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Trying to lose weight? Here’s why your genetics could be just as important as your exercise regime

<a href="https://theconversation.com/profiles/henry-chung-1279176">Henry Chung</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>; <a href="https://theconversation.com/profiles/chris-mcmanus-2226445">Chris McManus</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>, and <a href="https://theconversation.com/profiles/sally-waterworth-2226444">Sally Waterworth</a>, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a> Weight loss is a complicated process. There are so many factors involved including your diet, how much sleep you get each night and the kind of exercise you do. Our recent study shows that your <a href="https://www.tandfonline.com/doi/full/10.1080/02701367.2024.2404981">specific genetic profile</a> may also have a dominant effect on how well you lose weight through exercise. This might explain why two people who do an identical workout will see very different results. We identified 14 genes that appeared to significantly contribute to how much weight a person lost through running. This suggests that some of us have a natural talent when it comes to burning fat and losing weight through exercise. To conduct our study, we recruited 38 men and women born in the UK aged between 20 and 40. None of the participants regularly exercised at the start of the study. The group was randomly divided, with one half following a strict eight-week endurance programme that consisted of three weekly runs of 20-30 minutes. The other group acted as a <a href="https://www.britannica.com/science/control-group">control</a>. They were instructed to refrain from exercise and continue their daily routines as normal over this study period, including diet and lifestyle habits. All participants conducted a running test to see how far they could run in 12 minutes, and were weighed before and after the study period. This was to gauge their initial fitness level and see how much they changed over the duration of the study. <a href="https://www.nhs.uk/conditions/obesity/">Body mass index</a> (BMI) was also calculated. Additionally, a saliva sample was collected from each person with a <a href="https://muhdo.com/?gclid=Cj0KCQjwiIOmBhDjARIsAP6YhSUB3WI81JP4Q_snYLhh-SBVNeCJNy2m63C8bKJFvO-nJ5UsHuCCdqMaAhTeEALw_wcB">DNA test kit</a> at the end of the study to assess their unique genetic profile. It’s important to note that everyone who participated in the study had a similar body weight, BMI and aerobic fitness level at the start of the study. This is beneficial for <a href="https://casp-uk.net/news/homogeneity-in-research/">multiple reasons</a>. It meant everyone was at the same starting point, and some <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/confounding-variable">confounding variables</a> were already controlled for such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128125/">fitness level</a>. This ultimately improves accuracy in interpreting the results. <h2>Exercise genes</h2> Everyone in the exercise group managed to lose weight – around 2kg on average. The control group, on the other hand, put on a little bit of weight. While a 2kg weight loss may not sound like a lot, it’s significant considering the exercise regime only lasted eight weeks and participants made no <a href="https://www.intechopen.com/chapters/87186">changes to their diet</a>. More significant, however, was the large variation in results among those that exercised – with an up to 10kg difference in weight loss between some of the participants. In fact, everyone within the exercise group improved at different rates. Since we controlled for factors such as the <a href="https://pubmed.ncbi.nlm.nih.gov/3529283/">intensity, duration and frequency</a> of the exercises and used participants who’d had a similar body weight and fitness level at the start of the study, this suggests that some people naturally benefited more than others from endurance training. When we looked at the genetic profiles of our participants, we found that differences in each person’s response to the exercise was strongly associated with their specific genetics. We showed there was a strong linear correlation between the amount of weight participants lost and 14 genes that have previously been shown to be associated with body weight, metabolism or <a href="https://www.nature.com/articles/s41380-018-0017-5">psychological conditions</a> that affect BMI. The greater number of these genes a participant had, the more weight they lost. Our results also revealed that around 63% of the variance in weight lost among participants were explained by the genes identified. For example, research has shown the <a href="https://www.ncbi.nlm.nih.gov/gene/10891">PPARGC1A gene</a> plays a role in metabolism and the <a href="https://link.springer.com/article/10.1007/S11033-020-05801-Z">use of fats for energy</a> while exercising. Our study found that all participants who lost more than 1.5kg from exercise had this gene. Those who lost less than this did not have this gene. Our findings align with what <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249501&s2=P875440273_1683331208925004155">previous studies</a> have shown. But while previous papers have only looked at the link between individual genes and weight loss, ours is the first to show that 14 different genes appear to work in combination to affect whether a person loses weight from endurance exercise. <h2>Piece of the puzzle</h2> Our study also suggests that while some people possess genes that make it easier for them to get fit and lose weight, people with these favourable genetics can only flourish if they actually exercise. In fact, our control group also had a number of these listed genes, but without exercise these genes could not activate, and so the participants did not lose any weight. While our study provides compelling findings, it’s not without limitations. Since we only looked at endurance-based exercise, it will be important for future studies to investigate whether there are similar links between weight loss, genetics and combinations of different types of training (such as a mixture of endurance and strength sessions into a training plan). It’s also worth mentioning that exercise is only <a href="https://www.who.int/activities/controlling-the-global-obesity-epidemic">one piece of the puzzle</a> when it comes to weight loss. So even if you have all 14 of these genes, you won’t lose any weight or get fit if you don’t exercise and maintain a healthy diet and sleep pattern. On the flip side, someone that only has a few of these favourable genes can still benefit if they exercise and are mindful of other aspects of their lifestyle.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/240506/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/henry-chung-1279176">Henry Chung</a>, Lecturer in Sport and Exercise Science, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>; <a href="https://theconversation.com/profiles/chris-mcmanus-2226445">Chris McManus</a>, Lecturer, School of Sport, Rehabilitation and Exercise Sciences, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a>, and <a href="https://theconversation.com/profiles/sally-waterworth-2226444">Sally Waterworth</a>, Lecturer, School of Sport, Rehabilitation and Exercise Sciences, <a href="https://theconversation.com/institutions/university-of-essex-1291">University of Essex</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/trying-to-lose-weight-heres-why-your-genetics-could-be-just-as-important-as-your-exercise-regime-240506">original article</a>.

Body

Ozempic, Wegovy, Rybelsus: Are we losing sight of overall health? Here’s what the science says

<a href="https://theconversation.com/profiles/aude-bandini-1488512">Aude Bandini</a>, <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a>; <a href="https://theconversation.com/profiles/jean-philippe-drouin-chartier-1533338">Jean-Philippe Drouin-Chartier</a>, <a href="https://theconversation.com/institutions/universite-laval-1407">Université Laval</a>; <a href="https://theconversation.com/profiles/pierre-marie-david-1375228">Pierre-Marie David</a>, <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a>, and <a href="https://theconversation.com/profiles/remi-rabasa-lhoret-1533515">Rémi Rabasa-Lhoret</a>, <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a> The craze for new drugs in the GLP-1 (Glucagon-like peptide 1) and GIP (Gastric inhibitory polypeptide) analogue class, better known under the trade names Ozempic and Wegovy, is remarkable, but it’s not totally unprecedented in the history of pharmaceutical blockbusters. The volume of prescriptions and the budget allocated to them by public health insurance schemes are exploding, as are the <a href="https://www.forbes.com/sites/roberthart/2024/05/02/ozempic-maker-novo-nordisk-beats-profit-forecasts-amid-weight-loss-drug-frenzy/">profits of the companies that manufacture them</a>. Part of the popularity of these drugs owes to social networks, but these are not always the best source for health information. When it comes to the subject of weight loss, both fantasy and prejudice come into play. This works to the detriment of everyone’s well-being, but particularly those who are already stigmatized. As specialists in the philosophy of medicine (Université de Montréal), nutrition and food science (Université Laval), the sociology of medication (Université de Montréal) and endocrinology (Institut de recherches cliniques de Montréal), we feel it’s necessary to step back and take stock of both the promises and the limitations of these new treatments. <h2>The best of both worlds</h2> GLP-1/GIP analogues were originally developed to regulate glycemia (blood sugar levels) in people with Type 2 diabetes, thereby preventing the complications associated with this disease. When studies were carried out to assess their safety and efficacy, it was discovered that these drugs also led to weight loss. This prompted new research which showed that at higher doses, the drugs could lead to <a href="https://pubmed.ncbi.nlm.nih.gov/38078870/">very significant weight loss</a>, from 15 to 25 per cent of the starting weight. The mode of action of these drugs on blood sugar regulation is clear: they simulate incretin hormones which, in turn, increase insulin secretion. Weight loss, on the other hand, was only explained after the fact: in addition to the pancreas, these molecules also act on the brain by regulating the sensation of satiety and, indirectly, on the stomach by slowing gastric emptying. These two combined effects reduce appetite and lead to weight reduction. This is how a new use for the drug appeared, at which point the company Novo Nordisk began marketing the same drug under two different names: Ozempic to treat Type 2 diabetes, and <a href="https://theconversation.com/considering-taking-wegovy-to-lose-weight-here-are-the-risks-and-benefits-and-how-it-differs-from-ozempic-237308">Wegovy to manage obesity</a>. <h2>A new era</h2> GLP-1/GIP analogues are a welcome therapeutic breakthrough at a time when the <a href="https://www.diabetes.ca/advocacy---policies/advocacy-reports/national-and-provincial-backgrounders/diabetes-in-canada">prevalence of Type 2 diabetes</a> and <a href="https://www.statcan.gc.ca/o1/en/plus/5742-overview-weight-and-height-measurements-world-obesity-day">obesity</a> is exploding and affecting people younger and younger. These diseases particularly affect women, members of racialized groups and socio-economically disadvantaged populations. The physical and mental suffering these cause and the costs associated with treating them are both considerable. So the arrival of new weapons in the therapeutic arsenal is a source of hope. Draconian changes in lifestyle are certainly effective. But they are very difficult to implement and maintain over time for reasons that go beyond the individual sphere; on the one hand, genetic predisposition plays a major role in the development of Type 2 diabetes and obesity; on the other, because these conditions are <a href="https://obesitycanada.ca/managing-obesity/">multifactorial</a>, management of them must be comprehensive to be effective and long lasting: it must combine medical interventions but also nutritional, functional, psycho-social, environmental and even institutional interventions. Support services of this kind do exist, but only in large university hospital centres to which many people do not have access. Nor do many people have easy access to <a href="https://health-infobase.canada.ca/health-inequalities/index">healthy and varied food options</a>, sports facilities or social and psychological support. <h2>Treating the effects but not the causes</h2> To be effective over the long term, GLP-1/GIP analogues must be taken continuously: without drastic lifestyle changes, the <a href="https://pubmed.ncbi.nlm.nih.gov/35441470/">weight that was lost is regained within a year of stopping</a>, and glycemic control is compromised once again. In other words, the drugs treat the effects of Type 2 diabetes and obesity but not their causes. And yet some of these causes are modifiable: for example, according to <a href="https://www150.statcan.gc.ca/n1/pub/75-006-x/2023001/article/00013-eng.htm">Statistics Canada</a>, less than half the Canadian population (49.2 per cent for adults; 43.9 per cent for young people and children) achieves the recommended amount of weekly physical activity. According to the same source, <a href="https://www150.statcan.gc.ca/n1/pub/75-006-x/2023001/article/00013-eng.htm">food insecurity</a> affects around 14 per cent of the Québec population (22 per cent in Alberta). Pharmacological treatment, even if it allows an individual to eat less, does not necessarily mean that person will <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10837702/">eat better</a>. Similarly, losing weight does not mean one will become more active or healthier. So these new drugs do not cure Type 2 diabetes or obesity. Nor do they prevent these diseases from developing, although they do help to limit the many complications to which they give rise. <h2>Prescribe and treat</h2> A drug such as Mounjaro is as effective at weight loss as bariatric surgery. Much easier to administer and much less risky, it could be a real game changer in the treatment of obesity. Prescribed directly by family doctors and dispensed in pharmacies, it would also be much more accessible and easier to administer for those who need it. This raises the question of costs and reimbursement, but not only that: prescribing is not the same as treating. Here, the manufacturers are following the recommendations of the health authorities: this treatment must be preceded by a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10748770/">careful assessment</a>, then management, and above all a close and regular monitoring of diet, physical activity, mental health, and if necessary, socio-economic assistance. This requires not only time that GPs do not have, but also co-ordination with other players in the health-care network. The problem is not whether the treatment will be effective, but what can happen if it is. Losing 25 per cent of your body weight in just a few months has serious consequences, which are not always beneficial: it involves a loss of body fat, but also of muscle mass, which is associated with intense fatigue. Nor should we underestimate the <a href="https://pubmed.ncbi.nlm.nih.gov/37990685/">challenge of adapting physically and psychologically</a> to a body transformation of this scale. Losing weight doesn’t solve everything, and expectations must remain realistic. <h2>What lessons can we learn?</h2> The clinical effectiveness of GLP-1/GIP analogues in reducing the complications associated with Type 2 diabetes and obesity is indisputable. However, these drugs are not suitable for everyone, and they are certainly not miracle cures that will make it possible for one to regain health without making any changes to lifestyle or environment. We must bear in mind that their success, both commercial and medical, is also the result of a failure: that of our societies to prevent these diseases, to promote healthy lifestyles and to develop environments conducive to the health of all.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/238484/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/aude-bandini-1488512">Aude Bandini</a>, Professeure agrégée, Philosophie (épistémologie et philosophie de la médecine), <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a>; <a href="https://theconversation.com/profiles/jean-philippe-drouin-chartier-1533338">Jean-Philippe Drouin-Chartier</a>, Professeur agrégé, Faculté de pharmacie, <a href="https://theconversation.com/institutions/universite-laval-1407">Université Laval</a>; <a href="https://theconversation.com/profiles/pierre-marie-david-1375228">Pierre-Marie David</a>, Professeur adjoint à la faculté de pharmacie, <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a>, and <a href="https://theconversation.com/profiles/remi-rabasa-lhoret-1533515">Rémi Rabasa-Lhoret</a>, Professeur de médecine et de nutrition, <a href="https://theconversation.com/institutions/universite-de-montreal-1743">Université de Montréal</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/ozempic-wegovy-rybelsus-are-we-losing-sight-of-overall-health-heres-what-the-science-says-238484">original article</a>.

Body

Considering taking Wegovy to lose weight? Here are the risks and benefits – and how it differs from Ozempic

<a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a> The weight-loss drug <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2022-PI-01930-1&d=20240731172310101&d=20240827172310101">Wegovy</a> is now <a href="https://www.tga.gov.au/safety/shortages/medicine-shortage-alerts/new-semaglutide-product-becomes-available">available</a> in Australia. Wegovy is administered as a once-weekly injection and is approved specifically for weight management. It’s intended to be used <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2022-PI-01930-1&d=20240731172310101">in combination</a> with a reduced-energy diet and increased physical activity. So how does Wegovy work and how much weight can you expect to lose while taking it? And what are the potential risks – and costs – for those who use it? Let’s look at what the science says. <h2>What is Wegovy?</h2> Wegovy is a brand name for the medication semaglutide. Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1RA). This means it makes your body’s own glucagon-like peptide-1 hormone, called GLP-1 for short, work better. Normally when you eat, the body releases the GLP-1 hormone which helps signal to your brain that you are full. Semaglutides enhance this effect, leading to a feeling of fullness, even when you haven’t eaten. Another role of GLP-1 is to stimulate the body to produce more insulin, a hormone which helps lower the level of glucose (sugar) in the blood. That’s why semaglutides have been used for <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231279/">several years</a> to treat type 2 diabetes. <h2>How does Wegovy differ from Ozempic?</h2> Like Wegovy, Ozempic is a semaglutide. The way Wegovy and Ozempic work in the body are essentially the same. They’re made by the same pharmaceutical company, Novo Nordisk. But there are two differences: 1) They are approved for two different (but related) reasons. In Australia (and the United States), Ozempic is <a href="https://www.tga.gov.au/resources/prescription-medicines-registrations/ozempic-novo-nordisk-pharmaceuticals-pty-ltd">approved for use</a> to improve blood glucose levels in adults with type 2 diabetes. By managing blood glucose levels effectively, the medication aims to reduce the risk of major complications, such as heart disease. Wegovy is <a href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2022-PI-01930-1&d=20240731172310101">approved for use</a> alongside diet and exercise for people with a body mass index (BMI) of 30 or greater, or 27 or greater but with other conditions such as high blood pressure. Wegovy can also be used in people aged 12 years and older. Like Ozempic, Wegovy aims to reduce the risk of future health complications, including heart disease. 2) They are both injected but come in different strengths. Ozempic is available in pre-loaded single-dose pens with varying dosages of 0.25 mg, 0.5 mg, 1 mg, or 2 mg per injection. The dose can be slowly increased, up to a maximum of 2 mg per week, if needed. Wegovy is available in prefilled single-dose pens with doses of 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg. The treatment starts with a dose of 0.25 mg once weekly for four weeks, after which the dose is gradually increased until reaching a maintenance dose of 2.4 mg weekly. While it’s unknown what the impact of Wegovy’s introduction will be on Ozempic’s availability, Ozempic is still <a href="https://www.tga.gov.au/safety/shortages/information-about-major-medicine-shortages/about-ozempic-semaglutide-shortage-2022-2024">anticipated to be in low supply</a> for the remainder of 2024. <h2>Is Wegovy effective for weight loss?</h2> Given Wegovy is a semaglutide, there is <a href="https://www.cochranelibrary.com/central/doi/10.1002/central/CN-02495006/full">very strong evidence</a> it can help people lose weight and maintain this weight loss. A recent <a href="https://www.nature.com/articles/s41591-024-02996-7">study</a> found that over four years, participants taking Wevovy as indicated experienced an average weight loss of 10.2% body weight and a reduction in waist circumference of 7.7cm. For those who stop taking the medication, analyses have shown that about two-thirds of weight lost is <a href="https://pubmed.ncbi.nlm.nih.gov/35441470/">regained</a>. <h2>What are the side effects of Wegovy?</h2> The most common <a href="https://www.wegovy.com/dashboard/my-library/week-02-tips-for-managing-common-side-effects.html">side effects</a> are nausea and vomiting. However, other serious side effects are also possible because of the whole-of-body impact of the medication. Thyroid tumours and cancer have been detected as a risk in animal studies, yet are rarely seen in human <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050669/">scientific literature</a>. In the four-year Wegovy <a href="https://www.nejm.org/doi/10.1056/NEJMoa2307563">trial</a>, 16.6% of participants who received Wegovy (1,461 people) experienced an adverse event that led to them permanently discontinuing their use of the medication. This was higher than the 8.2% of participants (718 people) who received the placebo (with no active ingredient). Side effects included gastrointestinal disorders (including nausea and vomiting), which affected 10% of people who used Wegovy compared to 2% of people who used the placebo. Gallbladder-related disorders occurred in 2.8% of people who used Wegovy, and 2.3% of people who received the placebo. Recently, concerns about suicidal thoughts and behaviours have been raised, after a <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822453">global analysis</a> reviewed more than 36 million reports of adverse events from semaglutide (Ozempic or Wegovy) since 2000. There were 107 reports of suicidal thoughts and self-harm among people taking semaglutide, sadly including six actual deaths. When people stopped the medication, 62.5% found the thoughts went away. What we don’t know is whether dose, weight loss, or previous mental health status or use of antidepressants had a role to play. Finally, concerns are growing about the negative effect of semaglutides on our social and emotional connection with food. <a href="https://www.theguardian.com/food/2022/nov/09/i-miss-eating-weight-loss-drug-ozempic-food-repulsive">Anecdotal</a> and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839771/">scientific</a> evidence suggests people who use semaglutides significantly reduce their daily dietary intake (as anticipated) by skipping meals and avoiding social occasions – not very enjoyable for people and their loved ones. <h2>How can people access Wegovy?</h2> Wegovy is available for purchase at pharmacists with a prescription from a doctor. But there is a hefty price tag. Wegovy is <a href="https://www.diabetesaustralia.com.au/news/wegovy-to-be-available-in-australia/">not currently subsidised</a> through the Pharmaceutical Benefits Scheme, leaving patients to cover the cost. The current cost is <a href="https://www1.racgp.org.au/newsgp/clinical/wegovy-launches-in-australia#:%7E:text=Novo%20Nordisk%20told%20newsGP%20the,each%20dose%20lasting%20one%20month.">estimated at around A$460</a> per month dose. If you’re considering Wegovy, <a href="https://www1.racgp.org.au/newsgp/clinical/wegovy-launches-in-australia#:%7E:text=The%20manufacturer%20assured%20GPs%20supply,cost%20to%20customers%20than%20Ozempic.">make an appointment</a> with your doctor for individual advice.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/237308/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, Professor of Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, Accredited Practising Dietitian and Lecturer, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/considering-taking-wegovy-to-lose-weight-here-are-the-risks-and-benefits-and-how-it-differs-from-ozempic-237308">original article</a>.

Body

Flight cancelled after crew member loses it at passenger

An Air Canada flight heading from Morocco to Montreal was cancelled on Friday after a flight attendant lost it at a passenger who reportedly requested a blanket. Viral footage of the incident showed a female flight attendant yelling: “You will behave or we will get off!” at a female passenger. “I’ll tell the captain right away. Yes or no?” When a passenger asked the flight attendant to call the captain, she refused and said: “I don’t want no bullying against my crew”. She then stormed up the aisle before she turned around and yelled: “Everyone behave! Be quiet … or you’re getting off.” <blockquote class="twitter-tweet"> Stress levels are quite high in the sky these days : An Air Canada flight from Casablanca (CMN) to Montreal (YUL) was canceled due to the inappropriate behavior of a flight attendant on July 26, 2024. The Airbus A330-343 aircraft (C-GHLM) did the taxi aiming a departure while… <a href="https://t.co/h3s4fbGF5A">pic.twitter.com/h3s4fbGF5A</a> — FL360aero (@fl360aero) <a href="https://twitter.com/fl360aero/status/1817249195960455420?ref_src=twsrc%5Etfw">July 27, 2024</a></blockquote> According to CTV News, the meltdown occurred after the passenger asked for a blanket. In a statement to the publication, Air Canada said the flight had been rescheduled for Saturday with a different crew. “We are taking this incident very seriously. It is under review, and we will take appropriate action,” the statement read. “It is under review, and we will take appropriate action. We apologise to our customers and deeply regret that their experience today fell far short of what they have come to expect when flying with Air Canada.” The airline has also offered compensation to all passengers affected by the delay. Images: X

Travel Trouble

“Grief eats you away”: Prince Harry's candid interview about losing his mother

Prince Harry has spoken candidly about his ongoing struggles with grief following the death of his mother, the late Princess Diana, when he was just 12 years old. Upon his brief return to the UK, the Duke of Sussex opened up in a new interview as part of his role as global ambassador for Armed Forces charity Scotty’s Little Soldiers, who work to support children who have lost parents in the military, admitting that “grief eats you away”. Harry detailed how difficult it was losing his mother at such a young age, admitting he spent nearly two decades “not thinking” about her death and was forced to eventually get help after years of “total chaos”. He added that learning how to celebrate a late loved one is difficult for a child, as it made them “sad”. “But realising if I do talk about it, and I’m celebrating their life, then things become easier,” he said. Harry went on, “You convince yourself that the person you’ve lost wants you, or you need to be sad for as long as possible to prove to them that they are missed … Especially when every defence mechanism in your mind, nervous system and everything else is saying ‘do not go there.” <iframe title="YouTube video player" src="https://www.youtube.com/embed/YY-W6VEXlZM?si=SBQyGGCKAOhELxlv" width="560" height="315" frameborder="0" allowfullscreen="allowfullscreen"></iframe> "But then there’s this realisation of, no, they must want me to be happy”. The 39-year-old royal shared how, after decades of silent mourning, he learned suppressing grief was “in fact not” the best form of coping with loss. “It can be for a period of time,” he went on to say. “But…if you suppress this for too long, you can’t suppress it forever it’s not sustainable and it will east away at you inside." “Once realising that if I do talk about it and I’m celebrating their life then actually things become easier.” Image credits: YouTube

Caring

Weight loss: drinking a gallon of water a day probably won’t help you lose weight

<a href="https://theconversation.com/profiles/duane-mellor-136502">Duane Mellor</a>, <a href="https://theconversation.com/institutions/aston-university-1107">Aston University</a> It’s often claimed that if you’re trying to lose weight, one of the things you should do each day is drink plenty of water – with some internet advice even suggesting this should be as much as a gallon (about 4.5 litres). The claim is that water helps burn calories and reduce appetite, which in turn leads to weight loss. But while we all might wish it was this easy to lose weight, unfortunately there’s little evidence to back up these claims. <h2>Myth 1: water helps burn calories</h2> One <a href="https://pubmed.ncbi.nlm.nih.gov/14671205/">small study</a>, of 14 young adults, found drinking 500ml of water increased resting energy expenditure (the amount of calories our body burns before exercise) by about 24%. While this may sound great, this effect only lasted an hour. And this wouldn’t translate to a big difference at all. For an average 70kg adult, they would only use an additional 20 calories – a quarter of a biscuit – for every 500ml of water they drank. <a href="https://pubmed.ncbi.nlm.nih.gov/16822824/">Another study</a> of eight young adults only saw an increase in energy expenditure when the water was fridge cold – reporting a very modest 4% increase in calories burned. This may be because the body needs to use more energy in order to bring the water up to body temperature, or because it requires more energy for the body to filter the increased volume of fluid through the kidneys. And again, this effect was only seen for about an hour. So although scientifically it might be possible, the actual net increase in calories burned is tiny. For example, even if you drank an extra 1.5l of water per day, it would save fewer calories than you’d get in a slice of bread. It’s also worth noting that all this research was in young healthy adults. More research is needed to see whether this effect is also seen in other groups (such as middle-aged and older adults). <h2>Myth 2: water with meals reduces appetite</h2> This claim again seems sensible, in that if your stomach is at least partly full of water there’s less room for food – so you end up eating less. A number of studies actually support this, particularly those conducted in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859815/#:%7E:text=Thus%2C%20when%20combined%20with%20a,meal%20EI%20following%20water%20ingestion.">middle-aged and older adults</a>. It’s also a reason people who are unwell or have a poor appetite are advised <a href="https://www.ageuk.org.uk/bp-assets/globalassets/salford/forms/improve-your-food-and-drink-intake.pdf">not to drink before eating</a> as it may lead to under-eating. But for people looking to lose weight, the science is a little less straightforward. <a href="https://pubmed.ncbi.nlm.nih.gov/17228036/">One study</a> showed middle-aged and older adults lost 2kg over a 12-week period when they drank water before meals compared with people who didn’t drink any water with their meal. Younger participants (aged 21-35) on the other hand did not lose any weight, regardless of whether they drank water before their meal or not. But since the study didn’t use blinding (where information which may influence participants is withheld until after the experiment is finished), it means that participants may have become aware of why they were drinking water before their meal. This may have led some participants to purposefully change how much they ate in the hopes it might increase their changes of losing weight. However, this doesn’t explain why the effect wasn’t seen in young adults, so it will be important for future studies to investigate why this is. The other challenge with a lot of this kind of research is that it only focuses on whether participants eat less during just one of their day’s meals after drinking water. Although this might suggest the potential to lose weight, there’s <a href="https://pubmed.ncbi.nlm.nih.gov/20736036/">very little good-quality evidence</a> showing that reducing appetite in general leads to weight loss over time. Perhaps this is due to our body’s biological drive to <a href="https://pubmed.ncbi.nlm.nih.gov/28193517/">maintain its size</a>. It’s for this reason that no claims can be legally made in Europe about foods which help make you <a href="https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/satietyenhancing-products-for-appetite-control-science-and-regulation-of-functional-foods-for-weight-management/E4CCAE4C90A220994FD29C27FAE7F666">feel fuller for longer</a> with <a href="https://www.gov.uk/government/publications/nutrition-and-health-claims-guidance-to-compliance-with-regulation-ec-1924-2006-on-nutrition-and-health-claims-made-on-foods/nutrition-and-health-claims-guidance-to-compliance-with-regulation-ec-19242006#section-6">reference to weight loss</a>. So, although there might be some appetite-dulling effects of water, it seems that it might not result in long-term weight change – and may possibly be due to making conscious changes to your diet. <h2>Just water isn’t enough</h2> There’s a pretty good reason why water on its own is not terribly effective at <a href="https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/eating-habits-and-appetite-control-a-psychobiological-perspective/0D0605739F5150D1A7C49420D75F3CDF">regulating appetite</a>. If it did, prehistoric humans might have starved. But while appetite and satiation – feeling full and not wanting to eat again – aren’t perfectly aligned with being able to <a href="https://pubmed.ncbi.nlm.nih.gov/20736036/">lose weight</a>, it might be a helpful starting point. Part of what helps us to feel full is our stomach. When food enters the stomach, it triggers stretch receptors that in turn lead to the release of hormones which tell us we’re full. But since water is a liquid, it’s rapidly emptied from our stomach – meaning it doesn’t actually fill us up. Even more interestingly, due to the <a href="https://pubmed.ncbi.nlm.nih.gov/16934271/">stomach’s shape</a>, fluids can bypass any semi-solid food content that’s being digested in the lower part of the stomach. This means that water can still be quickly emptied from the stomach. So even if it’s consumed at the end of a meal it might not necessarily extend your feelings of fullness. If you’re trying to eat less and lose weight, drinking excessive amounts of water may not be a great solution. But there is evidence showing when water is mixed with other substances (such as <a href="https://pubmed.ncbi.nlm.nih.gov/30166637/">fibre</a>, <a href="https://www.sciencedirect.com/science/article/pii/0031938494903034">soups</a> or vegetable sauces) this can delay how fast the stomach empties its contents – meaning you feel fuller longer. But while water may not help you lose weight directly, it may still aid in weight loss given it’s the healthiest drink we can choose. Swapping high-calorie drinks such as soda and alcohol for water may be an easy way of reducing the calories you consume daily, which may help with weight loss.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/211311/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/duane-mellor-136502">Duane Mellor</a>, Lead for Evidence-Based Medicine and Nutrition, Aston Medical School, <a href="https://theconversation.com/institutions/aston-university-1107">Aston University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/weight-loss-drinking-a-gallon-of-water-a-day-probably-wont-help-you-lose-weight-211311">original article</a>.

Body

John Travolta's heartbreaking tribute years after losing wife and son

John Travolta has shared a heartbreaking post commemorating his late wife, Kelly Preston, and son, Jett Travolta. Jett was only 16 when he passed away while on vacation with his family in the Bahamas in 2009. He had a seizure at the time and hit his head on a bathtub at their vacation home. His wife Kelly died in July 2020 aged 57, two years after she was diagnosed with breast cancer. John took to Instagram to share a throwback photo of their family, on what would've been Jett's 32nd birthday over the weekend. “Happy birthday my Jetty — not a day goes by where you’re not with me,” he wrote. <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C5sBcYKN9ub/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C5sBcYKN9ub/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by John Travolta (@johntravolta)</a> </div> </blockquote> The post gained 400,000 likes with fans and fellow celebrities rushing to the comments to share their support. “Will never forget him, or Kelly,” wrote actress and good friend Rita Wilson. “Always in your heart forever and ever,” added actress Kristin Chenoweth. “And you will see him and her again.” “They are together and some day you’ll all be together again. Happy heavenly birthday Jett,” wrote one follower. "Happy Birthday to Jett and beautiful Kelly...two angels watching over you and family," added another. The couple had two other children together — daughter Ella, 24, and son Benjamin, 13. Images: Instagram/ Getty

Family & Pets

How much weight do you actually need to lose? It might be a lot less than you think

<a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> If you’re one of the <a href="https://www.finder.com.au/new-years-resolutions-statistics">one in three</a> Australians whose New Year’s resolution involved losing weight, it’s likely you’re now contemplating what weight-loss goal you should actually be working towards. But type “setting a weight loss goal” into any online search engine and you’ll likely be left with more questions than answers. Sure, the many weight-loss apps and calculators available will make setting this goal seem easy. They’ll typically use a body mass index (BMI) calculator to confirm a “healthy” weight and provide a goal weight based on this range. Your screen will fill with trim-looking influencers touting diets that will help you drop ten kilos in a month, or ads for diets, pills and exercise regimens promising to help you effortlessly and rapidly lose weight. Most sales pitches will suggest you need to lose substantial amounts of weight to be healthy – making weight loss seem an impossible task. But the research shows you don’t need to lose a lot of weight to achieve health benefits. <h2>Using BMI to define our target weight is flawed</h2> We’re a society fixated on numbers. So it’s no surprise we use measurements and equations to score our weight. The most popular is BMI, a measure of our body weight-to-height ratio. BMI classifies bodies as underweight, normal (healthy) weight, overweight or obese and can be a useful tool for weight and health screening. But it shouldn’t be used as the single measure of what it means to be a healthy weight when we set our weight-loss goals. This is <a href="https://theconversation.com/using-bmi-to-measure-your-health-is-nonsense-heres-why-180412">because</a> it: <ul> <li> fails to consider two critical factors related to body weight and health – body fat percentage and distribution </li> <li> does not account for significant differences in body composition based on gender, ethnicity and age. </li> </ul> <h2>How does losing weight benefit our health?</h2> Losing just 5–10% of our body weight – between 6 and 12kg for someone weighing 120kg – can significantly improve our health in four key ways. 1. Reducing cholesterol Obesity increases the chances of having too much low-density lipoprotein (LDL) cholesterol – also known as bad cholesterol – because carrying excess weight changes how our bodies produce and manage lipoproteins and triglycerides, another fat molecule we use for energy. Having too much bad cholesterol and high triglyceride levels is not good, narrowing our arteries and limiting blood flow, which increases the risk of heart disease, heart attack and stroke. But <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987606/">research</a> shows improvements in total cholesterol, LDL cholesterol and triglyceride levels are evident with just 5% weight loss. 2. Lowering blood pressure Our blood pressure is considered high if it reads more than 140/90 on at least two occasions. Excess weight is <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082272/">linked to</a> high blood pressure in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082272/">several ways</a>, including changing how our sympathetic nervous system, blood vessels and hormones regulate our blood pressure. Essentially, high blood pressure makes our heart and blood vessels work harder and less efficiently, damaging our arteries over time and increasing our risk of heart disease, heart attack and stroke. Like the improvements in cholesterol, a 5% weight loss <a href="https://onlinelibrary.wiley.com/doi/10.1002/oby.21358">improves</a> both systolic blood pressure (the first number in the reading) and diastolic blood pressure (the second number). A <a href="https://www.ahajournals.org/doi/10.1161/01.hyp.0000094221.86888.ae">meta-analysis of 25 trials</a> on the influence of weight reduction on blood pressure also found every kilo of weight loss improved blood pressure by one point. 3. Reducing risk for type 2 diabetes Excess body weight is the primary manageable risk factor for type 2 diabetes, particularly for people carrying a lot of visceral fat around the abdomen (belly fat). Carrying this excess weight can cause fat cells to release pro-inflammatory chemicals that disrupt how our bodies regulate and use the insulin produced by our pancreas, leading to high blood sugar levels. Type 2 diabetes can lead to serious medical conditions if it’s not carefully managed, including damaging our heart, blood vessels, major organs, eyes and nervous system. <a href="https://www.nejm.org/doi/full/10.1056/nejmoa012512">Research</a> shows just 7% weight loss reduces risk of developing type 2 diabetes by 58%. 4. Reducing joint pain and the risk of osteoarthritis Carrying excess weight can cause our joints to become inflamed and damaged, making us more prone to osteoarthritis. <a href="https://pubmed.ncbi.nlm.nih.gov/21425246/">Observational studies</a> show being overweight doubles a person’s risk of developing osteoarthritis, while obesity increases the risk fourfold. Small amounts of weight loss alleviate this stress on our joints. <a href="https://pubmed.ncbi.nlm.nih.gov/15986358/">In one study</a> each kilogram of weight loss resulted in a fourfold decrease in the load exerted on the knee in each step taken during daily activities. <h2>Focus on long-term habits</h2> If you’ve ever tried to lose weight but found the kilos return almost as quickly as they left, you’re not alone. An <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764193/">analysis</a> of 29 long-term weight-loss studies found participants regained more than half of the weight lost within two years. Within five years, they regained more than 80%. When we lose weight, we take our body out of its comfort zone and trigger its survival response. It then counteracts weight loss, triggering several <a href="https://pubmed.ncbi.nlm.nih.gov/25896063/">physiological responses</a> to defend our body weight and “survive” starvation. Just as the problem is evolutionary, the solution is evolutionary too. Successfully losing weight long-term comes down to: <ul> <li> losing weight in small manageable chunks you can sustain, specifically periods of weight loss, followed by periods of weight maintenance, and so on, until you achieve your goal weight </li> <li> making gradual changes to your lifestyle to ensure you form habits that last a lifetime. </li> </ul> Setting a goal to reach a healthy weight can feel daunting. But it doesn’t have to be a pre-defined weight according to a “healthy” BMI range. Losing 5–10% of our body weight will result in immediate health benefits. At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can <a href="https://redcap.sydney.edu.au/surveys/?s=RKTXPPPHKY">register here</a> to express your interest.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/217287/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, Charles Perkins Centre Research Program Leader, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-much-weight-do-you-actually-need-to-lose-it-might-be-a-lot-less-than-you-think-217287">original article</a>.

Body

I’m trying to lose weight and eat healthily. Why do I feel so hungry all the time? What can I do about it?

<a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Benjamin Franklin, one of the founding fathers of the United States, famously said nothing is certain except death and taxes. But I think we can include “you’ll feel hungry when you’re trying to lose weight” as another certainty. The reason is basic biology. So how does this work – and what can you do about it? <h2>Hormones control our feelings of hunger</h2> Several hormones play an essential role in regulating our feelings of hunger and fullness. The most important are ghrelin – often called the hunger hormone – and leptin. When we’re hungry, <a href="https://pubmed.ncbi.nlm.nih.gov/11739476/">ghrelin</a> is released by our stomach, lighting up a part of our brain called the hypothalamus to tell us to eat. When it’s time to stop eating, hormones, including <a href="https://pubmed.ncbi.nlm.nih.gov/8717038/">leptin</a>, are released from different organs, such as our gut and fat tissue, to signal to the brain that we’re full. <h2>Dieting disrupts the process</h2> But when we change our diet and start losing weight, we disrupt how these <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766925/">appetite hormones function</a>. This triggers a process that stems from our hunter-gatherer ancestors. Their bodies developed this mechanism as a survival response to adapt to periods of deprivation and protect against starvation. The levels of hormones <a href="https://pubmed.ncbi.nlm.nih.gov/23126426/">managing our hunger increase</a>, making us feel hungrier to tell us to eat more, while the ones responsible for signalling we’re full decrease their levels, intensifying our feelings of hunger. We end up increasing our calorie consumption so we eat more to regain the weight we lost. But worse, even after the kilos creep back on, <a href="https://pubmed.ncbi.nlm.nih.gov/22029981/">our appetite hormones don’t restore</a> to their normal levels – they keep telling us to eat more so we put on a little extra fat. This is our body’s way of preparing for the next bout of starvation we will impose through dieting. Fortunately, there are things we can do to manage our appetite, including: <h2>1. Eating a large, healthy breakfast every day</h2> One of the easiest ways to manage our feelings of hunger throughout the day is to eat most of our food earlier in the day and taper our meal sizes so dinner is the smallest meal. <a href="https://pubmed.ncbi.nlm.nih.gov/32073608/">Research</a> shows a low-calorie or small breakfast leads to increased feelings of hunger, specifically appetite for sweets, across the course of the day. <a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00344-8">Another study</a> found the same effect. Participants went on a calorie-controlled diet for two months, where they ate 45% of their calories for breakfast, 35% at lunch and 20% at dinner for the first month, before switching to eat their largest meal in the evening and their smallest in the morning. Eating the largest meal at breakfast resulted in decreased hunger throughout the day. <a href="https://pubmed.ncbi.nlm.nih.gov/32073608/">Research</a> also shows we burn the calories from a meal 2.5-times more efficiently in the morning than the evening. So emphasising breakfast over dinner is good not just for hunger control, but also weight management. <h2>2. Prioritising protein</h2> Protein helps contain feelings of hunger. This is because protein-rich foods such as lean meats, tofu and beans suppress the appetite-stimulating ghrelin and stimulate another hormone called <a href="https://www.sciencedirect.com/science/article/pii/S1550413106002713">peptide YY</a> that makes you feel full. And just as eating a breakfast is vital to managing our hunger, what we eat is important too, with <a href="https://pubmed.ncbi.nlm.nih.gov/24703415/">research</a> confirming a breakfast containing protein-rich foods, such as eggs, will leave us feeling fuller for longer. But this doesn’t mean just eating foods with protein. Meals need to be balanced and include a source of protein, wholegrain carb and healthy fat to meet our dietary needs. For example, eggs on wholegrain toast with avocado. <h2>3. Filling up with nuts and foods high in good fats and fibre</h2> Nuts often get a bad rap – thanks to the misconception they cause weight gain – but nuts can help us manage our hunger and weight. The filling fibre and good fats found in nuts take longer to digest, meaning our hunger is satisfied for longer. <a href="https://pubmed.ncbi.nlm.nih.gov/12791613/">Studies</a> suggest you can include up to 68 grams per day of nuts without affecting your weight. Avocados are also high in fibre and heart-healthy monounsaturated fats, making them another excellent food for managing feelings of fullness. This is backed by a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567160/">study</a> confirming participants who ate a breakfast incorporating avocado felt more satisfied and less hungry than participants who ate a meal containing the same calories but with lower fat and fibre content. Similarly, eating foods that are high in soluble fibre – such as <a href="https://pubmed.ncbi.nlm.nih.gov/24820437/">beans</a> and vegetables – make us feel fuller. This type of fibre attracts water from our gut, forming a gel that slows digestion. <h2>4. Eating mindfully</h2> When we take time to really be aware of and enjoy the food we’re eating, we slow down and eat far less. A <a href="https://pubmed.ncbi.nlm.nih.gov/28718396/">review</a> of 68 studies found eating mindfully helps us better recognise feelings of fullness. Mindful eating provides our brain enough time to recognise and adapt to the signals from our stomach telling us we’re full. Slow down your food consumption by sitting at the dinner table and use smaller utensils to reduce the volume of food you eat with each mouthful. <h2>5. Getting enough sleep</h2> Sleep deprivation disturbs our <a href="https://www.sciencedirect.com/science/article/abs/pii/S1389945708700133">appetite hormones</a>, increasing our feelings of hunger and <a href="https://www.nature.com/articles/ncomms3259">triggering cravings</a>. So aim to get at least seven hours of uninterrupted sleep a night. Try switching off your devices <a href="https://journals.sagepub.com/doi/full/10.1177/1477153515584979">two hours before bed</a> to boost your body’s secretion of sleep-inducing hormones like melatonin. <h2>6. Managing stress</h2> Stress increases our <a href="https://pubmed.ncbi.nlm.nih.gov/18568078/">body’s production of cortisol</a> and triggers food cravings. So take time out when you need it and set aside time for stress-relieving activities. This can be as simple as getting outdoors. A <a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00722/full">2019 study</a> found sitting or walking outdoors at least three times a week could reduce cortisol levels by 21%. <h2>7. Avoiding depriving ourselves</h2> When we change our diet to lose weight or eat healthier, we typically restrict certain foods or food groups. However, this <a href="https://pubmed.ncbi.nlm.nih.gov/18568078/">heightens activity</a> in our mesocorticolimbic circuit – the reward system part of the brain – often resulting in us craving the foods we’re trying to avoid. Foods that give us pleasure release feel-good chemicals called endorphins and learning chemicals called dopamine, which enable us to remember – and give in to – that feel-good response. When we change our diet, activity in our hypothalamus – the clever part of the brain that regulates emotions and food intake – <a href="https://pubmed.ncbi.nlm.nih.gov/18568078/">also reduces</a>, decreasing our control and judgement. It often triggers a psychological response dubbed the “what-the-hell effect”, when we indulge in something we think we shouldn’t feel guilty about and then go back for even more. Don’t completely cut out your favourite foods when you go on a diet or deprive yourself if you’re hungry. It will take the pleasure out of eating and eventually you’ll give into your cravings. At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can <a href="https://redcap.sydney.edu.au/surveys/?s=RKTXPPPHKY">register here</a> to express your interest.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/215808/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, Charles Perkins Centre Research Program Leader, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/im-trying-to-lose-weight-and-eat-healthily-why-do-i-feel-so-hungry-all-the-time-what-can-i-do-about-it-215808">original article</a>.

Body

"Losing his speech": Home Alone star's major health update

Home Alone star Ken Hudson Campbell's daughter has shared a health update for fans after the actor underwent surgery to remove a tumour in his mouth. Speaking to People Magazine, Michaela revealed that her father is "doing well" after his 10-hour surgery last week, but there are still a few challenges their family will have to face, as Campbell will need to have radiation treatment five times a week. "I think the hardest part of this is going to be him losing his speech and his ability to talk. So speech therapy is going to play a big role in it," she told the publication. "We're kind of playing it one step at a time, depending on how debilitated he is. "If he needs extra help, we might put him into a nursing home for a little while, but if not, we're going to take him back home and we still will be hiring post-op care help with that." This comes after Michaela and her family managed to raise $102,000 USD ($AU 152,000) for their father's treatment through crowd-funding, after the actor lost his SAG-AFTRA health insurance in January last year. Campbell, who played Santa Claus in Home Alone, "burst into tears" when he saw the messages and well wishes on the crowd-funding page. He was diagnosed with Squamous cell carcinoma - or oral cancer, on October 27. His family are hoping for a full recovery for the actor who they described as "a loving father of two children with an admirable lust for life, and a passion for acting, writing, & sports." Images: Instagram

Caring

Can I actually target areas to lose fat, like my belly?

<a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Spend some time scrolling social media and you’re all-but-guaranteed to see an ad promising to help you with targeted fat loss. These ads promote a concept known as “spot reduction”, claiming you can burn fat in a specific body area, usually the belly, with specially designed exercises or workouts. It’s also common to see ads touting special diets, pills and supplements that will blast fat in targeted areas. These ads – which often feature impressive before and after photos taken weeks apart – can seem believable. Unfortunately, spot reduction is another weight-loss myth. It’s simply not possible to target the location of fat loss. Here’s why. <h2>1. Our bodies are hardwired to access and burn all our fat stores for energy</h2> To understand why spot reduction is a myth, it’s important to understand how body fat is stored and used. The fat stored in our bodies takes the form of triglycerides, which are a type of lipid or fat molecule we can use for energy. Around 95% of the dietary fats <a href="https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/triglycerides">we consume are triglycerides</a>, and when we eat, our bodies also convert any unused energy consumed into triglycerides. Triglycerides are stored in special fat cells called adipocytes, and they’re released into our bloodstream and transported to adipose tissue – tissue we more commonly refer to as body fat. This body fat is found all over our bodies, but it’s primarily stored as subcutaneous fat under our skin and as visceral fat around our internal organs. These fat stores serve as a vital energy reserve, with our bodies mobilising to access stored triglycerides to provide energy during periods of prolonged exercise. We also draw on these reserves when we’re dieting and fasting. However, contrary to what many spot-reduction ads would have us think, our muscles can’t directly access and burn specific fat stores when we exercise. Instead, they use a process called lipolysis to convert triglycerides into free fatty acids and a compound called glycerol, which then travels to our muscles via our bloodstream. As a result, the fat stores we’re using for energy when we exercise come from everywhere in our bodies – not just the areas we’re targeting for fat loss. Research reinforces how our bodies burn fat when we exercise, confirming spot reduction is a weight-loss myth. This includes a randomised <a href="https://pubmed.ncbi.nlm.nih.gov/25766455/">12-week clinical trial</a> which found no greater improvement in reducing belly fat between people who undertook an abdominal resistance program in addition to changes in diet compared to those in the diet-only group. Further, <a href="https://www.termedia.pl/A-proposed-model-to-test-the-hypothesis-of-exerciseinduced-localized-fat-reduction-spot-reduction-including-a-systematic-review-with-meta-analysis,129,45538,0,1.html">a 2021 meta-analysis</a> of 13 studies involving more than 1,100 participants found that localised muscle training had no effect on localised fat deposits. That is, exercising a specific part of the body did not reduce fat in that part of the body. <a href="https://www.mdpi.com/1660-4601/18/7/3845">Studies</a> purporting to show spot-reduction benefits have small numbers of participants with results that aren’t clinically meaningful. <h2>2. Our bodies decide where we store fat and where we lose it from first</h2> Factors outside of our control influence the areas and order in which our bodies store and lose fat, namely: <ul> <li> our genes. Just as DNA prescribes whether we’re short or tall, genetics plays a significant role in how our fat stores are managed. Research shows our genes can account for <a href="https://pubmed.ncbi.nlm.nih.gov/24632736/">60% of where fat is distributed</a>. So, if your mum tends to store and lose weight from her face first, there’s a good chance you will, too </li> <li> our gender. Our bodies, by nature, have distinct fat storage characteristics <a href="https://pubmed.ncbi.nlm.nih.gov/11706283/">driven by our gender</a>, including females having more fat mass than males. This is primarily because the female body is designed to hold fat reserves to support pregnancy and nursing, with women tending to lose weight from their face, calves and arms first because they impact childbearing the least, while holding onto fat stored around the hips, thighs and buttocks </li> <li> our age. The ageing process triggers changes in muscle mass, metabolism, and hormone levels, which can impact where and how quickly fat is lost. Post-menopausal <a href="https://theconversation.com/is-menopause-making-me-put-on-weight-no-but-its-complicated-198308">women</a> and middle-aged <a href="https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/sex-differences-in-fat-storage-fat-metabolism-and-the-health-risks-from-obesity-possible-evolutionary-origins/00950AD6710FB3D0414B13EAA67D4327">men</a> tend to store visceral fat around the midsection and find it a stubborn place to shift fat from. </li> </ul> <h2>3. Over-the-counter pills and supplements cannot effectively target fat loss</h2> Most advertising for these pills and dietary supplements – including products claiming to be “the best way to lose belly fat” – will also proudly claim their product’s results are backed by “clinical trials” and “scientific evidence”. But the reality is a host of independent studies don’t support these claims. This includes two recent studies by the University of Sydney that examined data from more than 120 placebo-controlled trials of <a href="https://pubmed.ncbi.nlm.nih.gov/31984610/">herbal</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/33976376/">dietary</a> supplements. None of the supplements examined provided a clinically meaningful reduction in body weight among overweight or obese people. <h2>The bottom line</h2> Spot reduction is a myth – we can’t control where our bodies lose fat. But we can achieve the results we’re seeking in specific areas by targeting overall fat loss. While you may not lose the weight in a specific spot when exercising, all physical activity helps to burn body fat and preserve muscle mass. This will lead to a change in your body shape over time and it will also help you with long-term weight management. This is because your metabolic rate – how much energy you burn at rest – is determined by how much muscle and fat you carry. As muscle is more metabolically active than fat (meaning it burns more energy than fat), a person with a higher muscle mass will have a faster metabolic rate than someone of the same body weight with a higher fat mass. Successfully losing fat long term comes down to losing weight in small, manageable chunks you can sustain – periods of weight loss, followed by periods of weight maintenance, and so on, until you achieve your goal weight. It also requires gradual changes to your lifestyle (diet, exercise and sleep) to ensure you form habits that last a lifetime. At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can <a href="https://redcap.sydney.edu.au/surveys/?s=RKTXPPPHKY">register here</a> to express your interest.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/205203/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, Charles Perkins Centre Research Program Leader, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/can-i-actually-target-areas-to-lose-fat-like-my-belly-205203">original article</a>.

Body

It wasn’t just a tree: why it feels so bad to lose the iconic Sycamore Gap tree and others like it

<a href="https://theconversation.com/profiles/rebecca-banham-830381">Rebecca Banham</a>, <a href="https://theconversation.com/institutions/university-of-tasmania-888">University of Tasmania</a> The famous <a href="https://oversixty.co.nz/finance/legal/you-can-t-forgive-that-teen-arrested-after-felling-of-iconic-200-year-old-tree" target="_blank" rel="noopener">Sycamore Gap tree</a> was felled last week, prompting global expressions of sorrow, anger and horror. For some, the reaction was puzzling. Wasn’t it just a single tree in northern England? But for many, the tree felt profoundly important. Its loss felt like a form of grief. Trees tell us something important about ourselves and who we are in the world. That is, they contribute to <a href="https://www.tandfonline.com/doi/full/10.1080/23251042.2020.1717098">ontological security</a> – our sense of trust that the world and our selves are stable and predictable. Trees – especially those celebrated like England’s sycamore or Tasmania’s 350-year-old El Grande mountain ash – feel like they are stable and unchanging in a world where change is constant. Their loss can destabilise us. <h2>What makes a tree iconic?</h2> Individual trees can become important to us for many reasons. When the wandering ascetic Siddhartha Gautama sat at the foot of a sacred fig around 500 BCE, he achieved the enlightenment which would, a few centuries later, lead to his fame as the Buddha. This sacred fig would become known as the Bodhi Tree. One of its descendants <a href="https://www.britannica.com/plant/Bo-tree">attracts millions</a> of pilgrims every year. Sometimes a tree becomes iconic because of its association with pop culture. U2’s hit 1987 album The Joshua Tree has inspired fans to seek out the tree on the cover in the United States’ arid southwest – <a href="https://www.rollingstone.com/feature/u2s-the-joshua-tree-10-things-you-didnt-know-106885/">a potentially dangerous trip</a>. Other trees become famous because they’re exceptional in some way. The location of the world’s tallest tree – a 115-metre high redwood known as Hyperion – is <a href="https://www.smithsonianmag.com/smart-news/the-worlds-tallest-tree-is-officially-off-limits-180980509/">kept secret for its protection</a>. Niger’s Tree of Ténéré was known as the world’s most isolated, eking out an existence in the Sahara before the lonely acacia was accidentally knocked down by a truck driver in 1973. Its site is <a href="https://www.atlasobscura.com/places/last-tree-tenere">marked by a sculpture</a>. In 2003, the mountain ash known as El Grande – then the world’s largest flowering plant – was accidentally killed in a burn conducted by Forestry Tasmania. The death of the enormous tree – 87 metres tall, with a 19 metre girth – drew <a href="https://catalogue.nla.gov.au/catalog/3945157">“national and international”</a> media attention. This year, <a href="https://www.abc.net.au/news/2023-08-14/vandalism-sacred-birthing-tree-buangor-police-investigate/102726014">vandals damaged</a> a birthing tree sacred to the local Djab Wurrung people amidst conflicts about proposed road works in western Victoria. And in 2006, someone poisoned Queensland’s Tree of Knowledge – a 200-year-old ghost gum <a href="https://www.australiantraveller.com/qld/outback-qld/longreach/tree-of-knowledge-is-dead/">famous for its connection</a> to the birth of trade unionism in Australia. Under its limbs, shearers organised and marched for better conditions. The dead tree has been preserved in a memorial. <h2>What is it to lose a tree?</h2> Sociologist Anthony Giddens defines ontological security as a <a href="https://books.google.com.au/books/about/Modernity_and_Self_Identity.html?id=Jujn_YrD6DsC&redir_esc=y">“sense of continuity and order in events”</a>. To sustain it, we seek out feelings of safety, trust, and reassurance by engaging with comfortable and familiar objects, beings and people around us – especially those important to our self-identity. When there is an abrupt change, it challenges us. If your favourite tree in your street or garden dies, you mourn it – and what it gave you. But we mourn at a distance too – the Sycamore Gap tree was <a href="https://www.theguardian.com/uk-news/gallery/2023/sep/28/hadrians-wall-sycamore-gap-tree-in-pictures">world-famous</a>, even if you never saw it in real life. In <a href="https://figshare.utas.edu.au/articles/thesis/Seeing_the_forest_for_the_trees_ontological_security_and_experiences_of_Tasmanian_forests/23238422">my research</a>, I have explored how Tasmanian forests – including iconic landscapes and individual trees – can give us that sense of security we all seek in ourselves. As one interviewee, Leon, told me: <blockquote> These places should be left alone, because in 10,000 years they could still be there. Obviously I won’t be, we won’t be, but perhaps [the forest will be]. </blockquote> Temporality matters here. That is, we know what to expect by looking to the past and imagining what the future could be. Trees – especially ancient ones – act as a living link between the past, present, and future. As my interviewee Catherine said: <blockquote> You lie under an old myrtle and you just go, ‘wow - so what have you seen in your lifetime?’ Shitloads more than me. </blockquote> That’s why the loss of the Sycamore Gap tree has upset seemingly the entire United Kingdom. The tree was famous for its appearance: a solitary tree in a <a href="https://www.northumberlandnationalpark.org.uk/places-to-visit/hadrians-wall/sycamore-gap/">photogenic dip</a> in the landscape. Its loss means a different future for those who knew it. It’s as if you were reading a book you know – but someone changed the ending. <h2>Loss of connection</h2> We respond very differently when humans do the damage compared to natural processes. In one study, UK homeowners found it <a href="https://www.tandfonline.com/doi/full/10.1080/13698570802381162">harder to accept</a> their house being burgled than for it to be flooded, seeing flooding as more natural and thus less of a blow to their sense of security. This is partly why the sycamore’s death hurt. It didn’t fall in a storm. It was cut down deliberately – something that wasn’t supposed to happen. The sycamore was just a tree. But it was also not just a tree – it was far more, for many of us. It’s more than okay to talk about what this does to us – about how the loss of this thread of connection makes us grieve. Yes, we have lost the Sycamore Gap tree, just as we lost El Grande and many others. It is useful to talk about this - and to remember the many other beautiful and important trees that live on. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/214841/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/rebecca-banham-830381">Rebecca Banham</a>, Postdoctoral fellow, <a href="https://theconversation.com/institutions/university-of-tasmania-888">University of Tasmania</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/it-wasnt-just-a-tree-why-it-feels-so-bad-to-lose-the-iconic-sycamore-gap-tree-and-others-like-it-214841">original article</a>.

Travel Trouble

What is ‘budget Ozempic’ that’s all over social media? Can it help me lose weight?

<a href="https://theconversation.com/profiles/nial-wheate-96839">Nial Wheate</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/jessica-pace-1401278">Jessica Pace</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Social media is lighting up over what influencers are calling “<a href="https://www.forbes.com/sites/brucelee/2023/09/09/budget-ozempic-tiktok-trend-how-its-contributing-to-the-laxative-shortage/?sh=1f54511b1569">budget Ozempic</a>”. These are drugs normally used as laxatives and stool softeners, but people are taking them to lose weight. The demand is so high in the United States, there are reports this is contributing to <a href="https://www.wsj.com/health/wellness/laxative-shortage-diet-weight-loss-5a15bf02">shortages</a> in pharmacies. These laxatives are just the latest alternatives influencers are touting for the <a href="https://www.abc.net.au/news/2023-09-09/ozempic-maker-novo-nordisk-becomes-biggest-company-in-europe/102812584">blockbuster drug</a> Ozempic. So, does “budget Ozempic” help you lose weight? Any weight loss is likely to be temporary and using these laxatives long term may be dangerous. <h2>Ozempic is in short supply</h2> Ozempic contains the active ingredient semaglutide. It is a prescription-only drug used to treat type 2 diabetes. One side effect of taking it is significant weight loss. This has led to so many people trying to obtain the drug there have been <a href="https://www.tga.gov.au/safety/shortages/information-about-major-medicine-shortages/about-ozempic-semaglutide-shortage-2022-and-2023">shortages</a>. Instead, some people have turned to more easily accessible over-the-counter alternatives to try to lose weight. That includes <a href="https://theconversation.com/natures-own-ozempic-or-berberine-is-all-over-social-media-but-does-it-really-help-you-lose-weight-206855">berberine</a>, which has been dubbed “nature’s own Ozempic”. <h2>What is ‘budget Ozempic’?</h2> “Budget Ozempic” is different to “nature’s own Ozempic”. It is the polymer polyethylene glycol 3350, or PEG 3350 for short. Chemically, it’s similar to other polymers used as ingredients in cosmetics, drug delivery, <a href="https://www.chemistryworld.com/features/raiders-of-the-lost-pigments/3007237.article">archaeological preservative paints</a>, soaps and even <a href="https://navyrecognition.com/index.php/naval-news/naval-news-archive/2023/june/13261-northrop-grumman-hits-production-milestone-with-trident-ii-d5-s-2000th-rocket-motor.html">missile fuel</a>. It’s not to be confused with ethylene glycol, which is used in antifreeze. Medically, PEG 3350 is mainly sold in Australia through pharmacies in <a href="https://australianprescriber.tg.org.au/articles/managing-constipation-in-adults.html">laxative and stool softening</a> products. It is also used to clean out your bowels before a colonoscopy. The products are referred to as <a href="https://www.healthdirect.gov.au/medicines/medicinal-product/aht,22630/macrogol-3350">macrogols</a>. Brands include DulcoSoft, Movicol, OsmoLax, ClearLax and ColonLYTELY. <h2>How can it cause weight loss?</h2> PEG 3350 is known as an <a href="https://www.nhs.uk/conditions/laxatives/#:%7E:text=Osmotic%20laxatives%20draw%20water%20from,brand%20names%20Duphalac%20and%20Lactugal">osmotic laxative</a>. It uses osmosis – how your body manages the balance of electrolytes in your blood serum – to soften your stools and treat constipation. When you swallow a drink with PEG 3350 the polymer isn’t absorbed by the body. Instead, as it passes through your intestines it draws water to it, making your faeces much more watery. Because it draws more water out of your body than you put into it from the drink, your weight goes down. That is, it just makes you dehydrated. This means any weight loss is likely to be short-lived; when you next drink, your body will retain more of the water to replace what was lost. To have any significant and sustained weight loss you’d need to take a lot of PEG 3350 every day. And at most, you would only lose a few kilograms. This is different to how <a href="https://www.nps.org.au/assets/medicines/42ccacc2-2326-42ad-ad14-abd6010499a4.pdf">Ozempic</a> works. Ozempic is similar to a family of hormones in your body called <a href="https://pubmed.ncbi.nlm.nih.gov/29364588/">incretins</a>. These have a number of actions that control both blood sugar levels and weight. For example, they slow how quickly food is absorbed from the stomach and decrease appetite, both of which help with sustained weight loss. <h2>Dangers and side effects</h2> PEG 3350 can make you <a href="https://www.healthdirect.gov.au/dehydration">dehydrated</a>. You may feel dizzy or light-headed, have a headache and have a dry mouth, lips or eyes. The concentration of electrolytes in your blood, such as salt, may also be too high (known as hypertonic blood serum). Hypertonic blood serum can affect the shape of your red blood cells, making it harder for them to carry oxygen around your body. This results in symptoms that include fatigue and tiredness, and those other symptoms of being dehydrated. In extreme cases it can result in <a href="https://psmf.org/story/emily-jerry/">death</a>. Incorrect levels of electrolytes can lead to other serious problems, affecting your heart and muscles. It can also lead to seizures, confusion, and coma. It can be dangerous to take PEG 3350 if you have heart disease, if your doctor has put you on a sodium-restricted diet, or if you already have an electrolyte disorder, such as <a href="https://www.healthdirect.gov.au/potassium">hyperkalaemia</a> (high potassium levels). These products are also dangerous for elderly people, those with kidney problems, and in very young children. Common side effects include anal irritation, vomiting, diarrhoea, nausea, cramps, pain, and swelling of your abdomen. Some people can have allergic reactions. If you use laxatives, including PEG 3350-based products, for a long period of time (over a period of weeks or months) then you may experience <a href="https://www.eatingdisorders.org.au/wp-content/uploads/2019/10/Eating-disorders-and-laxatives.pdf">withdrawal symptoms</a> if you stop taking them suddenly. These include constipation, bloating, weight gain and fluid retention. <h2>In a nutshell</h2> Overall, if you’ve been struggling with weight loss, then PEG 3350-based products are not a safe and effective solution. Any weight loss you experience will be temporary and may put your health at risk. Safer and more effective solutions are available. Eating healthily and exercising regularly are important first steps for anyone who wishes to lose weight. Otherwise, your GP or local pharmacist can help you with both lifestyle changes and medication options to help with weight loss.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/213457/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nial-wheate-96839">Nial Wheate</a>, Associate Professor of the Sydney Pharmacy School, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/jessica-pace-1401278">Jessica Pace</a>, Associate Lecturer, Sydney Pharmacy School, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-budget-ozempic-thats-all-over-social-media-can-it-help-me-lose-weight-213457">original article</a>.

Body

Location, Location, Location host loses both parents in tragic accident

In heart-wrenching news has shaken the world of television, beloved Location, Location, Location host Phil Spencer has spoken out about the devastating loss of his parents in a tragic accident on their family farm. Spencer paid a somber tribute to his father Richard, known affectionately as David, aged 89, and his mother Anne, 82, who were both tragically lost. In a poignant display of love, Phil, now 53, shared an image of the couple and wrote: "Very sadly both of my amazing parents died on Friday. "As a family we are all trying to hold onto the fact Mum and Dad went together and that neither will ever have to mourn the loss of the other one. Which is a blessing in itself." Spencer went on to disclose the harrowing details surrounding the accident, giving a glimpse into the tragic events that unfolded on that fateful day: "The car, going very slowly, toppled over a bridge on the farm drive, upside down into the river. There were no physical injuries and I very much doubt they would have even fought it - they would have held hands under the water and quietly slipped away. Spencer acknowledged the heroic efforts of his brother, who valiantly attempted to save their parents in the aftermath of the crash. "As many farmers do - my brother had a penknife and so was able to cut the seat belts - he pulled them out of the river but they never regained consciousness. "Although desperately sad and shocked beyond all belief - all family are clear that if there can ever be such a thing as having a 'good end' - this was it." Spencer also recalled a poignant conversation he had with his mother, a conversation now weighed down by the melancholy of hindsight: "Although they were both on extremely good form in the days before (hence the sudden idea to go out to lunch), Mums Parkinson's and Dads Dementia had been worsening and the long term future was set to be a challenge. "So much so that Mum said to me only a week ago that she had resigned to thinking 'now it looks like we will probably go together'. And so they did." As he concluded his heartfelt statement, Spencer mused on the overwhelming nature of their passing, acknowledging the future comfort that might come from the knowledge that they departed from a place they held dear. "It feels horrendous right now, but after almost 60 years of marriage - to die together on the farm they so loved will, I know, be a comfort in the future. "Mum Dad are together which is precisely where they would have wanted to be. ❤️" <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CwKpOWJr4Wj/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CwKpOWJr4Wj/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Phil Spencer (@philspencertv)</a> </div> </blockquote> Kirstie Allsopp, Phil's co-host on Location, Location, Location, a dear friend, was among the first to respond, her words echoing the collective grief felt by many: "Such a brave and loving statement and so typical of you & your lovely family. So many people have you all in their thoughts and prayers. xxx" Tragically, David and Anne were en route to a local pub for lunch when their car veered off the access road, plunging into a shallow river on their estate. Emergency services, fire brigade and police attended the scene, and an air ambulance landing nearby at the Littlebourne farm in Kent. Despite efforts to save them, Richard succumbed at the hospital, with Anne following suit shortly thereafter. Kirstie reflected: “I’ve spoken to Phil and it’s tragic for the Spencer family, but his parents were together and that’s something that is a great source of solace to them all. “The family is very loving and close. There are four children, Phil, Robert, Caryn and Helen, and they had eight grandchildren. “This is awful for all of the family, but they were together at the end and they were lovely people." Images: Instagram

Family & Pets

Weight loss: why you don’t just lose fat when you’re on a diet

<a href="https://theconversation.com/profiles/adam-collins-1179004">Adam Collins</a>, <a href="https://theconversation.com/institutions/university-of-surrey-1201">University of Surrey</a> When you go on a diet, you don’t just lose fat – you lose muscle too. This can have many repercussions – not only on your fitness and strength, but on your metabolism. To lose weight (body fat), you need to be in a calorie deficit. This means consuming fewer calories than your body uses, or exercising to burn more calories than you consume. During the first few days in a calorie deficit, the body uses up its small reservoir of <a href="https://pubmed.ncbi.nlm.nih.gov/1615908/">glycogen stores</a> for energy. Glycogen is a string of glucose (sugar) that comes from the carbohydrates you eat. Since carbs are the body’s main energy source, this is why any glucose the body doesn’t immediately use is stored to use for energy later. But as carbohydrate molecules bind with water, this means that when the body stores glycogen, it also stores water in the muscles. As these glycogen stores are used up, the body also releases a significant amount of water. This is often called “water weight”, and explains why some may feel they lose considerable weight early in their diet. Given you only have days’ worth of glycogen stores, this is why the body uses fat to store extra calories for when you need it. Once the glycogen stores are used up, the body shifts to metabolising fat to get the energy it needs to function. But not all tissues can use fat for energy – such as the brain. This is why the body needs to metabolise your muscles when you’re in a calorie deficit. Protein (from the food you eat) is stored in your muscles. The body can convert this stored protein into glucose for energy. But this means you subsequently lose the muscle tissue itself when that happens. This has significant consequences – including <a href="https://pubmed.ncbi.nlm.nih.gov/35103583/">slowing the metabolism</a>, which may ultimately drive weight regain after losing weight. <h2>Muscle loss</h2> Many factors can affect how much muscle you lose while in a calorie deficit. While it was once thought that the more fat you had, the <a href="https://pubmed.ncbi.nlm.nih.gov/10673906/">less muscle you lost</a> in a calorie deficit, this has since been disproved – with both <a href="https://pubmed.ncbi.nlm.nih.gov/3066619/">lean</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/17367567/">obese people</a> losing significant rates of muscle when dieting. <a href="https://pubmed.ncbi.nlm.nih.gov/29957829/">Ethnicity</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/32734691/">genetics</a> may, however, play a role – with studies showing black people tend to lose more muscle mass in a calorie deficit than white people do. Some research also suggests that genetic variants may make some people more susceptible to <a href="https://pubmed.ncbi.nlm.nih.gov/32734691/">certain dietary changes</a>, which may determine how much muscle mass they end up losing. Muscle loss will also happen regardless of whether you lose weight <a href="https://pubmed.ncbi.nlm.nih.gov/30925026/">gradually or quickly</a>. A better determinant of how much muscle you’ll lose depends on <a href="https://pubmed.ncbi.nlm.nih.gov/30925026/">how much weight you end up losing</a>. If a person loses 10% of their body weight, typically around 20% of this is fat-free mass (the proportion of body mass that isn’t fat – such as muscle). This can equate to several kilograms of muscle. Many people also think that what you eat while losing weight may determine how much muscle you lose, with it commonly believed that if you eat plenty of protein you’re less likely to lose muscle mass. This is <a href="https://pubmed.ncbi.nlm.nih.gov/19246357/">debatable</a>, with research showing people lose as much muscle on high-protein weight loss diets as people who followed other types of diets. Low-carb diets have also been claimed to promote more fat loss. But studies comparing <a href="https://pubmed.ncbi.nlm.nih.gov/22258266/">different types of diets</a> have found that low-fat high-carb diets seem to offer <a href="https://pubmed.ncbi.nlm.nih.gov/28193517/">the same, if not better, fat loss</a> than low-carb, high-fat diets – with no differences in muscle loss. <h2>Protein and exercise</h2> Given all that has been said, the only way to prevent muscle loss somewhat while losing weight is to combine exercise (particularly <a href="https://pubmed.ncbi.nlm.nih.gov/18356845/">resistance exercise</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/28507015/">endurance exercise</a>) with a diet higher in protein. This is because exercise stimulates muscle growth – but this process can only happen if you have an adequate supply of protein. It’s suggested adults normally aim to consume <a href="https://pubmed.ncbi.nlm.nih.gov/34371981/">0.8g of protein per kilogram of body weight</a> per day to maintain muscle mass. But given the extra demand exercise places on the muscles, a person will probably need to consume 1.2-1.5g of protein per kilogram of body weight to preserve muscle during weight loss. People who exercise a lot may need to increase that to more than <a href="https://pubmed.ncbi.nlm.nih.gov/28642676/">2g per kilogram of body weight</a> when losing weight. <a href="https://pubmed.ncbi.nlm.nih.gov/22221216/">Older people</a> may also need to consume more protein than average. Just be wary of consuming too much protein (more than 2.5g per kilogram of body weight) as eating more than your body uses could have an <a href="https://pubmed.ncbi.nlm.nih.gov/28507015/">adverse effect</a> on your metabolism by potentially making the body less able to draw upon glucose for energy. It may also put greater pressure on the kidneys and liver – which could lead to serious <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460905/#:%7E:text=High%20dietary%20protein%20intake%20can,a%20role%20in%20kidney%20health.">health issues</a>, such as liver and kidney damage. Even if you prevent muscle loss when losing weight, other metabolic changes still happen that promote weight regain – such as changes in your metabolic rate (the minimum amount of calories your body needs to survive) and <a href="https://pubmed.ncbi.nlm.nih.gov/21677272/">increases in appetite and hunger</a>. This is why, when trying to lose weight, the most important thing to consider is how sustainable your diet and lifestyle changes are. The easier these are to maintain, the better chances you have of keeping the weight off.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/209258/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/adam-collins-1179004">Adam Collins</a>, Principal Teaching Fellow, Nutrition, <a href="https://theconversation.com/institutions/university-of-surrey-1201">University of Surrey</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/weight-loss-why-you-dont-just-lose-fat-when-youre-on-a-diet-209258">original article</a>.

Body

This eating habit is key to losing weight

New research has found the time of day you eat is key to losing weight. The findings reveal that your best efforts to cut back may prove ineffective if you’re not timing your meals correctly. A study found that mice lost weight when they were given a reduced calorie diet and only ate during the day. Rodents who consumed the same diet but ate at night did not reap the same results. Lead author of the study, Dr Joseph Takahashi, said, “Translated into human behaviour, these studies suggest that dieting will only be effective if calories are consumed during the daytime when we are awake and active.” Dr Takahashi added, “They further suggest that eating at the wrong time at night will not lead to weight loss even when dieting.” Scientists from the University of Texas Southwestern Medical Center also believe the timing of meals is important as it also affects circadian rhythms, the body’s 24-hour clock. They have highlighted how the research may explain how dietary habits impact lifespan. The study observed this by testing the day/night cycles of mice under different feeding schedules. Two groups of mice were fed at the wrong time during their normal cycle. One group was given 30 per cent less calories and the other group had unlimited food, but both groups were more active at night. Various research has associated sleep problems with an increased risk of obesity. “'It has been known for decades that calorie restriction prolongs lifespan in animals, but these types of studies are very difficult to conduct because they required manual feeding of subjects over many years," Dr Takahashi said “This automated system, which can be scaled up for large and very long longevity studies, provides the means to address open questions about what mechanisms extend lifespan in mammals.” Image credit: Shutterstock The research was published in the journal Cell Metabolism.

Body

‘We lose ourselves’: carers talk about the lonely, stressful work of looking after loved ones

<a href="https://theconversation.com/profiles/fleur-sharafizad-1138251">Fleur Sharafizad</a>, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a>; <a href="https://theconversation.com/profiles/esme-franken-947855">Esme Franken</a>, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a>, and <a href="https://theconversation.com/profiles/uma-jogulu-1278812">Uma Jogulu</a>, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a> An informal personal carer is someone who looks after a family member, neighbour or friend in need of care due to disability, illness or age. In Australia, there are approximately 2.8 million informal personal carers, including 906,000 who are primary carers. Projections suggest the national demand for carers will <a href="https://www.carersaustralia.com.au/wp-content/uploads/2020/07/FINAL-Value-of-Informal-Care-22-May-2020_No-CIC.pdf">rise 23% by 2030</a>. Around one in ten Australians are informal carers: <a href="https://www.aihw.gov.au/reports/australias-welfare/informal-carers">most of these unpaid</a>. This group of people support one of society’s most foundational needs and our economy would struggle without them. Yet, little is understood about their experiences. <a href="https://bristoluniversitypressdigital.com/view/journals/ijcc/aop/article-10.1332-239788223X16789866214981/article-10.1332-239788223X16789866214981.xml">Our recent research</a> reveals how this group of carers lack necessary support for their own wellbeing. <h2>Our research</h2> We interviewed 36 informal personal primary carers living across Western Australia and Queensland. Respondents were aged between 34 and 69 years, and had all been the primary carer for a child, parent, partner, or in-law, for between two and 21 years. Data was collected in two waves: one in 2020 and the other in 2021. Respondents were recruited with the help of an Australian carers’ organisation. <h2>‘I’d rather it be someone else’s problem’</h2> Many of the carers we spoke to said they were not caring by choice, but by necessity. They said they feel both unseen and undervalued. A husband who had been caring for his wife who suffers from Alzheimer’s said: "I would rather work. I really don’t like being a carer. I’d rather it be someone else’s problem. Being a carer, you just get forgotten." Carers generally provide care around-the-clock, yet their compensations (such as <a href="https://www.servicesaustralia.gov.au/carer-payment">carer payments</a>) are far from equivalent to full-time pay. The carer payment, for example, equates to only <a href="https://www.carersaustralia.com.au/programs-projects/caring-costs-us/">28% of weekly ordinary time earnings</a> in Australia, and carers can expect to lose <a href="https://www.carersaustralia.com.au/carers-are-17700-worse-off-every-year-in-superannuation-payments/#:%7E:text=Caring%20Costs%20Us%3A%20The%20economic%20impact%20on%20lifetime,every%20year%20they%20are%20in%20that%20caring%20role.">approximately $17,700 in superannuation</a> every year they provide care. Few of <a href="https://www.carersaustralia.com.au/wp-content/uploads/2023/02/FINAL-Carers-Australia-2023-24-Jan-2023-Budget-Submission.pdf">Carers Australia’s pre-budget submission items</a> to benefit carers were adopted in the most recent federal budget. Instead, the budget contained items which may indirectly benefit carers through <a href="https://www.carersaustralia.com.au/wp-content/uploads/2023/05/2023-24-Budget-What-it-means-for-carers.pdf">increased support for the cared-for</a>. But these measures do not explicitly recognise and support carers’ wellbeing. Similarly, the recent draft of the <a href="https://www.pmc.gov.au/resources/draft-national-strategy-care-and-support-economy">National Strategy for the Care and Support Economy</a> recognises the contribution informal carers make to Australia’s economy but focuses on paid care and support. Our interviewees spoke about the personal costs of their work, and the stress and loneliness they experience. They shared feelings of being taken for granted as if their role was not work, let alone difficult work. One mum caring for her disabled son shared: "I just want people to see that, [a] carer doesn’t have any leave, paid leave, or recognition. People just think that’s your loved one, that’s your job. But I do want people to understand that I did not choose to be a carer as my career, but I will do it because it is important." This played into a feeling of people losing their sense of self, because caring work was so demanding and time consuming. A mother who had been caring for her daughter for 17 years after she had been involved in an accident said, "People don’t realise how much we put our life on hold to support the people that need that emotional and mental and physical and spiritual support. We put ourselves in the back shed while we’re supporting them, so we lose ourselves." <h2>A mental toll</h2> Many spoke of how they once had individual goals and ambitions, which they now considered unachievable. All of our interviewees had quit jobs and halted careers to take on personal care full-time. One mother caring for her ill child said: "I think if I had a crystal ball, I don’t know that I would perhaps have become a parent, I think I would have just stuck to my corporate life and had a cat and be done with it." The mental health toll experienced by carers in our study was clear throughout all interviews. A mother looking after her child with mental health challenges expressed: "Every carer has mental health impacts from being a carer. They won’t say it’s depression or anxiety, but it’s mental health because when the hierarchy of needs is not being met for you, you can’t provide them for somebody else." As one interviewee explained, the demanding nature of the work had left them exhausted and as though they “can’t do it”. Our interviewees spoke of “falling apart” under the strain of constantly caring for high-needs people in their households. One mother who cared for her children who were both on the autism spectrum recalled: "How many times, if I don’t go to the bathroom and have a shower to cool down myself, I could kill the kids and myself easily. That’s how bad. We are not ever in the category to get help." <h2>Feeling abandoned</h2> Because so much of their work happens in pre-existing relationships and behind closed doors, carers talked about not just feeling unseen but abandoned. A common theme across all interviews was how carers felt abandoned by institutions, health professionals and, in many cases, friends and family members. One husband who had cared for his wife for close to 20 years said: "The government doesn’t even care about the carers […] we’re not really getting anything and then they’re trying to take the crumbs off us." Carers do not have psychological, institutional or social support for themselves as individuals, separate from their role. But these support pillars are necessary so the entire responsibility of care does not fall solely on informal carers. <a href="https://www.carersaustralia.com.au/wp-content/uploads/2023/02/FINAL-Carers-Australia-2023-24-Jan-2023-Budget-Submission.pdf">Carer-inclusive activities</a> could be a good start. But policy should also be responsive to the unique and unmet needs of carers. These relate to the lack of personal and professional development, feelings of abandonment and social isolation. With an ageing population, a pandemic, and an emerging crisis over the quality of care for older Australians and people with disabilities, the role of informal carers has become increasingly important. The truth is that most of us will likely, at some point, undertake care work or be the person being cared for. Better formalised support for carers will ultimately improve the care for the most vulnerable among us and society as a whole. If this article has raised issues for you, or if you’re concerned about someone you know, call <a href="http://lifeline.org.au/">Lifeline</a> on 13 11 14. <a href="https://theconversation.com/profiles/fleur-sharafizad-1138251">Fleur Sharafizad</a>, Lecturer in Management, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a>; <a href="https://theconversation.com/profiles/esme-franken-947855">Esme Franken</a>, Lecturer in Management, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a>, and <a href="https://theconversation.com/profiles/uma-jogulu-1278812">Uma Jogulu</a>, Senior Lecturer, School of Business and Law, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/we-lose-ourselves-carers-talk-about-the-lonely-stressful-work-of-looking-after-loved-ones-206409">original article</a>.

Caring

Is it true the faster you lose weight the quicker it comes back? Here’s what we know about slow and fast weight loss

<a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> When people decide it’s time to lose weight, they’re usually keen to see quick results. Maybe they have an event coming up or want relief from health problems and discomfort. But expert guidelines typically recommend slower weight loss for the treatment of obesity. This tallies with a a widely held opinion that fast weight loss is more quickly regained. Slow weight loss is generally perceived as better for your health and more sustainable. Many programs offering “the fastest way to lose weight” are considered fad diets that severely restrict calories or eliminate some foods. But does slow and steady really win the weight-loss race? Or is fast weight loss just as effective and safe? <h2>What’s the difference between slow and fast weight loss?</h2> Governing bodies typically <a href="https://www.betterhealth.vic.gov.au/health/healthyliving/weight-loss-a-healthy-approach">recommend</a> a weight loss of 0.5 to 1 kilogram each week, which would be defined as slow weight loss. So <a href="https://medlineplus.gov/ency/patientinstructions/000885.htm#:%7E:text=Rapid%20weight%20loss%20diet%20is,a%20week%20over%20several%20weeks.">fast weight loss</a> – also termed “rapid weight loss” – is losing more than 1 kilo a week over several weeks. <h2>What does the research say about fast weight loss?</h2> There are several well-conducted studies examining differing approaches. One <a href="https://pubmed.ncbi.nlm.nih.gov/25459211/">study</a> of 200 people randomly assigned them to fast or slow weight loss – 12 weeks versus 36 weeks – aimed at a 15% reduction in weight. The fast weight loss group was put on a very low energy diet using meal replacements, including shakes, bars and soups, three times per day. The slow weight loss group was advised on the <a href="https://www.eatforhealth.gov.au/guidelines/australian-guide-healthy-eating">Australian Guide to Healthy Eating</a> with the goal to eat 500 calories less than they used for energy (creating a calorie deficit) each day. They also used one to two meal replacements daily. Some 50% of the slow weight loss group and 81% of the fast weight loss group achieved 12.5% or more weight loss during this time. After this initial phase, those who had lost 12.5% or more were then placed on a weight maintenance diet for approximately 2.75 years. By the three-year mark, 76% of those in the slow weight loss and the same percentage of those in the fast weight loss group had regained their lost weight. So, it didn’t matter if they had lost it slow or fast, they still regained the weight. However, another <a href="https://www.sciencedirect.com/science/article/pii/S2405844020308513#bib17">study</a> on 101 postmenopausal women found fast weight loss resulted in better outcomes than a slow weight loss group at the three-year mark. But there are other factors to consider, aside from weight loss, when it comes to the differing ways of losing weight – such as changes in body composition and bone mineral density. This is best highlighted by a large <a href="https://pubmed.ncbi.nlm.nih.gov/32576318/">meta-analysis</a>. These type of studies combine the results of all previous well-conducted studies on the topic. While this <a href="https://pubmed.ncbi.nlm.nih.gov/32576318/">analysis</a> found the magnitude of weight loss was similar for both approaches, slow weight loss resulted in better outcomes than fast weight loss with respect to metabolism or how many calories we burn at rest. There were no differences in the amount of fat-free mass or muscle mass lost between the slow and fast weight loss groups. But slow weight loss resulted in greater reductions in fat mass and therefore a better fat-to-muscle ratio. Slow weight loss also seems better for bone density, because rapid weight loss results in a <a href="https://www.sciencedirect.com/science/article/pii/S2405844020308513#bib17">twice as much bone loss</a> and puts a person at increased risk of brittle bones or osteoporosis. <h2>What about other diet approaches?</h2> Research shows it doesn’t matter what type of macronutrient diet you follow – moderate or high-protein diet, low or high-carbodyrate diet, low or high-fat diet. All diet approaches achieve similar <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa0804748">weight loss outcomes</a>. The same can be said for fashionable ways of cutting calories from the diet, such as intermittent fasting. <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2114833">Research</a> has shown such diets don’t result in any better weight loss results than any of its predecessors. This is because our body is extremely good at <a href="https://theconversation.com/whats-the-weight-set-point-and-why-does-it-make-it-so-hard-to-keep-weight-off-195724">protecting against weight loss</a>. <h2>When you want to lose weight consider …</h2> Your metabolism When you lose large amounts of weight, you resting metabolic rate – the energy you burn at rest – will lower. Keeping your resting metabolic rate high is essential for keeping the weight off. Unfortunately, once it slows down, your resting metabolic rate doesn’t recover to the level it was pre-dieting <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21538">even after you regain weight</a>. However, research has confirmed <a href="https://pubmed.ncbi.nlm.nih.gov/32576318/">slow weight loss</a> preserves your resting metabolic rate compared with rapid weight loss. As does a weight loss program <a href="https://www.sciencedirect.com/science/article/pii/S2161831323002867?via%3Dihub">that includes exercise</a> rather than one that focuses on diet alone. Side effects While restrictive diets can achieve rapid results, studies suggest they can come with adverse effects. This includes a <a href="https://pubmed.ncbi.nlm.nih.gov/16350561/">higher risk of gallstones</a> and deficiencies that can result in poor immune function, fatigue and a <a href="https://pubmed.ncbi.nlm.nih.gov/32613096/">decrease in bone density</a>. Such restrictive diets can make it challenging to meet your nutritional needs. Sustainability Many fast weight loss diets restrict or exclude foods required for long-term health. Carbohydrates are often banned, yet wholegrain carbohydrates are an essential source of nutrition, helping with weight loss and <a href="https://www.sciencedirect.com/science/article/pii/S0002822301001948">prevention of disease</a>. Including meal replacements as part of a restrictive diet is also not sustainable for long. <h2>The bottom line?</h2> Regardless of how you lose the weight, it’s very difficult to maintain losses. Our bodies work to keep our weight around a <a href="https://theconversation.com/whats-the-weight-set-point-and-why-does-it-make-it-so-hard-to-keep-weight-off-195724">set point</a> by adjusting our biological systems and imposing a series of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766925/">physiological changes</a> within the body to ensure we regain weight we lose. This stems from our hunter-gatherer ancestors, whose bodies developed this survival response to adapt to periods of deprivation when food was scarce. Successful long-term weight loss comes down to: 1. following evidence-based programs based on what we know about the science of obesity 2. losing weight under the supervision of qualified health-care professionals 3. making gradual changes to your lifestyle – diet, exercise and sleep – to ensure you form health habits that last a lifetime. At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register for free <a href="https://redcap.sydney.edu.au/surveys/?s=RKTXPPPHKY">here</a> to express your interest.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/198301/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, Charles Perkins Centre Research Program Leader, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/is-it-true-the-faster-you-lose-weight-the-quicker-it-comes-back-heres-what-we-know-about-slow-and-fast-weight-loss-198301">original article</a>.

Body

Backlash to new kids clothing line sees Target lose billions

Target has lost billions in market valuation as its Pride-themed kids line continues to face backlash. Target shares were trading at $160.96 (A$246.18) a share, which means their market valuation was roughly around $74.3 billion (A$113 billion) The Minneapolis-based retailer’s stock value dropped drastically following the calls to boycott their “PRIDE” collection, at just $138.93 (A$212) a share as of Friday, which is a 14 per cent drop in value to around $64.2 billion (A$98 billion) , according to The New York Times. This roughly translates to a $10.1 billion (A$15 billion) loss in valuation. The plummet is the retailer's lowest stock price in nearly three years, and the last time any company’s stock plummeted this intensely was in 2022 after the stocks equalised during the pandemic. Target has since moved its Pride section away from the front of the store in some Southern states, following displays being knocked over by protesters, who also confronted the workers. They also said they would remove items from the collection but didn’t specify which ones. Some of the clothes receiving backlash were the rainbow-themed children’s clothing, and a “tuck-friendly” swimsuit for trans women, who have not yet had their gender-affirming surgeries, to conceal their genitalia. Target CEO Brian Cornell has defended the LBGTQ-friendly clothing line and has said that selling them was “the right thing for society.” Images: Getty

Money & Banking

Russell Crowe loses best friend in tragic accident

Gladiator star Russell Crowe has announced the tragic passing of his puppy, Louis. The actor broke the news on Twitter, explaining that his “tiny, cheeky, [and] brave” boy had been hit by a truck, and despite the best efforts of vets, had lost his life. "This is Louis the Papillion. 16 months old. Tiny, cheeky, brave. He won my heart," he wrote alongside an image of the pup. “Unfortunately today, on the second anniversary of my fathers passing, Louis was hit by a truck. "We tried to get him to the vet, but he died in my arms while I was telling him how much we loved him." Condolences poured in through Russell’s comment section, with many noting that their hearts were breaking for his family in this difficult time. “We are heartbroken for you and so deeply sorry for your loss. Louis will be in your heart forever. Sending all of our love, comfort, and strength,” wrote animal rights group PETA. “So sorry to hear this Russel. My heart goes out to you,” said fellow actor Vincent D’Onofrio. “I am so sorry! What a beautiful face and those eyes. I like to think our pets wait for us to join them one day, loyal as ever,” self-proclaimed ‘dog devotee’ Alicia Rancilio shared. And as Today’s Michelle Stephenson summed it up, “Well this is just so heartbreaking”. <blockquote class="twitter-tweet"> This is Louis the Papillion. 16 months old. Tiny, cheeky, brave. He won my heart. Unfortunately today, on the second anniversary of my fathers passing, Louis was hit by a truck. We tried to get him to the vet, but he died in my arms while I was telling him how much we loved him. <a href="https://t.co/zIwzUz8Ljx">pic.twitter.com/zIwzUz8Ljx</a> — Russell Crowe (@russellcrowe) <a href="https://twitter.com/russellcrowe/status/1641302352161562624?ref_src=twsrc%5Etfw">March 30, 2023</a></blockquote> Russell’s loss came as a sort of double tragedy, hitting him just two years after his father had passed away at the age of 85. The 58-year-old made that painful news public through Twitter as well, writing at the time that “I arrived back in the bush last night. Today, although the sun is shining and the torrential rain has abated, this date will forever be tinged with sadness. “My dear old man, my beautiful dad, the most gentle of men, has passed away.” Despite the grief sure to be weighing heavily on his shoulders, Russell and his family will always have their happy memories with Louis - and Russell’s dad - to hold on to. Like the dress up day Russell and Louis shared in December 2021, where Russell overcame his distaste for “dressing dogs up” to match his little friend. After sharing that it wasn’t his thing - as well as a photo of the two with their heads together and a smile on Russell’s face - he went on to explain in a tweet that a friend had bought a Ralph Lauren polo shirt for “little Louis … so he can match with dad. “I think the other dogs on the farm are going to get jealous. Pretty funny.” <blockquote class="twitter-tweet"> I’m not at all a fan of dressing dogs up, but, a friend bought little Louis a ⁦<a href="https://twitter.com/RalphLauren?ref_src=twsrc%5Etfw">@RalphLauren</a>⁩ polo so he can match with dad. I think the other dogs on the farm are going to get jealous. Pretty funny. <a href="https://t.co/odmCZwfvA8">pic.twitter.com/odmCZwfvA8</a> — Russell Crowe (@russellcrowe) <a href="https://twitter.com/russellcrowe/status/1605404835599159296?ref_src=twsrc%5Etfw">December 21, 2022</a></blockquote> Images: Twitter

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