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We tend to underestimate our future expenses – here’s one way to prevent that

<div class="theconversation-article-body"><a href="https://theconversation.com/profiles/ray-charles-chuck-howard-1361224">Ray Charles "Chuck" Howard</a>, <a href="https://theconversation.com/institutions/texas-aandm-university-1672">Texas A&M University</a>; <a href="https://theconversation.com/profiles/abigail-sussman-227057">Abigail Sussman</a>, <a href="https://theconversation.com/institutions/university-of-chicago-952">University of Chicago</a>; <a href="https://theconversation.com/profiles/david-j-hardisty-753777">David J. Hardisty</a>, <a href="https://theconversation.com/institutions/university-of-british-columbia-946">University of British Columbia</a>, and <a href="https://theconversation.com/profiles/marcel-lukas-1236384">Marcel Lukas</a>, <a href="https://theconversation.com/institutions/university-of-st-andrews-1280">University of St Andrews</a> <h2>The big idea</h2> When asked to estimate how much money they would spend in the future, people underpredicted the total amount by more than C$400 per month. However, when prompted to think about unexpected spending in addition to typical expenses, people made much more accurate predictions. These are the main findings of a series of <a href="https://doi.org/10.1177%2F00222437211068025">studies and experiments that we conducted</a> and which have just been published in the <a href="https://journals.sagepub.com/home/mrj">Journal of Marketing Research</a>. In our first study, we began by asking 187 members of a Canadian credit union to predict their weekly spending for the next five weeks. Then, at the end of each week, we asked them how much they actually spent. For the first four weeks, people underpredicted their weekly spending by about $100 per week or $400 for the month. In the study’s fifth and final week, we ran an experiment to see if we could improve people’s prediction accuracy. Specifically, we randomly assigned participants to one of two groups. In group one, participants estimated their spending for the next week just as they had done in previous weeks. These folks once again significantly underpredicted their spending. In group two, participants were asked to think of three reasons why their spending for the next week might be different than usual before making their estimate. This led them to make higher and much more accurate predictions – coming within just $7 of what they actually spent. Importantly, participants in each group spent roughly the same amount of money that week, on average. The only difference between the two groups was whether they accurately predicted that amount. <iframe id="WlDv3" class="tc-infographic-datawrapper" style="border: 0;" src="https://datawrapper.dwcdn.net/WlDv3/3/" width="100%" height="400px" frameborder="0" scrolling="no"></iframe> Next, we conducted nine experiments to better understand why people underpredict their spending and whether being prompted to think of unusual expenses helps improve accuracy. In all, over 5,800 people participated in these experiments, including a representative sample of U.S. residents. These experiments revealed two important insights. First, people primarily base their spending predictions on typical expenses like groceries, gasoline and rent. They usually fail to account for irregular – though still common – expenses like car repairs, last-minute concert tickets or one-off health care bills. This is what leads to underprediction. Second, prompting people to think of irregular expenses in addition to typical expenses helps them to make more accurate spending predictions. In our studies, people did not factor in atypical expenses unless we asked them to do so. <h2>Why it matters</h2> Helping people improve the accuracy of their spending predictions could help them improve their financial well-being. Underpredicting expenses can be costly. For example, 12 million Americans <a href="https://www.pewtrusts.org/en/research-and-analysis/reports/2012/07/19/who-borrows-where-they-borrow-and-why">borrow a total of more than $7 billion</a> in payday loans each year because they can’t meet their monthly expenses. These loans typically have extremely high interest rates – <a href="https://www.pewtrusts.org/en/research-and-analysis/data-visualizations/2022/how-well-does-your-state-protect-payday-loan-borrowers">more than 250% in some states</a>. Payday loans also come due in full so quickly that around three in four borrowers <a href="https://www.pewtrusts.org/en/research-and-analysis/reports/2012/07/19/who-borrows-where-they-borrow-and-why">end up borrowing again</a> to pay off the original loan. If consumers could better anticipate how much money they will spend in the future, it might help motivate them to spend less and save more in the present. In fact, one of our studies shows that our suggested prediction strategy <a href="https://doi.org/10.1177/0022243721106802">not only boosted spending estimates</a>, it also increased intentions to save. <h2>What’s next</h2> Members of our research team are currently investigating if, when and why underpredicting one’s expenses may be beneficial. For example, if a person sets an optimistically low budget and actively tracks their spending against it, does that help them reduce their spending? We are also investigating whether people who work in the gig economy show a corresponding tendency to mispredict their future income.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/189100/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/ray-charles-chuck-howard-1361224">Ray Charles "Chuck" Howard</a>, Assistant Professor of Marketing, <a href="https://theconversation.com/institutions/texas-aandm-university-1672">Texas A&M University</a>; <a href="https://theconversation.com/profiles/abigail-sussman-227057">Abigail Sussman</a>, Professor of Marketing, <a href="https://theconversation.com/institutions/university-of-chicago-952">University of Chicago</a>; <a href="https://theconversation.com/profiles/david-j-hardisty-753777">David J. Hardisty</a>, Assistant Professor of Marketing & Behavioral Science, <a href="https://theconversation.com/institutions/university-of-british-columbia-946">University of British Columbia</a>, and <a href="https://theconversation.com/profiles/marcel-lukas-1236384">Marcel Lukas</a>, Lecturer in Banking and Finance, <a href="https://theconversation.com/institutions/university-of-st-andrews-1280">University of St Andrews</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/we-tend-to-underestimate-our-future-expenses-heres-one-way-to-prevent-that-189100">original article</a>. </div>

Money & Banking

Walking can prevent low back pain, a new study shows

<a href="https://theconversation.com/profiles/tash-pocovi-1293184">Tash Pocovi</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/christine-lin-346821">Christine Lin</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/mark-hancock-1463059">Mark Hancock</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/petra-graham-892602">Petra Graham</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>, and <a href="https://theconversation.com/profiles/simon-french-713564">Simon French</a>, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a> Do you suffer from low back pain that recurs regularly? If you do, you’re not alone. Roughly <a href="https://pubmed.ncbi.nlm.nih.gov/31208917/">70% of people</a> who recover from an episode of low back pain will experience a new episode in the following year. The recurrent nature of low back pain is a major contributor to the <a href="https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(23)00098-X/fulltext">enormous burden</a> low back pain places on individuals and the health-care system. In our new study, published today in <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00755-4/fulltext">The Lancet</a>, we found that a program combining walking and education can effectively reduce the recurrence of low back pain. <h2>The WalkBack trial</h2> We randomly assigned 701 adults who had recently recovered from an episode of low back pain to receive an individualised walking program and education (intervention), or to a no treatment group (control). Participants in the intervention group were guided by physiotherapists across six sessions, over a six-month period. In the first, third and fifth sessions, the physiotherapist helped each participant to develop a personalised and progressive walking program that was realistic and tailored to their specific needs and preferences. The remaining sessions were short check-ins (typically less than 15 minutes) to monitor progress and troubleshoot any potential barriers to engagement with the walking program. Due to the COVID pandemic, most participants received the entire intervention via telehealth, using video consultations and phone calls. The program was designed to be manageable, with a target of five walks per week of roughly 30 minutes daily by the end of the six-month program. Participants were also encouraged to continue walking independently after the program. Importantly, the walking program was combined with education provided by the physiotherapists during the six sessions. This education aimed to give people a better understanding of pain, reduce fear associated with exercise and movement, and give people the confidence to self-manage any minor recurrences if they occurred. People in the control group received no preventative treatment or education. This reflects what <a href="https://www.sciencedirect.com/science/article/abs/pii/S2468781222001308?via%3Dihub">typically occurs</a> after people recover from an episode of low back pain and are discharged from care. <h2>What the results showed</h2> We monitored the participants monthly from the time they were enrolled in the study, for up to three years, to collect information about any new recurrences of low back pain they may have experienced. We also asked participants to report on any costs related to their back pain, including time off work and the use of health-care services. The intervention reduced the risk of a recurrence of low back pain that limited daily activity by 28%, while the recurrence of low back pain leading participants to seek care from a health professional decreased by 43%. Participants who received the intervention had a longer average period before they had a recurrence, with a median of 208 days pain-free, compared to 112 days in the control group. Overall, we also found this intervention to be cost-effective. The biggest savings came from less work absenteeism and less health service use (such as physiotherapy and massage) among the intervention group. This trial, like all studies, had some limitations to consider. Although we tried to recruit a wide sample, we found that most participants were female, aged between 43 and 66, and were generally well educated. This may limit the extent to which we can generalise our findings. Also, in this trial, we used physiotherapists who were up-skilled in health coaching. So we don’t know whether the intervention would achieve the same impact if it were to be delivered by other clinicians. <h2>Walking has multiple benefits</h2> We’ve all heard the saying that “prevention is better than a cure” – and it’s true. But this approach has been largely neglected when it comes to low back pain. Almost all <a href="https://www.sciencedirect.com/science/article/pii/S0140673618304896?via%3Dihub">previous studies</a> have focused on treating episodes of pain, not preventing future back pain. A limited number of <a href="https://pubmed.ncbi.nlm.nih.gov/26752509/">small studies</a> have shown that exercise and education can help prevent low back pain. However, most of these studies focused on exercises that are not accessible to everyone due to factors such as high cost, complexity, and the need for supervision from health-care or fitness professionals. On the other hand, walking is a free, accessible way to exercise, including for people in rural and remote areas with limited access to health care. Walking also delivers many other <a href="https://www.vichealth.vic.gov.au/sites/default/files/VH_Benefits-of-Walking-Summary2020.pdf">health benefits</a>, including better heart health, improved mood and sleep quality, and reduced risk of several chronic diseases. While walking is not everyone’s favourite form of exercise, the intervention was well-received by most people in our study. Participants <a href="https://pubmed.ncbi.nlm.nih.gov/37271689/">reported</a> that the additional general health benefits contributed to their ongoing motivation to continue the walking program independently. <h2>Why is walking helpful for low back pain?</h2> We don’t know exactly why walking is effective for preventing back pain, but <a href="https://www.e-jer.org/journal/view.php?number=2013600295">possible reasons</a> could include the combination of gentle movements, loading and strengthening of the spinal structures and muscles. It also could be related to relaxation and stress relief, and the release of “feel-good” endorphins, which <a href="https://my.clevelandclinic.org/health/body/23040-endorphins">block pain signals</a> between your body and brain – essentially turning down the dial on pain. It’s possible that other accessible and low-cost forms of exercise, such as swimming, may also be effective in preventing back pain, but surprisingly, <a href="https://pubmed.ncbi.nlm.nih.gov/34783263/">no studies</a> have investigated this. Preventing low back pain is not easy. But these findings give us hope that we are getting closer to a solution, one step at a time.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/231682/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/tash-pocovi-1293184">Tash Pocovi</a>, Postdoctoral research fellow, Department of Health Sciences, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/christine-lin-346821">Christine Lin</a>, Professor, Institute for Musculoskeletal Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/mark-hancock-1463059">Mark Hancock</a>, Professor of Physiotherapy, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>; <a href="https://theconversation.com/profiles/petra-graham-892602">Petra Graham</a>, Associate Professor, School of Mathematical and Physical Sciences, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a>, and <a href="https://theconversation.com/profiles/simon-french-713564">Simon French</a>, Professor of Musculoskeletal Disorders, <a href="https://theconversation.com/institutions/macquarie-university-1174">Macquarie University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/walking-can-prevent-low-back-pain-a-new-study-shows-231682">original article</a>.

Body

Independent you: preventing, and recovering from, elder abuse

From implementing safeguards to stop it from beginning to taking back control if it does, there is a lot of power in your hands to avoid elder abuse. Previously, we explored the warning signs of elder abuse and how <a href="https://www.oversixty.com.au/finance/retirement-income/are-you-a-victim-of-elder-abuse-without-even-realising-it">it is possible to be a victim without even realising it</a>. And with more wealth owned by people over 60 now than ever before, the potential for abuse only continues to grow. So, how can you prevent elder abuse happening to you? And if you are already experiencing it, what can you do to regain control over your finances, independence and wellbeing? Prevention better than cure The best way to avoid the impacts of elder abuse is to protect yourself against it beginning in the first place. Awareness is the first step, so having <a href="https://www.oversixty.com.au/finance/retirement-income/are-you-a-victim-of-elder-abuse-without-even-realising-it">read this article and knowing the warning signs</a>, you’re already ahead of the game! Other preventative actions include: <ul> <li>Maintaining contact: social interactions are important not just for warding off loneliness but providing access to other points of view and avenues for support. </li> <li>External advisers: engage your own advisers – don’t simply employ who someone tells you to. They should be an impartial, qualified set of eyes to monitor things for you and point out anything that doesn’t seem right. This includes a financial advisor, lawyer, accountant, doctor and so on. A support person attending appointments with you may give you extra assurance.</li> <li>Power of attorney/guardianship: nominate multiple people, so that no one individual has all the say. It can be useful to include someone who is not a relative for impartiality, such as a trusted friend or your lawyer. </li> <li>Superannuation beneficiaries: super is separate from your will, but beneficiary nominations can only be spouse, child, dependent or interdependent otherwise it will go to you Will. In your Will you can direct to other people or charities. Some beneficiaries lapse, so will need to be renewed.</li> <li>Wills: review your will to ensure it reflects YOUR wishes, not someone else’s. People can jostle over not only their own inheritance but may try to influence you to leave others out. </li> <li>Documenting everything: keep a written record, especially where money is concerned – such as acting as Bank of Mum and Dad for adult kids to purchase property. Outline how much is given, what if any interest/repayments are expected and when, and what happens if their relationship subsequently breaks down.</li> <li>Encouraging independence: people who have come to expect handouts can become abusive if those handouts stop or requests for more are denied. Support and encourage others, especially your kids, to be financially independent and self-sufficient.</li> </ul> Taking back control Sadly, prevention is no longer an option for an <a href="https://www.aihw.gov.au/family-domestic-and-sexual-violence/population-groups/older-people?xd_co_f=YjAzZDU4YTUtYzA5YS00YTNkLWJkNDQtNjdiZTM5ZmY5ZjQx#abuse">estimated 598,000 Australians</a> already experiencing elder abuse. However, it is still possible to break the cycle. Don’t be embarrassed or stick your head in the sand hoping things will improve. You have done nothing wrong. You are entitled to enjoy your retirement years. To take back control over your affairs, your wellbeing and your independence: <ul> <li>Ensure your physical safety first and foremost.</li> <li>Seek medical attention for your physical and mental health (the latter is crucial for making good decisions around the other points on this list).</li> <li>Get support from another relative, close friend, neighbour, or other trusted person. Don’t be alone.</li> <li>Secure a roof over your head. Having a stable place to live gives you the security and focus to tackle other concerns.</li> <li>Freeze access to your money – bank accounts, credit cards etc. This will stop (further) unauthorised withdrawals or purchases being charged to you.</li> <li>Seek professional advice. Your financial adviser, tax accountant and lawyer will be able to guide you through protecting your home, money, guardianship and estate planning matters.</li> <li>Make informed changes. Don’t do anything rashly – make necessary changes once you have sought independent advice and considered your options. This may involve making changes to your power of attorney, will, superannuation, bank accounts, even your phone number in extreme cases.</li> <li>Consider counselling. Your abuser may not realise the severity of their actions. An independent counsellor may be able to help them see this and change their ways, and ultimately salvage your relationship.</li> </ul> If you or someone you know is experiencing elder abuse, seek help straight away. Speak to a trusted relative or friend. Seek independent legal and financial advice about your affairs. Or call the government’s free elder abuse line on 1800 353 374. And if your life is in danger, call triple zero (000) immediately. Helen Baker is a licensed Australian financial adviser and author of On Your Own Two Feet: The Essential Guide to Financial Independence for all Women. Helen is among the 1% of financial planners who hold a master’s degree in the field. Proceeds from book sales are donated to charities supporting disadvantaged women and children. Find out more at <a href="http://www.onyourowntwofeet.com.au/">www.onyourowntwofeet.com.au</a> Disclaimer: The information in this article is of a general nature only and does not constitute personal financial or product advice. Any opinions or views expressed are those of the authors and do not represent those of people, institutions or organisations the owner may be associated with in a professional or personal capacity unless explicitly stated. Helen Baker is an authorised representative of BPW Partners Pty Ltd AFSL 548754. Image credits: Getty Images

Caring

Kate Middleton is having ‘preventive chemotherapy’ for cancer. What does this mean?

<a href="https://theconversation.com/profiles/ian-olver-1047">Ian Olver</a>, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a> Catherine, Princess of Wales, is undergoing treatment for cancer. In a video thanking followers for their messages of support after her major abdominal surgery, the Princess of Wales explained, “tests after the operation found cancer had been present.” “My medical team therefore advised that I should undergo a course of preventative chemotherapy and I am now in the early stages of that treatment,” she said in the two-minute video. No further details have been released about the Princess of Wales’ treatment. But many have been asking what preventive chemotherapy is and how effective it can be. Here’s what we know about this type of treatment. <h2>It’s not the same as preventing cancer</h2> To <a href="https://www.cancer.org.au/about-us/how-we-help/prevention">prevent cancer developing</a>, lifestyle changes such as diet, exercise and sun protection are <a href="https://www.cancer.org.au/about-us/how-we-help/prevention">recommended</a>. Tamoxifen, a hormone therapy drug can be used to reduce the risk of cancer for some patients at <a href="https://www.mayoclinic.org/diseases-conditions/breast-cancer/in-depth/breast-cancer/art-20045353">high risk of breast cancer</a>. Aspirin <a href="https://www.cancer.gov/about-cancer/causes-prevention/research/aspirin-cancer-risk">can also be used</a> for those at high risk of bowel and other cancers. <h2>How can chemotherapy be used as preventive therapy?</h2> In terms of treating cancer, prevention refers to giving chemotherapy after the cancer has been removed, to prevent the cancer from returning. If a cancer is localised (limited to a certain part of the body) with no evidence on scans of it spreading to distant sites, local treatments such as surgery or radiotherapy can remove all of the cancer. If, however, cancer is first detected after it has spread to distant parts of the body at diagnosis, clinicians use treatments such as chemotherapy (anti-cancer drugs), hormones or immunotherapy, which circulate <a href="https://www.healthline.com/health/cancer/metastatic-cancer">around the body</a> . The other use for chemotherapy is to add it before or after surgery or radiotherapy, to prevent the primary cancer <a href="https://www.verywellhealth.com/adjuvant-therapy-5198903">coming back</a>. The surgery may have cured the cancer. However, in some cases, undetectable microscopic cells may have spread into the bloodstream to distant sites. This will result in the cancer returning, months or years later. With some cancers, treatment with chemotherapy, given before or after the local surgery or radiotherapy, can kill those cells and prevent the cancer coming back. If we can’t see these cells, how do we know that giving additional chemotherapy to prevent recurrence is effective? We’ve learnt this from clinical trials. Researchers have compared patients who had surgery only with those whose surgery was followed by additional (or often called adjuvant) chemotherapy. The additional therapy resulted in patients not relapsing and surviving longer. <h2>How effective is preventive therapy?</h2> The effectiveness of preventive therapy depends on the type of cancer and the type of chemotherapy. Let’s consider the common example of bowel cancer, which is at high risk of returning after surgery because of its size or spread to local lymph glands. The <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564362/">first chemotherapy tested</a> improved survival by 15%. With more intense chemotherapy, the chance of surviving six years is approaching 80%. Preventive chemotherapy is usually given for three to six months. <h2>How does chemotherapy work?</h2> Many of the chemotherapy drugs stop cancer cells dividing by disrupting the DNA (genetic material) in the centre of the cells. To improve efficacy, drugs which work at different sites in the cell are given in combinations. Chemotherapy is not selective for cancer cells. It kills any dividing cells. But cancers consist of a higher proportion of dividing cells than the normal body cells. A <a href="https://www.canceraustralia.gov.au/cancer-types/breast-cancer/treatment/chemotherapy/how-does-chemotherapy-work#:%7E:text=Chemotherapy%20works%20by%20killing%20cells%20that%20are%20rapidly,cells%20can%20repair%20the%20damage%20and%20can%20recover.">greater proportion of the cancer is killed</a> with each course of chemotherapy. Normal cells can recover between courses, which are usually given three to four weeks apart. <h2>What are the side effects?</h2> The side effects of chemotherapy are usually reversible and are seen in parts of the body where there is normally a high turnover of cells. The production of blood cells, for example, is temporarily disrupted. When your white blood cell count is low, there is an increased risk of infection. Cell death in the lining of the gut leads to mouth ulcers, nausea and vomiting and bowel disturbance. Certain drugs sometimes given during chemotherapy can attack other organs, such as causing numbness in the hands and feet. There are also generalised symptoms such as <a href="https://www.cancervic.org.au/cancer-information/treatments/treatments-types/chemotherapy/side_effects_of_chemotherapy.html">fatigue</a>. Given that preventive chemotherapy given after surgery starts when there is no evidence of any cancer remaining after local surgery, patients can usually resume normal activities within weeks of completing the courses of chemotherapy.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/226461/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/ian-olver-1047">Ian Olver</a>, Adjunct Professsor, School of Psychology, Faculty of Health and Medical Sciences, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/kate-middleton-is-having-preventive-chemotherapy-for-cancer-what-does-this-mean-226461">original article</a>.

Body

Taking more than 5 pills a day? ‘Deprescribing’ can prevent harm – especially for older people

<a href="https://theconversation.com/profiles/emily-reeve-1461339">Emily Reeve</a>, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a>; <a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L Johnson</a>, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a>; <a href="https://theconversation.com/profiles/janet-sluggett-146318">Janet Sluggett</a>, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a>, and <a href="https://theconversation.com/profiles/kate-ohara-1462183">Kate O'Hara</a>, <a href="https://theconversation.com/institutions/university-of-newcastle-1060">University of Newcastle</a> People are living longer and with more <a href="https://www.aihw.gov.au/reports/older-people/older-australia-at-a-glance/contents/health-functioning/health-disability-status">chronic health conditions</a> – including heart disease, diabetes, arthritis and dementia – than ever before. As societies continue to grow older, one pressing concern is the use of multiple medications, a phenomenon known as <a href="https://www.who.int/docs/default-source/patient-safety/who-uhc-sds-2019-11-eng.pdf">polypharmacy</a>. About <a href="https://onlinelibrary.wiley.com/doi/full/10.5694/mja2.50244">1 million older Australians</a> experience polypharmacy and this group is increasing. They may wake up in the morning and pop a pill for their heart, then another one or two to control blood pressure, a couple more if they have diabetes, a vitamin pill and maybe one for joint pain. Polypharmacy is usually <a href="https://www.safetyandquality.gov.au/sites/default/files/2021-04/fourth_atlas_2021_-_6.1_polypharmacy_75_years_and_over.pdf">defined</a> as taking five or more different medications daily. In aged care homes, <a href="https://doi.org/10.1016/j.archger.2022.104849">90% of residents</a> take at least five regular medications every single day. That can put their health at risk with increased costs for them and the health system. <h2>Adding up over time</h2> As people age, the effects of medications can change. Some medications, which were once beneficial, might start to do more harm than good or might not be needed anymore. About <a href="https://www.psa.org.au/wp-content/uploads/2020/02/Medicine-Safety-Aged-Care-WEB-RES1.pdf">half of older Australians</a> are taking a medication where the likely harms outweigh the potential benefits. While polypharmacy is sometimes necessary and helpful in managing multiple health conditions, it can lead to unintended consequences. <a href="https://www.nps.org.au/living-with-multiple-medicines/costs">Prescription costs</a> can quickly add up. Taking multiple medications can be difficult to manage particularly when there are specific instructions to crush them or take them with food, or when extra monitoring is needed. There is also a risk of <a href="https://www.nps.org.au/consumers/understanding-drug-interactions">drug interactions</a>. Medications bought “over the counter” without a prescription, such as vitamins, herbal medications or pain relievers, can also cause <a href="https://onlinelibrary.wiley.com/doi/abs/10.5694/mja11.10698">problems</a>. Some people might take an over-the-counter medication each day due to previous advice, but they might not need it anymore. Just like prescription medications, over-the-counter medications add to the overall burden and cost of polypharmacy as well as drug interactions and side effects. Unfortunately, the more medications you take, the more likely you are to have <a href="https://www.nps.org.au/consumers/managing-your-medicines#risks-of-taking-multiple-medicines">problems with your medications</a>, a reduced quality of life and increased risk of falls, hospitalisation and death. Each year, <a href="https://www.psa.org.au/wp-content/uploads/2019/01/PSA-Medicine-Safety-Report.pdf">250,000 Australians</a> are admitted to hospital due to medication-related harms, many of which are preventable. For example, use of multiple medications like sleeping pills, strong pain relievers and some blood pressure medications can cause drowsiness and dizziness, potentially resulting in a <a href="https://betterhealthwhileaging.net/preventing-falls-10-types-of-medications-to-review/">fall</a> and broken bones. <h2>Prescribing and deprescribing are both important</h2> Ensuring safe and effective use of medications involves both prescribing, and <a href="https://www.racgp.org.au/clinical-resources/clinical-guidelines/key-racgp-guidelines/view-all-racgp-guidelines/silver-book/part-a/deprescribing">deprescribing</a> them. <a href="https://www.australiandeprescribingnetwork.com.au/474-2/">Deprescribing</a> is a process of stopping (or reducing the dose of) medications that are no longer required, or for which the risk of harm outweighs the benefits for the person taking them. The process involves reviewing all the medications a person takes with a health-care professional to identify medications that should be stopped. Think of deprescribing as spring cleaning your medicine cabinet. Just like how you tidy up your house and get rid of objects that are causing clutter without being useful, deprescribing tidies up your medication list to keep only the ones truly required. <h2>But care is needed</h2> The process of deprescribing requires close monitoring and, for many medications, slow reductions in dose (tapering). This helps the body adjust gradually and can prevent sudden, unpleasant changes. Deprescribing is often done on a trial basis and medication can be restarted if symptoms come back. Alternatively, a safer medication, or non-drug treatment may be started in its place. Studies show deprescribing is a safe process when managed by a health-care professional, both for people living at <a href="https://link.springer.com/article/10.1007/s11606-020-06089-2">home</a> and those in <a href="https://doi.org/10.1016/j.jamda.2018.10.026">residential aged care</a>. You should always talk with your care team before stopping any medications. Deprescribing needs to be a team effort involving the person, their health-care team and possibly family or other carers. Shared decision-making throughout the process empowers the person taking medications to have a say in their health care. The team can work together to clarify treatment goals and decide which medications are still serving the person well and which can be safely discontinued. If you or a loved one take multiple medications you might be eligible for a free visit from a pharmacist (<a href="https://www.nps.org.au/assets/NPS/pdf/NPSMW2390_Anticholinergics_HMR_Factsheet.pdf">a Home Medicines Review</a>) to help you get the best out of your medications. <h2>What’s next?</h2> Health care has traditionally focused on prescribing medications, with little focus on when to stop them. Deprescribing is not happening as often as it should. <a href="https://www.australiandeprescribingnetwork.com.au/">Researchers</a> are working hard to develop tools, resources and service models to support deprescribing in the community. Health-care professionals may think older adults are not open to deprescribing, but about <a href="https://academic.oup.com/biomedgerontology/article/77/5/1020/6352400">eight out of ten people</a> are willing to stop one or more of their medications. That said, of course some people may have concerns. If you have been taking a medication for a long time, you might wonder why you should stop or whether your health could get worse if you do. These are important questions to ask a doctor or pharmacist. We need more <a href="https://shpa.org.au/news-advocacy/MedsAware">public awareness</a> about polypharmacy and deprescribing to turn the tide of increasing medication use and related harms. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/211424/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/emily-reeve-1461339">Emily Reeve</a>, Senior Research Fellow in the Centre for Medicine Use and Safety , <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a>; <a href="https://theconversation.com/profiles/jacinta-l-johnson-1441348">Jacinta L Johnson</a>, Senior Lecturer in Pharmacy Practice, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a>; <a href="https://theconversation.com/profiles/janet-sluggett-146318">Janet Sluggett</a>, Enterprise Fellow, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a>, and <a href="https://theconversation.com/profiles/kate-ohara-1462183">Kate O'Hara</a>, PhD student, Clinical Pharmacology and Toxicology, <a href="https://theconversation.com/institutions/university-of-newcastle-1060">University of Newcastle</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/taking-more-than-5-pills-a-day-deprescribing-can-prevent-harm-especially-for-older-people-211424">original article</a>.

Body

Daily aspirin doesn’t prevent strokes in older, healthy people after all

<a href="https://theconversation.com/profiles/nial-wheate-96839">Nial Wheate</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/tina-hinton-329706">Tina Hinton</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> The daily use of <a href="https://www.nps.org.au/australian-prescriber/articles/drugs-in-secondary-stroke-prevention">low dose aspirin</a> has been a mainstay of preventing strokes for decades. While there has always been a risk of bleeding associated with aspirin use, the benefits were thought to outweigh the risk. Now <a href="https://dx.doi.org/10.1001/jamanetworkopen.2023.25803">new research</a> led by Monash University has shown daily, low-dose aspirin doesn’t prevent strokes in relatively healthy people aged over 70. And it increases their risk of bleeding on the brain after falls or other injuries. But if you’re taking aspirin, it doesn’t mean you should abruptly stop. It may still have a role to play in treating people at high risk of stroke. Or, after talking to your doctor, there might be better options available. <h2>Why has aspirin been used to prevent strokes?</h2> Aspirin is an anti-platelet medicine, which is commonly known as a blood-thinner. <a href="https://www.lifeblood.com.au/blood/learn-about-blood/platelets">Platelets</a> are the component of blood primarily responsible for its clotting action. They are what stop you from continuously bleeding any time you have a cut or scrape on your skin. A <a href="https://strokefoundation.org.au/about-stroke/learn/what-is-a-stroke">stroke</a> is when oxygen can’t get into the brain because of a burst or blocked blood vessel. A blockage can occur when platelets in the bloodstream form a clot and it gets stuck in the artery. Because aspirin acts on platelets, it can help prevent the clots that can lead to a stroke. But because aspirin acts on platelets, it can also increase the risk of <a href="https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797#:%7E:text=While%20daily%20aspirin%20can%20help,of%20developing%20a%20stomach%20ulcer.">unwanted bleeding</a>, usually in the stomach. It can also increase your risk of bleeding more when you have another injury, like hitting your head. Aspirin isn’t just used for the prevention of strokes. It is also the first aid treatment for someone undergoing a <a href="https://www.nps.org.au/australian-prescriber/articles/acute-myocardial-infarction-early-treatment">heart attack</a>. <h2>Findings of the Monash trial</h2> New <a href="https://dx.doi.org/10.1001/jamanetworkopen.2023.25803">research from Australia and the United States</a> reports results from the Aspirin in Reducing Events in the Elderly (ASPREE) trial. The researchers examined the protective use of daily low-dose aspirin (100 mg) in nearly 2,000 people who were aged 70 years and older and had no history of heart disease or stroke and whose blood pressure and cholesterol were well managed. When compared with placebo, aspirin didn’t reduce or increase the risk of stroke. Of the participants who took the aspirin, 195 or 4.6% had a stroke. Of those who took the placebo, 203 people or 4.7% had a stroke. But it did statistically increase the rate of non-stroke bleeding in the participants’ brains, for example when they injured their head. Those on aspirin showed a rate of bleeding in the brain of 1.1% (108 participants) compared with 0.8% (79 people) for those on placebo. This is a relatively, low but serious, risk. These findings are not entirely new. <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1800722?query=featured_home">Research</a> published five years ago based on the same ASPREE trial showed a similar result: a higher rate of bleeding among those taking low-dose aspirin compared with placebo. However as the study authors note, aspirin continues to be widely used for the prevention of stroke. <h2>What are the study’s limitations?</h2> The researchers examined aspirin in mostly people of white European heritage. So we don’t know whether the results are translatable to people with different ethnic backgrounds. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594139/">Genetics and ethnicity</a> can significantly impact the efficacy and safety of some drugs. The clinical trial only included people who were not significantly at risk of a stroke, and had no history of heart disease. Younger age groups were not studied either, so we cannot make any conclusions about their use of low dose aspirin to prevent stroke. It’s also possible the potential benefits and risks are different for those who have underlying heart problems or who have previously had a stroke and are therefore at higher risk of another stroke. <h2>I’m taking aspirin, what should I do?</h2> If you’re taking daily low-dose aspirin and are concerned by the results of the study, it’s important you don’t just stop taking your medicine. Speak to your doctor or pharmacist. For people who are at high risk of having a stroke, or have previously had one, low-dose aspirin may remain their treatment of choice despite the slight bleeding risk. If you’re at high risk of bleeding, for example because of falls and other accidents due to advanced age, frailty, or another underlying condition, your doctor may be able to reduce the amount of aspirin you take by adding in <a href="https://www.nps.org.au/australian-prescriber/articles/dipyridamole">dipyridamole</a> or prescribing a different medicine completely, such as <a href="https://www.nps.org.au/australian-prescriber/articles/clopidogrel">clopidogrel</a>.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/210388/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/nial-wheate-96839">Nial Wheate</a>, Associate Professor of the Sydney Pharmacy School, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/tina-hinton-329706">Tina Hinton</a>, Associate Professor of Pharmacology, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> Image credits: Getty Images This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/daily-aspirin-doesnt-prevent-strokes-in-older-healthy-people-after-all-210388">original article</a>.

Body

How to prevent travel-related deep vein thrombosis

No matter your transportation of choice, sitting motionless for long periods of time puts people at increased risk of deep vein thrombosis (DVT). DVT refers to blood clots that form deep in your veins, usually in the calf or leg, and results in the sensation of a swollen, painful limb. If you’ve been susceptible to DVT in your past travels, there are a few simple things to do to combat the problem. <ul> <li>Stand up and walk around at least every hour to keep blood flowing</li> <li>Exercise your calf muscles by standing on tip-toes a few times</li> <li>If you can’t walk around, exercise legs by stretching them, flexing feet and curling or pressing toes frequently</li> <li>Drink lots of fluids, especially water, to prevent dehydration</li> <li>Reduce alcohol and coffee consumption, which contributes to dehydration</li> <li>Avoid crossing your legs when seated or at least for long periods of time</li> <li>Wear compression stockings that put on gentle pressure on leg muscles.</li> <li>Don’t wear regular socks that are right or have tight elastic bands at top</li> <li>Skip the aspirin; there’s no evidence that it’s effective as a preventative measure</li> </ul> Image credits: Getty Images

Travel Tips

13 things neurologists do to help prevent Alzheimer’s disease

Understand Alzheimer's disease Alzheimer’s disease is the leading cause of dementia. But all dementia is not Alzheimer’s, says Dr David Knopman, a neurologist at the Mayo Clinic in Minnesota. Dementia is a general term used to describe a set of symptoms that may include memory loss and difficulties with thinking, problem-solving or language. Alzheimer’s is a physical disease that targets the brain, causing problems with memory, thinking and behaviour. It is also age-related (symptoms usually start at age 65) and progressive, as symptoms usually worsen over time. Research shows that plaques and tangles two proteins that build up and block connections between nerve cells and eventually kill nerve cells in the brain, cause Alzheimer’s symptoms. Get enough sleep When you toss and turn all night, levels of brain-damaging proteins in the cerebrospinal fluid can rise: A 2017 study in Brain suggests that those with chronic sleep problems during middle age may increase their risk of Alzheimer’s later in life. “You have to commit to the importance of sleep,” says neurologist Dr Gayatri Devi. “I prioritise sleep as one of the most important activities I do – I will leave a party early in order to get a good night’s sleep.” Stay socially active Say yes to those social invitations! A 2019 study published in PLOS Medicine found that social activity with friends in your 60s could lower your risk of dementia by 12%. “There is something intrinsically valuable about social engagement,” says Dr Knopman. “It makes sense that those who are more engaged, especially socially, will think more positively and have a better outlook on life.” Keep learning People with advanced degrees have a lower risk of Alzheimer’s, according to 2017 research published in the BMJ. Education seems to build a ‘cognitive reserve’, which enables the brain to better resist neurological damage. “Higher education has a powerful effect,” says Dr Knopman. It’s never too late, check out the continuing education courses offered online or near you. Learn a second language Speaking more than one language can protect against Alzheimer’s disease and other types of dementia, according to 2017 research published in Clinical Interventions in Aging. While no one is sure why a second language helps so much, Dr Knopman theorises that the effort to communicate bilingually is like a workout for the brain, helping preserve grey matter and neurons. Do it yourself Challenging your brain in new ways can enhance memory as you age. Dr Devi has her own take on this: “If there is a problem with the phone or the plumbing, I will try to fix it,” she says. “If I try to figure out how to fix this on my own, it is good for my brain.” Right now she’s designing and building a window seat. “It is a way to keep different parts of my brain thriving.” Stay active Exercise is crucial to your wellness and your brain. Research published in Cureus in 2020, found that people who exercise regularly can slow cognitive decline. According to the Alzheimer’s Society, the combined results of 11 studies indicate that regular exercise can reduce the risk of developing dementia by about 30%; it drops the risk of Alzheimer’s by 45%. “When you are physically active, you burn more calories and you’re less likely to be obese,” explains Dr Knopman. “You’ll have better cardiovascular health because you are pushing your heart rate.” Take care of your heart “What is good for the heart is good for the brain,” says Dr Devi. Conditions such as high blood pressure, diabetes and high cholesterol, which increase the risk of cardiovascular disease, may also increase the risk of developing Alzheimer’s, and a 2017 study in JAMA found that middle-aged people with risk factors for heart attacks and stroke are also more likely to develop changes in the brain that can lead to the disease. “Anything that keeps the heart healthy is directly related to brain health,” Dr Devi says. It also reduces the risk of stroke, which can cause its own kind of dementia – vascular dementia. Lower your stress levels Persistent stress can take a toll on the brain, and 2018 research published in Neurobiology of Stress indicates that chronic stress can accelerate Alzheimer’s disease. When you’re stressed, your body releases cortisol, a hormone linked to memory trouble. In addition, experts have found that stress can lead to conditions such as depression and anxiety, which also increases the risk for dementia, according to research in Current Opinion in Psychiatry. “Eliminating stress helps reduce the amount of cortisol and optimises glucose utilisation, which your brain needs for food,” says Dr Devi. Try the MIND diet A combination of the Mediterranean diet and the DASH (Dietary Approaches to Stop Hypertension) diet, the MIND diet is designed specifically for brain health. (MIND is short for Mediterranean-DASH Diet Intervention for Neurodegenerative Delay.) The diet is pretty pleasant: you eat at least three servings of whole grains a day, two portions of vegetables (one of which must be a leafy green), snack on nuts, eat lean proteins like chicken and fish, berries, and have a glass of wine a day. According to research in Alzheimer’s & Dementia, those who adhered to the diet rigorously were able to lower their risk of cognitive decline later in life. You can’t trust all diets, warns Dr Knopman, but he likes this approach: “I tell my patients that if you follow a reasonable diet with lots of fresh fruits and vegetable that balances different food groups, and avoid obesity, you will be okay.” Get your snoring checked out Another way to wreck your sleep without realising it is with sleep apnea. According to the US National Institutes of Health, sleep apnoea occurs when a person’s upper airway becomes blocked repeatedly during sleep, reducing or completely stopping airflow. Many factors – from obesity to large tonsils to neuromuscular disorders – can cause sleep apnoea. Sleep apnoea not only prevents restful sleep, but untreated it can increase the risk of developing certain health conditions. “If left untreated, sleep apnoea has significant cardiovascular consequences and consequences of mental function,” says Dr Knopman. Protect your head According to the Alzheimer’s Association, there is a strong link between serious head trauma and developing Alzheimer’s later in life, especially if the injury involves loss of consciousness. A 2017 review of research in PLOS One suggests head injuries that require medical attention may increase the risk of dementia and Alzheimer’s disease. Wear a helmet while cycling, make your home fall-proof, and always use a seat belt to help protect your noggin. Drink a cup of tea Green tea has loads of health benefits – including some for your brain. A 2019 systematic review in Nutrients found that green tea might reduce the risk of dementia. And research in the Journal of the American Chemical Society found that it’s a compound in the beverage that can disrupt the formation of toxic plaques that contribute to Alzheimer’s disease. Image credits: Getty Images This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/conditions/13-things-neurologists-do-to-help-prevent-alzheimers-disease?pages=1" target="_blank" rel="noopener">Reader's Digest</a>.

Mind

COVID nasal sprays may one day prevent and treat infection

We have vaccines to boost our immune response to SARS-CoV-2, the virus that causes COVID. We have medicines you can take at home (and in hospital) to treat COVID. Now researchers are trialling something new. They want to develop drugs that stop the virus getting into the body in the first place. That includes nasal sprays that stop the virus attaching to cells in the nose. Other researchers are looking at the potential for nasal sprays to stop the virus replicating in the nose, or to make the nose a hostile place to enter the body. Here’s where the science is up to and what we can expect next. <h2>How could we block the virus?</h2> “Viral blockade”, as the name suggests, is a simple premise based on blocking SARS-CoV-2. In other words, if something gets in its way, the virus cannot attach to a cell and it can’t infect you. As SARS-CoV-2 is a respiratory virus, it makes sense to deliver this type of medicine where the virus mainly enters the body – via the nose, in a nasal spray. There are various groups around the world working on this concept. Some research is still being conducted in the lab. Some agents have progressed to preliminary human trials. None are yet available for widespread use. Heparin Heparin is a common medicine that’s been used for decades to thin the blood. Studies in mice show that when heparin is delivered via the nose, <a href="https://link.springer.com/article/10.1007/s11095-022-03191-4" target="_blank" rel="noopener">it’s safe</a> and <a href="https://journals.asm.org/doi/10.1128/JVI.01987-20" target="_blank" rel="noopener">effective</a> in preventing the virus binding to nose cells. Researchers believe heparin binds to the virus itself and stops the virus attaching to the cells it’s trying to infect. A <a href="https://clinicaltrials.gov/ct2/show/NCT05204550" target="_blank" rel="noopener">clinical trial</a> is being <a href="https://www.premier.vic.gov.au/covid-nasal-spray-treatment-clinical-trials-begin" target="_blank" rel="noopener">conducted in Victoria</a> in collaboration between multiple Melbourne-based research centres and the University of Oxford. Covixyl-V Covixyl-V (ethyl lauroyl arginine hydrochloride) is another nasal spray <a href="https://assets.researchsquare.com/files/rs-911449/v1/0577f1f1-56f8-476f-97f6-d27d332ea9ca.pdf?c=1643375660" target="_blank" rel="noopener">under development</a>. It aims to prevent COVID by blocking or modifying the cell surface to prevent the virus from infecting. This compound has been explored for use in various viral infections, and <a href="https://assets.researchsquare.com/files/rs-911449/v1/0577f1f1-56f8-476f-97f6-d27d332ea9ca.pdf?c=1643375660" target="_blank" rel="noopener">early studies</a> in cells and small animals has shown it can prevent attachment of SARS-CoV-2 and reduce the overall viral load. Iota-carrageenan This molecule, which is extracted from seaweed, acts by blocking virus entry into <a href="https://www.frontiersin.org/articles/10.3389/fviro.2021.746824/full" target="_blank" rel="noopener">airway cells</a>. One study of about 400 health-care workers suggests a nasal spray may reduce the incidence of COVID <a href="https://www.dovepress.com/efficacy-of-a-nasal-spray-containing-iota-carrageenan-in-the-postexpos-peer-reviewed-fulltext-article-IJGM" target="_blank" rel="noopener">by up to 80%</a>. IGM-6268 This is <a href="https://www.nature.com/articles/s41586-021-03673-2" target="_blank" rel="noopener">an engineered antibody</a> that binds to SARS-CoV-2, <a href="https://www.sciencedaily.com/releases/2021/06/210603171306.htm" target="_blank" rel="noopener">blocking</a> the virus from attaching to cells in the nose. A nasal and oral (mouth) spray are in a clinical trial <a href="https://clinicaltrials.gov/ct2/show/NCT05184218?term=IGM-6268&draw=2&rank=2" target="_blank" rel="noopener">to assess safety</a>. Cold atmospheric plasma This is a gas that contains charged particles. At cold temperatures, it can <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165322" target="_blank" rel="noopener">alter the surface</a> of a cell. A <a href="https://www.thno.org/v12p2811.htm" target="_blank" rel="noopener">lab-based study</a> shows the gas changes expression of receptors on the skin that would normally allow the virus to attach. This results in less SARS-CoV-2 attachment and infection. Scientists now think this technology could be adapted to a nasal spray to prevent SARS-CoV-2 infection. <h2>How could we stop the virus replicating?</h2> Another tactic is to develop nasal sprays that stop the virus replicating in the nose. Researchers are designing genetic fragments that bind to the viral RNA. These fragments – known as “<a href="https://www.nature.com/articles/s41467-022-32216-0" target="_blank" rel="noopener">locked nucleic acid antisense oligonucleotides</a>” (or LNA ASOs for short) – put a proverbial spanner in the works and stop the virus from replicating. A spray of these genetic fragments delivered into the nose <a href="https://www.nature.com/articles/s41467-022-32216-0" target="_blank" rel="noopener">reduced virus replication in the nose</a> and prevented disease in small animals. <h2>How could we change the nose?</h2> A third strategy is to change the nose environment to make it less hospitable for the virus. That could be by using a nasal spray to change moisture levels (with saline), alter the pH (making the nose more acidic or alkaline), or adding a virus-killing agent (iodine). Saline can reduce the amount of <a href="https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2768627" target="_blank" rel="noopener">SARS-CoV-2 in the nose</a> by simply washing away the virus. One study has even found that saline nasal irrigation <a href="https://journals.sagepub.com/doi/10.1177/01455613221123737" target="_blank" rel="noopener">can lessen COVID disease</a> severity. But we would need further research into saline sprays. An Australian-led study has found that an iodine-based nasal spray <a href="https://www.theajo.com/article/view/4466/html" target="_blank" rel="noopener">reduced the viral load</a> in the nose. Further <a href="https://www.uwa.edu.au/news/Article/2022/February/Study-finds-nasal-spray-could-aid-battle-against-COVID" target="_blank" rel="noopener">clinical trials</a> are planned. <a href="https://www.sciencedirect.com/science/article/pii/S1386653222001809#!" target="_blank" rel="noopener">One study</a> used a test spray – containing ingredients including eucalyptus and clove oils, potassium chloride and glycerol. The aim was to kill the virus and change the acidity of the nose to prevent the virus attaching. This novel formulation has been tested in the lab and in a <a href="https://www.sciencedirect.com/science/article/pii/S1386653222001809#!" target="_blank" rel="noopener">clinical trial</a> showing it to be safe and to reduce infection rate from about 34% to 13% when compared to placebo controls. <h2>Barriers ahead</h2> Despite promising data so far on nasal sprays for COVID, one of the <a href="https://www.nature.com/articles/d41586-022-03341-z" target="_blank" rel="noopener">major barriers</a> is keeping the sprays in the nose. To overcome this, most sprays need multiple applications a day, sometimes every few hours. So based on what we know so far, nasal sprays will not singlehandedly beat COVID. But if they are shown to be safe and effective in clinical trials, and receive regulatory approval, they might be another tool to help prevent it. This article originally appeared on <a href="https://theconversation.com/covid-nasal-sprays-may-one-day-prevent-and-treat-infection-heres-where-the-science-is-up-to-193840" target="_blank" rel="noopener">The Conversation</a>. Image: Shutterstock

Body

Sounds great: Scientists are manipulating dreams to prevent nightmares

It’s estimated that at any given time, around 4% of adults suffer <a href="https://cosmosmagazine.com/health/one-side-of-your-brain-might-be-giving-you-nightmares/" target="_blank" rel="noreferrer noopener">chronic nightmares</a> but researchers in Switzerland have a new approach which will be music to the ears of night-terror-sufferers. Basing their study on the relationship between the types of <a href="https://cosmosmagazine.com/science/biology/nightmares-and-night-terrors-in-kids-when-do-they-stop-being-normal/" target="_blank" rel="noreferrer noopener">emotions experienced in dreams</a> and our emotional well-being, researchers have investigated how to help people by manipulating emotions in their dreams. Traditional methods to help chronic nightmare patients involves ‘imagery rehearsal therapy’, during which they are coached to rehearse the dream scenario during the day and redirect it towards a more positive ending. A <a href="https://link.springer.com/article/10.1007/s11818-021-00320-w" target="_blank" rel="noreferrer noopener">2021 study</a> of 28 participants showed 3 in 5 patients benefitted from this approach, however, it doesn’t work for everyone. <div class="newsletter-box"> <div id="wpcf7-f6-p220659-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> In a <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(22)01477-4" target="_blank" rel="noreferrer noopener">study from Geneva University</a>, over a two-week period, researchers asked a group of 18 patients to create an association between the positively redirected version of their dream and a sound during an imagination exercise. The patients then wore wireless headbands during night which would play the specific sound during the REM (Rapid Eye Movement) stage of sleep – when <a href="https://www.mayoclinic.org/diseases-conditions/nightmare-disorder/symptoms-causes/syc-20353515" target="_blank" rel="noreferrer noopener">nightmares typically occur</a>. When compared to 18 patients who undertook only the image rehearsal therapy, those who received the combined rehearsal and sound therapy had fewer nightmares. This trend continued even after three months post-intervention, with those receiving combination therapy also reporting experiencing more positive emotions such as ‘joy’ in their dreams. “We were positively surprised by how well the participants respected and tolerated the study procedures, for example performing imagery rehearsal therapy every day and wearing the sleep headband during the night,” says Lampros Perogamvros, senior author of the study and a psychiatrist at the Sleep Laboratory of the Geneva University Hospitals and the University of Geneva. “We observed a fast decrease of nightmares, together with dreams becoming emotionally more positive. For us, researchers and clinicians, these findings are very promising both for the study of emotional processing during sleep and for the development of new therapies.” <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=220659&title=Sounds+great%3A+Scientists+are+manipulating+dreams+to+prevent+nightmares" width="1" height="1" /> <div id="contributors"> <a href="https://cosmosmagazine.com/health/sounds-great-preventing-nightmares/" target="_blank" rel="noopener">This article</a> was originally published on Cosmos Magazine and was written by Clare Kenyon. Image: Getty Images </div>

Mind

Your dog can get dementia - here’s how to prevent it

Just like us, dogs can experience cognitive decline as they age. They can also risk developing a neurodegenerative condition called Canine Cognitive Dysfunction (CCD), a condition similar to Alzhheimer’s Disease. Like Alzheimer’s, symptoms dogs with CCD can experience include a loss of spatial awareness, memory deficiencies, disrupted sleep, and altered social interactions. Both CCD and Alzheimer’s also share symptoms found in the brain itself, including <a href="https://oversixty.com.au/health/mind/alzheimer-s-marker-found-in-the-brain" target="_blank" rel="noopener">the buildup of fragments of a protein called beta-amyloid</a> in between nerve cells. According to a new study published in the journal <a href="https://doi.org/10.1038/s41598-022-15837-9" target="_blank" rel="noopener">Scientific Reports</a>, the risk of developing CCD increases by 68 percent each year after dogs turn 10. The team studied a whopping 15,019 dogs that took part in a longitudinal study called the Dog Ageing Project. Between 2019 and 2020, the owners of participating pets completed two surveys about the health status and physical activity of their dogs. They also completed the Canine Social and Learned Behaviour survey, which tested for symptoms of CCD such as dogs failing to recognise familiar people. But, they also found that older pooches that were very active had a much smaller risk of developing the condition in comparison to less active dogs of the same breed and health - with the more sedentary dogs having a 6.47 times higher risk of having CCD. They stress that their study doesn’t show that a lack of physical activity causes CCD, and are calling for more research to determine whether CCD is caused by less physical activity or if the inactivity is caused by CCD. Because of the similarities between CCD and Alzheimer’s disease, the team argue that means that researching CCD could have implications for our understanding and treatment of Alzheimer’s, and vice versa. For example, the association between physical activity and lower risks of CCD come after numerous studies showing this relationship in rodents <a href="https://oversixty.com.au/health/mind/the-surprising-reason-exercise-improves-symptoms-of-alzheimer-s" target="_blank" rel="noopener">and in humans</a>. “These observations may reflect a variety of biologic mechanisms, including a reduction of pro-inflammatory cytokines in the brain that otherwise contribute to neural damage and death, and an increase in neural plasticity,” they write of the studies with rodents and people, adding that these mechanisms might also explain the link between physical activity and CCD risk. “Given increasing evidence of the parallels between canine and human cognitive disease, accurate CCD diagnosis in dogs may provide researchers with more suitable animal models in which to study ageing in human populations.” Image: Getty Images

Family & Pets

Having ‘good’ posture doesn’t prevent back pain, and ‘bad’ posture doesn’t cause it

Back pain is the leading cause of <a href="https://pubmed.ncbi.nlm.nih.gov/24665116/" target="_blank" rel="noopener">disability</a> worldwide. Most people experience an episode of back pain in their lifetime. It often emerges during <a href="https://pubmed.ncbi.nlm.nih.gov/29112007/" target="_blank" rel="noopener">adolescence</a> and becomes more common in adults. For <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771685/" target="_blank" rel="noopener">25%</a> of people who develop back pain, it can become persistent, disabling and distressing. It can affect a person’s ability to participate in activities of <a href="https://pubmed.ncbi.nlm.nih.gov/31369481/" target="_blank" rel="noopener">daily living, physical activity and work</a>. Activities such as sitting, standing, bending and lifting frequently aggravate back pain. There is a common belief that “good” posture is important to protect the spine from damage, as well as prevent and treat back pain. Good posture is commonly defined as sitting “upright”, standing “tall and aligned”, and lifting with a squat technique and “straight back”. Conversely, “slump” sitting, “slouch” standing and lifting with a “round back” or stooped posture are frequently warned against. This view is widely held by people <a href="https://pubmed.ncbi.nlm.nih.gov/23806489/" target="_blank" rel="noopener">with and without back pain</a>, as well as clinicians in both <a href="https://pubmed.ncbi.nlm.nih.gov/30553985/" target="_blank" rel="noopener">occupational health and primary care</a> settings. Surprisingly, there is a lack of evidence for a strong relationship between “good” posture and back pain. Perceptions of “good” posture originate from a combination of social desirability and unfounded presumptions. Systematic reviews (studies looking at a number of studies in one area) have found <a href="https://pubmed.ncbi.nlm.nih.gov/20360197/" target="_blank" rel="noopener">ergonomic interventions</a> for workers, and advice for manual workers on the <a href="https://pubmed.ncbi.nlm.nih.gov/19734238/" target="_blank" rel="noopener">best posture for lifting</a>, have not reduced work-related back pain. <h2>Sitting and standing posture</h2> Our group has conducted several studies exploring the relationship between spine posture and back pain. We investigated whether “slump” sitting or “non-neutral” standing postures (overarching or slouching the back, for example), in a large population of adolescents, were <a href="https://pubmed.ncbi.nlm.nih.gov/21350031/%20https://pubmed.ncbi.nlm.nih.gov/18758367/" target="_blank" rel="noopener">associated with</a>, or <a href="https://pubmed.ncbi.nlm.nih.gov/28915771/" target="_blank" rel="noopener">predicted</a> future back pain. We found little support for this view. These findings are consistent with systematic reviews that have found no consistent differences in <a href="https://pubmed.ncbi.nlm.nih.gov/31451200/" target="_blank" rel="noopener">sitting</a> or <a href="https://pubmed.ncbi.nlm.nih.gov/25012528/" target="_blank" rel="noopener">standing</a> posture between adult populations with and without back pain. People adopt a range of different spine postures, and no single posture <a href="https://pubmed.ncbi.nlm.nih.gov/31366294/" target="_blank" rel="noopener">protects a person from back pain</a>. People with both slumped and upright postures can experience <a href="https://pubmed.ncbi.nlm.nih.gov/16540876/" target="_blank" rel="noopener">back pain</a>. <h2>Lifting posture</h2> Globally accepted occupational health practices about “good” or safe back postures during lifting also lack evidence. Our systematic review found no evidence lifting with a <a href="https://pubmed.ncbi.nlm.nih.gov/31775556/" target="_blank" rel="noopener">round-back posture</a> is associated with or predictive of back pain. Our <a href="https://pubmed.ncbi.nlm.nih.gov/34288926/" target="_blank" rel="noopener">recent lab study</a> found people without back pain, employed in manual work for more than five years, were more likely to lift with a more stooped, round-back posture. In comparison, manual workers with back pain tended to adopt more of a squat lift with a <a href="https://pubmed.ncbi.nlm.nih.gov/34288926/" target="_blank" rel="noopener">straighter back</a>. In other words, people with back pain tend to <a href="https://pubmed.ncbi.nlm.nih.gov/31730537/" target="_blank" rel="noopener">follow “good” posture advice</a>, but people who don’t lift in the “good” way don’t have more back pain. In a small study, as people with disabling back pain recovered, they became <a href="https://pubmed.ncbi.nlm.nih.gov/32621351/" target="_blank" rel="noopener">less protective</a> and generally moved away from the “good” posture advice. <h2>If not posture – what else?</h2> There is no evidence for a single “good posture” to prevent or reduce back pain. People’s spines come in all shapes and sizes, so posture is highly individual. Movement is important for back health, so learning to <a href="https://pubmed.ncbi.nlm.nih.gov/31366294/" target="_blank" rel="noopener">vary and adopt different postures</a> that are comfortable is likely to be more helpful than rigidly adhering to a specific “good” posture. While back pain can be intense and distressing, for most people (90%) back pain is not associated with identifiable <a href="https://pubmed.ncbi.nlm.nih.gov/27745712/" target="_blank" rel="noopener">tissue damage or pathology</a>. Back pain can be like a sprain related to awkward, sudden, heavy or unaccustomed loads on our <a href="https://pubmed.ncbi.nlm.nih.gov/25665074/" target="_blank" rel="noopener">back</a>, but can also occur like a bad headache where there is no injury. Importantly, people are more vulnerable to back pain when their health is compromised, such as if someone is: <ul> <li> feeling <a href="https://pubmed.ncbi.nlm.nih.gov/20393261/" target="_blank" rel="noopener">stressed</a> </li> <li> experiencing low mood </li> <li> <a href="https://pubmed.ncbi.nlm.nih.gov/25665074/" target="_blank" rel="noopener">tired or fatigued</a> </li> <li> <a href="https://pubmed.ncbi.nlm.nih.gov/16741460/" target="_blank" rel="noopener">sleeping poorly</a> </li> <li> being less active. </li> </ul> Back pain is more likely to persist if a person: <ul> <li> becomes overly <a href="https://pubmed.ncbi.nlm.nih.gov/12446259/" target="_blank" rel="noopener">worried and fearful</a> about their back pain </li> <li> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771685/" target="_blank" rel="noopener">overprotects their back</a> and avoids movement, physical activity, work and social engagement. </li> </ul> <h2>What can people do about back pain?</h2> In a small group (1-5%), <a href="https://pubmed.ncbi.nlm.nih.gov/27745712" target="_blank" rel="noopener">back pain</a> can be caused by pathology including a fracture, malignancy, infection or nerve compression (the latter is associated with leg pain, and a loss of muscle power and sensation). In these cases, seek medical care. For most people (90%), back pain is associated with sensitisation of the back structures, but not identifiable tissue damage. In this situation, too much focus on maintaining “good” posture can be a distraction from other factors known to be important for spine health. These include: <ul> <li> moving and relaxing your back </li> <li> engaging in regular physical activity of your preference </li> <li> building confidence and keeping fit and strong for usual daily tasks </li> <li> maintaining healthy sleep habits and body weight </li> <li> caring for your general <a href="https://pubmed.ncbi.nlm.nih.gov/31892534/" target="_blank" rel="noopener">physical and mental health</a>. </li> </ul> Sometimes this requires some support and coaching with a skilled clinician. So if you are sitting or standing, find comfortable, relaxed postures and vary them. If you are lifting, the <a href="https://pubmed.ncbi.nlm.nih.gov/34288926/" target="_blank" rel="noopener">current evidence</a> suggests it’s OK to lift naturally – even with a round back. But make sure you are fit and strong enough for the task, and care for your overall health. This article originally appeared on <a href="https://theconversation.com/having-good-posture-doesnt-prevent-back-pain-and-bad-posture-doesnt-cause-it-183732" target="_blank" rel="noopener">The Conversation</a>. Image: Shutterstock

Body

I’m getting older, how can I prevent falls?

Falls are common. Each year <a href="https://www.who.int/publications/i/item/9789241563536">one in every three</a> people aged over 65 will fall. Around <a href="https://protect-au.mimecast.com/s/TmbBC6XQ4LfoyR3W3CpQkee?domain=cambridge.org">one in ten falls</a> lead to serious injury. Most of us have a friend or relative who has experienced an injury from a fall and know what a life-changing event it can be. The most common serious injuries are fractures and brain injuries. Falls can also result in a loss of confidence, which can lead to restriction of activity and a lower quality of life. Many older people never regain their pre-fall level of function and might even struggle to keep living by themselves. The consequences of falls cost Australia a staggering <a href="https://www.aihw.gov.au/reports/injury/falls-in-older-australians-2019-20-hospitalisation/contents/about">$4.3 billion</a> every year. The good news is <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012424.pub2/full">20-30% of falls</a> among older Australians can be prevented. Why do we fall in older age? Falls happen when there is a mismatch between our physical abilities and the immediate demands of the environment or activity being undertaken. Falls become more common as we get older because as we age, there is a natural decline in muscle strength, balance and vision, all of which are important for helping us stay upright. The risk of falls is increased by certain medical conditions (such as Parkinson’s disease, dementia and stroke) and certain medications (such as sleeping tablets). But this doesn’t mean falls are inevitable. Exercise makes the most difference <a href="https://bjsm.bmj.com/content/54/15/885">Exercise</a> that aims to improve balance and leg strength is the most effective in preventing falls. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=400&fit=crop&dpr=1 600w, https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=400&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=400&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=503&fit=crop&dpr=1 754w, https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=503&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/462685/original/file-20220512-15-imz9uz.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=503&fit=crop&dpr=3 2262w" alt="Older people doing yoga" /></a><figcaption>Exercise for strength and balance should be done often. Shutterstock</figcaption></figure> This means exercise that is carried out while standing (not while seated), with the feet positioned close together or while standing on one leg (if safe to do so), while performing controlled movement of the upper body (leaning and reaching movements, for example). Balance training combined with strength training for the major muscle groups is most effective. These exercises need to be tailored to individual abilities. Middle-aged people with good physical function will benefit from harder exercises (such as functional training at a gym or boot camp incorporating squats and step-ups). <a href="https://www.safeexerciseathome.org.au/">Effective exercises</a> for people with impaired physical function or frailty will follow the same principles but should be modified for safety and effectiveness. These include everyday activities such as standing up from a seated position without using arms for support, walking up and down stairs, walking in one line, stepping over obstacles or balancing on one leg. For lasting impacts, it’s important this type of exercise is done often. The <a href="https://www.who.int/news-room/fact-sheets/detail/physical-activity">World Health Organization</a> recommends incorporating these exercises two to three times a week as part of the 150-300 minutes a week of moderate activity recommended for improving health. Not everyone enjoys exercising, which means some people struggle to prioritise it. It’s very important to know nobody is ever “too old” to start exercising, and benefits are gained at any age. But don’t hold off to start exercising either – the earlier we start to build our strength and balance, the better off we will be in our older years. Starting small and building up the amount and intensity of activity, and choosing something enjoyable, are the best ways to start. If you can’t reach a high dose of exercise initially, any amount is better than nothing. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=420&fit=crop&dpr=1 600w, https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=420&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=420&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=528&fit=crop&dpr=1 754w, https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=528&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/462622/original/file-20220512-12-qljf6d.png?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=528&fit=crop&dpr=3 2262w" alt="Woman sitting in chair. Woman pushing herself up with her legs. Woman standing." /></a><figcaption>Simple sit-to-stand exercises can improve strength and balance. Shutterstock</figcaption></figure> If you like exercising in a group, consider finding a local program and invite a friend along for added support and social connection. Your <a href="https://www.activeandhealthy.nsw.gov.au/">state government</a> or local council should have their classes listed online. If you’re not sure where to start, the best thing to do is to seek professional help to select exercises that suit your abilities and health conditions. Talk to your GP, local <a href="https://choose.physio/find-a-physio">physio</a> or <a href="https://www.essa.org.au/find-aep/">exercise physiologist</a>. What else can we do to prevent falls? In addition to exercise to improve balance and strength, other actions that can reduce the risk of falls include talking to your doctor or pharmacist to review your medications, seeing a podiatrist if you have painful feet, and maximising the safety of your home environment by installing adequate lighting and grab rails, and ensuring walkways are free from clutter and liquid spills. <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=1000&fit=clip"><img src="https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=400&fit=crop&dpr=1 600w, https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=400&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=400&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=503&fit=crop&dpr=1 754w, https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=503&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/462669/original/file-20220512-20-arf332.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=503&fit=crop&dpr=3 2262w" alt="Man with his GP" /></a><figcaption>If you have had a fall or are worried about mobility, talk to your GP. Shutterstock</figcaption></figure> Falls are not inevitable as we age. We need investment in strategies to help older Australians stay active and independent, and avoid falls. Despite knowing what works to avoid them, we have no national policy or strategy to implement and fund fall prevention programs. Doing so would not only help older Australians, but the budget bottom-line too.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/182043/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/anne-tiedemann-409380" target="_blank" rel="noopener">Anne Tiedemann</a>, Professor of Physical Activity and Health, <a href="https://theconversation.com/institutions/university-of-sydney-841" target="_blank" rel="noopener">University of Sydney</a>; <a href="https://theconversation.com/profiles/cathie-sherrington-561141" target="_blank" rel="noopener">Cathie Sherrington</a>, Professor, <a href="https://theconversation.com/institutions/university-of-sydney-841" target="_blank" rel="noopener">University of Sydney</a>, and <a href="https://theconversation.com/profiles/kim-delbaere-667" target="_blank" rel="noopener">Kim Delbaere</a>, Senior Principal Research Scientist, <a href="https://theconversation.com/institutions/neuroscience-research-australia-976" target="_blank" rel="noopener">Neuroscience Research Australia</a> This article is republished from <a href="https://theconversation.com" target="_blank" rel="noopener">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/im-getting-older-how-can-i-prevent-falls-182043" target="_blank" rel="noopener">original article</a>. Image: Getty Images

Body

6 warning signs of kidney stones – and what you can do to prevent them

Who develops kidney stones? Professor of urology, Dr Christopher Coogan, says about 10 to 15 per cent of the population will develop kidney stones in their lifetimes, small hard mineral deposits formed in the kidney that can be painful to pass, with white men ages 40 to 60 the most likely to have kidney stones. Those who already have had a kidney stone have a 50 per cent chance of developing another within 10 years. But how do you know if what you have is a kidney stone opposed to stomach or back pain? Sudden and severe pain Adults are often diagnosed with kidney stones after a trip to the emergency room or visit to their primary physician because of sudden severe abdominal and/or back pain they’ve been experiencing. This sudden and severe pain in the stomach and/or one side of the back is one of the classic symptoms of kidney stones. “Pain associated with kidney stones often comes on suddenly and is sometimes described as excruciating as the pain associated with labour,” says Dr Douglas Propp. Severe pain from which you can find no relief helps differentiate pain associated with kidney stones from a stomach ache or back strain. Pain associated with kidney stones can sometimes be confused with a backache because pain associated with kidney stones can start higher up in the back. As the stone moves closer to the bladder, the location of the pain can move lower. An important difference though: the back pain that accompanies kidney stones is unlike the pain of typical back strains because it is not associated with any movement. “One can usually figure out which side the kidney stone is on because the pain will typically, although not always, be on one side of the stomach versus the other,” says Dr Coogan. Kidney stones can range in size; Dr Coogan notes the average size of a kidney stone is 5 millimetres. However, the size of the stone doesn’t necessarily affect how much pain someone is in. Even a very tiny kidney stone can cause a “whole lot of hurt,” says Dr Coogan. Kidney stones can be so painful that they awaken people from sleep and prevent them from finding a standing, sitting, or lying down position that provides relief. “The pain can come on at any time and is severe, typically preventing the individual from finding a comfortable position, says Dr Propp. Blood in the urine Another possible warning sign of kidney stones is finding blood in one’s urine. Dr Coogan says this occurs in the majority of patients who have kidney stones. Blood in the urine is an abnormal condition and you should get evaluated if you notice this symptom. Other warning signs While sudden and severe stomach and/or back pain and blood in the urine can be key indicators of kidney stones, Dr Propp and Dr Coogan noted other warning signs that patients should look for: <ul> <li>Nausea</li> <li>Vomiting</li> <li>Perspiring</li> <li>Turning very pale because of the pain</li> <li>Certain types of kidney stones can also cause infections, which can lead to fevers.</li> </ul> “When the kidney gets obstructed, it can lead to fever because there can be back up of urine and that can lead to an infection,” says Dr Coogan. How kidney stones are diagnosed and treated Kidney stones can be diagnosed through X-ray, ultrasound, or CAT scan and are typically found after a person visits the emergency room or makes an appointment with their primary care physician because of the pain they’ve been experiencing. Dr Propp says most patients pass their kidney stones, leading to significant relief of their symptoms. But some kidney stones require surgery to remove them. Doctors sometimes prescribe medication to either manage the pain associated with kidney stones or to help the stone pass. “The smaller the stone is the more likely it is to pass on its own, not requiring surgery,” says Dr Coogan. How to prevent kidney stones Dr Coogan says one way people can prevent kidney stones from developing is to drink enough water, as dehydration is considered one of the main causes. Water helps to dilute the substances in urine that lead to kidney stones. You should also watch your sodium intake. A high-sodium diet can increase the amount of calcium in your urine. When calcium combines with oxalate or phosphorus, it creates kidney stones. Keep your sodium intake to no more than 2300 milligrams (mg) a day; if you’ve had kidney stones in the past, reduce that amount to 1500 mg. Limiting your animal protein can also help. Too much animal protein, such as red meat, poultry, eggs, and seafood, increases the amount of uric acid in your body. Uric acid is another kidney stone culprit. Written by Colette Harris. This article first appeared in <a href="https://www.readersdigest.com.au/healthsmart/6-warning-signs-of-kidney-stones-and-what-you-can-do-to-prevent-them" target="_blank" rel="noopener">Reader’s Digest</a>. For more of what you love from the world’s best-loved magazine, <a href="http://readersdigest.innovations.com.au/c/readersdigestemailsubscribe?utm_source=over60&utm_medium=articles&utm_campaign=RDSUB&keycode=WRA87V" target="_blank" rel="noopener">here’s our best subscription offer.</a>

Body

How having pets could prevent owners from memory loss

A recent study has concluded that owning a pet may help owners reduce the chance of memory loss later in life. The study, conducted by The University of Michigan Medical Centre, tested more than 1,300 people with an average age of 65. Fifty-three per cent of the participants had pets at the time the study commenced, and almost a third of this group had owned their pet for more than five years. The participants of the study were asked to partake in linguistic and numerical tests over a series of sessions to test their long and short term memory. Owners of animals including dogs, cats and rabbits were found to have held onto more of their cognitive abilities when tracked over a six year period. There is increasing evidence that stress can lead to cognitive decline, with experts believing that pets may help us to stay mentally sharp by reducing stress. Those with dogs also benefit from regular walks as exercise is linked to a healthier brain. Dr Tiffany Braley, who led the study, said, “Prior studies have suggested that the human-animal bond may have health benefits like decreasing blood pressure and stress.” “Our results suggest pet ownership may also be protective against cognitive decline.” While the results of the study seem overwhelmingly positive, there is yet to be any definitive research on the long-term clinical benefits of owning a pet. Responding to the research, Dr Rosa Sancho, head of research at Alzheimer's Research UK, said, “Humans love their animals, and pets can be an important source of companionship and comfort throughout our lives.” “While this US-based study linked owning a pet with some protection in memory and thinking decline, it can't tell us if these are long-term benefits, or whether owning a pet has any bearing on dementia risk.” Image credits: Getty Images

Mind

Coffee may prevent chronic liver disease

<div class="copy"> Drinking coffee – whichever way you take it – may reduce the risk of liver disease, according to a new <a rel="noreferrer noopener" href="https://doi.org/10.1186/s12889-021-10991-7" target="_blank">study</a> published in the journal BMC Public Health. A team of researchers, from the universities of Southampton and Edinburgh in the UK, analysed <a rel="noreferrer noopener" href="https://www.ukbiobank.ac.uk/" target="_blank">UK Biobank</a> data on 495,585 participants, followed over roughly 11 years, to monitor the development of chronic liver disease and its relationship to coffee consumption. Coffee drinkers had a 21% reduced risk of chronic liver disease and a 49% reduced risk of death from liver disease, according to the study. The maximum benefit was found among those who drank ground coffee, which contains high levels of the ingredients kahweol and cafestol – which have been <a rel="noreferrer noopener" href="https://pubmed.ncbi.nlm.nih.gov/17590492/" target="_blank">shown</a> to be beneficial against liver disease in animal trials. But even instant coffee, which has low levels of these two key ingredients, had a marked benefit in reducing risk of liver disease, suggesting other ingredients or combinations are also beneficial. The find is important because chronic liver disease is a <a rel="noreferrer noopener" href="https://www.ncbi.nlm.nih.gov/books/NBK554597/" target="_blank">growing cause</a> of morbidity and mortality worldwide. “Coffee is widely accessible and the benefits we see from our study may mean it could offer a potential preventative treatment for chronic liver disease,” says lead author Oliver Kennedy, of the University of Southampton. “This would be especially valuable in countries with lower income and worse access to healthcare and where the burden of chronic liver disease is highest.” Coffee has <a rel="noreferrer noopener" href="https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/coffee-and-health/faq-20058339" target="_blank">often had a bad rap</a>, with early studies suggesting negative health impacts and a <a rel="noreferrer noopener" href="https://hellogiggles.com/lifestyle/health-fitness/health-benefits-caffeine-free/" target="_blank">bevy</a> of health gurus and online blogs espousing the benefits of abandoning the drink. But in recent years, a number of studies have demonstrated the potential benefits of coffee against a range of illnesses, including <a rel="noreferrer noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1125458/" target="_blank">Parkinson’s disease</a>, <a rel="noreferrer noopener" href="https://care.diabetesjournals.org/content/29/2/398" target="_blank">type 2 diabetes</a>, and <a rel="noreferrer noopener" href="https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.119.006799" target="_blank">heart failure</a>. The authors conducted their research based on the “biological plausibility” of coffee as a preventive factor in liver disease. Caffeine is a non-selective antagonist of the A2aA receptor. When activated, the A2aA receptor stimulates collagen production by hepatic stellate cells, which mitigate against liver fibrosis. Other active ingredients including kahweol, cafestol and chlorogenic acid have also been shown to protect against fibrosis in animal studies. The authors note that coffee consumption was only reported at initial enrolment into the study, so long-term changes in consumption are not accounted for. The participants in the study were also predominantly white and from higher socio-economic backgrounds, skewing the results towards particular physiologies and lifestyle factors, highlighting the need for further research. Image credits: Getty Images </div> <div id="contributors"> This article was originally published on <a href="https://cosmosmagazine.com/health/coffee-may-prevent-chronic-liver-disease/">cosmosmagazine.com</a> and was written by Amalyah Hart. </div>

Body

Safe, respected and free from violence: preventing violence against women in the Northern Territory

The Northern Territory has the <a href="https://territoryfamilies.nt.gov.au/__data/assets/pdf_file/0006/464775/Domestic,-Family-and-Sexual-Violence-Reduction-Framework.pdf">highest rates</a> of domestic, family, and sexual violence in Australia. Aboriginal women in the Northern Territory are among the most <a href="https://territoryfamilies.nt.gov.au/__data/assets/pdf_file/0006/464775/Domestic,-Family-and-Sexual-Violence-Reduction-Framework.pdf">victimised groups</a> of people in the entire world. Programs and services in the Northern Territory attempting to address these unacceptable levels of violence must do so with little support and funding. <a href="https://www.anrows.org.au/project/safe-respected-and-free-from-violence-an-evaluation-of-primary-prevention-projects/">A recent report</a> evaluated two community projects that aim to prevent violence against women by changing attitudes towards women and girls. It found these Indigenous-led community projects were having some success in helping to shift attitudes about gender stereotypes. <h2>Community-driven prevention projects</h2> The Tangentyere women’s group, a group of senior Aboriginal women from Alice Springs town camps that campaigns against family violence, has run two prevention projects that were recently evaluated: <a href="https://www.tangentyere.org.au/girls-can-boys-can">Girls Can Boys Can</a> and <a href="https://www.italkstudios.com.au/oldwaysarestrong/">Old Ways Are Strong</a>. These projects aimed to increase positive strength-based representations of Aboriginal children and families. Both of these projects were developed in partnership between the <a href="https://www.tangfamilyviolenceprevention.com.au/">Tangentyere Family Violence Prevention Program</a>, Larapinta Child and Family Centre, and iTalk Studio. The projects were also co-designed with Town Campers in Mparntwe/Alice Springs. These prevention projects focused on the drivers of violence against Aboriginal women, such as: • gendered factors, including gender inequality • the impacts of colonisation on Aboriginal people, families and communities • the power imbalance between non-Indigenous people and Aboriginal people, including systemic and structural inequalities. Girls Can Boys Can developed gender-equitable messaging and resources for early childhood educators to be used in classroom and playgroup settings. This messaging aimed to help structure conversations around gender equality and challenge gender stereotypes. Old Ways Are Strong developed animations to challenge the racist attitude that violence is a part of traditional Aboriginal cultures. The messages and resources from these projects were distributed throughout the community through workshops, merchandise and posters, as well as across social media and local television networks. <h2>How the programs were evaluated</h2> <a href="https://www.anrows.org.au/project/safe-respected-and-free-from-violence-an-evaluation-of-primary-prevention-projects/">The evaluation</a> of these programs involved 60 surveys with local community members and 16 interviews with project staff. There were also 110 social media surveys, 18 animation audience surveys and 36 training feedback surveys. The data from the surveys and interviews was compared to the data collected before the projects began (the baseline) to see whether they had any impact on people’s attitudes, beliefs and/or knowledge about gender, violence and Aboriginal cultures. These are three key findings: 1. Violence prevention staff lacks training and funding The evaluation showed workforce capacity grew considerably through the projects. Most project staff were early childhood educators or working in learning centres, while some worked in specialist domestic, family, and sexual violence services. Staff knowledge about violence against women, its drivers, and how to prevent it increased dramatically through their work on the projects. However, the evaluation also found Northern Territory primary prevention work (which focuses on the causes of violence) receives limited funding, and there is also no funding for the workforce itself. As a result, the staff do this prevention work on top of their usual roles. They were continuing to teach their classes or support women experiencing violence, while also planning and delivering primary prevention workshops. As an analogy, this is akin to a doctor in the emergency department dealing with car crash casualties while also producing resources that explain the importance of wearing a seat belt. The project staff essentially learned about violence prevention on the job. They received little or no prior training and received no support outside of the partner organisations. They also reported high levels of burnout and vicarious trauma, and felt unsupported in their primary prevention work. One key participant reflected: <blockquote> That’s generally how the roles transpire is that you do end up in a crisis response mode, rather than being given the tools to (actually do) that work. </blockquote> 2. Explicit direct messaging could shift people’s attitudes A small number of the survey participants, who were mostly from Alice Springs Town Camps, were surveyed at the beginning and end of the evaluation. Although the sample size was small, there was a shift in their attitudes towards gender roles. In the baseline survey, the respondents said things such as “girls can’t play footy” or “boys can’t cry”. In the survey at the end, 90% of the respondents demonstrated at least one positive shift toward the idea that girls/women and boys/men can do the same things. The most positive changes were found among respondents who had a high level of participation in the projects. This perhaps shows repeated and intensive messaging is needed for messages to resonate among people. 3. How ‘jealousing’ is used to justify violence The surveys also showed a high proportion of respondents justified violence against women in certain situations (44% in the baseline group, and 52% in the post-project group). It’s important to note these groups were made up of mostly different people. The justification of violence was linked to jealousy or “jealousing”. Respondents were more likely to justify violence in cases or situations associated with real or imagined sexual misconduct, for example, if a woman comes home late or looks at another man. Said one participant: <blockquote> It’s not alright (to use violence), but a lot of (jealous violence) does happen. A woman shouldn’t be texting another man if they have feelings for her. </blockquote> The surveys showed how this concept of “jealousing” plays out in gendered ways. For men in particular, perceived sexual entitlement might play a role in justifying violence and coercive and controlling behaviour. Although the projects were not targeted at the problem of “jealousing”, this finding could provide direction for future work. <h2>How can we improve violence prevention programs?</h2> The evaluation showed the importance of explicit and direct messaging – or “talking straight” as it’s called in Central Australia. Messaging about gender-based violence that was implied but not explicitly stated had less of an impact. In future projects, explicit and accessible messaging should be used to challenge highly entrenched attitudes and beliefs, such as the misconception that traditional Aboriginal cultures condone violence against women. The link between “jealousing” and justification of violence highlighted the need for education about healthy relationships in schools and communities. Explicit messaging must challenge the notion that possessiveness is “normal”, acceptable or even “desirable” in a partner. This is one of the most important and urgent issues for the domestic, family, and sexual violence sector to tackle in the Northern Territory. Funding for dedicated primary prevention workers is also important. These workers need a commitment from different levels of government to adequately fund, resource, and support their work.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/172243/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/chay-brown-1252113">Chay Brown</a>, Research and Partnerships Manager, The Equality Institute, & Postdoctoral fellow, <a href="https://theconversation.com/institutions/australian-national-university-877">Australian National University</a>; <a href="https://theconversation.com/profiles/carmel-simpson-1292133">Carmel Simpson</a>, Co-coordinator of Tangentyere Women’s Family Safety Group, <a href="https://theconversation.com/institutions/indigenous-knowledge-4846">Indigenous Knowledge</a>, and <a href="https://theconversation.com/profiles/shirleen-campbell-1292134">Shirleen Campbell</a>, Co-coordinator of Tangentyere Women’s Family Safety Group, <a href="https://theconversation.com/institutions/indigenous-knowledge-4846">Indigenous Knowledge</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/safe-respected-and-free-from-violence-preventing-violence-against-women-in-the-northern-territory-172243">original article</a>.

Family & Pets

Could Viagra help prevent Alzheimer’s disease?

Viagra is used by millions of people each year to treat erectile dysfunction. But new research shows that it might not just be helpful in the bedroom – there’s a suggestion that Viagra may also help to prevent Alzheimer’s disease. Despite what it’s best known for, sildenafil – marketed as Viagra – isn’t a one-trick pony. It was <a rel="noreferrer noopener" href="https://cosmosmagazine.com/science/biology/how-i-discovered-viagra/" target="_blank">originally developed to treat angina</a> – although it didn’t make it through trials – and there’s some evidence it could <a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">help </a><a rel="noreferrer noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">t</a><a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">reat malaria</a>. Tadalafil, a similar drug to Viagra, <a rel="noreferrer noopener" href="https://cosmosmagazine.com/health/medicine/sex-med-looks-promising-as-heart-failure-drug/" target="_blank">has been proposed</a> as a heart failure treatment. A <a rel="noreferrer noopener" href="https://doi.org/10.1038/s43587-021-00138-z" target="_blank">paper</a> in Nature Aging has expanded its potential further, using records from insurance claims to examine the link between Viagra and Alzheimer’s disease. The researchers, who are based in the US, examined the insurance records of 7.23 million people, alongside genetic and other biological data. They looked through the data to pull out indicators of Alzheimer’s disease, and then examined the relationship between these indicators and over 1,600 prescribed medicinal drugs. Viagra had the highest link to lower chance of Alzheimer’s, with its prescription being associated with a 69% reduced risk of the disease. The researchers point out that while this link is significant, it doesn’t establish causality: it may be that Viagra prevents Alzheimer’s, or it may be that people who have fewer biological precursors to Alzheimer’s are also more likely to recieve a Viagra prescription. There could also be other confounding factors at play. Sildenafil, for instance, is more likely to be prescribed to wealthy people, and wealthy people are also less likely to get Alzheimer’s disease. The sample size of Viagra users was also – unsurprisingly – mostly male. “Taken together, the association between sildenafil usage and decreased incidence of AD [Alzheimer’s disease] does not establish causality or its direction,” write the researchers in their paper. “Our results therefore warrant rigorous clinical trial testing of the treatment efficacy of sildenafil in patients with AD, inclusive of both sexes and controlled by placebo.”  <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=175427&title=Could+Viagra+help+prevent+Alzheimer%E2%80%99s+disease%3F" alt="" width="1" height="1" />  <div id="contributors"> <a rel="noopener" href="https://cosmosmagazine.com/health/medicine/viagra-prevent-alzheimers-disease-study/" target="_blank">This article</a> was originally published on <a rel="noopener" href="https://cosmosmagazine.com" target="_blank">Cosmos Magazine</a> and was written by <a rel="noopener" href="https://cosmosmagazine.com/contributor/ellen-phiddian" target="_blank">Ellen Phiddian</a>. Ellen Phiddian is a science journalist at Cosmos. She has a BSc (Honours) in chemistry and science communication, and an MSc in science communication, both from the Australian National University. Image: Getty Images </div>

Mind

Could Viagra help prevent Alzheimer’s disease?

<h1>Insurance shows a link between Viagra prescription and a lower chance of the disease. </h1> <div class="copy"> Viagra is used by millions of people each year to treat erectile dysfunction. But new research shows that it might not just be helpful in the bedroom – there’s a suggestion that Viagra may also help to prevent Alzheimer’s disease. Insurance shows a link between Viagra prescription and a lower chance of the disease. Despite what it’s best known for, sildenafil – marketed as Viagra – isn’t a one-trick pony. It was <a rel="noreferrer noopener" href="https://cosmosmagazine.com/science/biology/how-i-discovered-viagra/" target="_blank">originally developed to treat angina</a> – although it didn’t make it through trials – and there’s some evidence it could <a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">help </a><a rel="noreferrer noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">t</a><a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">reat malaria</a>. Tadalafil, a similar drug to Viagra, <a rel="noreferrer noopener" href="https://cosmosmagazine.com/health/medicine/sex-med-looks-promising-as-heart-failure-drug/" target="_blank">has been proposed</a> as a heart failure treatment. A <a rel="noreferrer noopener" href="https://doi.org/10.1038/s43587-021-00138-z" target="_blank">paper</a> in Nature Aging has expanded its potential further, using records from insurance claims to examine the link between Viagra and Alzheimer’s disease. The researchers, who are based in the US, examined the insurance records of 7.23 million people, alongside genetic and other biological data. They looked through the data to pull out indicators of Alzheimer’s disease, and then examined the relationship between these indicators and over 1,600 prescribed medicinal drugs. Viagra had the highest link to lower chance of Alzheimer’s, with its prescription being associated with a 69% reduced risk of the disease. The researchers point out that while this link is significant, it doesn’t establish causality: it may be that Viagra prevents Alzheimer’s, or it may be that people who have fewer biological precursors to Alzheimer’s are also more likely to receive a Viagra prescription. There could also be other confounding factors at play. Sildenafil, for instance, is more likely to be prescribed to wealthy people, and wealthy people are also less likely to get Alzheimer’s disease. The sample size of Viagra users was also – unsurprisingly – mostly male. “Taken together, the association between sildenafil usage and decreased incidence of AD [Alzheimer’s disease] does not establish causality or its direction,” write the researchers in their paper. “Our results therefore warrant rigorous clinical trial testing of the treatment efficacy of sildenafil in patients with AD, inclusive of both sexes and controlled by placebo.”  <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=175427&title=Could+Viagra+help+prevent+Alzheimer%E2%80%99s+disease%3F" alt="" width="1" height="1" /> </div> <div id="contributors"> <a href="https://cosmosmagazine.com/health/medicine/viagra-prevent-alzheimers-disease-study/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/ellen-phiddian">Ellen Phiddian</a>. </div>

Retirement Life

Plant based diets could prevent type 2 diabetes

Eating a diet high in plant foods with little or no red meat has been linked to a lower risk of type 2 diabetes in the most comprehensive scrutiny of this connection so far. This protective effect is even stronger for diets high in healthier plant foods such as fruits, vegetables, whole grains, legumes and nuts. Diabetes has been called “the fastest growing health crisis of our time”. At the same time, plant-based diets are gaining popularity. Therefore, the researchers thought it was important to quantify their link with diabetes risk, says first author Frank Qian from the Harvard TH Chan School of Public Health, US – especially given the large variation in these diets. The analysis, published in the Journal of the American Medical Association, included nine studies with more than 300,000 participants – of whom 23,544 had type 2 diabetes – over two to 28 years of follow-up. In the primary evaluation, Qian and co-authors focussed on an overall higher intake of plant-based foods along with little or no animal-based foods. Therefore, this included vegetarian or vegan dietary patterns. They found that people with the highest adherence to predominantly plant-based diets had a 23% reduced risk of type 2 diabetes compared to those with the lowest consumption of plant foods. But these dietary patterns didn’t exclude plant-derived foods that have been linked to higher diabetes risk, such as sugar and refined carbohydrates. When narrowing the analysis to four studies that defined a plant-based diet as the healthy whole food options, they found a 30% lower risk of type 2 diabetes. While it must be noted that the studies are observational, most, if not all, adjusted for well-known risk factors, including body mass index (BMI), gender, smoking status and family history of diabetes, among other potentially confounding variables. Several factors could explain the associations, the authors say. Plant-based diets typically include healthy plant foods packed with nutrients, polyphenols and fibre, which can improve insulin sensitivity, lower blood pressure, reduce inflammation and help maintain a healthy weight. All of these can lower the risk of type 2 diabetes. Conversely, eating red and processed meat has been linked to higher risk. Because the studies controlled for BMI, and excess weight and type 2 diabetes are a deadly duo, the authors suggest the associations they found could underestimate the actual degree of protection conferred by the diets. “Overall,” says senior author Qi Sun, “these data highlight the importance of adhering to plant-based diets to achieve or maintain good health.”  <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=26041&title=Plant-based+diets+could+prevent+type+2+diabetes" alt="" width="1" height="1" />  <div id="contributors"> <a href="https://cosmosmagazine.com/health/nutrition/plant-based-diets-could-prevent-type-2-diabetes/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/natalie-parletta">Natalie Parletta</a>. </div>

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Plant based diets could prevent type 2 diabetes