <a href="https://pubmed.ncbi.nlm.nih.gov/29852087/">Mediterranean diet</a>, is linked to lower risks of <a href="https://doi.org/10.3390/ijerph14111364">physical function impairment</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/31685303/">death</a>. Most centenarians also preferred a low-salt diet. While only one study in our review measured the mean daily sodium intake, finding 1.6 grams, this was within the <a href="https://www.who.int/data/gho/indicator-metadata-registry/imr-details/3082#:%7E:text=A%20salt%20intake%20of%20less,much%20more%20salt%20than%20recommended">World Health Organization’s</a> recommendation of less than 2g of sodium per day (equivalent to about 5g of salt). The <a href="https://pubmed.ncbi.nlm.nih.gov/20234038/">traditional Okinawan diet</a>, known for its consumption by Japanese centenarians on Okinawa Island, contains an estimated 1.1g of sodium. We found higher salt intake (those who preferred salty food or added extra salt to meals) had a 3.6-fold increased risk of physical function impairment compared to those without a preference for salt. Practically, these findings suggest we should include plenty of wholegrains, root vegetables, beans, legumes, fruits and vegetables in our diet, minimise red meat consumption and opt for lean poultry, fish, and plant-based protein, and monitor salt in our food. <h2>2. Lower medication use</h2> Centenarians are not free from chronic conditions but typically develop them much later than average adults. More than half of the people in our review experienced common issues such as hypertension (high blood pressure), dementia, or cognitive impairment. We found people in our review took an average of 4.6 medications. The most frequently used medications included blood pressure medications and drugs for heart disease. This is similar to the results of <a href="https://doi.org/10.3390/jcm9051563">a large health register-based study</a> in Spain, which found centenarians took an average of 4.9 medications. Non-centenarians in this study took 6.7 medications on average. The fact centenarians appear to take fewer medications may indicate better health with fewer medical conditions. However, data on medication use is often self-reported and so may not be entirely accurate, especially among those with cognitive impairment. <a href="https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00007-2/fulltext">Polypharmacy</a> is often defined as taking five or more medications simultaneously, and is common in older adults. Inappropriate polypharmacy is associated with <a href="https://www.nia.nih.gov/news/dangers-polypharmacy-and-case-deprescribing-older-adults">increased risks</a> of adverse events such as falls, cognitive impairment and hospitalisation, due to harmful drug interactions. While the type or number of prescribed medications may not be within a patient’s control, it’s important for doctors to <a href="https://link.springer.com/article/10.1186/s12875-017-0642-0">prescribe medications</a> only when necessary, fully inform patients about benefits and risks, and regularly review treatment plans. <h2>3. Getting good sleep</h2> Sleep quality and quantity <a href="https://newsinhealth.nih.gov/2013/04/benefits-slumber">affect</a> the immune system, stress hormones, and cardiometabolic functions such as obesity, high blood pressure, and diabetes. Good <a href="https://academic.oup.com/biomedgerontology/article/74/2/204/4837199">sleep</a> is associated with extended years of good health and reduced risks of chronic diseases. In our review, 68% of the centenarians were satisfied with their sleep quality. In a survey of adults’ sleep satisfaction in 13 countries in 2020, sleep satisfaction ranged from <a href="https://www.statista.com/statistics/1233775/adults-worldwide-satisfied-sleep-country/">29% to 67%</a>. The <a href="https://academic.oup.com/biomedgerontology/article/74/2/204/4837199">optimal sleep duration</a> is between seven and eight hours per night. Tips to <a href="https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/sleep/art-20048379">achieving better sleep</a> include keeping a regular sleep routine, creating a restful environment, exercising regularly and managing stress. <h2>4. Living environment</h2> More than 75% of the centenarians and near-centenarians in our review lived in rural areas. This is a pattern reflected in “<a href="https://www.bluezones.com/">blue zones</a>”, areas known for high concentrations of centenarians, such as Okinawa in Japan, Sardinia in Italy, the Nicoya Peninsula in Costa Rica, and Ikaria in Greece. This may be partly related to the connection between nature and health and wellbeing. For example, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562165/">exposure to green space</a> has been associated with lower stress, depression, blood pressure, type 2 diabetes and heart disease, potentially increasing <a href="https://doi.org/10.1016/j.envint.2023.107785">life expectancy</a>. <h2>Other important factors</h2> We didn’t look at all lifestyle factors associated with longevity in our review. Research also shows <a href="https://www.sciencedirect.com/science/article/abs/pii/S053155650700143X">not smoking</a>, <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802963">avoiding alcohol</a> or drinking moderately, staying <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618983/">physically active</a> and maintaining <a href="https://doi.org/10.1098/rspb.2019.1991">social connections</a> are important for boosting a person’s chances of living to 100. Of course, adopting the lifestyle changes discussed in this article won’t guarantee you’ll reach the ripe old age of 100. And on the flip side, some centenarians have shared <a href="https://theconversation.com/why-you-should-never-take-nutrition-advice-from-a-centenarian-229159">questionable</a> health habits. But many older adults are seeking to adopt <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092121/">healthier lifestyles</a> to prevent and manage chronic conditions, while health-care professionals are similarly recognising the value of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638636/">lifestyle medicine</a>. The earlier you can adopt positive lifestyle changes and healthier habits, the better placed you’ll be to achieve a long and healthy life. Becoming a centenarian is a lifelong endeavour.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/235100/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/zhaoli-dai-keller-1547476">Zhaoli Dai-Keller</a>, Honorary Senior Lecturer, School of Pharmacy, University of Sydney; Nutritional epidemiologist and Lecturer, School of Population Health, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a> and <a href="https://theconversation.com/profiles/perminder-sachdev-46869">Perminder Sachdev</a>, Scientia Professor of Neuropsychiatry, Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, <a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/we-reviewed-the-health-habits-of-centenarians-these-4-things-could-lead-to-a-longer-life-235100">original article</a>.

Body

Woman “bullied” on plane over budget seating trick

A young woman has recalled a flight from hell when she was “bullied” by a couple who were trying to utilise a seating hack that went viral on TikTok. The solo traveller took to Reddit to recount the story and ask social media users if she was in the wrong for her action. The woman began by saying she usually pays more to select her plane seat ahead of time, but a medical emergency on another plane had her waiting on standby and left with no option other than to sit in a middle seat. When she was finally able to board, she was greeted by a couple who had purchased both the window and aisle seats in a bid to have more space, utilising a travel “trick” that has been popular on TikTok. The method, which has been dubbed the 'poor man's business class', usually leaves travellers with an empty middle seat and more space, and few travellers opt to pick a middle seat. “When I got to my row the man and woman were chatting and sharing a snack... it was obvious they were together. I mentioned to the man that I'm in the middle, and he got up to let me in,” the unsuspecting traveller wrote on Reddit. “I asked them if they would prefer to sit together, I said I was totally okay with that. The woman reacted rudely to this and said ‘you're not supposed to be sitting here anyway’.” After noticing how the plane was full, she offered to show the pair her new ticket with the correct seat number on it. “She flicked her hand at my ticket and made a disgusted sound. I offered again if they wanted to sit together to which she didn't reply, her partner said it's okay and... made some small talk,” she continued. The man’s girlfriend then interrupted their conversation to ask,”'Did you use one of those third party websites to book your flight? It's so frustrating when people cheap out to inconvenience others.” The American woman explained that she had booked her flight directly and she had been placed on standby like everyone else and didn't choose the middle seat - she was assigned it. She then tried to keep the peace by refusing to engage with the furious woman. “I was so done with her attitude, I put my headphones on and attempted to do my own thing,” she explained. But the “entitled” girlfriend wasn't letting it go, as the woman explained, “This woman kept reaching over me and tapping her partner and trying to talk to him in a way that was super intrusive.” “I could tell even her partner was trying to engage her less so that she would hopefully stop, but she didn't.” “I think they tried to pull that tactic where they don't sit together on purpose...hoping no one will sit between them. But on full flights it doesn't work. And even so - it's not the other person's fault.” The traveller's post was met with hundreds of comments slamming the girlfriend’s behaviour, as one person wrote, “It's like a toddler having a tantrum.” “She was disappointed and a total a**hole. Gross entitled people,” another added. Another person applauded the traveller’s level-headed behaviour, writing, “Wow! You are my hero for keeping it classy - I’m afraid I would not have been as kind as you.” Image credits: Shutterstock

Travel Trouble

Could the shingles vaccine lower your risk of dementia?

<a href="https://theconversation.com/profiles/ibrahim-javed-1552271">Ibrahim Javed</a>, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> A <a href="https://www.nature.com/articles/s41591-024-03201-5">recent study</a> has suggested Shingrix, a relatively new vaccine given to protect older adults against shingles, may delay the onset of dementia. This might seem like a bizarre link, but actually, <a href="https://pubmed.ncbi.nlm.nih.gov/34697158/">research</a> has previously shown an older version of the shingles vaccine, Zostavax, reduced the risk of dementia. In this new study, published last week in the journal Nature Medicine, researchers from the United Kingdom found Shingrix delayed dementia onset by 17% compared with Zostavax. So how did the researchers work this out, and how could a shingles vaccine affect dementia risk? <h2>From Zostavax to Shingrix</h2> Shingles is a viral infection caused by the varicella-zoster virus. It causes <a href="https://www.healthdirect.gov.au/shingles">painful rashes</a>, and affects older people in particular. Previously, Zostavax was used to vaccinate against shingles. It was administered as a single shot and provided good protection for about <a href="https://immunisationhandbook.health.gov.au/contents/vaccine-preventable-diseases/zoster-herpes-zoster">five years</a>. Shingrix has been developed based on a newer vaccine technology, and is thought to offer stronger and longer-lasting protection. Given in two doses, it’s now the preferred option for shingles vaccination in Australia and elsewhere. In November 2023, Shingrix replaced Zostavax on the <a href="https://www.health.gov.au/news/national-immunisation-program-changes-to-shingles-vaccination-from-1-november-2023">National Immunisation Program</a>, making it available for free to those at highest risk of complications from shingles. This includes all adults aged 65 and over, First Nations people aged 50 and older, and younger adults with certain medical conditions that affect their immune systems. <h2>What the study found</h2> Shingrix was approved by the US Food and Drugs Administration in <a href="https://www.drugs.com/history/shingrix.html">October 2017</a>. The researchers in the new study used the transition from Zostavax to Shingrix in the United States as an opportunity for research. They selected 103,837 people who received Zostavax (between October 2014 and September 2017) and compared them with 103,837 people who received Shingrix (between November 2017 and October 2020). By analysing data from electronic health records, they found people who received Shingrix had a 17% increase in “diagnosis-free time” during the follow-up period (up to six years after vaccination) compared with those who received Zostavax. This was equivalent to an average of 164 extra days without a dementia diagnosis. The researchers also compared the shingles vaccines to other vaccines: influenza, and a combined vaccine for tetanus, diphtheria and pertussis. Shingrix and Zostavax performed around 14–27% better in lowering the risk of a dementia diagnosis, with Shingrix associated with a greater improvement. The benefits of Shingrix in terms of dementia risk were significant for both sexes, but more pronounced for women. This is not entirely surprising, because we know women have <a href="https://www.alzheimers.org.uk/blog/why-dementia-different-women">a higher risk</a> of developing dementia due to interplay of biological factors. These include being more sensitive to certain genetic mutations associated with dementia and hormonal differences. <h2>Why the link?</h2> The idea that vaccination against viral infection can lower the risk of dementia has been around for more than two decades. Associations have been <a href="https://pubmed.ncbi.nlm.nih.gov/11762573/">observed</a> between vaccines, such as those for diphtheria, tetanus, polio and influenza, and subsequent dementia risk. Research has shown Zostavax vaccination can <a href="https://bmjopen.bmj.com/content/11/10/e045871">reduce the risk</a> of developing dementia by 20% compared with people who are unvaccinated. But it may not be that the vaccines themselves protect against dementia. Rather, it may be the resulting lack of viral infection creating this effect. Research indicates bacterial infections in the gut, as well as viral infections, are associated with a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169152/">higher risk of dementia</a>. Notably, untreated infections with herpes simplex (herpes) virus – closely related to the varicella-zoster virus that causes shingles – can <a href="https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12119">significantly increase</a> the risk of developing dementia. Research has also shown shingles increases the risk of a later dementia diagnosis. The mechanism is not entirely clear. But there are two potential pathways which may help us understand why infections could increase the risk of dementia. First, certain molecules are produced when a baby is developing in the womb to help with the body’s development. These molecules have the potential to cause inflammation and accelerate ageing, so the production of these molecules is silenced around birth. However, viral infections such as shingles can <a href="https://doi.org/10.1016/j.virol.2018.07.011">reactivate</a> the production of these molecules in adult life which could <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717685/#:%7E:text=The%20disease%20mechanisms%20of%20AD,may%20lead%20to%20new%20therapies.">hypothetically lead to dementia</a>. Second, in Alzheimer’s disease, a specific protein called Amyloid-β go rogue and kill brain cells. Certain proteins produced by viruses <a href="https://www.biorxiv.org/content/10.1101/2024.05.16.594465v1">such as COVID</a> and <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202001299">bad gut bacteria</a> have the potential to support Amyloid-β in its toxic form. In laboratory conditions, these proteins have been shown to <a href="https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003537">accelerate the onset</a> of dementia. <h2>What does this all mean?</h2> With an ageing population, the burden of dementia is only likely to become greater in the years to come. There’s a lot more we have to learn about the causes of the disease and what we can potentially do to prevent and treat it. This new study has some limitations. For example, time without a diagnosis doesn’t necessarily mean time without disease. Some people may have underlying disease with delayed diagnosis. This research indicates Shingrix could have a silent benefit, but it’s too early to suggest we can use antiviral vaccines to prevent dementia. Overall, we need more research exploring in greater detail how infections are linked with dementia. This will help us understand the root causes of dementia and design potential therapies.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/235597/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/ibrahim-javed-1552271">Ibrahim Javed</a>, Enterprise and NHMRC Emerging Leadership Fellow, UniSA Clinical & Health Sciences, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/could-the-shingles-vaccine-lower-your-risk-of-dementia-235597">original article</a>.

Mind

Does screen use really impact our thinking skills? Our analysis suggests it could

<a href="https://theconversation.com/profiles/michoel-moshel-1433565">Michoel Moshel</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/jennifer-batchelor-1485101">Jennifer Batchelor</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/joanne-bennett-1485102">Joanne Bennett</a>, <a href="https://theconversation.com/institutions/australian-catholic-university-747">Australian Catholic University</a>, and <a href="https://theconversation.com/profiles/wayne-warburton-402810">Wayne Warburton</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a> Screens have become seamlessly integrated into our daily lives, serving as indispensable tools for work, education and leisure. But while they enrich our lives in countless ways, we often fail to consider the potential impact of screen time on our cognitive abilities. In a <a href="https://link.springer.com/article/10.1007/s11065-023-09612-4">new meta-analysis</a> of dozens of earlier studies, we’ve found a clear link between disordered screen use and lower cognitive functioning. The findings suggest we should exercise caution before advocating for more screen time, and before introducing screens into even more aspects of daily life. <h2>Young people’s screen time is increasing</h2> In 2020, a UNSW Gonski Institute for Education report <a href="https://www.gie.unsw.edu.au/sites/default/files/documents/UNSW%20GIE%20GUD%20Phase%201%20Technical%20Report%20MAR20%20v2.pdf">noted a concerning statistic</a>: about 84% of Australian educators believe digital technologies are distracting in a learning environment. And according to the ABC, a recent Beyond Blue <a href="https://www.abc.net.au/news/2023-09-18/mental-health-depression-anxiety-support-coming-for-schools/102831464">survey</a> of Australian teachers identified excessive screen time as the second-most significant challenge for young people, just behind mental health issues. Despite mounting concerns, more than half of Australian schools have embraced a “<a href="https://www.linewize.io/anz/blog/the-rise-of-byod-in-australian-schools">bring your own device</a>” policy. Students are spending more time online than <a href="https://read.oecd-ilibrary.org/education/students-computers-and-learning_9789264239555-en#page46">ever before</a> and starting at increasingly younger ages. A 2021 report by <a href="https://www.commonsensemedia.org/sites/default/files/research/report/8-18-census-integrated-report-final-web_0.pdf">Common Sense Media</a> estimated tweens spend an average of 5 hours and 33 minutes using screen-based entertainment each day, while teenagers devote a whopping 8 hours and 39 minutes. A surge in screen use has led to some individuals, including children, adolescents and adults, developing screen-related addictions. One example is gaming disorder, for which <a href="https://journals.sagepub.com/doi/full/10.1177/0004867420962851">2–3% of people</a> meet the criteria. <h2>What is ‘disordered screen use’?</h2> The impact of screens on our cognitive abilities – that is, our thinking skills such as attention, memory, language and problem-solving – has sparked much debate. On one hand, some researchers and reporters claim screen use can have negative effects, such as <a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-022-12701-3">health problems</a>, shortened attention <a href="https://time.com/3858309/attention-spans-goldfish/">spans</a> and hindered <a href="https://www.researchgate.net/publication/312489265_The_relationship_between_television_exposure_and_children's_cognition_and_behaviour_A_systematic_review">development</a>. On the other, schools are <a href="https://www.smh.com.au/education/tech-takeover-classrooms-crowded-with-digital-devices-20200125-p53ul1.html">increasingly adopting</a> technology to boost student engagement. Tech companies are also marketing their products as tools to help you enhance your problem-solving and memory skills. Our <a href="https://link.springer.com/article/10.1007/s11065-023-09612-4">recent study</a> sought to understand the potential cognitive consequences of “disordered screen-related behaviours”. This is a broad category of problematic behaviours that may include screen dependency, and persisting with screen use even when it’s harmful. We conducted a meta-analysis of 34 studies that explored various forms of screen use (including gaming, internet browsing, smartphone use and social media use) and compared the cognitive performance of individuals with disordered screen use to those without it. Our findings paint a concerning picture. <h2>Differences in cognitive function</h2> Across these rigorously peer-reviewed studies, individuals with disordered screen use consistently demonstrated significantly poorer cognitive performance compared to others. The most affected cognitive domain was attention, and specifically sustained attention, which is the ability to maintain focus on an unchanging stimulus for an extended period. The second-most notable difference was in their “executive functioning” – particularly in impulse control, which is the ability to control one’s automatic responses. Interestingly, the type of screen activity didn’t make a difference in the results. The trend also wasn’t confined to children, but was observed across all age groups. <h2>Two ways to interpret the results</h2> Why do people with disordered screen-related behaviours have poorer cognitive functioning? The first explanation is that disordered screen use actually leads to poorer cognitive function, including poorer attention skills (but we’ll need more experimental and longitudinal studies to establish causality). If this is the case, it may be the result of being constantly bombarded by algorithms and features designed to capture our attention. By diverting our focus outward, screen use may weaken one’s intrinsic ability to concentrate over time. Crucially, impaired attention also <a href="https://akjournals.com/view/journals/2006/10/1/article-p77.xml">makes it harder to disengage</a> from addictive behaviours, and would therefore make it harder to recognise when screen use has become a problem. The second explanation is that people who already have poorer cognitive functioning (such as less inhibitory control) are more likely to engage in disordered screen use. This could be a result of the plethora of addictive cues designed to keep us glued to our screens. Being bombarded by these could make it harder to <a href="https://akjournals.com/view/journals/2006/9/4/article-p990.xml">pull the brakes</a> on screen use. Although the literature doesn’t seem to favour this explanation – and does seem to suggest that cognitive functioning is impaired as a result of disordered screen use – it’s still a possibility we can’t rule out. Attention is the bedrock of everyday tasks. People with weakened attention may struggle to keep up in less stimulating environments, such as a static workplace or classroom. They may find themselves turning to a screen as a result. Similarly, people with less inhibitory control would also find it more challenging to moderate their screen use. This could be what drives them towards problematic screen-related behaviours in the first place. <h2>Who should shoulder the responsibility?</h2> Research indicates people with impaired cognitive functioning usually aren’t as well equipped to moderate their own screen time. Many users with disordered screen use are <a href="https://www.sciencedirect.com/science/article/pii/S0747563220302326?casa_token=BQv_N_MFffYAAAAA:AsGkAfdwXjCZHJB463G40Mx-ckS2Q1c8jSOn2SWR_9iW64eWaQsru1IJAZBDCgSPXwhZ3Qwl">young</a>, with mainly males engaging in internet gaming and mainly females engaging in social media use. Neurodiverse people are <a href="https://www.mdpi.com/1660-4601/19/9/5587">also at greater risk</a>. Tech companies are driven by the goal of <a href="https://www.theguardian.com/technology/2017/apr/18/netflix-competitor-sleep-uber-facebook">capturing our attention</a>. For instance, Netflix chief executive Reed Hastings acknowledged the company’s <a href="https://www.theguardian.com/technology/2017/apr/18/netflix-competitor-sleep-uber-facebook">most formidable competitor was sleep</a>. At the same time, researchers find themselves struggling to keep up with the pace of technological innovation. A potential path forward is to encourage open-access data policies from tech companies, so researchers can delve deeper into the study of screen use and its effect on individuals. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/216828/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/michoel-moshel-1433565">Michoel Moshel</a>, PhD/Masters Clinical Neuropsychology Candidate, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/jennifer-batchelor-1485101">Jennifer Batchelor</a>, Associate Professor, School of Psychological Sciences, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/joanne-bennett-1485102">Joanne Bennett</a>, Lecturer, <a href="https://theconversation.com/institutions/australian-catholic-university-747">Australian Catholic University</a>, and <a href="https://theconversation.com/profiles/wayne-warburton-402810">Wayne Warburton</a>, Associate Professor, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/does-screen-use-really-impact-our-thinking-skills-our-analysis-suggests-it-could-216828">original article</a>.

Mind

Why can’t I sleep? It could be your sheets or doona

<div class="theconversation-article-body"> <a href="https://theconversation.com/profiles/chin-moi-chow-169404">Chin Moi Chow</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/cynthia-xinzhu-li-1532937">Cynthia (Xinzhu) Li</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/mark-halaki-1532934">Mark Halaki</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> It’s winter, so many of us will be bringing out, or buying, winter bedding. But how much of a difference does your bedding make to your thermal comfort? Can a particular textile help you sleep? Is it wool, or other natural fibres, such as cotton? How about polyester? With so much choice, it’s easy to be confused. Here’s what we <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.14217">found</a> when we reviewed the evidence – not just for winter, but also for the summer ahead. <h2>The importance of bedding</h2> We <a href="https://doi.org/10.1016/j.enbuild.2020.110097">rely on our bedding</a> to maintain a comfortable temperature to help us sleep. And the <a href="https://www.sciencedirect.com/science/article/abs/pii/S0378778817317681">right textiles</a> can help regulate our body temperature and <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527342587.ch31">wick away moisture</a> from sweat, promoting better sleep. In the cooler months, we’re mainly concerned about a textile’s insulation properties – keeping body heat in and the cold out. As the temperature climbs, we’re less concerned about insulation and more concerned about wicking away moisture from sweat. Another factor to consider is a textile’s breathability – how well it allows air to pass through it. A breathable textile helps keep you cool, by allowing warmth from your body to escape. It also helps keep you comfortable by preventing build-up of moisture. By releasing excess heat and moisture, a breathable textile makes it feel cooler and more comfortable against the skin. <h2>Different textiles have different properties</h2> Some textiles are better than others when it comes to insulation, wicking away moisture or breathability. For instance, cotton and wool have tiny air pockets that <a href="https://nopr.niscair.res.in/bitstream/123456789/24505/1/IJFTR%2031(1)%20177-186.pdf">act as insulation</a> to provide <a href="https://www.sciencedirect.com/science/article/abs/pii/0379711281900072">warmth</a> in cold weather. Thicker fabrics with more air pockets tend to be warmer, softer and more breathable. But these factors are also affected by the type of fibre, the weave of the fabric and the manufacturing process. Cotton and wool are also breathable fabrics, meaning they help regulate temperature. <hr /> <iframe id="CqVe0" class="tc-infographic-datawrapper" style="border: none;" src="https://datawrapper.dwcdn.net/CqVe0/" width="100%" height="400px" frameborder="0"></iframe> <hr /> While cotton absorbs moisture (sweat) from your skin, it doesn’t wick it away efficiently. This retained moisture can make cotton feel clingy and uncomfortable, potentially leading to chills in warm weather. But wool is <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.14217">highly absorbent</a> and wicks moisture effectively. In warmer weather, when we sweat, wool fibres allow for airflow and moisture transfer, promoting efficient sweat evaporation and cooling, and preventing overheating. So wool (in different thicknesses) can be a good option in both summer and winter. Linen, although breathable and having moisture-wicking properties, provides less insulation than wool and cotton due to its hollow fibres. This makes linen less effective for keeping warm in winter but is effective for keeping cool in summer. Polyester is a synthetic fibre that can be made to trap air for insulation, but it is not naturally breathable. Usually, it absorbs moisture poorly. So it can trap sweat next to the skin, causing discomfort. However, polyester can be specially treated to help control moisture from sweat. <h2>Which sheets help you sleep?</h2> As part of our review, we couldn’t find any studies that directly compared sheets made from different textiles (for instance, regular cotton and flannelette) and their impact on sleep when it’s cold. However, linen sheets are particularly effective in warmer conditions. In one study, conducted at 29°C and high humidity, linen sheets <a href="https://openurl.ebsco.com/EPDB%3Agcd%3A10%3A26460954/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A87732897&crl=c">promoted</a> less wakefulness and fewer stages of light sleep than cotton sheets. <h2>How about doonas?</h2> If you don’t heat your bedroom at night in winter, a goose down doona (one made from fine, goose feathers) might be an option. These promoted the <a href="https://www.sciencedirect.com/science/article/abs/pii/S0378778818321728">longest, deep-sleep</a>, followed by duck down, then cotton when sleeping at 11°C. This may be because down offers better insulation (by trapping more air) than cotton. Down also has lower thermal conductivity than cotton, meaning it’s better at keeping warmth in. Choosing between a wool or polyester doona? In a wool-industry funded <a href="https://www.tandfonline.com/doi/full/10.2147/NSS.S100271">study</a> two of us (Chow and Halaki) co-authored, there wasn’t much difference. The study in young adults found no significant difference on sleep at 17°C or 22°C. <h2>So how do I choose?</h2> The choice of bedding is highly individual. What feels comfortable to one person is not the same for the next. That’s because of variations in body size and metabolic rate, local climate, bedroom temperature and building insulation. These can also affect sleep. This variability, and a wide range of study designs, also makes it hard to compare different studies about the impact of different textiles on sleep. So you might need to experiment with different textiles to discover what works for you. <hr /> Many factors can affect your sleep, not just your bedding. So if you’re having trouble sleeping, you can find more information from the <a href="https://www.sleephealthfoundation.org.au/">Sleep Health Foundation</a>. If symptoms continue, see your GP.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/229604/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/chin-moi-chow-169404">Chin Moi Chow</a>, Associate Professor of Sleep and Wellbeing, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/cynthia-xinzhu-li-1532937">Cynthia (Xinzhu) Li</a>, PhD candidate studying menopause and sleep, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/mark-halaki-1532934">Mark Halaki</a>, Professor of Human Movement, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-cant-i-sleep-it-could-be-your-sheets-or-doona-229604">original article</a>. </div>

Body

Almost half the men surveyed think they could land a passenger plane. Experts disagree

<div class="theconversation-article-body"><a href="https://theconversation.com/profiles/guido-carim-junior-1379129">Guido Carim Junior</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/chris-campbell-1414564">Chris Campbell</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/elvira-marques-1362476">Elvira Marques</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/nnenna-ike-1490692">Nnenna Ike</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>, and <a href="https://theconversation.com/profiles/tim-ryley-1253269">Tim Ryley</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a> Picture this: you’re nestled comfortably in your seat cruising towards your holiday destination when a flight attendant’s voice breaks through the silence: <blockquote> Ladies and gentlemen, both pilots are incapacitated. Are there any passengers who could land this plane with assistance from air traffic control? </blockquote> If you think you could manage it, you’re not alone. <a href="https://today.yougov.com/topics/politics/survey-results/daily/2023/01/02/fd798/3">Survey results</a> published in January indicate about one-third of adult Americans think they could safely land a passenger aircraft with air traffic control’s guidance. Among male respondents, the confidence level rose to nearly 50%. Can a person with no prior training simply guide everyone to a smooth touchdown? We’ve all heard stories of passengers who saved the day when the pilot became unresponsive. For instance, last year <a href="https://www.youtube.com/watch?v=qbMoyWukjbs">Darren Harrison</a> managed to land a twin-engine aircraft in Florida – after the pilot passed out – with the guidance of an air traffic controller who also happened to be a flight instructor. However, such incidents tend to take place in small, simple aircraft. Flying a much bigger and heavier commercial jet is a completely different game. <h2>You can’t always rely on autopilot</h2> A pilot spends about 90% of their time monitoring autopilot systems and making sure everything is working as intended. The other 10% is spent managing problems, taxiing, taking off and landing. Takeoffs and landings are arguably the most difficult tasks pilots perform, and are always performed manually. Only on very few occasions, and in a handful of aircraft models, can a pilot use autopilot to land the aircraft for them. This is the exception, and not the rule. For takeoff, the aircraft must build up speed until the wings can generate enough lift to pull it into the air. The pilot must <a href="https://youtu.be/16XTAK-4Xbk?si=66yDo5g5I086Q2y2&t=65">pay close attention</a> to multiple instruments and external cues, while keeping the aircraft centred on the runway until it reaches lift-off speed. Once airborne, they must coordinate with air traffic control, follow a particular path, retract the landing gear and maintain a precise speed and direction while trying to climb. Landing is even more complicated, and requires having precise control of the aircraft’s direction and descent rate. <a href="https://youtu.be/u_it9OiTnSM?si=xNZrLB9ZH870LEa3&t=360">To land successfully</a>, a pilot must keep an appropriate speed while simultaneously managing gear and flap configuration, adhering to air traffic regulations, communicating with air traffic control and completing a number of paper and digital checklists. Once the aircraft comes close to the runway, they must accurately judge its height, reduce power and adjust the rate of descent – ensuring they land on the correct area of the runway. On the ground, they will use the brakes and reverse thrust to bring the aircraft to a complete stop before the runway ends. This all happens within just a few minutes. <figure><iframe src="https://www.youtube.com/embed/Nyx4NyMrvOs?wmode=transparent&start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> Both takeoff and landing are far too quick, technical and concentration-intensive for an untrained person to pull off. They also require a range of skills that are only gained through extensive training, such as understanding the information presented on different gauges, and being able to coordinate one’s hands and feet in a certain way. <h2>Training a pilot</h2> The journey from student to commercial pilot is a long one. It normally starts with a recreational licence, followed by a private licence, and then a commercial licence (which allows them to fly professionally). Even before stepping into a cockpit, the student must study aerodynamics, air law and flight rules, meteorology, human factors, navigation, aircraft systems, and performance and flight planning. They also need to spend time learning about the specific aircraft they will be flying. Once the fundamentals are grasped, an instructor takes them for training. Most of this training is conducted in small, lightweight aircraft – with a simulator introduced briefly towards the end. During a lesson, each manoeuvre or action is demonstrated by the instructor before the student attempts it. Their attempt may be adjusted, corrected or even terminated early in critical situations. The first ten to fifteen lessons focus on takeoff, landing, basic in-flight control and emergency management. When the students are ready, they’re allowed to “go solo” – wherein they conduct a complete flight on their own. This is a great milestone. After years of experience, they are ready to transition to a commercial aircraft. At this point they might be able to take off and land reasonably well, but they will still undergo extensive training specific to the aircraft they are flying, including hours of advanced theory, dozens of simulator sessions and hundreds of hours of real aircraft training (most of which is done with passengers onboard). So, if you’ve never even learned the basics of flying, your chances of successfully landing a passenger aircraft with air traffic control’s help are close to zero. <h2>Yet, flying is a skill like any other</h2> Aviation training has been democratised by the advent of high-end computers, virtual reality and flight simulation games such as Microsoft’s <a href="https://www.flightsimulator.com/">Flight Simulator</a> and <a href="https://www.x-plane.com/">X-Plane</a>. Anyone can now rig up a desktop flight simulator for a few thousand dollars. Ideally, such a setup should also include the basic physical controls found in a cockpit, such as a control yoke, throttle quadrant and pedals. Flight simulators provide an immersive environment in which professional pilots, students and aviation enthusiasts can develop their skills. So if you really think you could match-up against a professional, consider trying your hand at one. You almost certainly won’t be able to land an actual passenger plane by the end of it – but at least you’ll gain an appreciation for the immense skill pilots possess.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/218037/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/guido-carim-junior-1379129">Guido Carim Junior</a>, Senior Lecturer in Aviation, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/chris-campbell-1414564">Chris Campbell</a>, Adjunct Associate Professor, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/elvira-marques-1362476">Elvira Marques</a>, Aviation PhD candidate, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>; <a href="https://theconversation.com/profiles/nnenna-ike-1490692">Nnenna Ike</a>, Research Assistant, Griffith Aviation, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a>, and <a href="https://theconversation.com/profiles/tim-ryley-1253269">Tim Ryley</a>, Professor and Head of Griffith Aviation, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/almost-half-the-men-surveyed-think-they-could-land-a-passenger-plane-experts-disagree-218037">original article</a>. </div>

Travel Trouble

Kick up your heels – ballroom dancing offers benefits to the aging brain and could help stave off dementia

<div class="theconversation-article-body"><a href="https://theconversation.com/profiles/helena-blumen-1231899">Helena Blumen</a>, <a href="https://theconversation.com/institutions/albert-einstein-college-of-medicine-3638">Albert Einstein College of Medicine</a> <h2>The big idea</h2> Social ballroom dancing can improve cognitive functions and reduce brain atrophy in older adults who are at increased risk for Alzheimer’s disease and other forms of dementia. That’s the key finding of my team’s <a href="https://doi.org/10.1123/japa.2022-0176">recently published study</a> in the Journal of Aging and Physical Activity. In our study, we enrolled 25 adults over 65 years of age in either six months of twice-weekly ballroom dancing classes or six months of twice-weekly treadmill walking classes. None of them were engaged in formal dancing or other exercise programs. The overall goal was to see how each experience affected cognitive function and brain health. While none of the study volunteers had a dementia diagnosis, all performed a bit lower than expected on at least one of our dementia screening tests. We found that older adults that completed six months of social dancing and those that completed six months of treadmill walking improved their executive functioning – an umbrella term for planning, reasoning and processing tasks that require attention. Dancing, however, generated significantly greater improvements than treadmill walking on one measure of executive function and on processing speed, which is the time it takes to respond to or process information. Compared with walking, dancing was also associated with reduced brain atrophy in the hippocampus – a brain region that is key to memory functioning and is particularly affected by Alzheimer’s disease. Researchers also know that this part of our brain can undergo neurogenesis – or grow new neurons – <a href="https://doi.org/10.1073/pnas.0611721104">in response to aerobic exercise</a>. <figure><iframe src="https://www.youtube.com/embed/unmbhUvnGow?wmode=transparent&start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption>Research shows those who regularly dance with a partner have a more positive outlook on life.</figcaption></figure> While several previous studies suggest that dancing has beneficial effects <a href="https://doi.org/10.1093/ageing/afaa270">on cognitive function in older adults</a>, only a few studies have compared it directly with traditional exercises. Our study is the first to observe both better cognitive function and improved brain health following dancing than walking in older adults at risk for dementia. We think that social dancing may be more beneficial than walking because it is physically, socially and cognitively demanding – and therefore strengthens a wide network of brain regions. While dancing, you’re not only using brain regions that are important for physical movement. You’re also relying on brain regions that are important for interacting and adapting to the movements of your dancing partner, as well as those necessary for learning new dance steps or remembering those you’ve learned already. <h2>Why it matters</h2> Nearly 6 million older adults in the U.S. and 55 million worldwide <a href="https://doi.org/10.1016/j.jalz.2019.01.010">have Alzheimer’s disease</a> or a <a href="https://www.who.int/news-room/fact-sheets/detail/dementia">related dementia</a>, yet there is no cure. Sadly, the efficacy and ethics surrounding recently developed drug treatments <a href="https://doi.org/10.1080/21507740.2022.2129858">are still under debate</a>. The good news is that older adults can potentially <a href="https://doi.org/10.1016/S0140-6736(20)30367-6">lower their risk for dementia</a> through lifestyle interventions, even later in life. These include reducing social isolation and physical inactivity. Social ballroom dancing targets both isolation and inactivity. In these later stages of the COVID-19 pandemic, a better understanding of the <a href="https://doi.org/10.1177/23337214211005223">indirect effects of COVID-19</a> – particularly those that increase dementia risk, such as social isolation – is urgently needed. In my view, early intervention is critical to prevent dementia from becoming the next pandemic. Social dancing could be a particularly timely way to overcome the adverse cognitive and brain effects associated with isolation and fewer social interactions during the pandemic. <h2>What still isn’t known</h2> Traditional aerobic exercise interventions such as treadmill-walking or running have been shown to lead to modest but reliable improvements in cognition – <a href="https://doi.org/10.1177/1745691617707316">particularly in executive function</a>. My team’s study builds on that research and provides preliminary evidence that not all exercise is equal when it comes to brain health. Yet our sample size was quite small, and larger studies are needed to confirm these initial findings. Additional studies are also needed to determine the optimal length, frequency and intensity of dancing classes that may result in positive changes. Lifestyle interventions like social ballroom dancing are a promising, noninvasive and cost-effective path toward staving off dementia as we – eventually – leave the COVID-19 pandemic behind.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/194969/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/helena-blumen-1231899">Helena Blumen</a>, Associate Professor of Medicine and Neurology, <a href="https://theconversation.com/institutions/albert-einstein-college-of-medicine-3638">Albert Einstein College of Medicine</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/kick-up-your-heels-ballroom-dancing-offers-benefits-to-the-aging-brain-and-could-help-stave-off-dementia-194969">original article</a>. </div>

Mind

What is childhood dementia? And how could new research help?

<a href="https://theconversation.com/profiles/kim-hemsley-1529322">Kim Hemsley</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/nicholas-smith-1529324">Nicholas Smith</a>, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a>, and <a href="https://theconversation.com/profiles/siti-mubarokah-1529323">Siti Mubarokah</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a> “Childhood” and “dementia” are two words we wish we didn’t have to use together. But sadly, around <a href="https://doi.org/10.1093/brain/awad242">1,400 Australian children and young people</a> live with currently untreatable childhood dementia. Broadly speaking, childhood dementia is caused by any one of <a href="https://www.childhooddementia.org/what-is-childhood-dementia#what">more than 100</a> rare genetic disorders. Although the causes differ from dementia acquired later in life, the progressive nature of the illness is the same. <a href="https://doi.org/10.1093/brain/awad242">Half</a> of infants and children diagnosed with childhood dementia will not reach their tenth birthday, and most will die <a href="https://www.childhooddementia.org/what-is-childhood-dementia#what">before turning 18</a>. Yet this devastating condition has lacked awareness, and importantly, the research attention needed to work towards treatments and a cure. <h2>More about the causes</h2> Most types of childhood dementia are <a href="https://academic.oup.com/brain/article/146/11/4446/7226999">caused</a> by <a href="https://www.genome.gov/genetics-glossary/Mutation">mutations</a> (or mistakes) in our <a href="https://www.genome.gov/genetics-glossary/Deoxyribonucleic-Acid">DNA</a>. These mistakes lead to a range of rare genetic disorders, which in turn cause childhood dementia. <a href="https://doi.org/10.1093/brain/awad242">Two-thirds</a> of childhood dementia disorders are caused by “<a href="https://www.ncbi.nlm.nih.gov/books/NBK459183/">inborn errors of metabolism</a>”. This means the metabolic pathways involved in the breakdown of carbohydrates, lipids, fatty acids and proteins in the body fail. As a result, nerve pathways fail to function, neurons (nerve cells that send messages around the body) die, and progressive cognitive decline occurs. <h2>What happens to children with childhood dementia?</h2> Most children initially appear unaffected. But after a period of apparently normal development, children with childhood dementia <a href="https://doi.org/10.1016/j.pediatrneurol.2023.09.006">progressively lose</a> all previously acquired skills and abilities, such as talking, walking, learning, remembering and reasoning. Childhood dementia also leads to significant changes in behaviour, such as aggression and hyperactivity. Severe sleep disturbance is common and vision and hearing can also be affected. Many children have seizures. The age when symptoms start can vary, depending partly on the particular genetic disorder causing the dementia, but the average is around <a href="https://doi.org/10.1093%2Fbrain%2Fawad242">two years old</a>. The symptoms are caused by significant, progressive brain damage. <h2>Are there any treatments available?</h2> Childhood dementia treatments currently <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">under evaluation</a> or approved are for a very limited number of disorders, and are only available in some parts of the world. These include gene replacement, <a href="https://doi.org/10.1002/jmd2.12378">gene-modified cell therapy</a> and protein or <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1712649">enzyme replacement therapy</a>. Enzyme replacement therapy is available in Australia for <a href="https://australianprescriber.tg.org.au/articles/cerliponase-alfa-for-neuronal-ceroid-lipofuscinosis-type-2-disease.html">one form of childhood dementia</a>. These therapies attempt to “fix” the problems causing the disease, and have shown promising results. Other experimental therapies include ones that <a href="https://doi.org/10.3390/life12050608">target</a> faulty protein production or <a href="https://doi.org/10.1056/nejmoa2310151">reduce inflammation</a> in the brain. <h2>Research attention is lacking</h2> Death rates for Australian children with cancer <a href="http://www.childhooddementia.org/getasset/2WX39O">nearly halved</a> between <a href="https://www.aihw.gov.au/reports/children-youth/australias-children/contents/health/cancer-incidence-survival">1997 and 2017</a> thanks to research that has enabled the development of multiple treatments. But over recent decades, <a href="http://www.childhooddementia.org/getasset/2WX39O">nothing has changed</a> for children with dementia. In 2017–2023, research for childhood cancer received over four times more funding per patient compared to funding for <a href="https://www.childhooddementia.org/getasset/2WX39O">childhood dementia</a>. This is despite childhood dementia causing a <a href="https://doi.org/10.1093/brain/awad242">similar number of deaths</a> each year as childhood cancer. The success <a href="https://www.aihw.gov.au/reports/children-youth/australias-children/contents/health/cancer-incidence-survival">for childhood cancer sufferers</a> in recent decades demonstrates how adequately funding medical research can lead to improvements in patient outcomes. Another bottleneck for childhood dementia patients in Australia is the lack of access to clinical trials. An <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">analysis</a> published in March this year showed that in December 2023, only two clinical trials were recruiting patients with childhood dementia in Australia. Worldwide however, 54 trials were recruiting, meaning Australian patients and their families are left watching patients in other parts of the world receive potentially lifesaving treatments, with no recourse themselves. That said, we’ve seen a slowing in the establishment of <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">clinical trials</a> for childhood dementia across the world in recent years. In addition, we know from <a href="https://www.childhooddementia.org/join-us/professionals/impacts">consultation with families</a> that current care and support systems <a href="https://www.childhooddementia.org/getasset/44MLP8">are not meeting the needs</a> of children with dementia and their families. <h2>New research</h2> Recently, we were awarded <a href="https://www.premier.sa.gov.au/media-releases/news-items/major-funding-boost-for-research-into-childhood-dementia">new funding</a> for <a href="https://www.flinders.edu.au/giving/our-donors/impact-of-giving/improving-the-lives-of-children-with-dementia">our research</a> on childhood dementia. This will help us continue and expand studies that seek to develop lifesaving treatments. More broadly, we need to see increased funding in Australia and around the world for research to develop and translate treatments for the broad spectrum of childhood dementia conditions. Dr Kristina Elvidge, head of research at the <a href="https://www.childhooddementia.org/our-people">Childhood Dementia Initiative</a>, and Megan Maack, director and CEO, contributed to this article.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/228508/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/kim-hemsley-1529322">Kim Hemsley</a>, Head, Childhood Dementia Research Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/nicholas-smith-1529324">Nicholas Smith</a>, Head, Paediatric Neurodegenerative Diseases Research Group, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a>, and <a href="https://theconversation.com/profiles/siti-mubarokah-1529323">Siti Mubarokah</a>, Research Associate, Childhood Dementia Research Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-childhood-dementia-and-how-could-new-research-help-228508">original article</a>.

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‘Girl math’ may not be smart financial advice, but it could help women feel more empowered with money

<div class="theconversation-article-body"><a href="https://theconversation.com/profiles/ylva-baeckstrom-1463175">Ylva Baeckstrom</a>, <a href="https://theconversation.com/institutions/kings-college-london-1196">King's College London</a> If you’ve ever calculated cost per wear to justify the price of an expensive dress, or felt like you’ve made a profit after returning an ill-fitting pair of jeans, you might be an expert in <a href="https://www.standard.co.uk/news/world/girl-maths-tiktok-trend-its-basically-free-b1100504.html">“girl math”</a>. With videos about the topic going viral on social media, girl math might seem like a silly (<a href="https://www.glamourmagazine.co.uk/article/girl-math-womens-spending-taken-seriously">or even sexist</a>) trend, but it actually tells us a lot about the relationship between gender, money and emotions. Girl math introduces a spend classification system: purchases below a certain value, or made in cash, don’t “count”. Psychologically, this makes low-value spending feel safe and emphasises the importance of the long-term value derived from more expensive items. For example, girl math tells us that buying an expensive dress is only “worth it” if you can wear it to multiple events. This approach has similarities to <a href="https://www.investopedia.com/terms/m/modernportfoliotheory.asp">portfolio theory</a> – a method of choosing investments to maximise expected returns and minimise risk. By evaluating how each purchase contributes to the shopping portfolio, girl math shoppers essentially become shopping portfolio managers. <h2>Money and emotions</h2> People of all genders, rich or poor, feel anxious when dealing with their personal finances. Many people in the UK do not understand pensions or saving enough to <a href="https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/workplacepensions/articles/pensionparticipationatrecordhighbutcontributionsclusteratminimumlevels/2018-05-04">afford their retirement</a>. Without motivation to learn, people avoid dealing with money altogether. One way to find this motivation, as girl math shows, is by having an emotional and tangible connection to our finances. On the surface, it may seem that women are being ridiculed and encouraged to overspend by using girl math. From a different perspective, it hints at something critical: for a person to really care about something as seemingly abstract as personal finance, they need to feel that they can relate to it. Thinking about money in terms of the value of purchases can help create an <a href="https://www.thetimes.co.uk/article/every-time-i-use-my-card-my-phone-buzzes-and-that-stops-me-shopping-ps0fjx6nj">emotional relationship</a> to finance, making it something people want to look after. <figure><iframe src="https://www.youtube.com/embed/GPzA7B6dcxc?wmode=transparent&start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <h2>The girl math we need</h2> Women are a consumer force to be reckoned with, controlling <a href="https://www.forbes.com/sites/bridgetbrennan/2015/01/21/top-10-things-everyone-should-know-about-women-consumers/#7679f9d6a8b4">up to 80%</a> of consumer spending globally. The girl math trend is a demonstration of women’s mastery at applying portfolio theory to their shopping, making them investment powerhouses whose potential is overlooked by the financial services industry. <a href="https://www.theguardian.com/world/2019/oct/28/women-paid-less-than-men-over-careers-gender-pay-gap-report">Women are disadvantaged</a> when it comes to money and finance. Women in the UK earn on average £260,000 less than men during their careers and the retirement income of men is twice as high as women’s. As I’ve found in <a href="https://www.routledge.com/Gender-and-Finance-Addressing-Inequality-in-the-Financial-Services-Industry/Baeckstrom/p/book/9781032055572">my research</a> on gender and finance, women have lower financial self-efficacy (belief in their own abilities) compared to men. This is not helped by women feeling patronised when seeking financial advice. Because the world of finance was created by men for men, its language and culture are <a href="https://www.routledge.com/Gender-and-Finance-Addressing-Inequality-in-the-Financial-Services-Industry/Baeckstrom/p/book/9781032055572">intrinsically male</a>. Only in the mid-1970s did women in the UK gain the legal right to open a bank account without a male signature and it was not until 1980 that they could apply for credit independently. With the law now more (<a href="https://www.worldbank.org/en/news/press-release/2023/03/02/pace-of-reform-toward-equal-rights-for-women-falls-to-20-year-low">but not fully</a>) gender equal, the financial services industry has failed to connect with women. Studies show that 49% of women are <a href="https://www.ellevest.com/magazine/disrupt-money/ellevest-financial-wellness-survey">anxious about their finances</a>. However they have not bought into patronising offers and <a href="https://www.fa-mag.com/news/gender-roles-block-female-financial-experience--ubs-says-73531.html">mansplaining by financial advisers</a>. This outdated approach suggests that it is women, rather than the malfunctioning financial system, <a href="https://www.theguardian.com/commentisfree/2020/sep/16/women-are-not-financially-illiterate-they-need-more-than-condescending-advice">who need fixing</a>. Women continue to feel that they do not belong to or are able to trust the world of finance. And why would women trust an industry with a <a href="https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/earningsandworkinghours/bulletins/genderpaygapintheuk/2019">gender pay gap</a> of up to 59% and a severe lack of women in senior positions? Girl math on its own isn’t necessarily good financial advice, but if it helps even a handful of women feel more empowered to manage and understand their finances, it should not be dismissed.  <a href="https://theconversation.com/profiles/ylva-baeckstrom-1463175">Ylva Baeckstrom</a>, Senior Lecturer in Finance, <a href="https://theconversation.com/institutions/kings-college-london-1196">King's College London</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/girl-math-may-not-be-smart-financial-advice-but-it-could-help-women-feel-more-empowered-with-money-211780">original article</a>. </div>

Money & Banking

Could not getting enough sleep increase your risk of type 2 diabetes?

<a href="https://theconversation.com/profiles/giuliana-murfet-1517219">Giuliana Murfet</a>, <a href="https://theconversation.com/institutions/university-of-technology-sydney-936">University of Technology Sydney</a> and <a href="https://theconversation.com/profiles/shanshan-lin-1005236">ShanShan Lin</a>, <a href="https://theconversation.com/institutions/university-of-technology-sydney-936">University of Technology Sydney</a> Not getting enough sleep is a common affliction in the modern age. If you don’t always get as many hours of shut-eye as you’d like, perhaps you were concerned by news of a <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815684">recent study</a> that found people who sleep less than six hours a night are at higher risk of type 2 diabetes. So what can we make of these findings? It turns out the relationship between sleep and diabetes is complex. <h2>The study</h2> Researchers analysed data from the <a href="https://www.ukbiobank.ac.uk/">UK Biobank</a>, a large biomedical database which serves as a global resource for health and medical research. They looked at information from 247,867 adults, following their health outcomes for more than a decade. The researchers wanted to understand the associations between sleep duration and type 2 diabetes, and whether a healthy diet reduced the effects of short sleep on diabetes risk. As part of their involvement in the UK Biobank, participants had been asked roughly how much sleep they get in 24 hours. Seven to eight hours was the average and considered normal sleep. Short sleep duration was broken up into three categories: mild (six hours), moderate (five hours) and extreme (three to four hours). The researchers analysed sleep data alongside information about people’s diets. Some 3.2% of participants were diagnosed with type 2 diabetes during the follow-up period. Although healthy eating habits were associated with a lower overall risk of diabetes, when people ate healthily but slept less than six hours a day, their risk of type 2 diabetes increased compared to people in the normal sleep category. The researchers found sleep duration of five hours was linked with a 16% higher risk of developing type 2 diabetes, while the risk for people who slept three to four hours was 41% higher, compared to people who slept seven to eight hours. One limitation is the study defined a healthy diet based on the number of servings of fruit, vegetables, red meat and fish a person consumed over a day or a week. In doing so, it didn’t consider how dietary patterns such as time-restricted eating or the Mediterranean diet may modify the risk of diabetes among those who slept less. Also, information on participants’ sleep quantity and diet was only captured at recruitment and may have changed over the course of the study. The authors acknowledge these limitations. <h2>Why might short sleep increase diabetes risk?</h2> In people with <a href="https://www.diabetesaustralia.com.au/about-diabetes/type-2-diabetes/">type 2 diabetes</a>, the body becomes resistant to the effects of a hormone called insulin, and slowly loses the capacity to produce enough of it in the pancreas. Insulin is important because it regulates glucose (sugar) in our blood that comes from the food we eat by helping move it to cells throughout the body. We don’t know the precise reasons why people who sleep less may be at higher risk of type 2 diabetes. But <a href="https://doi.org/10.7759/cureus.23501">previous research</a> has shown sleep-deprived people often have increased <a href="https://doi.org/10.1186/1476-511X-9-125">inflammatory markers</a> and <a href="https://doi.org/10.1007/s00125-015-3500-4">free fatty acids</a> in their blood, which <a href="https://doi.org/10.1007/s11892-018-1055-8">impair insulin sensitivity</a>, leading to <a href="https://doi.org/10.7759/cureus.23501">insulin resistance</a>. This means the body struggles to use insulin properly to regulate blood glucose levels, and therefore increases the risk of type 2 diabetes. Further, people who don’t sleep enough, as well as people who sleep in irregular patterns (such as shift workers), experience disruptions to their body’s natural rhythm, known as the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995632/">circadian rhythm</a>. This can interfere with the release of hormones like <a href="https://doi.org/10.1210/edrv.18.5.0317">cortisol, glucagon and growth hormones</a>. These hormones are released through the day to meet the body’s changing energy needs, and normally keep blood glucose levels nicely balanced. If they’re compromised, this may reduce the body’s ability to handle glucose as the day progresses. These factors, and <a href="https://www.science.org/doi/10.1126/sciadv.aar8590">others</a>, may contribute to the increased risk of type 2 diabetes seen among people sleeping less than six hours. While this study primarily focused on people who sleep eight hours or less, it’s possible longer sleepers may also face an increased risk of type 2 diabetes. Research has previously shown a U-shaped correlation between sleep duration and type 2 diabetes risk. A <a href="https://doi.org/10.2337/dc14-2073">review</a> of multiple studies found getting between seven to eight hours of sleep daily was associated with the lowest risk. When people got less than seven hours sleep, or more than eight hours, the risk began to increase. The reason sleeping longer is associated with increased risk of type 2 diabetes may be linked to <a href="https://doi.org/10.2337/dc15-0186">weight gain</a>, which is also correlated with longer sleep. Likewise, people who don’t sleep enough are more likely to be <a href="https://doi.org/10.1016/j.sleh.2017.07.013">overweight or obese</a>. <h2>Good sleep, healthy diet</h2> Getting enough sleep is an important part of a healthy lifestyle and may reduce the risk of type 2 diabetes. Based on this study and other evidence, it seems that when it comes to diabetes risk, seven to eight hours of sleep may be the sweet spot. However, other factors could influence the relationship between sleep duration and diabetes risk, such as individual differences in sleep quality and lifestyle. While this study’s findings question whether a healthy diet can mitigate the effects of a lack of sleep on diabetes risk, a wide range of evidence points to the benefits of <a href="https://www.who.int/initiatives/behealthy/healthy-diet">healthy eating</a> for overall health. The <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815684">authors of the study</a> acknowledge it’s not always possible to get enough sleep, and suggest doing <a href="https://pubmed.ncbi.nlm.nih.gov/33137489/">high-intensity interval exercise</a> during the day may offset some of the potential effects of short sleep on diabetes risk. In fact, exercise <a href="https://doi.org/10.1016/j.jshs.2023.03.001">at any intensity</a> can improve blood glucose levels.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/225179/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/giuliana-murfet-1517219">Giuliana Murfet</a>, Casual Academic, Faculty of Health, <a href="https://theconversation.com/institutions/university-of-technology-sydney-936">University of Technology Sydney</a> and <a href="https://theconversation.com/profiles/shanshan-lin-1005236">ShanShan Lin</a>, Senior Lecturer, School of Public Health, <a href="https://theconversation.com/institutions/university-of-technology-sydney-936">University of Technology Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/could-not-getting-enough-sleep-increase-your-risk-of-type-2-diabetes-225179">original article</a>.

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Could not getting enough sleep increase your risk of type 2 diabetes?